Optimizing profile line interval for enhanced accuracy in rock joint morphology and shear strength assessments

2D profile lines play a critical role in cost-effectively evaluating rock joint properties and shear strength.However, the interval(ΔI_(L)) between these lines significantly impacts roughness and shear strength assessments. A detailed study of 45 joint samples using four statistical measures across 500 different ΔI_(L)values identified a clear line interval effect with two stages: stable and fluctuation-discrete.Further statistical analysis showed a linear relationship between the error bounds of four parameters,shear strength evaluation, and their corresponding maximum ΔI_(L)values, where the gradient k of this linear relationship was influenced by the basic friction angle and normal stress. Accounting for these factors,lower-limit linear models were employed to determine the optimal ΔI_(L)values that met error tolerances(1%–10%) for all metrics and shear strength. The study also explored the consistent size effect on joints regardless of ΔI_(L)changes, revealing three types of size effects based on morphological heterogeneity.Notably, larger joints required generally higher ΔI_(L)to maintain the predefined error limits, suggesting an increased interval for large joint analyses. Consequently, this research provides a basis for determining the optimal ΔI_(L), improving accuracy in 2D profile line assessments of joint characteristics.

Functionalized selenium nanoparticles ameliorated acetaminophen-induced hepatotoxicity through synergistically triggering PKCδ/Nrf2 signaling pathway and inhibiting CYP 2E1

Selenium nanoparticles(SeNPs)have been demonstrated potential for use in diseases associated with oxidative stress.Functionalized SeNPs with lower toxicity and higher biocompatibility could bring better therapeutic activity and clinical application value.Herein,this work was conducted to investigate the protective effect of Pleurotus tuber-regium polysaccharide-protein complex funtionnalized SeNPs(PTR-SeNPs)against acetaminophen(APAP)-induced oxidative injure in HepG2 cells and C57BL/6J mouse liver.Further elucidation of the underlying molecular mechanism,in particular their modulation of Nrf2 signaling pathway was also performed.The results showed that PTR-SeNPs could significantly ameliorate APAP-induced oxidative injury as evidenced by a range of biochemical analysis,histopathological examination and immunoblotting study.PTR-SeNPs could hosphorylate and activate PKCδ,depress Keap1,and increase nuclear accumulation of Nrf2,resulting in upregulation of GCLC,GCLM,HO-1 and NQO-1 expression.Besides,PTR-SeNPs suppressed the biotransformation of APAP to generate intracellular ROS through CYP 2E1 inhibition,restoring the mitochondrial morphology.Furthermore,the protective effect of PTR-SeNPs against APAP induced hepatotoxicity was weakened as Nrf2 was depleted in vivo,indicating the pivotal role of Nrf2 signaling pathway in PTR-SeNPs mediated hepatoprotective efficacy.Being a potential hepatic protectant,PTR-SeNPs could serve as a new source of selenium supplement for health-promoting and biomedical applications.

BV Structure on Hochschild Cohomology of Quantum Exterior Algebra with Two Variables

Let Ag=k(x,y)/(x^(2),xy+qyx,y^(2))over a field k.We give a clear character-ization of the Batalin-Vilkovisky algebraic structure on Hochschild cohomology of A_(q)for any q≠O,and the Gerstenhaber algebraic structure on Hochschild cohomology of A_(q)for q=0.

不同力度屏蔽蓝光对正常成年人眼视功能的影响

目的：探索不同程度屏蔽420．460nm波段蓝光镜片对人眼视功能的防护作用。方法：自身对照研究。2016年8月至2017年3月选择来自同济大学的健康大学生志愿者20例，先后在未戴镜，配戴屏蔽20％、30％、40％、60％防蓝光护目镜下，完成24个色区辨识评分和75min阅读任务。检测调节幅度、品状体调节力等指标，并做视疲劳问卷评分。采用配对秩和检验对各组数值进行分析。结果：配戴屏蔽30％、40％和60％防蓝光护目镜和未戴镜比较时，多个色区得分均低于未戴镜（P〈0．05）；而屏蔽20％与未戴镜比较，差异均无统计学意义。完成阅读任务后，在视疲劳调查问卷总得分上，屏蔽20％、30％、40％、60％蓝光得分低于未戴镜（均P〈0．05）。在用眼前后单眼调节幅度差值上、正相对调节差值上，屏蔽20％、30％、40％、60％蓝光变化幅度小于与未戴镜（均P〈0．05）；在用眼前后负相对调节差值上，40％、60％蓝光变化幅度小于未戴镜（P〈0．05）；屏蔽20％、30％蓝光和未戴镜比较差异无统计学意义。在用眼前后晶状体调节力差值上，屏蔽20％、30％、40％、60％蓝光和未戴镜相比差异无统计学意义。结论：屏蔽蓝光的波段以440nm为中心，带宽20nm，屏蔽力度20％以上时，可以改善人眼调节力、视疲劳主观症状。但屏蔽该段蓝光力度达30％以上时，会造成色差症状。