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Association of physical activity with risk of chronic kidney disease in China:A population-based cohort study 被引量:1
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作者 Kexiang Shi Yunqing Zhu +12 位作者 jun lv Dianjianyi Sun Pei Pei Huaidong Du Yiping Chen Ling Yang Bing Han Rebecca Stevens junshi Chen Zhengming Chen Liming Li Canqing Yu China Kadoorie Biobank collaborative group 《Journal of Sport and Health Science》 SCIE CAS CSCD 2024年第2期204-211,共8页
Background:Information on the association between physical activity(PA)and the risk of chronic kidney disease(CKD)is limited.We aimed to explore the associations of total,domain-specific,and intensity-specific PA with... Background:Information on the association between physical activity(PA)and the risk of chronic kidney disease(CKD)is limited.We aimed to explore the associations of total,domain-specific,and intensity-specific PA with CKD and its subtypes in China.Methods:The study included 475,376 adults from the China Kadoorie Biobank aged 30-79 years during 2004-2008 at baseline.An interviewer-administered questionnaire was used to collect the information about PA,which was quantified as metabolic equivalent of task hours per day(MET-h/day)and categorized into 4 groups based on quartiles.Cox regression was used to analyze the association between PA and CKD risk.Results:During a median follow-up of 12.1 years,5415 incident CKD cases were documented,including 1159 incident diabetic kidney disease(DKD)cases and 362 incident hypertensive nephropathy(HTN)cases.Total PA was inversely associated with CKD risk,with an adjusted hazard ratio(HR,95%confidence interval(95%CI))of 0.83(0.75-0.92)for incident CKD in the highest quartile of total PA as compared with participants in the lowest quartile.Similar results were observed for risk of DKD and HTN,and the corresponding HRs(95%CIs)were 0.75(0.58-0.97)for DKD risk and 0.56(0.37-0.85)for HTN risk.Increased nonoccupational PA,low-intensity PA,and moderate-to-vigorous-intensity PA were significantly associated with a decreased risk of CKD,with HRs(95%CIs)of 0.80(0.73-0.88),0.85(0.77-0.94),and 0.85(0.76-0.95)in the highest quartile,respectively.Conclusion:PA,including nonoccupational PA,low-intensity PA,and moderate-to-vigorous-intensity PA,was inversely associated with the risk of CKD,including DKD,HTN,and other CKD,and such associations were dose dependent. 展开更多
关键词 Chronic kidney disease DOMAIN INTENSITY Physical activity
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Application of hydrochemistry and strontium isotope for understanding the hydrochemical characteristics and genesis of strontium-rich groundwater in karst area,Gongcheng County,Southwest China
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作者 Mi Tang jun lv +3 位作者 Shi Yu Yan Liu Shao-hong You Ping-ping Jiang 《Journal of Groundwater Science and Engineering》 2024年第3期264-280,共17页
Understanding the hydrochemical characteristics and genesis mechanisms of strontium-rich groundwater is pivotal for supporting the exploitation and utilization of natural strontium-rich groundwater.In this research,27... Understanding the hydrochemical characteristics and genesis mechanisms of strontium-rich groundwater is pivotal for supporting the exploitation and utilization of natural strontium-rich groundwater.In this research,27 groundwater samples were collected.By analyzing major ion chemistry and strontium isotope data,and considering the hydrogeological context,various analytical approaches,including multivariate statistics,ion ratios,and isotopes,were used to reveal the characteristics and genesis mechanisms of strontium-rich groundwater in the study area.The findings indicate that the predominant hydrochemical type of groundwater is HCO_(3)-Ca,with Ca^(2+)and HCO_(3)^(-)as the primary cations and anions.The hydrochemistry of the strontium-rich groundwater is predominantly influenced by rock weathering processes.A combination of factors,including ion exchange,and anthropogenic activities,shapes the compositional characteristics of the groundwater in the region.The dissolution of calcite due to weathering emerges as the principal source of strontium in the groundwater.While ion exchange processes are not conducive to strontium enrichment in groundwater,their effect is relatively limited.The impact of human activities on the groundwater is minor. 展开更多
关键词 Hydrochemistry analysis STRONTIUM ^(87)Sr/^(86)Sr GROUNDWATER Karst
