Microbial metabolic interaction in fermentation ecosystem and cooperation in flavor compounds formation of Chinese cereal vinegar

Shanxi aged vinegar(SAV)is a famous cereal vinegar in China,which is produced through a solid-state fermentation where diverse microbes spontaneously and complex interactions occur.Here,combined with the metatranscriptomics,the microbial co-occurrence network was constructed,indicating that Lactobacillus,Acetobacter and Pediococcus are the most critical genera to maintain the fermentation stability.Based on an extensive collection of 264 relevant literatures,a transport network containing 2271 reactions between microorganisms and compounds was constructed,showing that glucose(84%of all species),fructose(67%)and maltose(67%)are the most frequently utilized substrates while lactic acid(64%),acetic acid(45%)are the most frequently occurring metabolites.Specifically,the metabolic influence of species pairs was calculated using a mathematical calculation model and the metabolic influence network was constructed.The topology properties analysis found that Lactobacillus was the key role with robust metabolic control of vinegar fermentation ecosystem and acetic acid and lactic acid were the main metabolites with feedback regulation in microbial metabolism of SAV.Furthermore,systematic coordination of positive and negative impacts was proved to be inevitable to form flavor compounds and maintain a natural microbial ecosystem.This study provides a new perspective for understanding microbial interactions in fermented food.

Joint Resource Allocation and Coordinated Computation Offloading for Fog Radio Access Networks

The cloud radio access network(C-RAN) and the fog computing have been recently proposed to tackle the dramatically increasing traffic demands and to provide better quality of service(QoS) to user equipment(UE).Considering the better computation capability of the cloud RAN(10 times larger than that of the fog RAN) and the lower transmission delay of the fog computing,we propose a joint resource allocation and coordinated computation offloading algorithm for the fog RAN(F-RAN),which takes the advantage of C-RAN and fog computing.Specifically,the F-RAN splits a computation task into the fog computing part and the cloud computing part.Based on the constraints of maximum transmission delay tolerance,fronthaul and backhaul capacity limits,we minimize the energy cost and obtain optimal computational resource allocation for multiple UE,transmission power allocation of each UE and the event splitting factor.Numerical results have been proposed with the comparison of existing methods.

Efficacy and safety of anlotinib plus S-1as thirdly-line or later-line treatmentin advanced non-small cell lung cancer

Objective Anlotinib,an oral vascular endothelial growth factor receptor 2(VEGFR2)inhibitor,has confirmed antitumor activity in lung cancer in both in vitro and in vivo assays,and has been recommended as third-line treatment agent in non-oncogene driven non-small cell lung cancer(NSCLC).This prospective study aimed to investigate the efficacy and safety of anlotinib plus S-1 for third-or later-line treatment in patients with advanced NSCLC.Methods Patients with histologically or cytologically confirmed NSCLC,and documented disease progression following second-line chemotherapy,and/or epidermal growth factor receptor-tyrosine kinase inhibitor(EGFR-TKI)treatment were enrolled in this study.The patients were treated anlotinib(8 mg daily d 1–14)and S-1(60 mg/m^2 d 1–14)and the treatment was repeated every 3 weeks.Treatment was continued until disease progression or unacceptable toxicity occurred.The objective response rate(ORR),disease control rate(DCR),progression-free survival(PFS),and adverse events(AEs)were reviewed and evaluated.Results Forty-one patients were enrolled in the study between June 2018 and December 2018.The total ORR and DCR were 26.8%and 80.5%,respectively.The median PFS was 5.2 months[95%confidence interval(CI),3.9 to 6.6 months].In the univariate analysis,there was a significant difference in the median PFS between patients with brain metastases and those without brain metastases(4.8 months vs 5.9 months,respectively;P=0.039).The Eastern Cooperative Oncology Group(ECOG)performance status(P=0.002),lines of therapy(P=0.015),and therapeutic evaluation(P=0.014)were independent factors that influenced PFS.The most common AEs were hypertension,proteinuria,myelosuppression,gastrointestinal reactions,fatigue,and mucositis.Conclusion Anlotinib plus S-1 is an effective and safe regimen for advanced NSCLC as third-or later-line therapy.

