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雷公藤红素抑制成人T细胞白血病细胞增殖及机制 被引量:6
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作者 方金勇 衣凯宁 +3 位作者 宋早文 陈梦云 徐玲玲 赵铁军 《生物工程学报》 CAS CSCD 北大核心 2018年第9期1491-1499,共9页
本研究旨在分析雷公藤红素对成人T细胞白血病细胞增殖、凋亡的影响,并探讨其分子机制。使用不同浓度的雷公藤红素溶液处理多种成人T细胞白血病细胞株,通过四唑盐比色法(MTT)、克隆形成实验检测细胞的增殖情况;Annexin V/PI双染检测细胞... 本研究旨在分析雷公藤红素对成人T细胞白血病细胞增殖、凋亡的影响,并探讨其分子机制。使用不同浓度的雷公藤红素溶液处理多种成人T细胞白血病细胞株,通过四唑盐比色法(MTT)、克隆形成实验检测细胞的增殖情况;Annexin V/PI双染检测细胞凋亡情况;最后通过Western blotting及双荧光素酶报告基因技术探究雷公藤红素抑制成人T细胞白血病细胞生长的调控机制。结果表明雷公藤红素能显著抑制成人T细胞白血病细胞增殖并诱导其凋亡,随着雷公藤红素浓度的增加Bax/Bcl-2蛋白比率明显升高,凋亡途径中Caspase-3/7蛋白也随之被切割活化,同时病毒编码的癌蛋白Tax的表达也明显受到抑制。以上结果表明,雷公藤红素通过调控Bcl-2家族蛋白,激活了Caspase途径诱导细胞凋亡,并通过抑制病毒关键蛋白Tax的表达,从而有效抑制了成人T细胞白血病细胞的增殖。该研究为临床应用雷公藤红素治疗成人T细胞白血病提供了实验依据。 展开更多
关键词 雷公藤红素 成人T细胞白血病 增殖 凋亡 TAX蛋白
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Design of a wideband random phase gradient metasurface by using line-shaped element 被引量:1
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作者 Jiangniu Wu Yakuan Zhang +3 位作者 Chen Su Jing Sun jinyong fang Song Xia 《Journal of Advanced Dielectrics》 CAS 2020年第6期45-50,共6页
Based on phase randomization theory, a method for manufacturing metasurface with diffuse scatter performance is proposed. By using the line-shaped elements with random rotate angles and random distributing positions, ... Based on phase randomization theory, a method for manufacturing metasurface with diffuse scatter performance is proposed. By using the line-shaped elements with random rotate angles and random distributing positions, the metasurface can achieve good diffusion scatter performance with polarization independent characteristic. This paper studies the effects of the length of line-shaped elements on the metasurface response frequency and the radar cross section (RCS) reduction bandwidth. The simulated result shows that the wideband properties of metasurface benefit from two different length line-shaped elements. The proposed metasurface can reduce the RCS significantly for both normal and oblique incident waves. The line-shaped element is suitable for all sizes of detected objects and it can be directly sprayed on the detected object surface. To demonstrate the effectiveness of the proposed method, the metasurface prototype is fabricated and measured. Experimental results show that the fabricated metasur-face can effectively reduce RCS, and it has great application prospects in stealth technology. Keywords: Diffuse scatter characteristics;polarization independent;radar cross section reduction. 展开更多
关键词 Diffuse scatter characteristics polarization independent radar cross section reduction
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