Penehyclidine hydrochloride can promote microcirculation and reduce vascular permeability. However, the role of penehyclidine hydrochlodde in cerebral ischemia-reperfusion injury remains unclear. In this study, in viv...Penehyclidine hydrochloride can promote microcirculation and reduce vascular permeability. However, the role of penehyclidine hydrochlodde in cerebral ischemia-reperfusion injury remains unclear. In this study, in vivo middle cerebral artery occlusion models were established in experimental rats, and penehyclidine hydrochloride pretreatment was given via intravenous injection prior to model establishment. Tetrazolium chloride, terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate-biotin nick end labeling and immunohistochemical staining showed that, penehyclidine hydrochloride pretreatment markedly attenuated neuronal histopathological changes in the cortex, hippocampus and striatum, reduced infarction size, increased the expression level of BcI-2, decreased the expression level of caspase-3, and inhibited neuronal apoptosis in rats with cerebral ischemia-reperfusion injury. Xanthine oxidase and thiobarbituric acid chromogenic results showed that penehyclidine hydrochloride upregulated the activity of superoxide dismutase and downregulated the concentration of malondialdehyde in the ischemic cerebral cortex and hippocampus, as well as reduced the concentration of extracellular excitatory amino acids in rats with cerebral ischemia-reperfusion injury. In addition, penehyclidine hydrochloride inhibited the expression level of the NR1 subunit in hippocampal nerve cells in vitro following oxygen-glucose deprivation, as detected by PCR. Experimental findings indicate that penehyclidine hydrochloride attenuates neuronal apoptosis and oxidative stress injury after focal cerebral ischemia-reperfusion, thus exerting a neuroprotective effect.展开更多
The first Chinese Chemical Letters(CCL)Organic Chemistry Forum was held in Xiamen of Fujian in Jan.2018,followed by the successful events in Zhengzhou of Henan in Dec.2019 and Linzhi of Tibet in July 2021.The series o...The first Chinese Chemical Letters(CCL)Organic Chemistry Forum was held in Xiamen of Fujian in Jan.2018,followed by the successful events in Zhengzhou of Henan in Dec.2019 and Linzhi of Tibet in July 2021.The series of forums aim to build a high-level organic chemistry academic exchange platform for(Chinese)youthful organic chemists,fully showcase their latest fron-tier achievements,and enhance the international level of organic chemistry in China.At the same time,the convening of the series of forums has also played a positive role in promoting the devel-opment of China’s scientific journal publishing,accelerating the re-alization of the strategic goal of building a world-class journal.展开更多
Single-atomic catalysts(SACs)caught considerable attention due to their unique structural properties,complete exposed active site,and 100%atom utilization efficiency with remarkable catalytic activity.Mesoporous singl...Single-atomic catalysts(SACs)caught considerable attention due to their unique structural properties,complete exposed active site,and 100%atom utilization efficiency with remarkable catalytic activity.Mesoporous single-atomic cobalt catalyst with Co-N_(4) active sites was synthesized by using nitrogen-doped graphene derived from acrylonitrile.Single-atomic cobalt was observed by aberration-corrected high-angle annular dark-field scanning transmission electron microscopy(HAADF-STEM)in Co@Nx-C-800.Notably,the density functional theory(DFT)calculation and the extended X-ray absorption fine structures(EXAFS)fitting results indicate that the coordination structure of Co-N is four-coordinated.In this work,the practical hydrogenation of nitroarenes to anilines enabled by Co@Nx-C-800 was established with excellent yields and selectivity,which proved its advantages and potential applications.展开更多
Objective:To compare Roux-en-Y hepatico-jejunostomy with complete resection of the cyst or incomplete resection with 1-cm remnant proximal cyst wall in treating adult type I choledochal cyst(CC).Methods:The medical re...Objective:To compare Roux-en-Y hepatico-jejunostomy with complete resection of the cyst or incomplete resection with 1-cm remnant proximal cyst wall in treating adult type I choledochal cyst(CC).Methods:The medical records of 267 adult patients with type I CC from January 1998 to December 2015 were reviewed retrospectively.Among them,171 underwent Roux-en-Y hepatico-jejunostomy with complete resection(PBD 0-cm group)and 96 underwent Roux-en-Y hepatico-jejunostomy with 1-cm proximal cyst wall left(PBD 1-cm group).The short-and long-termpost-operative complications were compared between the two groups.Results:No significant difference was observed in operative time or anastomotic diameter between the two groups.The incidence of perioperative complications was significantly higher in the PBD 1-cm group than that in the PBD 0-cm group(28.1%vs 14.0%,p¼0.005),especially post-operative cholangitis(7.3%vs 1.2%,p¼0.021).The incidence of long-term post-operative complications was not significantly different,including anastomotic stricture,reflux cholangitis,intra-hepatic bile duct stones and bile leak(all p>0.05).Post-operative intra-pancreatic biliary malignancy occurred in one patient in the PBD 0-cm group at 25 months and one patient in the PBD 1-cm group at 5 month,respectively.Anatomical site malignancy was observed in one patient in the PBD 1-cm group at 10 months.Conclusion:Ease of performing anastomosis does not justify retaining a segment of choledochal cyst in type I CC due to its higher risk of post-operative complication and malignancy.A complete excision of the CC with anastomosis to the healthy proximal bile duct is necessary in treatment of type I CC.展开更多