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Tear inflammation related indexes after cataract surgery in elderly patients with type 2 diabetes mellitus
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作者 jun lv Cheng-Jian Cao +3 位作者 Wei Li Shuang-Le Li jun Zheng Xiu-Li Yang 《World Journal of Clinical Cases》 SCIE 2023年第2期385-393,共9页
BACKGROUND Quantitative studies on the changes in inflammation-related content in tears,especially the effect of diabetes,are lacking.In this study,we measured the preoperative and postoperative tear inflammatory medi... BACKGROUND Quantitative studies on the changes in inflammation-related content in tears,especially the effect of diabetes,are lacking.In this study,we measured the preoperative and postoperative tear inflammatory mediator levels in cataract patients,focusing on the expression of inflammatory factors in postoperative cataracts in the diabetic,and investigated the effect of drugs on the control of postoperative inflammation.AIM To study the expression of inflammatory factors in elderly people with type 2 diabetes after cataract surgery.METHODS Patients with a mean age of 70.3±6.3 years were divided into group A(composed of elderly patients with cataracts and type 2 diabetes,n=20 eyes)and group B(patients with age-related cataract,n=20 eyes).Their tears were collected before each operation and on days 1 and 3,and weeks 1,2,3,and 4 post-surgery.Saline(150μL)was dropped into the conjunctival sac of the surgical eye,followed by oculogyration in four directions.The fluid in the conjunctival sac was extracted using a sterile syringe and stored in Eppendorf tubes at-80°C until measurement.The expression levels of matrix metalloproteinase-2(MMP-2),MMP-9,tissue inhibitor of metalloproteinase-1(TIMP-1),TIMP-2,interleukin-6(IL-6),and IL-20 in tear fluid were measured using enzyme-linked immunosorbent assays.RESULTS The postoperative expression levels of MMP-2,MMP-9,TIMP-2,IL-6,and IL-20 in group A were significantly higher than those in group B,whereas the concentration of TIMP-1 in group A remained lower than that in group B.The levels of MMP-2 and IL-6 in both groups continuously increased until the peak in the first postoperative week,and then gradually decreased over the next three weeks.Ultimately,MMP-2 declined to a lower level than that preoperatively at week 4,but IL-6 decreased to the same level as that preoperatively.The level of MMP-9 peaked in the first two weeks postoperative and then returned to the same level as 1-day post-operation.The concentration of TIMP-1 post-operation remained constant at a lower level than before surgery,and TIMP-2 Levels remained stable in both groups.IL-20 content started to increase in the third week after surgery.CONCLUSION Inflammatory factor levels in tears fluctuated before and post-operation,which indicated more severe postoperative inflammation in the first two weeks. 展开更多
关键词 Type 2 diabetes mellitus Elderly patients Cataract surgery Tear inflammation-related indicators Temporal changes Prognosis
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调水工程对调蓄水库水温影响的研究 被引量:2
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作者 姚艳玲 张新周 +1 位作者 吕军 李祥 《水资源研究》 2018年第2期126-134,共9页
调水工程是解决地区水资源不足或时空分布不均衡问题的必要工程措施,不同水库间通过管道和河流调水会对调蓄水库水温产生影响。采用二维水流水温数学模型模拟了吉林省引松供水工程调水对调节水库石头口门水库水温的影响。计算结果表明,... 调水工程是解决地区水资源不足或时空分布不均衡问题的必要工程措施,不同水库间通过管道和河流调水会对调蓄水库水温产生影响。采用二维水流水温数学模型模拟了吉林省引松供水工程调水对调节水库石头口门水库水温的影响。计算结果表明,调水对调蓄水库水温影响的范围、时间主要和调水量、调水温差、水库水深、入水口位置等有密切关系。引松供水工程调水量和调蓄水库的水量相比很小,调水对水库水温分布的影响有限。调水入水口位于库尾,受影响的范围基本局限于水库库尾局部范围内,水温影响在1个月内即达到平衡,对整个库区和坝前影响很小。调水工程入水口远离坝址可以减小调水对调蓄水库及下游河流的影响程度。 展开更多
关键词 调水工程 调蓄水库 水温影响 数学模型
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Data mining in clinical big data:the frequently used databases,steps,and methodological models 被引量:24
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作者 Wen-Tao Wu Yuan-Jie Li +4 位作者 Ao-Zi Feng Li Li Tao Huang An-Ding Xu jun lv 《Military Medical Research》 SCIE CSCD 2021年第4期552-563,共12页
