Using Extreme Value Theory Approaches to Estimate High Quantiles for Stroke Data

This paper aims to explore the application of Extreme Value Theory (EVT) in estimating the conditional extreme quantile for time-to-event outcomes by examining the functional relationship between ambulatory blood pressure trajectories and clinical outcomes in stroke patients. The study utilizes EVT to analyze the functional connection between ambulatory blood pressure trajectories and clinical outcomes in a sample of 297 stroke patients. The 24-hour ambulatory blood pressure measurement curves for every 15 minutes are considered, acknowledging a censored rate of 40%. The findings reveal that the sample mean excess function exhibits a positive gradient above a specific threshold, confirming the heavy-tailed distribution of data in stroke patients with a positive extreme value index. Consequently, the estimated conditional extreme quantile indicates that stroke patients with higher blood pressure measurements face an elevated risk of recurrent stroke occurrence at an early stage. This research contributes to the understanding of the relationship between ambulatory blood pressure and recurrent stroke, providing valuable insights for clinical considerations and potential interventions in stroke management.

Functional Kernel Estimation of the Conditional Extreme Quantile under Random Right Censoring

The study of estimation of conditional extreme quantile in incomplete data frameworks is of growing interest. Specially, the estimation of the extreme value index in a censorship framework has been the purpose of many investigations when finite dimension covariate information has been considered. In this paper, the estimation of the conditional extreme quantile of a heavy-tailed distribution is discussed when some functional random covariate (i.e. valued in some infinite-dimensional space) information is available and the scalar response variable is right-censored. A Weissman-type estimator of conditional extreme quantiles is proposed and its asymptotic normality is established under mild assumptions. A simulation study is conducted to assess the finite-sample behavior of the proposed estimator and a comparison with two simple estimations strategies is provided.