文摘Penehyclidine hydrochloride can promote microcirculation and reduce vascular permeability. However, the role of penehyclidine hydrochlodde in cerebral ischemia-reperfusion injury remains unclear. In this study, in vivo middle cerebral artery occlusion models were established in experimental rats, and penehyclidine hydrochloride pretreatment was given via intravenous injection prior to model establishment. Tetrazolium chloride, terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate-biotin nick end labeling and immunohistochemical staining showed that, penehyclidine hydrochloride pretreatment markedly attenuated neuronal histopathological changes in the cortex, hippocampus and striatum, reduced infarction size, increased the expression level of BcI-2, decreased the expression level of caspase-3, and inhibited neuronal apoptosis in rats with cerebral ischemia-reperfusion injury. Xanthine oxidase and thiobarbituric acid chromogenic results showed that penehyclidine hydrochloride upregulated the activity of superoxide dismutase and downregulated the concentration of malondialdehyde in the ischemic cerebral cortex and hippocampus, as well as reduced the concentration of extracellular excitatory amino acids in rats with cerebral ischemia-reperfusion injury. In addition, penehyclidine hydrochloride inhibited the expression level of the NR1 subunit in hippocampal nerve cells in vitro following oxygen-glucose deprivation, as detected by PCR. Experimental findings indicate that penehyclidine hydrochloride attenuates neuronal apoptosis and oxidative stress injury after focal cerebral ischemia-reperfusion, thus exerting a neuroprotective effect.
文摘The first Chinese Chemical Letters(CCL)Organic Chemistry Forum was held in Xiamen of Fujian in Jan.2018,followed by the successful events in Zhengzhou of Henan in Dec.2019 and Linzhi of Tibet in July 2021.The series of forums aim to build a high-level organic chemistry academic exchange platform for(Chinese)youthful organic chemists,fully showcase their latest fron-tier achievements,and enhance the international level of organic chemistry in China.At the same time,the convening of the series of forums has also played a positive role in promoting the devel-opment of China’s scientific journal publishing,accelerating the re-alization of the strategic goal of building a world-class journal.
基金supported by the National Natural Science Foundation of China(Nos.22061017 and 21862006)Science and technology program of Gansu Province(Nos.22YF7GG127 and 23JRRG0002)Hexi University Research Start-up Fund Project(Nos.KYQD2020013).
文摘Single-atomic catalysts(SACs)caught considerable attention due to their unique structural properties,complete exposed active site,and 100%atom utilization efficiency with remarkable catalytic activity.Mesoporous single-atomic cobalt catalyst with Co-N_(4) active sites was synthesized by using nitrogen-doped graphene derived from acrylonitrile.Single-atomic cobalt was observed by aberration-corrected high-angle annular dark-field scanning transmission electron microscopy(HAADF-STEM)in Co@Nx-C-800.Notably,the density functional theory(DFT)calculation and the extended X-ray absorption fine structures(EXAFS)fitting results indicate that the coordination structure of Co-N is four-coordinated.In this work,the practical hydrogenation of nitroarenes to anilines enabled by Co@Nx-C-800 was established with excellent yields and selectivity,which proved its advantages and potential applications.
基金supported by grants from the Science&Technology Support Project of Sichuan Province(No.2014SZ0002–10 and No.2015FZ0076).
文摘Objective:To compare Roux-en-Y hepatico-jejunostomy with complete resection of the cyst or incomplete resection with 1-cm remnant proximal cyst wall in treating adult type I choledochal cyst(CC).Methods:The medical records of 267 adult patients with type I CC from January 1998 to December 2015 were reviewed retrospectively.Among them,171 underwent Roux-en-Y hepatico-jejunostomy with complete resection(PBD 0-cm group)and 96 underwent Roux-en-Y hepatico-jejunostomy with 1-cm proximal cyst wall left(PBD 1-cm group).The short-and long-termpost-operative complications were compared between the two groups.Results:No significant difference was observed in operative time or anastomotic diameter between the two groups.The incidence of perioperative complications was significantly higher in the PBD 1-cm group than that in the PBD 0-cm group(28.1%vs 14.0%,p¼0.005),especially post-operative cholangitis(7.3%vs 1.2%,p¼0.021).The incidence of long-term post-operative complications was not significantly different,including anastomotic stricture,reflux cholangitis,intra-hepatic bile duct stones and bile leak(all p>0.05).Post-operative intra-pancreatic biliary malignancy occurred in one patient in the PBD 0-cm group at 25 months and one patient in the PBD 1-cm group at 5 month,respectively.Anatomical site malignancy was observed in one patient in the PBD 1-cm group at 10 months.Conclusion:Ease of performing anastomosis does not justify retaining a segment of choledochal cyst in type I CC due to its higher risk of post-operative complication and malignancy.A complete excision of the CC with anastomosis to the healthy proximal bile duct is necessary in treatment of type I CC.