Many high quality studies have emerged from public databases,such as Surveillance,Epidemiology,and End Results(SEER),National Health and Nutrition Examination Survey(NHANES),The Cancer Genome Atlas(TCGA),and Medical I... Many high quality studies have emerged from public databases,such as Surveillance,Epidemiology,and End Results(SEER),National Health and Nutrition Examination Survey(NHANES),The Cancer Genome Atlas(TCGA),and Medical Information Mart for Intensive Care(MIMIC);however,these data are often characterized by a high degree of dimensional heterogeneity,timeliness,scarcity,irregularity,and other characteristics,resulting in the value of these data not being fully utilized.Data-mining technology has been a frontier field in medical research,as it demonstrates excellent performance in evaluating patient risks and assisting clinical decision-making in building disease-prediction models.Therefore,data mining has unique advantages in clinical big-data research,especially in large-scale medical public databases.This article introduced the main medical public database and described the steps,tasks,and models of data mining in simple language.Additionally,we described data-mining methods along with their practical applications.The goal of this work was to aid clinical researchers in gaining a clear and intuitive understanding of the application of data-mining technology on clinical big-data in order to promote the production of research results that are beneficial to doctors and patients. 展开更多
关键词 Clinical big data Data mining Machine learning Medical public database Surveillance Epidemiology and End Results National Health and Nutrition Examination Survey The Cancer Genome Atlas Medical Information Mart for Intensive Care
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Seven-day triple therapy is a better choice for Helicobacter pylori eradication in regions with low antibiotic resistance 被引量:12
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作者 Yue-Feng Tong jun lv +8 位作者 Li-Yuan Ying Fang Xu Bo Qin Ming-Tong Chen Fei Meng Miao-Ying Tu Ning-Min Yang You-Ming Li Jian-Zhong Zhang 《World Journal of Gastroenterology》 SCIE CAS 2015年第46期13073-13079,共7页
AIM: To investigate whether 7-d triple therapies are still valid in populations with low levels of resistance.METHODS: A total of 1106 Helicobacter pylori(H. pylori)-positive patients were divided into three groups,ea... AIM: To investigate whether 7-d triple therapies are still valid in populations with low levels of resistance.METHODS: A total of 1106 Helicobacter pylori(H. pylori)-positive patients were divided into three groups,each of which received one type of 7-d triple therapy. Therapeutic outcomes of the patients were assessed by the 13C-urea breath test at 8 wk after treatment. The susceptibility of H. pylori to antibiotics was determined by an agar-dilution method. Data analysis was performed by χ2 tests.RESULTS: The eradication rates in groups A,B and C were 90.71%(332/366),90.46%(313/346) and 90.87%(189/208),respectively(P = 0.986). The resistance rates were 8.91% for clarithromycin,14.78% for levofloxacin and 0% for amoxicillin. The eradication rate was significantly different between clarithromycin-and levofloxacin-resistant patients(P < 0.05) in group A. Patients whose treatment failed in group A also had a higher clarithromycin resistance rate than did successive patients(P = 0.034). However,levofloxacin resistance had no obvious influence on the eradication rate. Furthermore,three main antibiotics(clarithromycin,levofloxacin and amoxicillin) had lower DID(defined daily dose per 1000 inhabitants per day) in this city.CONCLUSION: Clarithromycin resistance is the main reason for the failure of 7-d triple therapy. In populations with low levels of resistance,a 7-d triple therapy is a viable choice. The choice of therapy should not be influenced by conditions in high antibiotic resistance regions. 展开更多
关键词 HELICOBACTER PYLORI Seven-day TRIPLE therapy Eradi
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Recent progress in pulsed electric field ablation for liver cancer 被引量:7
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作者 Zhen-Guo Liu Xin-Hua Chen +2 位作者 Zu-Jiang Yu jun lv Zhi-Gang Ren 《World Journal of Gastroenterology》 SCIE CAS 2020年第24期3421-3431,共11页
The number of liver cancer patients is likely to continue to increase in the coming decades due to the aging of the population and changing risk factors.Traditional treatments cannot meet the needs of all patients.New... The number of liver cancer patients is likely to continue to increase in the coming decades due to the aging of the population and changing risk factors.Traditional treatments cannot meet the needs of all patients.New treatment methods evolved from pulsed electric field ablation are expected to lead to breakthroughs in the treatment of liver cancer.This paper reviews the safety and efficacy of irreversible electroporation in clinical studies,the methods to detect and evaluate its ablation effect,the improvements in equipment and its antitumor effect,and animal and clinical trials on electrochemotherapy.We also summarize studies on the most novel nanosecond pulsed electric field ablation techniques in vitro and in vivo.These research results are certain to promote the progress of pulsed electric field in the treatment of liver cancer. 展开更多
