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Clinical features of multiple gastrointestinal stromal tumors:A pooling analysis combined with evidence and gap map 被引量:2
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作者 Chen Li Ke-Lu Yang +6 位作者 Quan Wang Jin-Hui Tian Yang Li Zhi-Dong Gao Xiao-Dong Yang Ying-jiang Ye ke-wei jiang 《World Journal of Gastroenterology》 SCIE CAS 2020年第47期7550-7567,共18页
BACKGROUND Multiple gastrointestinal stromal tumors(MGISTs)are a very rare type of gastrointestinal stromal tumor(GIST)and are usually observed in syndrome.AIM The paper aimed to describe the clinical and oncological ... BACKGROUND Multiple gastrointestinal stromal tumors(MGISTs)are a very rare type of gastrointestinal stromal tumor(GIST)and are usually observed in syndrome.AIM The paper aimed to describe the clinical and oncological features of MGISTs and to offer evidence for the diagnosis and treatment.METHODS Data of consecutive patients with MGISTs who were diagnosed at Peking University People’s Hospital(PKUPH)from 2008 to 2019 were retrospectively evaluated.Further,a literature search was conducted by retrieving data from PubMed,EMBASE,and the Cochrane library databases from inception up to November 30,2019.RESULTS In all,12 patients were diagnosed with MGISTs at PKUPH,and 43 published records were ultimately included following the literature review.Combined analysis of the whole individual patient data showed that female(59.30%),young(14.45%),and syndromic GIST(63.95%)patients comprised a large proportion of the total patient population.Tumors were mainly located in the small intestine(58.92%),and both CD117 and CD34 were generally positive.After a mean 78.32-mo follow-up,the estimated median overall survival duration(11.5 years)was similar to single GISTs,but recurrence-free survival was relatively poorer.CONCLUSION The clinical and oncological features are potentially different between MGISTs and single GIST.Further studies are needed to explore appropriate surgical approach and adjuvant therapy. 展开更多
关键词 Gastrointestinal stromal tumor MULTIPLE Pooling analysis Cross sectional study Evidence and gap map
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What is the best surgical procedure of transverse colon cancer?An evidence map and minireview 被引量:2
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作者 Chen Li Quan Wang ke-wei jiang 《World Journal of Gastrointestinal Oncology》 SCIE 2021年第5期391-399,共9页
Colorectal cancers comprise a large percentage of tumors worldwide,and transverse colon cancer(TCC)is defined as tumors located between hepatic and splenic flexures.Due to the anatomy and embryology complexity,and lac... Colorectal cancers comprise a large percentage of tumors worldwide,and transverse colon cancer(TCC)is defined as tumors located between hepatic and splenic flexures.Due to the anatomy and embryology complexity,and lack of large randomized controlled trials,it is a challenge to standardize TCC surgery.In this study,the current situation of transverse/extended colectomy,robotic/laparoscopic/open surgery and complete mesocolic excision(CME)concept in TCC operations is discussed and a heatmap is conducted to show the evidence level and gap.In summary,transverse colectomy challenges the dogma of traditional extended colectomy,with similar oncological and prognostic outcomes.Compared with conventional open resection,laparoscopic and robotic surgery plays a more important role in both transverse colectomy and extended colectomy.The CME concept may contribute to the radical resection of TCC and adequate harvested lymph nodes.According to published studies,laparoscopic or robotic transverse colectomy based on the CME concept was the appropriate surgical procedure for TCC patients. 展开更多
关键词 Evidence map Extended colectomy Review Surgical procedures Transverse colectomy Transverse colon cancer
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Diagnosis and Treatment of Cholangiocarcinoma: A Consensus from Surgical Specialists of China 被引量:2
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作者 Jian-qiang Cai Shou-wang Cai +50 位作者 Wen-ming Cong Min-shan Chen Ping Chen Xiao-ping Chen Yan-ling Chen Yi-fa Chen Chao-liu Dai Qiang Huang Zhi-yong Huang Bo jiang Bin jiang ke-wei jiang Bo Li Zong-fangLi Li-jian Liang Bin Liu Hui-chun Liu Lian-xin Liu Qing-guang Liu Rong Liu Ying-bin Liu Jian-guo Lu Shi-chun Lu Yi Lu Yi-lei Mao Bin Mei Jun Niu Bao-gang Peng Xiao Qin Yu-dong Qiu Guang-yi Wang Yao-don Wangg Zhi-ming Wang Ren-hua Wan Ya-fu Wu Bao-cai Xing Feng Xia Ge-liang Xu Jia-mei Yang Xiao-fang Yu Yong Zeng Yong-yi Zeng Bi-xiang Zhang Bin-hao Zhang Qi-yu Zhang Shui-jun Zhang Wan-guang Zhang Yong-jie Zhang Zhi-wei Zhang Dong Zhou Wei-ping Zhou 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2014年第4期469-475,共7页
