Objective:The purpose of this study was to evaluate the effect of continuous care on postpartum anxiety in primipara mothers in China.Methods:A quasi-experimental,non-equivalent control group design was employed.The i...Objective:The purpose of this study was to evaluate the effect of continuous care on postpartum anxiety in primipara mothers in China.Methods:A quasi-experimental,non-equivalent control group design was employed.The initial screening involved 120 primipara women from two hospitals in Shandong Province.Based on the inclusion criteria,60 eligible primipara mothers were selected to participate in the study.Results:The findings indicated that continuous care significantly reduced the anxiety levels of primipara mothers,as shown by a marked decrease in the scores on a researcher-developed anxiety scale.Conclusion:Continuous care has been proven to be an effective intervention for alleviating postpartum anxiety in Chinese primipara mothers and has a positive impact on their mental health and postpartum recovery.展开更多
The coronavirus disease 2019(COVID-19)pandemic is challenging the current public health emergency response systems(PHERSs)of many countries.Although environmental factors,such as those influencing the survival of viru...The coronavirus disease 2019(COVID-19)pandemic is challenging the current public health emergency response systems(PHERSs)of many countries.Although environmental factors,such as those influencing the survival of viruses and their transmission between species including humans,play important roles in PHERSs,little attention has been given to these factors.This study describes and elucidates the roles of environmental factors in future PHERSs.To improve countries’capability to respond to public health emergencies associated with viral infections such as the COVID-19 pandemic,a number of environmental factors should be considered before,during,and after the responses to such emergencies.More specifically,to prevent pandemic outbreaks,we should strengthen environmental and wildlife protection,conduct detailed viral surveillance in animals and hotspots,and improve early-warning systems.During the pandemic,we must study the impacts of environmental factors on viral behaviors,develop control measures to minimize secondary environmental risks,and conduct timely assessments of viral risks and secondary environmental effects with a view to reducing the impacts of the pandemic on human health and on ecosystems.After the pandemic,we should further strengthen surveillance for viruses and the prevention of viral spread,maintain control measures for minimizing secondary environmental risks,develop our capability to scientifically predict pandemics and resurgences,and prepare for the next unexpected resurgence.Meanwhile,we should restore the normal life and production of the public based on the“One Health”concept,that views global human and environmental health as inextricably linked.Our recommendations are essential for improving nations’capability to respond to global public health emergencies.展开更多
Dear Editor,The timing of the spring bud f lush(TBF)is a crucial agro-nomic trait for the tea plant,as it strongly influences the yield and economic value of harvested fresh tea leaves.The TBF of tea plant is generall...Dear Editor,The timing of the spring bud f lush(TBF)is a crucial agro-nomic trait for the tea plant,as it strongly influences the yield and economic value of harvested fresh tea leaves.The TBF of tea plant is generally defined as the date when>30%of the growing tender shoots have reached the stage of one bud with one to three leaves,referred as to the stage of one and a bud,two and a bud,and three and a bud,respectively.展开更多
Parvimonas is a group of Grampositive bacteria that are common anaerobic cocci in the oral cavity and the gastrointestinal tract and one of the pathogens of periodontitis,,^([1])and Prevotella is a group of Gramnegati...Parvimonas is a group of Grampositive bacteria that are common anaerobic cocci in the oral cavity and the gastrointestinal tract and one of the pathogens of periodontitis,,^([1])and Prevotella is a group of Gramnegative anaerobic bacteria that are found mainly in the oral cavity and intestinal tract and are mainly involved in periodontal infections.展开更多
Aiming at achieving tunable reentrant structures with rigidity and uniformity,respectively,the C-shaped and S-shaped reentrant metamaterials were proposed by the bionic design of animal structures.Utilizing beam theor...Aiming at achieving tunable reentrant structures with rigidity and uniformity,respectively,the C-shaped and S-shaped reentrant metamaterials were proposed by the bionic design of animal structures.Utilizing beam theory and energy methodology,the analytical expressions of the equivalent elastic modulus of the metamaterials were derived.Differences in deformation modes,mechanical properties,and energy absorption capacities were characterized by using experiments and the finite element analysis method.The effects of ligament angle and thickness on the mechanical characteristics of two novel metamaterials were investigated by using a parametric analysis.The results show that the stiffness,deformation mode,stress-strain curve,and energy absorption effects of three metamaterials are significantly different.This design philosophy can be extended from 2D to 3D and is applicable at multiple dimensions.展开更多
