Clinicopathological significance and immunotherapeutic outcome of claudin 18.2 expression in advanced gastric cancer:A retrospective study

Objective: Immunotherapeutic outcomes and clinical characteristics of claudin 18 isoform 2 positive(CLDN18.2-positive) gastric cancer(GC) vary in different clinical studies, making it difficult to optimize antiCLDN18.2 therapy. We conducted a retrospective analysis to explore the association of CLDN18.2 expression with clinicopathological characteristics and immunotherapeutic outcomes in GC.Methods: A total of 536 advanced GC patients from 2019 to 2021 in the CT041-CG4006 and CT041-ST-01clinical trials were included in the analysis. CLDN18.2 expression on ≥40% of tumor cells(2+, 40%) and CLDN18.2 expression on ≥70% of tumor cells(2+, 70%) were considered the two levels of positively expressed GC. The clinicopathological characteristics and immunotherapy outcomes of GC patients were analyzed according to CLDN18.2 expression status.Results: CLDN18.2 was expressed in 57.6%(cut-off: 2+, 40%) and 48.9%(cut-off: 2+, 70%) of patients.Programmed death-ligand 1(PD-L1) and CLDN18.2 were co-expressed in 19.8% [combined positive score(CPS)≥1, CLDN18.2(cut-off: 2+, 40%)] and 17.2% [CPS≥5, CLDN18.2(cut-off: 2+, 70%)] of patients.CLDN18.2 expression positively correlated with younger age, female sex, non-gastroesophageal junction(nonGEJ), and diffuse phenotype(P<0.001). HER2 and PD-L1 expression were significantly lower in CLDN18.2-positive GC(both P<0.05). Uterine adnexa metastasis(P<0.001) was more frequent and liver metastasis(P<0.001)was less common in CLDN18.2-positive GC. Overall survival and immunotherapy-related progression-free survival(ir PFS) were inferior in the CLDN18.2-positive group.Conclusions: CLDN18.2-positive GC is associated with poor prognosis and worse immunotherapeutic outcomes. The combination of anti-CLDN18.2 therapy, anti-PD-L1/PD-1 therapy, and chemotherapy for GC requires further investigation.

Surface engineering of P2-type cathode material targeting long-cycling and high-rate sodium-ion batteries

The widespread interest in layered P2-type Mn-based cathode materials for sodium-ion batteries(SIBs)stems from their cost-effectiveness and abundant resources.However,the inferior cycle stability and mediocre rate performance impede their further development in practical applications.Herein,we devised a wet chemical precipitation method to deposit an amorphous aluminum phosphate(AlPO_(4),denoted as AP)protective layer onto the surface of P2-type Na_(0.55)Ni_(0.1)Co_(0.7)Mn_(0.8)O_(2)(NCM@AP).The resulting NCM@5AP electrode,with a 5 wt%coating,exhibits extended cycle life(capacity retention of78.4%after 200 cycles at 100 mA g^(-1))and superior rate performance(98 mA h g^(-1)at 500 mA g^(-1))compared to pristine NCM.Moreover,our investigation provides comprehensive insights into the phase stability and active Na^(+)ion kinetics in the NCM@5AP composite electrode,shedding light on the underlying mechanisms responsible for the enhanced performance observed in the coated electrode.

Application of Electronic Information Engineering in Hospital Management

To further enhance the overall service quality of China’s hospitals and improve the trust of the majority of patients in hospitals,this paper takes intelligent hospital management as the object of study,analyzes the importance of electronic information engineering technology applied in hospital management,and discusses the specific application methods of electronic information engineering in hospital management.This aims the existing problems in the current hospital management,such as insufficient degree of informatization,data sharing difficulties,lack of professionals,etc.Corresponding improvement measures are proposed,including strengthening the construction of informatization,promoting data sharing,and cultivating professionals.It is hoped that this study will enable the majority of hospital managers to make better use of electronic information engineering technology to effectively solve the current problems faced by hospitals and to continuously improve the comprehensive competitiveness of China’s hospitals.

Research and Implementation of Cancer Gene Data Classification Based on Deep Learning

Cancer has become a cause of concern in recent years. Cancer genomics is currently a key research direction in the fields of genetic biology and biomedicine. This paper analyzes 5 different types of cancer genes, such as breast, kidney, colon, lung and prostate through machine learning methods, with the goal of building a robust classification model to identify each type of cancer, which will allow us to identify each type of cancer early, thereby reducing mortality.