关键词 Hepatocellular carcinoma Pulsed electric field Irreversible electroporation ELECTROCHEMOTHERAPY Nanosecond pulsed electric fields Ablation treatment
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Prognostic significance of erythropoietin and erythropoietin receptor in gastric adenocarcinoma 被引量:3
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作者 Lin Wang Hai-Gang Li +2 位作者 Zhong-Sheng Xia Jian-Ming Wen jun lv 《World Journal of Gastroenterology》 SCIE CAS CSCD 2011年第34期3933-3940,共8页
AIM: To investigate the expression of Erythropoietin (Epo) and its receptor (EpoR) in gastric adenocarcinoma (GAC) and the correlation with angiogenesis and clinicopathological features. METHODS: The expressions of Ep... AIM: To investigate the expression of Erythropoietin (Epo) and its receptor (EpoR) in gastric adenocarcinoma (GAC) and the correlation with angiogenesis and clinicopathological features. METHODS: The expressions of Epo, EpoR and vascular endothelial growth factor (VEGF), as well as mi-crovessel density were evaluated in 172 GAC biopsies by immunohistochemical staining. The correlations between these parameters and patient’s clinicopathological features were analyzed statistically. RESULTS: The proportion of Epo and EpoR alterations in GAC was higher than that in adjacent normal mucosa (P = 0.035 and 0.030). Epo high-expression was associ-ated with EpoR high-expression, Lauren type, extensivelymph node metastasis and advanced stage of GAC (P = 0.018, 0.018, 0.004 and 0), while EpoR expression was linked with older age, World Health Organization type, extensive lymph node metastasis and advanced stage (P = 0.001, 0.013, 0.008 and 0.001). VEGF high expression was significantly correlated with EpoR low-expression, Lauren type, extensive lymph node metastasis and advanced stage (P = 0.001, 0.001, 0.001 and 0.007). The expression of Epo or EpoR was associated with microvessel density (P = 0.004 and 0.046). On multivariate analysis, only lymph node metastasis, abnormal Epo expression and tumor nodes metastases stage were independently associated with survival. In addition, a strong association with the immunohistochemical expression of EpoR and the angiogenic protein, VEGF, was noted. CONCLUSION: Increased expression of Epo and EpoR may play a signif icant role in the carcinogenesis, angiogenesis and progression of GAC. Epo may be an inde-pendent prognostic factor. 展开更多
关键词 Erythropoietin Erythropoietin receptor Gas- tric adenocarcinoma Immunohistochemistry Prognosis
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Evaluation on Current Situation of the Water Ecology of the Main Rivers and Lakes in the Liaohe River Basin 被引量:1
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作者 Jisheng WU jun lv Tuanhao LIANG 《Meteorological and Environmental Research》 CAS 2020年第2期10-14,共5页
In this paper,15 rivers and 10 lake reservoirs in the Liaohe River basin were taken as research objects. Based on six indexes: satisfaction situation of ecological water demand,standard-reaching rate of water quality ... In this paper,15 rivers and 10 lake reservoirs in the Liaohe River basin were taken as research objects. Based on six indexes: satisfaction situation of ecological water demand,standard-reaching rate of water quality in water function area,eutrophication index of lakes and reservoirs,longitudinal connectivity of rivers,reserve rate of important wetlands and status of important aquatic habitat,water ecological conditions of main rivers and lakes in the basin were evaluated. The results showed that the rivers with better ecology were mainly distributed in east mountainous area of Liaoning,such as the upper reaches of the Hunhe River and the Taizi River;the problems of water pollution,ecological water shortage and habitat shrinkage were widespread in the Liaohe River basin,and the situation of water ecological security in the Liaohe River basin still faced great pressure. 展开更多
关键词 The Liaohe River BASIN MAIN RIVERS and LAKES EVALUATION on water ECOLOGY
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Expert consensus on prevention and cardiopulmonary resuscitation for cardiac arrest in COVID-19