Parametric optimization of packed bed for activated coal fly ash waste heat recovery using CFD techniques

Coal fly ash is an industrial solid waste generated from coal preparation during the processing and cleaning of coal for electric power generation.Comprehensive investigation on the reutilization of waste heat of activated coal fly ash is of great economic significance.The method of recovering the waste heat,proposed in this study,is the transfer of heat from activated coal fly ash to gas with the movement of air using the packed bed,providing valuable energy sources for preheating the raw coal fly ash to reduce the overall energy consumption.The investigation is carried on the heat transfer characteristics of gas–solid(activated coal fly ash)phases and air temperature fields of the packed bed under some key conditions via computational fluid dynamics.A two dimensional geometry is utilized to represent key parts of packed bed.The distribution mechanism of the temperature field for gas phase is analyzed based on the transient temperature contours at different times.The results show that the obtained rule of gas–solid heat transfer can effectively evaluate the influences of operating parameters on the air temperature in the packed bed.Simultaneously,it is found that no temperature differences exist in the hot air at the outlet of the packed bed.The investigation provides guidance for the design and optimization of other similar energy recovery apparatuses in industries.

Radio Access Network Slicing Based on C/U Plane Separation

Network slicing achieves many interests from industry and academics due to its flexibility and scalability.In this paper,we present a novel slicing scheme for radio access networks(RANs) based on control/user(C/U) plane separation.Firstly,we divide e NBs into two sub-e NBs called Ce NB and Ue NB,for transmitting control data and user data respectively,thereby facilitating C/U plane separation.Secondly,upon Ce NBs and Ue NBs being virtualized,we develop two RAN slices for control and user plane respectively.Experimental results show the feasibility of the proposed scheme.

The gravity and isostatic Moho in North China Craton and their implications to seismicity

The Bouguer gravity is the combination of field sources in different depths. Based on the multi-scale analysis of the Bouguer gravity,we can get the gravity anomaly caused by the Moho undulation. This study presents the various orders of approximation of gravity anomaly in North China Craton（NCC）,the possible source depths with radial logarithmic power spectrum,and the relationship between the deep structure and gravity anomaly. Furthermore,we discuss the isostatic compensation about the Moho depth from gravity and deep seismic sounding profiles（DSS）. The results show that：（1） the fourth approximation could have resulted from the Moho undulation,（2） in contrast to the isostatic Moho,the inverted gravity Moho and the DSS Moho show that most of NCC has been isostatically compensated,and（3） the isostatic compensation rate has some close relation to the seismicity.

A Discussion on the Pedagogical Concepts in Confucian Analects from the View of the Pedagogy of Performed Culture Approach

Confucian Analects contains many pedagogical concepts and viewpoints that have a significant influence on China’s culture and history.Many of the concepts can be interpreted and understood from the perspective of the pedagogy of Performed Culture Approach.This paper investigates the meanings of some Confucian pedagogical discussions and thoughts,such as communicating with other social members,the relationship between language and behavior,multiple procedures in learning,and how social contexts affect one’s language and performance in the Analects,which is mainly from the perspective of the relationship between language and Performed Culture Approach.

Comparison of the efficacy of drug-eluting balloon for de novo lesions and in-stent restenosis lesions of the femoropopliteal arteries

Objective:To compare the efficacy of drug-eluting balloons for de novo and in-stent restenosis(ISR)for lesions of the femoropopliteal arteries during 12-month follow-up.Materials and methods:A retrospective analysis of 66 patients was performed.These patients had lower extremity atherosclerosis obliterans and were treated with drug-eluting balloons from June 2016 to June 2017.All the lesions were femoropopliteal,including 47 de novo lesions and 19 ISR lesions.Clinical results were followed up at 6 months and 12 months postoperatively.The primary patency rate,target lesion revascularization,Rutherford classification,ankle-brachial index,amputation rate and mortality were compared between the two groups.Results:All the 66 patients underwent the treatment of femoropopliteal artery lesions with unilateral limbs.The surgical success rates were 100%.No adverse events such as acute ischemia or amputation occurred in the hospital.There was no difference between the two groups'Rutherford classification and the ankle-brachial index at the 6-month follow-up(p>0.05).At the 12-month follow-up,the de novo group's Rutherford classification was lower than the ISR group(p=0.026),and the ankle-brachial index of the ISR group was lower(0.66±0.033 vs 0.52±0.056,p=0.036).There was no difference between the patency rate of the de novo group and the ISR group(93.6%vs 84.2%,p=0.229)at the 6-month follow-up.However,the ISR group patency rate was lower at the 12-month follow-up(63.2%vs 85.1%,p=0.048).As for revascularization there was no significant difference between the two groups at the 6-month follow-up(4.2%vs 10.5%,p=0.334),but a higher rate occurred in the ISR group at the 12-month follow-up(26.3%vs 6.4%,p=0.025).There were no significant differences in the mortality or amputation rate between the two groups(p>0.05).Conclusions:Drug-eluting balloons were effective in treating both de novo lesions and ISR lesions in the atherosclerotic femoropopliteal artery,but the 12-month follow-up results of ISR lesions were less favorable than the de novo lesions.