Research and Implementation of Traffic Sign Recognition Algorithm Model Based on Machine Learning

Traffic sign recognition is an important task in intelligent transportation systems, which can improve road safety and reduce accidents. Algorithms based on deep learning have achieved remarkable results in traffic sign recognition in recent years. In this paper, we build traffic sign recognition algorithms based on ResNet and CNN models, respectively. We evaluate the proposed algorithm on public datasets and compare. We first use the dataset of traffic sign images from Kaggle. And then designed ResNet-based and CNN-based architectures that can effectively capture the complex features of traffic signs. Our experiments show that our ResNet-based model achieves a recognition accuracy of 99% on the test set, and our CNN-based model achieves a recognition accuracy of 98% on the test set. Our proposed approach has the potential to improve traffic safety and can be used in various intelligent transportation systems.

The neuroprotective effects of oxygen therapy in Alzheimer’s disease:a narrative review

Alzheimer’s disease(AD)is a degenerative neurological disease that primarily affects the elderly.Drug therapy is the main strategy for AD treatment,but current treatments suffer from poor efficacy and a number of side effects.Non-drug therapy is attracting more attention and may be a better strategy for treatment of AD.Hypoxia is one of the important factors that contribute to the pathogenesis of AD.Multiple cellular processes synergistically promote hypoxia,including aging,hypertension,diabetes,hypoxia/obstructive sleep apnea,obesity,and traumatic brain injury.Increasing evidence has shown that hypoxia may affect multiple pathological aspects of AD,such as amyloid-beta metabolism,tau phosphorylation,autophagy,neuroinflammation,oxidative stress,endoplasmic reticulum stress,and mitochondrial and synaptic dysfunction.Treatments targeting hypoxia may delay or mitigate the progression of AD.Numerous studies have shown that oxygen therapy could improve the risk factors and clinical symptoms of AD.Increasing evidence also suggests that oxygen therapy may improve many pathological aspects of AD including amyloid-beta metabolism,tau phosphorylation,neuroinflammation,neuronal apoptosis,oxidative stress,neurotrophic factors,mitochondrial function,cerebral blood volume,and protein synthesis.In this review,we summarized the effects of oxygen therapy on AD pathogenesis and the mechanisms underlying these alterations.We expect that this review can benefit future clinical applications and therapy strategies on oxygen therapy for AD.

Mitophagy-related gene signature predicts prognosis,immune infiltration and chemotherapy sensitivity in colorectal cancer

BACKGROUND Mitophagy plays essential role in the development and progression of colorectal cancer(CRC). However, the effect of mitophagy-related genes in CRC remains largely unknown.AIM To develop a mitophagy-related gene signature to predict the survival, immune infiltration and chemotherapy response of CRC patients.METHODS Non-negative matrix factorization was used to cluster CRC patients from Gene Expression Omnibus database(GSE39582, GSE17536, and GSE37892) based on mitophagy-related gene expression. The CIBERSORT method was applied for the evaluation of the relative infiltration levels of immune cell types. The performance signature in predicting chemotherapeutic sensitivity was generated using data from the Genomics of Drug Sensitivity in Cancer database.RESULTS Three clusters with different clinicopathological features and prognosis were identified. Higher enrichment of activated B cells and CD4+ T cells were observed in cluster Ⅲ patients with the most favorable prognosis. Next, a risk model based on mitophagy-related genes was developed. Patients in training and validation sets were categorized into low-risk and highrisk subgroups. Low risk patients showed significantly better prognosis, higher enrichment of immune activating cells and greater response to chemotherapy(oxaliplatin, irinotecan, and 5-fluorouracil) compared to high-risk patients. Further experiments identified CXCL3 as novel regulator of cell proliferation and mitophagy.CONCLUSION We revealed the biological roles of mitophagy-related genes in the immune infiltration, and its ability to predict patients’ prognosis and response to chemotherapy in CRC. These interesting findings would provide new insight into the therapeutic management of CRC patients.