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作者 Wei Song Jie Wei +42 位作者 Xiangdong Jian Deren Wang Yanhong Ouyang Yuanshui Liu Xianjin Du Ying Chen Yingqi Zhang Heping Xu Shuming Xianyu Qiong Ning Xiang Li Xiaotong Han Feng Zhan Tao Yu Wenteng Chen jun Zhang Wenwei Cai Sheng’ang Zhou Shengyang Yi Yu Cao Xiaobei Chen Shunjiang Xu Zong’an Liang Duohu Wu Fen Ai Zhong Wang Qingyi Meng Yuhong Mi Sisen Zhang Rongjia Yang Shouchun Yan Wenbin Han Yong Lin Chuanyun Qian Wenwu Zhang Yan Xiong jun lv Baochi Liu Yan Cao Xiaojun He Xuelian Sun Yufang Cao Tian’en Zhou 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2021年第6期241-253,共13页
Background:Cardiopulmonary resuscitation(CPR)strategies in COVID-19 patients differ from those in patients suffering from cardiogenic cardiac arrest.During CPR,both healthcare and non-healthcare workers who provide re... Background:Cardiopulmonary resuscitation(CPR)strategies in COVID-19 patients differ from those in patients suffering from cardiogenic cardiac arrest.During CPR,both healthcare and non-healthcare workers who provide resuscitation are at risk of infection.The Working Group for Expert Consensus on Prevention and Cardiopulmonary Resuscitation for Cardiac Arrest in COVID-19 has developed this Chinese Expert Consensus to guide clinical practice of CPR in COVID-19 patients.Main recommendations:1)A medical team should be assigned to evaluate severe and critical COVID-19 for early monitoring of cardiac-arrest warning signs.2)Psychological counseling and treatment are highly recommended,since sympathetic and vagal abnormalities induced by psychological stress from the COVID-19 pandemic can induce cardiac arrest.3)Healthcare workers should wear personal protective equipment(PPE).4)Mouth-to-mouth ventilation should be avoided on patients suspected of having or diagnosed with COVID-19.5)Hands-only chest compression and mechanical chest compression are recommended.6)Tracheal-intubation procedures should be optimized and tracheal-intubation strategies should be implemented early.7)CPR should be provided for 20-30 min.8)Various factors should be taken into consideration such as the interests of patients and family members,ethics,transmission risks,and laws and regulations governing infectious disease control.Changes in management:The following changes or modifications to CPR strategy in COVID-19 patients are proposed:1)Healthcare workers should wear PPE.2)Hands-only chest compression and mechanical chest compression can be implemented to reduce or avoid the spread of viruses by aerosols.3)Both the benefits to patients and the risk of infection should be considered.4)Hhealthcare workers should be fully aware of and trained in CPR strategies and procedures specifically for patients with COVID-19. 展开更多
关键词 SARS-CoV-2 COVID-19 Cardiac arrest CPR Nosocomial infection Personal protective equipment
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Thiourea-assisted coating of dispersed copper electrocatalysts on Si photocathodes for solar hydrogen production
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作者 Pin Wang Ziyu Yin +7 位作者 Linfeng Gao Hui Li Tongyu Zhang Qing Shen jun lv Yingfang Yao Wenjun Luo Zhigang Zou 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2020年第1期75-80,I0004,共7页
Photoelectrochemical water splitting can convert solar energy into clean hydrogen energy for storage.It is desirable to explore non-precious electrocatalysts for practical applications of a photoelectrode in a large s... Photoelectrochemical water splitting can convert solar energy into clean hydrogen energy for storage.It is desirable to explore non-precious electrocatalysts for practical applications of a photoelectrode in a large scale.Here,we developed a facile spin-coating and in-situ photoelectrochemical reduction method to prepare a dispersed Cu electrocatalyst on a Si photocathode,which improves the performance remarkably.We find that thiourea in the precursor solution for spin-coating plays an important role in obtaining dispersed Cu particles on the surface of a Si photoelectrode.With thiourea in the precursor,the Cu/Si photocathode shows higher performance than the one without thiourea.Moreover,the Cu/Si photocathode also indicates good stability after 16 h illumination. 展开更多
关键词 THIOUREA Hydrogen evolution reaction In-situ photoelectrochemical reduction Cu electrocatalyst
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Site Selection of Waste Slag Yard and Design of Protective Measures in Water Supply Project of Drawing from the Songhua River in Central Cities of Jilin
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作者 Hongchao LIU jun lv 《Meteorological and Environmental Research》 CAS 2021年第4期49-51,共3页