Cholangiocarcinoma refers to malignant tumors that develop in epithelial lining of biliary system, and it is divided into two categories according to tumor location, intrahepatic cholangiocarcinoma (ICC) and extrahe... Cholangiocarcinoma refers to malignant tumors that develop in epithelial lining of biliary system, and it is divided into two categories according to tumor location, intrahepatic cholangiocarcinoma (ICC) and extrahepatic cholangiocarcinoma (ECC). ICC occurs from the epithelial cells of the intrahepatic bile duct, its branches and interlobular biliary tree; and ECC is divided into hilar cholangiocarcinoma and distal cholangiocarcinoma by the circumscription at the confluence of cystic duct and the common hepatic duct. 展开更多
关键词 A Consensus from Surgical Specialists of China Diagnosis and Treatment of Cholangiocarcinoma
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Genetic mutations associated with sensitivity to neoadjuvant chemotherapy in metastatic colon cancer:A case report and review of literature 被引量:1
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作者 Long Zhao Quan Wang +5 位作者 Shi-Dong Zhao Jing Zhou ke-wei jiang Ying-jiang Ye Shan Wang Zhan-Long Shen 《World Journal of Clinical Cases》 SCIE 2021年第24期7099-7109,共11页
BACKGROUND Colorectal liver metastases(CLM)occur in 15%-30%of patients with colorectal cancer(CRC).Advancements in next generation sequencing(NGS)can provide more precise prognoses for cancer patients and help guide c... BACKGROUND Colorectal liver metastases(CLM)occur in 15%-30%of patients with colorectal cancer(CRC).Advancements in next generation sequencing(NGS)can provide more precise prognoses for cancer patients and help guide clinical treatment.However,the genetic variants that predict high sensitivity to neoadjuvant chemotherapy remain unclear,especially in patients with CLM.The aim of this study was to identify the relevant genetic variants in a single CLM patient and to summarize the current evidence on mutations and single nucleotide polymorphisms(SNPs)that objectively predict sensitivity to neoadjuvant chemotherapy.CASE SUMMARY A 76-year-old male patient,who was diagnosed as stage IV colon cancer with liver metastases,was found to have APC/TP53/KRAS mutations.He showed a good therapeutic response to 12 courses of oxaliplatin regimens combined with Bevacizumab.Genetic analysis of the patient identified 5 genes with 7 detected SNPs that may be related to a better response to chemotherapy drugs.In addition,a critical literature review was performed based on a standardized appraisal form after selecting the articles.Ultimately,21 eligible studies were appraised to assess the association between gene mutations and good prognosis.Mutations in KRAS,TP53,SMAD4,and APC were identified as being associated with a poor response to chemotherapy drugs,whereas mutations of CREBBP and POLD1 were associated with longer overall survival.CONCLUSION NGS can identify precise predictors of response to neoadjuvant chemotherapy,leading to improved outcomes for CRC patients. 展开更多
关键词 Colorectal liver metastases Next generation sequencing Neoadjuvant chemotherapy Genetic variants Case report
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Clinicopathological characteristics and longterm survival of patients with synchronous multiple primary gastrointestinal stromal tumors: A propensity score matching analysis
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作者 Hao Wu Chen Li +9 位作者 Han Li Liang Shang Hai-Yan Jing Jin Liu Zhen Fang Feng-Ying Du Yang Liu Meng-Di Fu ke-wei jiang Le-Ping Li 《World Journal of Gastroenterology》 SCIE CAS 2021年第36期6128-6141,共14页
