Ascending aorta dilatation reduces the influence of elevated pulse pressure on left ventricular hypertrophy:findings from a Chinese elderly hypertensive population

OBJECTIVE To determine the role of ascending aorta dilatation in the relationship between pulse pressure(PP)and left ventricular(LV)hypertrophy.METHODS A total of 1556 Chinese elderly hypertensive patients were retrospectively studied.Transthoracic echocardiography was used to obtain the aortic and cardiac structure measurements.In addition,brachial blood pressure was measured,and total arterial compliance,systemic vascular resistance,arterial elastance,and end-systolic LV elastance were calculated.The participants were divided into four groups according to the status of ascending aortic diameter and PP.RESULTS LV mass index increased in succession in the four groups,i.e.,the group with the normal aorta and lower PP,with the normal aorta and higher PP,with aortic dilatation and lower PP,and with aortic dilatation and higher PP(Ptrend<0.001).Total arterial compliance−1,arterial elastance,and end-systolic LV elastance were slightly higher in the individuals with normal aorta compared to those with aortic dilatation,regardless of PP being lower or higher(P<0.01).Compared to the group with the normal aorta and lower PP,individuals with aortic dilatation had a significantly increased multivariable adjusted risk of LV hypertrophy,and higher PP further exacerbated this risk[aortic dilatation with lower PP(OR=1.75,95%CI:1.01–3.04)and aortic dilatation with higher PP(OR=3.42,95%CI:2.03–5.77)].In the relation between PP and LV mass index(β=0.095,P<0.001),-41.3%of the total effect was attributable to mediation by ascending aortic diameter(P<0.0001).CONCLUSIONS In Chinese elderly patients with hypertension,ascending aorta dilatation could reduce the influence of elevated PP on LV hypertrophy.

A fast integral sliding mode controller with an extended state observer for position control of permanent magnet synchronous motor servo systems

Permanent magnet synchronous motor(PMSM)has been widely used in position control applications.Its performance is not satisfactory due to internal uncertainties and external load disturbances.To enhance the control performance of PMSM systems,a new method that has fast response and good robustness is proposed in this study.First,a modified integral terminal sliding mode controller is developed,which has a fast-sliding surface and a continuous reaching law.Then,an extended state observer is applied to measure the internal and external disturbances.Therefore,the disturbances can be compensated for in a feedforward manner.Compared with other sliding mode methods,the proposed method has faster response and better robustness against system disturbances.In addition,the position tracking error can converge to zero in a finite time.Simulation and experimental results reveal that the proposed control method has fast response and good robustness,and enables high-precision control.