Background:Considering the widespread of coronavirus disease 2019(COVID-19)pandemic in the world,it is important to understand the spatiotemporal development of the pandemic.In this study,we aimed to visualize time-as...Background:Considering the widespread of coronavirus disease 2019(COVID-19)pandemic in the world,it is important to understand the spatiotemporal development of the pandemic.In this study,we aimed to visualize time-associated alterations of COVID-19 in the context of continents and countries.展开更多
Background:Contrast-enhanced ultrasound(CEUS)can detect lesions hidden in inflammatory regions and find necrosis or areas of severe fibrosis within the lesion.This retrospective study aimed to compare the diagnostic a...Background:Contrast-enhanced ultrasound(CEUS)can detect lesions hidden in inflammatory regions and find necrosis or areas of severe fibrosis within the lesion.This retrospective study aimed to compare the diagnostic accuracy of solid pancreatic lesions using percutaneous ultrasound(US)-guided fine-needle aspiration(FNA)with or without CEUS assessment.Methods:Clinical,imaging,and pathologic data of 181 patients from January 2014 to December 2018 in Pecking Union Medical College Hospital,with solid pancreatic masses who underwent percutaneous US-FNA and ThinPrep cytologic test were retrospectively evaluated.Patients were divided into CEUS and US groups according to whether CEUS was performed before the biopsy.According to FNA cytology diagnoses,we combined non-diagnostic,neoplastic,and negative cases into a negative category.The positive category included malignant,suspicious,and atypical cases.The final diagnosis was confirmed by pathology or clinical and radiological follow-up for at least 12 months.The sensitivity,specificity,positive predictive value(PPV),negative predictive value(NPV),and accuracy of US-FNA were evaluated between the two groups.Results:This study enrolled 107 male and 74 female patients(average age:60 years).There were 58 cases in the US group and 123 cases in the CEUS group.No statistically significant differences in age,gender,or lesion size were found between the two groups.The diagnostic accuracy of the CEUS group was 95.1%(117/123),which was higher than the 86.2%(50/58)observed in the US group(P=0.036).The sensitivity,specificity,PPV,and NPV of the CEUS group were increased by 7.5%,16.7%,3.4%,and 18.8%,respectively,compared with the US group.However,the differences of the two groups were not statistically significant.Conclusions:Compared with the conventional US,the use of CEUS could improve the biopsy accuracy and avoid the need for a repeat biopsy,especially for some complicated FNA cases.展开更多
Hand, foot and mouth disease(HFMD) is a significant health concern in the Asia–Pacific regions for infants and young children in recent years. However, no vaccines or therapeutics are available at present. The causat...Hand, foot and mouth disease(HFMD) is a significant health concern in the Asia–Pacific regions for infants and young children in recent years. However, no vaccines or therapeutics are available at present. The causative agents for HFMD include human enterovirus 71(EV71), coxsackievirus A16(CVA16) and some other viruses. Recently, tremendous progress has been made in the development of monovalent and bivalent vaccines against HFMD. A few neutralizing monoclonal antibodies against EV71 or CVA16 have been identified and characterized. Here, we reviewed some achievements for the development of broadly protective vaccines and neutralizing antibodies against HFMD, and discussed challenges and prospects toward broadly protective multivalent vaccines and therapeutic antibodies against HFMD.展开更多
Along with the announcement of COVID-19 as a global pandemic by the World Health Organization(WHO)on March 12,2020,COVID-19 appeared to be spreading rapidly around the world.By 10:00 CET on March 25,2020,a total of 33...Along with the announcement of COVID-19 as a global pandemic by the World Health Organization(WHO)on March 12,2020,COVID-19 appeared to be spreading rapidly around the world.By 10:00 CET on March 25,2020,a total of 331,619 confirmed cases and 15,146 deaths were reported from 195 foreign countries and regions on 6 continents plus the Diamond Princess international cruise ship,and among them,124 countries and regions had local transmission.Cumulatively,the WHO website reported 15,918 confirmed COVID-19 cases from 16 countries and regions in the Western Pacific excluding China,220,516 cases from 60 countries and regions in Europe,2,344 cases from 10 countries and regions in South-East Asia,29,631 cases from 21 countries and regions in the Eastern Mediterranean,60,834 cases from 48 countries and regions in the Americas,and 1,664 cases from 39 countries and regions in Africa(1).展开更多