Estimation on wetland loss and its restoration potential in Modern Yellow River Delta,Shandong Province of China

Wetland is one of the most important ecosystems with varied functions and structures,and its loss has been a major issue.Wetland loss in Modem Yellow River Delta(MYRD) becomes a serious environmental problem,so its restoration attracts a great deal of attention from academia and governments.This article proposes a GIS-based multi-criteria comprehensive evaluation methodology for potential estimation of wetland restoration,using MYRD as an example.The model uses four kinds of data(hydrology,terrain,soil,and land use) and could be adapted by planners for use in identifying the suitability of locations as wetland mitigation sites at any site or region.In the application of the model in the MYRD,the research developed a lost wetland distributed map taking the better wetland situation of 1995 as the reference,and elevated the overall distribution trends of wetland restoration potential based on wetland polygon.The results indicated that the total area of wetland loss from 1995 to 2014 was 568.12 km^2,which includes 188.83 km^2 natural wetland and 21.80 km^2 artificial wetland,respectively.The areas of lost wetland with low,middle,and high resilience ability are 126.82 km^2,259.92 km^2,and 119.59 km^2,occupying 25.05%,51.33%,and 23.62%,respectively.The high-restoration-potential wetland included98.47 km^2 of natural wetland and 21.12 km^2 of artificial wetland,which are mainly bush,reed,and ponds.The highrestoration-potential wetland is mainly distributed in the vicinity of Gudong oil field,the Yellow River Delta protected areas,and the eastern sides of Kenli county and Dongying city.

Power Allocation for Wireless Powered MIMO Transmissions with Non-Linear RF Energy Conversion Models

We study a radio frequency(RF) wireless energy transfer(WET) enabled multiple input multiple output(MIMO) system. A time slotted transmission pattern is considered. Each slot can be divided into two phases, downlink(DL) WET and uplink(UL) wireless information transmission(WIT). Since energy conversion efficiency of the energy harvesting circuits are non.linear, the conventional linear model leads to a mismatch for resource allocation. In this paper, the power allocation algorithm considering the practical non.linear energy harvesting circuits is studied. The optimization problem is formulated to maximize the energy efficiency of system with multiple constraints, i.e., the transmission power, the received power and the minimum harvested energy, which is a non.convex problem. We transform the objective function from fractional form into an equivalent objective function in subtractive form and provide an iterative power allocation algorithm to achieve the optimal solution. Numerical results show that our proposed algorithm with the non.linear RF energy conversion models can achieve much better performance than the algorithm with the conventional linear model.

In vitro investigation of a new thrombus aspiration and autologous blood reinfusion system

Purpose: The aim of the study was to evaluate the feasibility of a new venous-thrombus aspiration and autologous blood(auto-blood) reinfusion system.Materials and methods: We constructed the venous model from polyvinyl chloride(PVC) tubes and three-way unions using a fresh clot of chicken blood as the venous thrombus. Eight French and 12 F aspiration catheters were used to aspirate the thrombus in the right–pulmonary-artery model, 8 French and 14 F aspiration catheters were used in the inferior–vena cava model, and 8 French and 10 F aspiration catheters were used in the left-–iliofemoral-vein model. A thrombus filtration and auto-blood reinfusion bottle was used to filter the thrombus and re-infuse auto-blood. We evaluated the thrombus aspiration capability of each catheter by comparing preaspirated with the post-aspirated thrombus volume, and we evaluated the difference in aspiration capability between the two catheters in each model by comparing their thrombus aspiration rates. We used Student’s t-test for statistical analysis.Results: Differences between pre-aspirated and post-aspirated thrombus volumes for each catheter were insignificant, as were those between the thrombus aspiration rates of the two catheters in each venous model. Using the thrombus aspiration and auto-blood reinfusion system, each aspiration catheter could fluently aspirate the thrombus out of the venous model.Conclusion: In this study, we designed a new venous-thrombus aspiration system. This system could be used to aspirate acute venous thrombi and re-infuse autologous blood.

