BACKGROUND Few studies have reported an association between an increased risk of acquiring cancers and survival in patients with 4q deletion syndrome.This study presents a rare association between chromosome 4q abnorm...BACKGROUND Few studies have reported an association between an increased risk of acquiring cancers and survival in patients with 4q deletion syndrome.This study presents a rare association between chromosome 4q abnormalities and fallopian tube highgrade serous carcinoma(HGSC)in a young woman.CASE SUMMARY A 35-year-old woman presented with acute dull abdominal pain and a known chromosomal abnormality involving 4q13.3 duplication and 4q23q24 deletion.Upon arrival at the emergency room,her abdomen appeared ovoid and distended with palpable shifting dullness.Ascites were identified through abdominal ultrasound,and computed tomography revealed an omentum cake and an enlarged bilateral adnexa.Blood tests showed elevated CA-125 levels.Paracentesis was conducted,and immunohistochemistry indicated that the cancer cells favored an ovarian origin,making us suspect ovarian cancer.The patient underwent debulking surgery,which led to a diagnosis of stage IIIC HGSC of the fallopian tube.Subsequently,the patient received adjuvant chemotherapy with carboplatin and paclitaxel,resulting in stable current condition.CONCLUSION This study demonstrates a rare correlation between a chromosome 4q abnormality and HGSC.UBE2D3 may affect crucial cancer-related pathways,including P53,BRCA,cyclin D,and tyrosine kinase receptors,thereby possibly contributing to cancer development.In addition,ADH1 and DDIT4 may be potential influencers of both carcinogenic and therapeutic responses.展开更多
The Tsinghua University-National Astronomical Observatories, Chinese Academy of Sciences （NAOC） Transient Survey is an automatic survey that conducts a systematic exploration of optical transients. This project util...The Tsinghua University-National Astronomical Observatories, Chinese Academy of Sciences （NAOC） Transient Survey is an automatic survey that conducts a systematic exploration of optical transients. This project utilizes a 60/90 cm Schmidt telescope at the Xinglong Station of NAOC. This survey repeatedly covers - 1000 square degrees of the northern sky with a cadence of 34 d. With an exposure of 60 s, the survey reaches a limiting unfiltered magnitude of about 19.5 mag, which enables us to discover supernovae in their relatively young stages. We describe the overall performance of our survey during the first year and present some preliminary results.展开更多
文摘BACKGROUND Few studies have reported an association between an increased risk of acquiring cancers and survival in patients with 4q deletion syndrome.This study presents a rare association between chromosome 4q abnormalities and fallopian tube highgrade serous carcinoma(HGSC)in a young woman.CASE SUMMARY A 35-year-old woman presented with acute dull abdominal pain and a known chromosomal abnormality involving 4q13.3 duplication and 4q23q24 deletion.Upon arrival at the emergency room,her abdomen appeared ovoid and distended with palpable shifting dullness.Ascites were identified through abdominal ultrasound,and computed tomography revealed an omentum cake and an enlarged bilateral adnexa.Blood tests showed elevated CA-125 levels.Paracentesis was conducted,and immunohistochemistry indicated that the cancer cells favored an ovarian origin,making us suspect ovarian cancer.The patient underwent debulking surgery,which led to a diagnosis of stage IIIC HGSC of the fallopian tube.Subsequently,the patient received adjuvant chemotherapy with carboplatin and paclitaxel,resulting in stable current condition.CONCLUSION This study demonstrates a rare correlation between a chromosome 4q abnormality and HGSC.UBE2D3 may affect crucial cancer-related pathways,including P53,BRCA,cyclin D,and tyrosine kinase receptors,thereby possibly contributing to cancer development.In addition,ADH1 and DDIT4 may be potential influencers of both carcinogenic and therapeutic responses.
基金Supported by the National Natural Science Foundation of China
文摘The Tsinghua University-National Astronomical Observatories, Chinese Academy of Sciences （NAOC） Transient Survey is an automatic survey that conducts a systematic exploration of optical transients. This project utilizes a 60/90 cm Schmidt telescope at the Xinglong Station of NAOC. This survey repeatedly covers - 1000 square degrees of the northern sky with a cadence of 34 d. With an exposure of 60 s, the survey reaches a limiting unfiltered magnitude of about 19.5 mag, which enables us to discover supernovae in their relatively young stages. We describe the overall performance of our survey during the first year and present some preliminary results.