The treatment of PML/RARA+acute promyelocytic leukemia(APL)with all-trans-retinoic acid and arsenic trioxide(ATRA/ATO)has been recognized as a model for translational medicine research.Though an altered microenvironme...The treatment of PML/RARA+acute promyelocytic leukemia(APL)with all-trans-retinoic acid and arsenic trioxide(ATRA/ATO)has been recognized as a model for translational medicine research.Though an altered microenvironment is a general cancer hallmark,how APL blasts shape their plasma composition is poorly understood.Here,we reported a cross-sectional correlation network to interpret multilayered datasets on clinical parameters,proteomes,and metabolomes of paired plasma samples from patients with APL before or after ATRA/ATO induction therapy.Our study revealed the two prominent features of the APL plasma,suggesting a possible involvement of APL blasts in modulating plasma composition.One was characterized by altered secretory protein and metabolite profiles correlating with heightened proliferation and energy consumption in APL blasts,and the other featured APL plasma-enriched proteins or enzymes catalyzing plasma-altered metabolites that were potential trans-regulatory targets of PML/RARA.Furthermore,results indicated heightened interferon-gamma signaling characterizing a tumor-suppressing function of the immune system at the first hematological complete remission stage,which likely resulted from therapy-induced cell death or senescence and ensuing supraphysiological levels of intracellular proteins.Overall,our work sheds new light on the pathophysiology and treatment of APL and provides an information-rich reference data cohort for the exploratory and translational study of leukemia microenvironment.展开更多
he triple planetary crisis—climate change,biodiversity loss,and pollution—threatens planetary health.In response to these challenges,the Intergovernmental Panel on Climate Change(IPCC)was established in 1988,followe...he triple planetary crisis—climate change,biodiversity loss,and pollution—threatens planetary health.In response to these challenges,the Intergovernmental Panel on Climate Change(IPCC)was established in 1988,followed by the formation of the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services(IPBES)in 2012.Ongoing global initiatives through IPCC and IPBES have significantly advanced scientific understanding,raised public awareness,and informed policy-making in relation to climate change and biodiversity loss.However,pollution remains a pressing concern in all three crises.展开更多
Microplastics(MPs)are emerging contaminants that have attracted worldwide attention in recent years.Compared with MPs,nanoplastics(NPs)may exhibit greater toxicity and higher potential risks because of their unique ph...Microplastics(MPs)are emerging contaminants that have attracted worldwide attention in recent years.Compared with MPs,nanoplastics(NPs)may exhibit greater toxicity and higher potential risks because of their unique physiochemical nanoscale properties.However,the environmental fate,ecosystem toxicity,and potential risks associated with NPs have been less explored.This study summarizes the current research status of NPs through a comprehensive bibliometric analysis.The research hotspots and future trends of NPs were identified.We comprehensively searched the Web of Science Core Collection scientific database from its inception(2004)to November 26,2020.The results showed that the number of papers on NPs has increased significantly since 2014.The keywords used in NP research were divided into three clusters.Cluster 1 related to the physical,chemical,and biological behaviors of NPs in aquatic environments.Cluster 2 represented a relatively new and hot research field concerning the exposure,accumulation,and toxicity of NPs in organisms.Cluster 3 corresponded to the identification and quantification of NPs in marine environments and sediments.Moreover,we systematically elaborated the main areas of NP research,such as the characterization,occurrence,environmental behavior,ecological toxicity,and human health risks of NPs.The results showed that the quantification of NPs at environmentally relevant concentrations remains a challenge.Most studies have investigated polystyrene NPs,spherical NPs,and NPs in marine environments,while few studies have examined the aggregation,deposition,and ecological toxicity of NPs under environmentally relevant conditions.In addition,much less is known about the human health risks associated with NPs because little research has been conducted on estimating the overall human exposure to NPs and its effect.Finally,the current challenges and future perspectives of NP research are discussed.展开更多
文摘Objective:The purpose of this study was to evaluate the effect of continuous care on postpartum anxiety in primipara mothers in China.Methods:A quasi-experimental,non-equivalent control group design was employed.The initial screening involved 120 primipara women from two hospitals in Shandong Province.Based on the inclusion criteria,60 eligible primipara mothers were selected to participate in the study.Results:The findings indicated that continuous care significantly reduced the anxiety levels of primipara mothers,as shown by a marked decrease in the scores on a researcher-developed anxiety scale.Conclusion:Continuous care has been proven to be an effective intervention for alleviating postpartum anxiety in Chinese primipara mothers and has a positive impact on their mental health and postpartum recovery.