离心叶轮流场对背压脉动的响应特性研究

本文首先采用数值模拟方法开展高速离心压缩机叶轮出口下游背压脉动的流场响应特性研究,分析指出高转速离心叶轮的气动性能波动随着背压脉动频率的增加而增大,但不同背压脉动频率下各时刻的流场分布具有相似结构。然后采用动态模态分解(DMD)方法对背压脉动下非定常流动的模态场进行分析,不同脉动频率下的非定常流场均包含叶轮转频的各阶谐波模态,流场响应的零阶模态为反映平均流场的基本模态,各阶谐波模态均为极限环模态,其它均为近似极限环振荡或衰减模态,流场响应的非定常成分主要由一阶谐波模态贡献。DMD分析结果表明:DMD方法能够对叶轮非定常流场变化特性进行降阶解构及准确预测。

Measurements of absolute electron capture cross sections in He^(2+)–He and Ne^(8+)–O_(2'), N_(2'), CH_4 collisions

The total absolute cross sections of single-and double-electron capture (SEC and DEC) in the collisions of He^(2+)with He and Ne^(8+)with O_(2),N_(2),and CH_(4) were studied in the energy ranges 3.5–50 keV/u and 2.8–40 keV/u,respectively.Through a deep analysis of the experimental systematic uncertainties in the measurement procedure and data evaluation,the error in the experimental results of the SEC cross sections is less than 9%.Within the uncertainties,the present results of the He^(2+)–He collision show good consistency with previous measurements,validating the experimental system and paving the way for precise measurements of EC cross sections for a variety of ions and neutral gases.The present measurements allow for a test of EC theory and provide crucial EC cross section data for the establishment of plasma models in fusion research and astrophysical X-ray studies.

Construction of Industrialization Development Model for"1+4+X"Community-Based Elderly Care in Gannan Old Revolutionary Base Area in the Context of Population Aging

In the context of controlling population development in a planned way,China entered an aging society in the early 21 st century.In this context,how to meet the needs of the elderly care and form an effective elderly care model has become a key problem to be solved urgently by local government departments.With the continuous advancement of the elderly care policy,the community-based elderly care has gradually become the mainstream and is in the stage of vigorous promotion.Taking the Gannan old revolutionary base area in Jiangxi Province as an example,this study puts forward"1+4+X"community-based elderly care model based on the policy system of community-based elderly care,the physical and mental health of the elderly,the material space and the construction of evaluation system,and explores how to promote the application of this community model efficiently in the form of industrialization,so as to drive the economic growth of the Gannan old revolutionary base area,promote the employment development and improve the community-based elderly care service.

透平叶轮内湿蒸汽凝结水滴流动的三维数值模拟

以水蒸汽为介质的透平膨胀机,其内部流场可能会出现湿蒸汽凝结现象,形成的水滴将进一步导致叶片损伤和机组效率降低。因此,研究透平叶轮内湿蒸汽凝结水滴的流动,对于评估叶片侵蚀损伤和气动设计,具有重要意义。本文在Euler-Lagrange两相流动模型的基础上,开发水滴示踪程序,用以捕捉三维流场中凝结水滴的运动轨迹。计算结果表明,该程序能较好地追踪水滴的运动及碰撞信息。

超声内镜在炎症性肠病诊断中的应用价值

炎症性肠病(inflammatory bowel disease,IBD)是指一组病因尚不十分明确的慢性非特异性肠道炎症性疾病,主要包括溃疡性结肠炎(ulcerative colitis,UC)和克罗恩病(Crohn’s disease,CD),其特点在于病情反复发作,迁延不愈。目前诊断缺乏金标准,主要依赖临床表现、内镜检查及病理、影像学检查综合判断。与普通内镜检查相比,超声内镜(endoscopic ultrasonography,EUS)检查在观察胃肠道黏膜的基础上,可以清晰观察受累肠壁的层次结构及周围系膜、淋巴结的特征,在IBD的诊断和评估病情活动性方面作用显著。此外,EUS还可用于对IBD患者合并肠道狭窄、瘘管、腹腔及肛周脓肿的观察及治疗。本文就EUS在IBD诊断中的应用价值进行综述。

《2020年国际指南:慢性胰腺炎内镜介入治疗》要点摘译

2020年5月国际胰腺病学会(IAP)、美国胰腺学会(APA)、日本胰腺学会(JPS)及欧洲胰腺学会(EPC)共同发布了《2020年国际共识指南:慢性胰腺炎内镜介入治疗》。该指南基于循证医学证据,就慢性胰腺炎内镜介入治疗的适应证等9个关键临床问题提出了26项声明。本文对该指南涵盖的临床问题及声明进行要点摘译。