INTRODUCTION In the past 7 days,COVID-19 continued rapidly spreading worldwide.According to the World Health Organization(WHO)website,by 10:00 CET on April 7,2020,209 foreign countries and territories on 6 continents ...INTRODUCTION In the past 7 days,COVID-19 continued rapidly spreading worldwide.According to the World Health Organization(WHO)website,by 10:00 CET on April 7,2020,209 foreign countries and territories on 6 continents plus the Diamond Princess international cruise ship reported 1,196,651 confirmed cases and 69,274 deaths;among them,178 countries and territories were confirmed to have local transmission.Cumulatively,the WHO website reported 30,570 confirmed COVID-19 cases from 18 countries and territories in the Western Pacific(excluding China),686,338 cases from 60 countries and territories in Europe,9,132 cases from 10 countries and territories in South-East Asia,78,565 cases from 21 countries and territories in the Eastern Mediterranean,384,242 cases from 53 countries and territories in the Americas,and 7,092 cases from 47 countries and territories in Africa(1).展开更多
Along with the announcement of COVID-19 as a global pandemic by the World Health Organization(WHO)on March 12,2020,COVID-19 appeared to be spreading rapidly around the world.By 10:00 CET on April 1,2020,a total of 740...Along with the announcement of COVID-19 as a global pandemic by the World Health Organization(WHO)on March 12,2020,COVID-19 appeared to be spreading rapidly around the world.By 10:00 CET on April 1,2020,a total of 740,995 confirmed cases and 37,277 deaths were reported from 204 foreign countries and regions on 6 continents plus the Diamond Princess international cruise ship;among them,161 countries and regions had local transmission.Cumulatively,the WHO website reported 23,791 confirmed COVID-19 cases from 18 countries and regions in the Western Pacific(excluding China),464,212 cases from 60 countries and regions in Europe,5,175 cases from 10 countries and regions in South-East Asia,54,281 cases from 21 countries and regions in the Eastern Mediterranean,188,751 cases from 51 countries and regions in the Americas,and 4,785 cases from 44 countries and regions in Africa(1).展开更多
文摘Background:Considering the widespread of coronavirus disease 2019(COVID-19)pandemic in the world,it is important to understand the spatiotemporal development of the pandemic.In this study,we aimed to visualize time-associated alterations of COVID-19 in the context of continents and countries.
基金The study is supported by grants from the National Natural Science Foundation of China(No.81873902)the CAMS Innovation Fund for Medical Sciences(Nos.2016-I2M-3-005,2020-I2M-C&T-B-039)。
文摘Background:Contrast-enhanced ultrasound(CEUS)can detect lesions hidden in inflammatory regions and find necrosis or areas of severe fibrosis within the lesion.This retrospective study aimed to compare the diagnostic accuracy of solid pancreatic lesions using percutaneous ultrasound(US)-guided fine-needle aspiration(FNA)with or without CEUS assessment.Methods:Clinical,imaging,and pathologic data of 181 patients from January 2014 to December 2018 in Pecking Union Medical College Hospital,with solid pancreatic masses who underwent percutaneous US-FNA and ThinPrep cytologic test were retrospectively evaluated.Patients were divided into CEUS and US groups according to whether CEUS was performed before the biopsy.According to FNA cytology diagnoses,we combined non-diagnostic,neoplastic,and negative cases into a negative category.The positive category included malignant,suspicious,and atypical cases.The final diagnosis was confirmed by pathology or clinical and radiological follow-up for at least 12 months.The sensitivity,specificity,positive predictive value(PPV),negative predictive value(NPV),and accuracy of US-FNA were evaluated between the two groups.Results:This study enrolled 107 male and 74 female patients(average age:60 years).There were 58 cases in the US group and 123 cases in the CEUS group.No statistically significant differences in age,gender,or lesion size were found between the two groups.The diagnostic accuracy of the CEUS group was 95.1%(117/123),which was higher than the 86.2%(50/58)observed in the US group(P=0.036).The sensitivity,specificity,PPV,and NPV of the CEUS group were increased by 7.5%,16.7%,3.4%,and 18.8%,respectively,compared with the US group.However,the differences of the two groups were not statistically significant.Conclusions:Compared with the conventional US,the use of CEUS could improve the biopsy accuracy and avoid the need for a repeat biopsy,especially for some complicated FNA cases.