基金the National Science Foundation of China(41925031,41991315,and 41521003).
文摘The coronavirus disease 2019(COVID-19)pandemic is challenging the current public health emergency response systems(PHERSs)of many countries.Although environmental factors,such as those influencing the survival of viruses and their transmission between species including humans,play important roles in PHERSs,little attention has been given to these factors.This study describes and elucidates the roles of environmental factors in future PHERSs.To improve countries’capability to respond to public health emergencies associated with viral infections such as the COVID-19 pandemic,a number of environmental factors should be considered before,during,and after the responses to such emergencies.More specifically,to prevent pandemic outbreaks,we should strengthen environmental and wildlife protection,conduct detailed viral surveillance in animals and hotspots,and improve early-warning systems.During the pandemic,we must study the impacts of environmental factors on viral behaviors,develop control measures to minimize secondary environmental risks,and conduct timely assessments of viral risks and secondary environmental effects with a view to reducing the impacts of the pandemic on human health and on ecosystems.After the pandemic,we should further strengthen surveillance for viruses and the prevention of viral spread,maintain control measures for minimizing secondary environmental risks,develop our capability to scientifically predict pandemics and resurgences,and prepare for the next unexpected resurgence.Meanwhile,we should restore the normal life and production of the public based on the“One Health”concept,that views global human and environmental health as inextricably linked.Our recommendations are essential for improving nations’capability to respond to global public health emergencies.
基金supported by grants from National Key Research and Development Program of China(2021YFD1200200)the Major Project of Agricultural Science and Technology in Breeding of Tea Plant Variety in Zhejiang Province(2021C02067)+2 种基金the Chinese Academy of Agricultural Sciences through the Agricultural Science and Technology Innovation Program(CAASASTIP-2017-TRICAAS)the Earmarked Fund for China Agriculture Research System of MOF and MARA(CARS-19)the National Natural Science Foundation of China(U22A20500,32202553).
文摘Dear Editor,The timing of the spring bud f lush(TBF)is a crucial agro-nomic trait for the tea plant,as it strongly influences the yield and economic value of harvested fresh tea leaves.The TBF of tea plant is generally defined as the date when>30%of the growing tender shoots have reached the stage of one bud with one to three leaves,referred as to the stage of one and a bud,two and a bud,and three and a bud,respectively.
文摘Parvimonas is a group of Grampositive bacteria that are common anaerobic cocci in the oral cavity and the gastrointestinal tract and one of the pathogens of periodontitis,,^([1])and Prevotella is a group of Gramnegative anaerobic bacteria that are found mainly in the oral cavity and intestinal tract and are mainly involved in periodontal infections.
基金supported by the Natural Science Foundation of Hebei Province of China(Grant No.A2020502005)the Independent Research and Development Project of China Aerospace Science and Technology Corporation(Grant No.0337000000003)the National Natural Science Foundation of China(Grant No.12272045).
文摘Aiming at achieving tunable reentrant structures with rigidity and uniformity,respectively,the C-shaped and S-shaped reentrant metamaterials were proposed by the bionic design of animal structures.Utilizing beam theory and energy methodology,the analytical expressions of the equivalent elastic modulus of the metamaterials were derived.Differences in deformation modes,mechanical properties,and energy absorption capacities were characterized by using experiments and the finite element analysis method.The effects of ligament angle and thickness on the mechanical characteristics of two novel metamaterials were investigated by using a parametric analysis.The results show that the stiffness,deformation mode,stress-strain curve,and energy absorption effects of three metamaterials are significantly different.This design philosophy can be extended from 2D to 3D and is applicable at multiple dimensions.