Water supply project of drawing from the Songhua River in central cities of Jilin is taken as research object.On the basis of analyzing project characteristics and natural conditions of the project area,site selection... Water supply project of drawing from the Songhua River in central cities of Jilin is taken as research object.On the basis of analyzing project characteristics and natural conditions of the project area,site selection of waste slag yard of water diversion project and design of water and soil conservation measures are discussed.Rationality of site selection of waste slag yard and pertinence of prevention and control measures of water and soil loss in waste slag yard are analyzed,and comprehensive utilization of waste slag in large-scale production and construction projects is explored. 展开更多
关键词 Waste slag yard Layout principle Prevention and control measures Comprehensive utilization of waste slag Water supply project of drawing from the Songhua River Jilin
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Analysis of Water Pollution Factors in the Downstream Water Functional Area of Songyuan City of the Songhua River
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作者 Fei YU jun lv +1 位作者 Hongchao LIU Wenbin SHAO 《Meteorological and Environmental Research》 CAS 2021年第4期43-47,共5页
Jihei buffer zone of the Second Songhua River in lower reaches of Songyuan City of the Songhua River was taken as the research object,and the current water quality,point source and non-point source pollution,and regio... Jihei buffer zone of the Second Songhua River in lower reaches of Songyuan City of the Songhua River was taken as the research object,and the current water quality,point source and non-point source pollution,and regional social and economic conditions of the buffer zone and its upstream water functional area were investigated.According to pollution sources and pollutant carrying capacity of water functional areas,analysis on main pollution factors in buffer zone was completed. 展开更多
关键词 Water quality Pollution source Pollutant carrying capacity Pollution factor
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Environmental Impact Assessment of Constructed Wetland in the Jiaohe River Estuary of the Songhua Lake
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作者 Chunfeng WEI Hongchao LIU jun lv 《Meteorological and Environmental Research》 CAS 2021年第4期52-53,56,共3页
Wetland plays an extremely important role in economy and ecological environment,and the construction of constructed wetland also has a certain impact on the environment.Via the evaluation on environmental status of co... Wetland plays an extremely important role in economy and ecological environment,and the construction of constructed wetland also has a certain impact on the environment.Via the evaluation on environmental status of constructed wetland,the main environmental problems are found out,and the impact of construction of constructed wetland project on local water environment and ecological environment is analyzed,and evaluation conclusion is obtained. 展开更多
关键词 Constructed wetland Environmental status Environmental impact assessment
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Preliminary Study on the Ecological Compensation of the Primary and Secondary Reserves in Drinking Water Source Area of the Shitoukoumen Reservoir
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作者 Chunfeng WEI Hongchao LIU jun lv 《Meteorological and Environmental Research》 CAS 2020年第3期12-15,20,共5页
The Shitoukoumen Reservoir is one of main drinking water source areas in Changchun City,and there is a contradiction between the protection and the economic development of water source areas. In this paper,the primary... The Shitoukoumen Reservoir is one of main drinking water source areas in Changchun City,and there is a contradiction between the protection and the economic development of water source areas. In this paper,the primary and secondary reserves in drinking water source area of the Shitoukoumen Reservoir are taken as research objects. Based on the theory of ecological compensation,the ecological compensation standard is accounted and determined from different perspectives,and the suggestion of the phased ecological compensation in water source areas is proposed. 展开更多
关键词 The Shitoukoumen Reservoir Water source area Ecological compensation
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A host E3 ubiquitin ligase regulates Salmonella virulence by targeting an SPI-2 effector involved in SIF biogenesis
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作者 Kun Meng Jin Yang +4 位作者 Juan Xue jun lv Ping Zhu Liuliu Shi Shan Li 《mLife》 CSCD 2023年第2期141-158,共18页