基金supported by the National Basic Research Program of China(2010CB912403)the National Natural Science Foundation of China(31370730 and 31070144)
文摘Hand, foot and mouth disease(HFMD) is a significant health concern in the Asia–Pacific regions for infants and young children in recent years. However, no vaccines or therapeutics are available at present. The causative agents for HFMD include human enterovirus 71(EV71), coxsackievirus A16(CVA16) and some other viruses. Recently, tremendous progress has been made in the development of monovalent and bivalent vaccines against HFMD. A few neutralizing monoclonal antibodies against EV71 or CVA16 have been identified and characterized. Here, we reviewed some achievements for the development of broadly protective vaccines and neutralizing antibodies against HFMD, and discussed challenges and prospects toward broadly protective multivalent vaccines and therapeutic antibodies against HFMD.
文摘Along with the announcement of COVID-19 as a global pandemic by the World Health Organization(WHO)on March 12,2020,COVID-19 appeared to be spreading rapidly around the world.By 10:00 CET on March 25,2020,a total of 331,619 confirmed cases and 15,146 deaths were reported from 195 foreign countries and regions on 6 continents plus the Diamond Princess international cruise ship,and among them,124 countries and regions had local transmission.Cumulatively,the WHO website reported 15,918 confirmed COVID-19 cases from 16 countries and regions in the Western Pacific excluding China,220,516 cases from 60 countries and regions in Europe,2,344 cases from 10 countries and regions in South-East Asia,29,631 cases from 21 countries and regions in the Eastern Mediterranean,60,834 cases from 48 countries and regions in the Americas,and 1,664 cases from 39 countries and regions in Africa(1).
基金supported by the foundation of the Science and Technology Department of“Evaluation and Analysis of the 2019-nCoV Transmission Epidemiology and Control Strategies”Project,“Public Security Risk Control&Emergency Technical Equipment”Key Program,National Key R&D Program of China(No.2012C33002).
文摘INTRODUCTION In the past 7 days,COVID-19 continued rapidly spreading worldwide.According to the World Health Organization(WHO)website,by 10:00 CET on April 7,2020,209 foreign countries and territories on 6 continents plus the Diamond Princess international cruise ship reported 1,196,651 confirmed cases and 69,274 deaths;among them,178 countries and territories were confirmed to have local transmission.Cumulatively,the WHO website reported 30,570 confirmed COVID-19 cases from 18 countries and territories in the Western Pacific(excluding China),686,338 cases from 60 countries and territories in Europe,9,132 cases from 10 countries and territories in South-East Asia,78,565 cases from 21 countries and territories in the Eastern Mediterranean,384,242 cases from 53 countries and territories in the Americas,and 7,092 cases from 47 countries and territories in Africa(1).
文摘Along with the announcement of COVID-19 as a global pandemic by the World Health Organization(WHO)on March 12,2020,COVID-19 appeared to be spreading rapidly around the world.By 10:00 CET on April 1,2020,a total of 740,995 confirmed cases and 37,277 deaths were reported from 204 foreign countries and regions on 6 continents plus the Diamond Princess international cruise ship;among them,161 countries and regions had local transmission.Cumulatively,the WHO website reported 23,791 confirmed COVID-19 cases from 18 countries and regions in the Western Pacific(excluding China),464,212 cases from 60 countries and regions in Europe,5,175 cases from 10 countries and regions in South-East Asia,54,281 cases from 21 countries and regions in the Eastern Mediterranean,188,751 cases from 51 countries and regions in the Americas,and 4,785 cases from 44 countries and regions in Africa(1).