烧伤患者创面感染的病原菌分布及相关危险因素分析

目的调查分析烧伤患者创面感染的病原菌分布,探讨烧伤患者创面感染的危险因素,以期为临床有效预防和治疗烧伤患者创面感染提供理论依据。方法选取解放军联勤保障部队第九二六医院2016年1月至2020年12月期间收治的245例烧伤患者,对其创面分泌物病原菌种类及抗菌药物敏感性进行检测,收集其临床相关资料,采用单因素比较法和多因素logistic回归法对引起烧伤创面感染的危险因素进行分析。结果245例烧伤患者中有184例患者发生创面感染,细菌感染率75.10%(184/245),其中多重耐药菌感染占42.93%(79/184)。共检出367株病原菌,其中革兰阳性菌19.62%(72/367),以金黄色葡萄球菌为主,占11.44%(42/367);革兰阴性杆菌株77.11%(283/367),以铜绿假单胞菌和鲍曼不动杆菌为主,分别占20.16%(74/367)和19.89%(73/367);真菌占3.27%(12/367),以曲霉菌为主,占1.91%(7/367)。药敏结果显示导致烧伤患者发生创面感染的病原菌对常见抗菌药物耐药性均较高。单因素分析结果显示,年龄(χ^(2)=8.629,P=0.013)、烧伤面积(χ^(2)=21.504,P=0.002)、烧伤深度(χ^(2)=17.139,P<0.01)、伴有低血容量性休克(χ^(2)=21.112,P=0.000)及住院时长(χ^(2)=21.967,P=0.000)均是导致烧伤创面感染的相关危险因素。多因素Logistic回归分析结果显示,患者年龄<4岁或>69岁(OR=8.414,95%CI:2.971~23.830,P=0.000)、烧伤面积>30%(OR=5.672,95%CI:1.029~31.272,P=0.046)、创面深度达Ⅲ度(OR=4.069,95%CI:1.396~11.858,P=0.010)、住院时间≥15 d(OR=2.593,95%CI:1.091~6.162,P=0.031)是引起烧伤患者创面感染的独立危险因素。结论烧伤患者创面细菌感染率及耐药率高,以革兰阴性菌为主,年龄、烧伤面积、烧伤深度、住院时间是烧伤患者创面感染的高危因素,可针对创面感染危险因素采取针对性措施,降低患者创面感染及医院感染的发生。

Reflection and transmission coefficient approximation at weak-contrast interfaces for strong VTI media

Reflection and transmission(R/T)responses characterize the propagation and energy distribution of incident and reflected waves on both sides of an interface which is crucial for imaging,amplitude variation with offset(AVO),and seismic inversion techniques.Subsurface media are typically characterized by anisotropy which can have a significant impact on the R/T response,even at small incident angles.Currently,anisotropic media problems including reflection,transmission,and inversion are generally discussed under a weak anisotropy assumption.However,this assumption is no longer valid in cases of large angles where anisotropy enhancement exacerbates the error of the conventional R/T coefficient approximation.An R/T coefficient approximation method for strong VTI media was proposed based on the assumption of weak-contrast of the media.In contrast to the conventional approach,which simplifies the phase velocity and polarization in an anisotropic background,the phase velocity and polarization at the weak-contrast interface of the elasticity and anisotropy parameters were approximated using a combination of the anisotropic background and perturbation terms.Specifically,a first-order approximation of the R/T coefficients for the VTI media characterized by elastic and anisotropic parameters was derived using Cramer's law to invert the anisotropic background matrix,avoiding the assumption of weak anisotropy.Subsequently,the exact solution of the Zoeppritz equations was used to correct the isotropic part,improving the accuracy of the R/T coefficients at interfaces with high-velocity contrast.Modeling tests on four classes of typical interfaces showed that the derived equations can be degraded to the Aki approximation in isotropic media,while exhibiting high accuracy in strong VTI media.Uncertainty analyses showed that a linear approximation that facilitates seismic inversion can be obtained by taking the S-to P-velocity ratio and anisotropy parameters in the coefficient terms a priori.