Head and neck squamous cell carcinoma (HNSCC) is a prevalent and lethal solid tumor with a high mortality rate. Conventional cancertreatments, including surgery, radiotherapy, and chemotherapy, primarily target cancer...Head and neck squamous cell carcinoma (HNSCC) is a prevalent and lethal solid tumor with a high mortality rate. Conventional cancertreatments, including surgery, radiotherapy, and chemotherapy, primarily target cancer cell eradication. However, uncontrolled proliferation and metabolic activities of these cells result in abnormalities in nutrient levels, hypoxia, and immunosuppression within the tumor microenvironment (TME). These factors constrain the efficacy of traditional treatments by promoting drug resistance, recurrence, and metastasis. Nanomaterials (NMs), such as nanozymes, can exhibit enzymatic activity similar to that of natural enzymes and offer a promising avenuefor the direct modification of the TME through catalytic oxidation-reduction processes. Moreover, they can serve as sensitizers or drug deliverycarriers, enhancing the efficacy of traditional treatment methods. Recently, NMs have garnered significant attention from oncologists. Thisreview begins with an overview of the composition and unique characteristics of the TME. Subsequently, we comprehensively exploredthe application of NMs in the treatment of HNSCC. Finally, we discuss the potential prospects and challenges associated with usingNMs in biomedical research.展开更多
The effect of the baicalin,a bio-active flavonoid extracted from Scutellaria baicalensis Georgi,on the carbon tetrachloride(CCl_(4))induced liver fibrosis was investigated.To compare the effect of baicalin on the live...The effect of the baicalin,a bio-active flavonoid extracted from Scutellaria baicalensis Georgi,on the carbon tetrachloride(CCl_(4))induced liver fibrosis was investigated.To compare the effect of baicalin on the liver fibrosis,five different groups of rats treated by 100,200,and 400 mg/kg baicalin were studied.Upon CCl_(4) treatment,the levels of procollagen type III,aspartate aminotransferase,aminotransferase,hyaluronic acid,and hydroxyproline were significantly increased,whereas the superoxide dismutase and glutathione peroxidase content were decreased.These changes in the biochemical parameters,which are associated with liver function,were significantly attenuated by the baicalin treatment,suggesting that baicalin can suppress the liver fibrosis induced by CCl_(4).Moreover,the histological staining analysis demonstrated that baicalin could effectively inhibit the degree of liver cell injury.The protein expression of AKT/JAK2/ERK in the serum were markedly increased by CCl_(4) but suppressed by the treatment of baicalin in a dose-dependent manner,implying that baicalin can attenuated cell apoptosis induced by CCl_(4).Overall,these results suggest that baicalin effectively protects hepatocytes from the CCl_(4) oxidative damage,likely due to the inhibition of free radical generation and cell apoptosis during the liver injury.展开更多
基金supported by medical science research joint construction project of Henan(71188)Henan Provincial Department of Education under grant no.21B320008.
文摘Head and neck squamous cell carcinoma (HNSCC) is a prevalent and lethal solid tumor with a high mortality rate. Conventional cancertreatments, including surgery, radiotherapy, and chemotherapy, primarily target cancer cell eradication. However, uncontrolled proliferation and metabolic activities of these cells result in abnormalities in nutrient levels, hypoxia, and immunosuppression within the tumor microenvironment (TME). These factors constrain the efficacy of traditional treatments by promoting drug resistance, recurrence, and metastasis. Nanomaterials (NMs), such as nanozymes, can exhibit enzymatic activity similar to that of natural enzymes and offer a promising avenuefor the direct modification of the TME through catalytic oxidation-reduction processes. Moreover, they can serve as sensitizers or drug deliverycarriers, enhancing the efficacy of traditional treatment methods. Recently, NMs have garnered significant attention from oncologists. Thisreview begins with an overview of the composition and unique characteristics of the TME. Subsequently, we comprehensively exploredthe application of NMs in the treatment of HNSCC. Finally, we discuss the potential prospects and challenges associated with usingNMs in biomedical research.
基金The animal study was approved by the Institutional Animal Care and Use Committee of Shanghai Rat&Mouse Biotech Co.,Ltd.(SHRM)(Approval No.SHRM-IACUC-045).
文摘The effect of the baicalin,a bio-active flavonoid extracted from Scutellaria baicalensis Georgi,on the carbon tetrachloride(CCl_(4))induced liver fibrosis was investigated.To compare the effect of baicalin on the liver fibrosis,five different groups of rats treated by 100,200,and 400 mg/kg baicalin were studied.Upon CCl_(4) treatment,the levels of procollagen type III,aspartate aminotransferase,aminotransferase,hyaluronic acid,and hydroxyproline were significantly increased,whereas the superoxide dismutase and glutathione peroxidase content were decreased.These changes in the biochemical parameters,which are associated with liver function,were significantly attenuated by the baicalin treatment,suggesting that baicalin can suppress the liver fibrosis induced by CCl_(4).Moreover,the histological staining analysis demonstrated that baicalin could effectively inhibit the degree of liver cell injury.The protein expression of AKT/JAK2/ERK in the serum were markedly increased by CCl_(4) but suppressed by the treatment of baicalin in a dose-dependent manner,implying that baicalin can attenuated cell apoptosis induced by CCl_(4).Overall,these results suggest that baicalin effectively protects hepatocytes from the CCl_(4) oxidative damage,likely due to the inhibition of free radical generation and cell apoptosis during the liver injury.
