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Small molecule inhibitors of RORγt for Th17 regulation in inflammatory and autoimmune diseases 被引量:2
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作者 jiuping zeng Mingxing Li +17 位作者 Qianyun Zhao Meijuan Chen Long Zhao Shulin Wei Huan Yang Yueshui Zhao Anqi Wang Jing Shen Fukuan Du Yu Chen Shuai Deng Fang Wang Zhuo Zhang Zhi Li Tiangang Wang Shengpeng Wang Zhangang Xiao Xu Wu 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2023年第6期545-562,共18页
As a ligand-dependent transcription factor,retinoid-associated orphan receptor gt(RORγt)that controls T helper(Th)17 cell differentiation and interleukin(IL)-17 expression plays a critical role in the progression of ... As a ligand-dependent transcription factor,retinoid-associated orphan receptor gt(RORγt)that controls T helper(Th)17 cell differentiation and interleukin(IL)-17 expression plays a critical role in the progression of several inflammatory and autoimmune conditions.An emerging novel approach to the therapy of these diseases thus involves controlling the transcriptional capacity of RORγt to decrease Th17 cell development and IL-17 production.Several RORγt inhibitors including both antagonists and inverse agonists have been discovered to regulate the transcriptional activity of RORγt by binding to orthosteric-or allosteric-binding sites in the ligand-binding domain.Some of small-molecule inhibitors have entered clinical evaluations.Therefore,in current review,the role of RORγt in Th17 regulation and Th17-related inflammatory and autoimmune diseases was highlighted.Notably,the recently developed RORγt inhibitors were summarized,with an emphasis on their optimization from lead compounds,efficacy,toxicity,mechanisms of action,and clinical trials.The limitations of current development in this area were also discussed to facilitate future research. 展开更多
关键词 T helper 17 RORΓT Small-molecule inhibitor Inflammatory disease Autoimmune disease
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Chinese herbal medicines for treating ulcerative colitis via regulating gut microbiota-intestinal immunity axis 被引量:9
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作者 Yifei Yang Yi Wang +13 位作者 Long Zhao Fang Wang Mingxing Li Qin Wang Haoming Luo Qianyun Zhao jiuping zeng Yueshui Zhao Fukuan Du Yu Chen Jing Shen Shulin Wei Zhangang Xiao Xu Wu 《Chinese Herbal Medicines》 CAS 2023年第2期181-200,共20页
Ulcerative colitis(UC)is one of types of inflammatory bowel disease with high recurrence.Recent studies have highlighted that microbial dysbiosis as well as abnormal gut immunity are crucial factors that initiate a se... Ulcerative colitis(UC)is one of types of inflammatory bowel disease with high recurrence.Recent studies have highlighted that microbial dysbiosis as well as abnormal gut immunity are crucial factors that initiate a series of inflammatory responses in the UC.Modulating the gut microbiota-intestinal immunity loop has been suggested as one of key strategies for relieving UC.Many Chinese herbal medicines including some of single herb,herbal formulas and the derived constituents have been reported with protective effect against UC through modulating gut microbiome and intestinal immunity.Some clinical trials have shown promising results.This review thus focused on the current knowledge on using Chinese herbal medicines for treating UC from the mechanism aspects of regulating intestinal homeostasis involving microbiota and gut immunity.The existing clinical trials are also summarized. 展开更多
关键词 Chinese herbal medicines gut microbiota INFLAMMATION inflammatory bowel disease intestinal immunity ulcerative colitis
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