Salmonella Typhimurium creates an intracellular niche for its replication by utilizing a large cohort of effectors,including several that function to interfere with host ubiquitin signaling.Although the mechanism of a... Salmonella Typhimurium creates an intracellular niche for its replication by utilizing a large cohort of effectors,including several that function to interfere with host ubiquitin signaling.Although the mechanism of action of many such effectors has been elucidated,how the interplay between the host ubiquitin network and bacterial virulence factors dictates the outcome of infection largely remains undefined.In this study,we found that the SPI‐2 effector SseK3 inhibits SNARE pairing to promote the formation of a Salmonella‐induced filament by Arg‐GlcNAcylation of SNARE proteins,including SNAP25,VAMP8,and Syntaxin.Further study reveals that host cells counteract the activity of SseK3 by inducing the expression of the E3 ubiquitin ligase TRIM32,which catalyzes K48‐linked ubiquitination on SseK3 and targets its membrane‐associated portion for degradation.Hence,TRIM32 antagonizes SNAP25 Arg‐GlcNAcylation induced by SseK3 to restrict Salmonella‐induced filament biogenesis and Salmonella replication.Our study reveals a mechanism by which host cells inhibit bacterial replication by eliminating specific virulence factors. 展开更多
关键词 E3 ligase SALMONELLA SIF biogenesis T3SS SPl-2 effector
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Current status of deep learning in abdominal image reconstruction
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作者 Guang-Yuan Li Cheng-Yan Wang jun lv 《Artificial Intelligence in Medical Imaging》 2021年第4期86-94,共9页
Abdominal magnetic resonance imaging(MRI)and computed tomography(CT)are commonly used for disease screening,diagnosis,and treatment guidance.However,abdominal MRI has disadvantages including slow speed and vulnerabili... Abdominal magnetic resonance imaging(MRI)and computed tomography(CT)are commonly used for disease screening,diagnosis,and treatment guidance.However,abdominal MRI has disadvantages including slow speed and vulnerability to motions,while CT suffers from problems of radiation.It has been reported that deep learning reconstruction can solve such problems while maintaining good image quality.Recently,deep learning-based image reconstruction has become a hot topic in the field of medical imaging.This study reviews the latest research on deep learning reconstruction in abdominal imaging,including the widely used convolutional neural network,generative adversarial network,and recurrent neural network. 展开更多
关键词 Abdominal imaging RECONSTRUCTION Magnetic resonance imaging Computed tomography Deep learning
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Fullerene-derived boron-doped defective nanocarbon for highly selective H_(2)O_(2) electrosynthesis
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作者 Wangqiang Shen Chang Zhang +7 位作者 Muneerah Alomar Zhiling Du Zepeng Yang junjie Wang Guangqing Xu Jian Zhang jun lv Xing Lu 《Nano Research》 SCIE EI CSCD 2024年第3期1217-1224,共8页
Electrochemical production of hydrogen peroxide(H_(2)O_(2))via the two-electron(2e-)pathway of oxygen reduction reaction(ORR)supplies an auspicious alternative to the current industrial anthraquinone process.Nonethele... Electrochemical production of hydrogen peroxide(H_(2)O_(2))via the two-electron(2e-)pathway of oxygen reduction reaction(ORR)supplies an auspicious alternative to the current industrial anthraquinone process.Nonetheless,it still lacks efficient electrocatalysts to achieve high ORR activity together with 2e-selectivity simultaneously.Herein,a boron-doped defective nanocarbon(B-DC)electrocatalyst is synthesized by using fullerene frameworks as the precursor and boric oxide as the boron source.The obtained B-DC materials have a hierarchical porous structure,befitting boron dopants,and abundant topological pentagon defects,exhibiting a high ORR onset potential of 0.78 V and a dominated 2e-selectivity(over 95%).Remarkably,when B-DC electrocatalyst is employed in a real device,it achieves a high H_(2)O_(2) yield rate(247 mg·L^(-1)·h^(-1)),quantitative Faraday efficiency(~100%),and ultrafast organic pollutant degradation rate.The theoretical calculation reveals that the synergistic effect of topological pentagon defects and the incorporation of boron dopants promote the activation of the O_(2) molecule and facilitates the desorption of oxygen intermediate.This finding will be very helpful for the comprehension of the synergistic effect of topological defects and heteroatom dopants for boosting the electrocatalytic performance of nanocarbon toward H_(2)O_(2) production. 展开更多