A Scheme of Dynamic Voltage Restorer to Improve Power Quality in Large Scale Industrial Enterprises

Loads in large scale industrial enterprises are always various and complex, causing insecure power quality. Meanwhile, some sensitive loads or precise instruments demand for high power quality. When voltage flicker or harmonics occurs, dynamic voltage restorer (DVR) can be used to stabilize the load-side voltage, which is a good manner of improving power quality. The paper explains the load demand in large scale industrial enterprises, analyzes several common voltage compensation scheme of DVR, and comes up with another voltage compensation scheme of DVR applied for double power supply with double load. A Simulink model according to the new scheme is also built in MATLAB/Simulink to test its performance. Simulation results show that the proposed scheme can guarantee the load-side voltage stability, which is an effective scheme for managing power quality.

全息影像技术在机器人辅助腹腔镜下肾部分切除术治疗肾门部肿瘤中的应用

目的评价全息影像技术引导机器人辅助腹腔镜下肾部分切除术(RAPN)治疗肾门部肿瘤的可行性与有效性。方法回顾性分析该院2019年6月-2019年10月收治的11例肾门部肿瘤患者的临床资料。其中,男3例,女8例;左侧4例,右侧7例;患者年龄32~75岁,平均62.6岁,体质指数19.45~28.12 kg/m^2,平均23.75 kg/m^2,肿瘤直径1.1~6.7 cm,平均2.76 cm,R.E.N.A.L.评分8~12分,平均10.7分,患肾肾小球滤过率(GFR)22~51 mL/min,平均35 mL/min。患者术前行全腹部增强CT,利用CT数据进行全息影像重建。术中应用该技术结合达芬奇机器人辅助系统,精准分离、剜除肿瘤,并记录手术持续时间、出血量、肾脏热缺血时间、有无并发症及切缘阳性率等。结果根据全息影像引导,11例患者均顺利剜除肿瘤,完成手术,无中转开放。手术时间60~130 min,平均90 min。术中出血量50~180 mL,平均100 mL,热缺血时间18~25 min,平均21 min,无术后发热、继发出血或漏尿等并发症。术后病理诊断肾透明细胞癌9例(FuhrmanⅠ和Ⅱ级),乳头状细胞癌1例,血管平滑肌脂肪瘤1例,无切缘阳性病例。术后随访3~7个月,平均4.3个月,患肾GFR 18~43 mL/min,平均31 mL/min。术后3个月复查肾脏CT平扫及增强,全部患者未出现复发。结论全息影像技术引导RAPN治疗肾门部肿瘤,围手术期并发症少,安全有效。

生命叙事:新冠肺炎疫情中的流言与武汉市民的集体行动

"武汉市民开窗大合唱"是抗击新型冠状病毒肺炎期间市民的首次大规模集体行动,本文通过对25位市民的深度访谈探查他们对流言的接触与态度等。研究认为:流言接触渠道具有显著的移动化特征,多模态流言则强化了集体行动的情感叙事;对行动规则的调试、健康信息的解释、集体行动的评价成为社会意义争夺的焦点;"远亲不如近邻"的社区共同体提升集体行动的效率和规模,社会结构在关系情境中被重塑;地方成为集体行动中记忆和文化的依托,并通过地方实现疫情中集体行动的延续。流言是我们关于病毒的生命叙事,也是我们融入全球社会的情感之径,其通过集体行动落地、验证和阐释,就有可能成为嵌入社会结构中的文化。

Does Postoperative Rehabilitation for Radical Cystectomy Call for Enhanced Recovery after Surgery?A Systematic Review and Metaanalysis