基金supported by the State Key Laboratory of Medical Genomics,the Double First-Class Project(No.WF510162602)from the Ministry of Educationthe Shanghai Collaborative Innovation Program on Regenerative Medicine and Stem Cell Research(No.2019CXJQ01)+5 种基金the Overseas Expertise Introduction Project for Discipline Innovation(111 Project,No.B17029)the National Natural Science Foundation of China(Nos.82230006 and 32170663)the Shanghai Clinical Research Center for Hematological disease(No.19MC1910700)the Shanghai Shenkang Hospital Development Center(No.SHDC2020CR5002)the Shanghai Major Project for Clinical Medicine(No.2017ZZ01002)the Innovative Research Team of High-level Local Universities in Shanghai and the Yangfan Program of the Science and Technology Commission of Shanghai Municipality(No.22YF1425500)。
文摘The treatment of PML/RARA+acute promyelocytic leukemia(APL)with all-trans-retinoic acid and arsenic trioxide(ATRA/ATO)has been recognized as a model for translational medicine research.Though an altered microenvironment is a general cancer hallmark,how APL blasts shape their plasma composition is poorly understood.Here,we reported a cross-sectional correlation network to interpret multilayered datasets on clinical parameters,proteomes,and metabolomes of paired plasma samples from patients with APL before or after ATRA/ATO induction therapy.Our study revealed the two prominent features of the APL plasma,suggesting a possible involvement of APL blasts in modulating plasma composition.One was characterized by altered secretory protein and metabolite profiles correlating with heightened proliferation and energy consumption in APL blasts,and the other featured APL plasma-enriched proteins or enzymes catalyzing plasma-altered metabolites that were potential trans-regulatory targets of PML/RARA.Furthermore,results indicated heightened interferon-gamma signaling characterizing a tumor-suppressing function of the immune system at the first hematological complete remission stage,which likely resulted from therapy-induced cell death or senescence and ensuing supraphysiological levels of intracellular proteins.Overall,our work sheds new light on the pathophysiology and treatment of APL and provides an information-rich reference data cohort for the exploratory and translational study of leukemia microenvironment.
文摘he triple planetary crisis—climate change,biodiversity loss,and pollution—threatens planetary health.In response to these challenges,the Intergovernmental Panel on Climate Change(IPCC)was established in 1988,followed by the formation of the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services(IPBES)in 2012.Ongoing global initiatives through IPCC and IPBES have significantly advanced scientific understanding,raised public awareness,and informed policy-making in relation to climate change and biodiversity loss.However,pollution remains a pressing concern in all three crises.
基金This work was supported by the National Natural Science Foundation of China[grant number 41925031,41991315,and 41521003].
文摘Microplastics(MPs)are emerging contaminants that have attracted worldwide attention in recent years.Compared with MPs,nanoplastics(NPs)may exhibit greater toxicity and higher potential risks because of their unique physiochemical nanoscale properties.However,the environmental fate,ecosystem toxicity,and potential risks associated with NPs have been less explored.This study summarizes the current research status of NPs through a comprehensive bibliometric analysis.The research hotspots and future trends of NPs were identified.We comprehensively searched the Web of Science Core Collection scientific database from its inception(2004)to November 26,2020.The results showed that the number of papers on NPs has increased significantly since 2014.The keywords used in NP research were divided into three clusters.Cluster 1 related to the physical,chemical,and biological behaviors of NPs in aquatic environments.Cluster 2 represented a relatively new and hot research field concerning the exposure,accumulation,and toxicity of NPs in organisms.Cluster 3 corresponded to the identification and quantification of NPs in marine environments and sediments.Moreover,we systematically elaborated the main areas of NP research,such as the characterization,occurrence,environmental behavior,ecological toxicity,and human health risks of NPs.The results showed that the quantification of NPs at environmentally relevant concentrations remains a challenge.Most studies have investigated polystyrene NPs,spherical NPs,and NPs in marine environments,while few studies have examined the aggregation,deposition,and ecological toxicity of NPs under environmentally relevant conditions.In addition,much less is known about the human health risks associated with NPs because little research has been conducted on estimating the overall human exposure to NPs and its effect.Finally,the current challenges and future perspectives of NP research are discussed.