关键词 FULLERENE electrochemical hydrogen peroxide production oxygen reduction reaction carbon nanomaterials
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Asymmetric NiH-Catalyzed Regioselective Hydroalkynylation of Unactivated Alkenes
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作者 Mengyuan Liu Haoran Shi +5 位作者 Xiao Meng Rui He Jie Huang Jiaxin Wang jun lv Chao Wang 《CCS Chemistry》 CSCD 2024年第8期1929-1940,共12页
Herein,we disclose a ligand-controlled,directing group-assisted strategy to facilitate NiH-catalyzed hydroalkynylation of allyl amides at remoteα-position adjacent to nitrogen and initial olefinic site in a predictab... Herein,we disclose a ligand-controlled,directing group-assisted strategy to facilitate NiH-catalyzed hydroalkynylation of allyl amides at remoteα-position adjacent to nitrogen and initial olefinic site in a predictable and switchable manner.Bromoalkynedependent regiodivergent hydroalkynylation and asymmetric hydroalkynylation with a wide alkyne scope were achieved,producingα-and(enantioenriched)β-branched alkynyl-functionalized amine derivatives from the same raw materials.The formation of a carbonyl-ligated 5-or 6-membered nickelacycle intermediate via Ni migration or nonmigration was believed to be the key step in controlling the regioselectivity.This asymmetric protocol could be applied to synthesizing other value-added chiral aliphatic amines. 展开更多
关键词 asymmetric catalysis hydroalkynylation regiodivergent chain-walking nickel catalysis
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Associations of polygenic risk scores with risks of stroke and its subtypes in Chinese
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作者 Songchun Yang Zhijia Sun +19 位作者 Dong Sun Canqing Yu Yu Guo Dianjianyi Sun Yuanjie Pang Pei Pei Ling Yang Iona Y Millwood Robin G Walters Yiping Chen Huaidong Du Yan Lu Sushila Burgess Daniel Avery Robert Clarke junshi Chen Zhengming Chen Liming Li jun lv On behalf of the China Kadoorie Biobank Collaborative Group 《Stroke & Vascular Neurology》 SCIE CSCD 2024年第4期399-406,I0044-I0065,共30页
Background and purpose Previous studies,mostly focusing on the European population,have reported polygenic risk scores(PRSs)might achieve risk stratification of stroke.We aimed to examine the association strengths of ... Background and purpose Previous studies,mostly focusing on the European population,have reported polygenic risk scores(PRSs)might achieve risk stratification of stroke.We aimed to examine the association strengths of PRSs with risks of stroke and its subtypes in the Chinese population.Methods Participants with genome-wide genotypic data in China Kadoorie Biobank were split into a potential training set(n=22191)and a population-based testing set(n=72150).Four previously developed PRSs were included,and new PRSs for stroke and its subtypes were developed.The PRSs showing the strongest association with risks of stroke or its subtypes in the training set were further evaluated in the testing set.Cox proportional hazards regression models were used to estimate the association strengths of different PRSs with risks of stroke and its subtypes(ischaemic stroke(IS),intracerebral haemorrhage(ICH)and subarachnoid haemorrhage(SAH)).Results In the testing set,during 872919 person-years of follow-up,8514 incident stroke events were documented.The PRSs of any stroke(AS)and IS were both positively associated with risks of AS,IS and ICH(p<0.05).The HR for per SD increment(HR_(SD))of PRSAS was 1.10(95%CI 1.07 to 1.12),1.10(95%CI 1.07 to 1.12)and 1.13(95%CI 1.07 to 1.20)for AS,IS and ICH,respectively.The corresponding HR_(SD) of PRS_(IS) was 1.08(95%CI 1.06 to 1.11),1.08(95%CI 1.06 to 1.11)and 1.09(95%CI 1.03 to 1.15).PRS_(ICH) was positively associated with the risk of ICH(HR_(SD)=1.07,95%CI 1.01 to 1.14).PRSS_(AH) was not associated with risks of stroke and its subtypes.The addition of current PRSs offered little to no improvement in stroke risk prediction and risk stratification.Conclusions In this Chinese population,the association strengths of current PRSs with risks of stroke and its subtypes were moderate,suggesting a limited value for improving risk prediction over traditional risk factors in the context of current genome-wide association study under-representing the East Asian population. 展开更多
关键词 testing PREDICTION INCREMENT
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