The aim of this review was to systematically compare the outcomes of enhanced recovery after surgery(ERAS)with standard care(SC)after radical cystectomy.We performed a systematic search of PubMed,Ovid?Web of Science,and the Cochrane Library to identify studies published until September 2017 which involved a comparison of ERAS and SC.A meta-analysis was performed to assess the outcomes of ERAS versus SC.Sixteen studies including 8 prospective and 8 retrospective trials met the eligibility criteria.A total of 2100 participants were assigned to ERAS(1258 cases)or SC(842 cases).The time to first flatus passage[WMD=-0.95 days,95%Cl(-1.50,-0.41),P=0.0006],time until return to a regular diet[WMD=-2.15 days,95%Cl(-2.86,—1.45),P<0.00001]and the length of hospital stay[WMD=-3.75 days,95%Cl(-5.13,-2.36),P<0.00001]were significantly shorter,and the incidence of postoperative complications[OR=0.60,95%Cl(0.44,0.83),P=0.002],especially postoperative paralytic ileus[OR=0.43,95%Cl(0.30,0.62),P<0.00001]and cardiovascular complications[OR=0.28,95%Cl(0.09,0.90),P=0.03]was significantly lower in the ERAS group than those in the SC group.This meta-analysis demonstrated that ERAS was associated with a shorter time to first flatus passage,return of bowel fimction,and the length of hospital stay than SC in patients undergoing radical cystectomy,as well as a lower rate of postoperative complications,especially paralytic ileus and cardiovascular complications.

卒中后失语症的评估及进展

功能评估是开展临床诊断和科学研究的前提和基础,对语言能力进行准确的诊断性评估需要一些工具。目前国内有很多关于脑血病意外后汉语失语症的研究。失语症是一种常见的脑卒中后遗症,严重影响患者的生活质量,因此,对言语能力的评估在失语症的评价、分型和康复中起着重要的作用。本文就目前应用广泛、评价较高的标准化语言评估工具进行介绍,供评估者选择使用。

prognostic significance of pretreatment serum carcinoembryonic antigen levels in gastric cancer with pathological lymph node-negative: A large sample singlecenter retrospective study

AIM To assess whether elevated serum carcinoembryonic antigen(CEA) is in the inferior prognosis for pathological lymph node-negative(p N_0) gastric cancer(GC) patients who underwent D_2 gastrectomy.METHODS About 469 p N0 GC patients,who received D^2 radical gastrectomy were retrospectively analyzed. The X-tile plots cut-off point for CEA were 30.02 ng/m L using minimum P-value from log-rank χ~2 statistics,and p N_0 GC patients were assigned to two groups: those more than 30.02 ng/m L(n = 48;CEA-high group) and those less than 30.02 ng/m L(n = 421;CEA-low group). Clinicopathologic characteristics were compared usingPearson's χ2 or Fisher's exact tests,and survival curves were so manufactured using the Kaplan-Meier method. Univariate and multivariate analysis were carried out using the logistic regression method.RESULTS The percentage of vessel carcinoma embolus(31.35% vs 17.1%) and advanced GC(T_(2-4b))(81.25% vs 65.32%) were higher in CEA-high group than CEA-low group. The CEA-positive patients had a significantly poorer prognosis than the CEA-nagetive patients in terms of overall survival(57.74% vs 90.69%,P < 0.05),and no different was found between subgroup of T category,differentiation,nerve invasion,and vessel carcinoma embolus(all P > 0.05). Multivariate survival analysis showed that CEA(OR = 4.924),and T category(OR = 2.214) were significant prognostic factors for stage p N0 GC(all P < 0.05). Besides,only T category(OR = 1.962) was an independent hazard factor in the CEA-high group(P < 0.05).CONCLUSION Those pretreatment serum CEA levels over 30.02 ng/m L on behalf of worse characteristics and unfavourable tumor behavior,and a poor prognosis for a nearly doubled risk of mortality in GC patients.

A Study on the Properties of Resin Transfer Molding Cyanate Ester and Its T800 Grade Carbon Fiber Composites

The properties of resin transfer molding(RTM)cyanate ester and its T800 grade carbon fiber composites were studied with the rheometer,differential scanning calorimetry(DSC),FT-IR,dynamic mechanical analyzer(DMA),thermal gravimetric analysis(TGA),mechanical property testing,and scanning electron microscopy(SEM).The results showed that the temperature of cyanate ester suitable for RTM process was 70℃.Curing process of the resin was 130℃/2 h+160℃/2 h+200℃/2 h+220℃/4 h.Glass transition temperature and heat decomposition temperature of the cured resin are 289℃and 415℃,respectively.Mechanical properties of T800/RTM cyanate composites are 13.5%higher than that of T700/RTM cyanate composites and equal to that of T800/Prepreg cyanate composites.Tg of T800/RTM cyanate composites was proved to be 291℃.Fracture pattern of the composites was flat,which proved excellent interface properties between fiber and resin in this composite.