The efficacy study of trinity permeation synergism on anti-aging

Background:More and more consumers are paying attention to skin rejuvenation.However,there is a lack of a non-invasive and efficient solution.Objective:To evaluate the efficacy of a trinity permeation synergism(TPS),which consists of a firming essence,an atomizer and a photoelectric penetrator,for facial anti-aging efficacy.Material and methods:In this work,in vitro cell experiments and human efficacy study were used to evaluate the firming and anti-wrinkle effects.Cell experiments were used to verify the effect of the firming essence on the cell proliferation,migration,and anti-inflammation in keratinocytes(HaCaT),and on the gene expression levels of type I and type III collagen(Col-1 and Col-3)and type I matrix metalloproteinase(MMP-1)in human skin fibroblasts(HSF).After in vitro test,60 women aged 35–60 years were enrolled in the randomized test,of which 30 subjects were randomly selected to be the experimental group and treated with the TPS system,while the left 30 subjects were treated with the firming essence only considered as control.After 28 days,skin elasticity,skin redness value,and skin wrinkles were measured to evaluate the efficacy of the TPS system.Results:Cell experiments showed that the firming essence can significantly improve the proliferation and the migration of HaCaT cells.It also promoted the expression level of Col-1 and Col-3 gene,and inhibited the expression level of MMP-1 gene in HSF cells.After confirming the efficacy of firming essence,the efficacy benefit of the TPS was further studied.The 28-day tests show that combined use firming essence with atomizer and penetrator can significantly increase skin elasticity,reduce skin hemoglobin value and skin wrinkles on Day 28.Moreover,all the mentioned improvements are significantly better than that in the control group.Conclusion:Through efficient delivery in the whole process,TPS boosts the efficacy of active components in the firming essence.TPS offers an efficient,non-invasive,and convenient way for enhanced facial rejuvenation efficacy.

Corrigendum to“3Cpro of FMDV inhibits type II interferon-stimulated JAK-STAT signaling pathway by blocking STAT1 nuclear translocation”[Virol Sin 38(2023)387–397]

Due to our negligence,the original version of this article,published online on Mar 14,2023,contained some mistakes in several Figs.In Fig.2D,the positions of the bands for protein 3A and 3B were incorrectly shifted.This has been modified in corrected Fig.2 as shown below.

3C^(pro)of FMDV inhibits type II interferon-stimulated JAK-STAT signaling pathway by blocking STAT1 nuclear translocation

Foot-and-mouth disease virus(FMDV)has developed various strategies to antagonize the host innate immunity.FMDV Lpro and 3Cpro interfere with type I IFNs through different mechanisms.The structural protein VP3 of FMDV degrades Janus kinase 1 to suppress IFN-γsignaling transduction.Whether non-structural proteins of FMDV are involved in restraining type II IFN signaling pathways is unknown.In this study,it was shown that FMDV replication was resistant to IFN-γtreatment after the infection was established and FMDV inhibited type II IFN induced expression of IFN-γ-stimulated genes(ISGs).We also showed for the first time that FMDV non-structural protein 3C antagonized IFN-γ-stimulated JAK-STAT signaling pathway by blocking STAT1 nuclear translocation.3C^(pro)expression significantly reduced the ISGs transcript levels and palindromic gamma-activated sequences(GAS)promoter activity,without affecting the protein level,tyrosine phosphorylation,and homodimerization of STAT1.Finally,we provided evidence that 3C protease activity played an essential role in degrading KPNA1 and thus inhibited ISGs mRNA and GAS promoter activities.Our results reveal a novel mechanism by which an FMDV non-structural protein antagonizes host type II IFN signaling.

Vertically stacked skin-like active-matrix display with ultrahigh aperture ratio

Vertically stacked all-organic active-matrix organic light-emitting diodes are promising candidates for high-quality skinlike displays due to their high aperture ratio,extreme mechanical flexibility,and low-temperature processing ability.However,these displays suffer from process interferences when interconnecting functional layers made of all-organic materials.To overcome this challenge,we present an innovative integration strategy called“discrete preparationmultilayer lamination”based on microelectronic processes.In this strategy,each functional layer was prepared separately on different substrates to avoid chemical and physical damage caused by process interferences.A single interconnect layer was introduced between each vertically stacked functional layer to ensure mechanical compatibility and interconnection.Compared to the previously reported layer-by-layer preparation method,the proposed method eliminates the need for tedious protection via barrier and pixel-defining layer processing steps.Additionally,based on active-matrix display,this strategy allows multiple pixels to collectively display a pattern of“1”with an aperture ratio of 83%.Moreover,the average mobility of full-photolithographic organic thin-film transistors was 1.04 cm2 V−1 s−1,ensuring stable and uniform displays.This strategy forms the basis for the construction of vertically stacked activematrix displays,which should facilitate the commercial development of skin-like displays in wearable electronics.