BACKGROUND Multiple gastrointestinal stromal tumors(MGISTs)are specific and rare.Little is known about the impact of MGISTs on the survival of patients with gastrointestinal stromal tumors(GIST).The diagnosis,treatmen... BACKGROUND Multiple gastrointestinal stromal tumors(MGISTs)are specific and rare.Little is known about the impact of MGISTs on the survival of patients with gastrointestinal stromal tumors(GIST).The diagnosis,treatment and follow-up strategies of MGISTs is not specifically described in guidelines.AIM To compare the clinicopathological characteristics and prognosis of MGISTs and solitary GISTs(SGISTs)METHODS Patients diagnosed with primary GISTs from March 2010 to January 2020 were included.Due to the inhomogeneous distribution of several baseline characteristics and uneven MGIST and SGIST group sizes,propensity score matching was performed according to comorbidities,body mass index,tumor location,mitotic index,sex,age and American Society of Anesthesiologists score.Differences in clinicopathological characteristics and prognosis between patients with MGISTs and patients with SGISTs were compared.RESULTS Among the entire cohort of 983 patients,the incidence of MGISTs was 4.17%.Before matching,patients with MGISTs and those with SGISTs had disparities in body mass index,surgical approach,tumor size and mitotic index.After 1:4 ratio matching,the clinical baseline data were comparable.The 5-year progression-free survival rate was 52.17%in the MGIST group and 75.00%in the SGIST group(P=0.031).On multivariate analysis,tumor location,tumor size,mitotic index,imatinib treatment and MGISTs(hazard ratio=2.431,95%confidence interval=1.097-5.386,P=0.029)were identified as independent prognostic factors of progression-free survival.However,overall survival was similar between the SGIST and MGIST groups.CONCLUSION Patients with MGISTs had poorer progression-free survival than patients with SGISTs.Risk criteria and diagnostic and treatment strategies should be developed to achieve personalized precision therapy and maximize the survival benefit. 展开更多
关键词 Gastrointestinal stromal tumors SYNCHRONOUS Multiple tumors Solitary tumor Propensity score matching PROGNOSIS
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Identifying a Safe Range of Stimulation Current for Intraoperative Neuromonitoring of the Recurrent Laryngeal Nerve: Results from a Canine Model
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作者 Tao Li Gang Zhou +8 位作者 Yang Yang Zhi-Dong Gao Peng Guo Zhan-Long Shen Xiao-Dong Yang Qi-Wei Xie Ying-jiang Ye ke-wei jiang Shan Wang 《Chinese Medical Journal》 SCIE CAS CSCD 2016年第15期1830-1834,共5页
Background: lntraoperative neuromonitoring (IONM) of the recunent laryngeal nerve (RLN) has been widely applied during thyroid surgery. However, the sale range of stimulation intensity for IONM remains undetermin... Background: lntraoperative neuromonitoring (IONM) of the recunent laryngeal nerve (RLN) has been widely applied during thyroid surgery. However, the sale range of stimulation intensity for IONM remains undetermined, Methods: Total thyroidectomies were performed on twenty dogs, and their RLNs were stimulated with a current of 5 20 mA (step-wise in 5 mA increments) for 1 min. The evoked electromyography (EMG) of vocal muscles before and after supramaximal stimulation were recorded and compared. Acute microstructural morphological changes in the RLNs were observed immediately postoperatively under an electron microscope. Results: The average stimulating threshold for RLNs stimulated with 15 mA and 20 mA showed no significant changes compared to the unstimulated RLNs (15 mA group: 0.320 ± 0.123 mA vs. 0.315 ±0.097 mA, P =0.847; 20 mA group: 0.305 ± 0.101 mA vs. 0.300 + 0.103 mA, P = 0.758). Similar outcomes were shown in average evoked EMG amplitude (15 mA group: 1,026 ± 268 p.V xs. 1,021 ± 273 p.V, P = 0.834; 20 mA group: 1,162 ± 275 μV vs. 1,200 ± 258μV, P = 0.148). However, obvious acute microstructural morphological changes were observed in the nerves that were stimulated with 20 mA. Conclusions: A stimulation intensity less than 15 mA might be safe for IONM of the RLN. 展开更多
关键词 Canine Model NEUROMONITORING Recurrent Laryngeal Nerve Safe Stimulation Intensity Thyroid Surgery
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Gastrointestinal Stromal Tumors with KIT Mutation Coexisting with Wild-type Gastrointestinal Stromal Tumors in a Patient with Neurofibromatosis Type 1 被引量:1
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作者 Yang Li Zhi-Dong Gao +3 位作者 Xiao-Dong Yang Ying-jiang Ye Shan Wang ke-wei jiang 《Chinese Medical Journal》 SCIE CAS CSCD 2018年第18期2244-2245,共2页
To the Editor: Neurofibromatosis type 1 (NFI) is one of the most common autosomal dominant inherited disorders with a prevalence of approximately 1 in 3000 individuals, Gastrointestinal stromal tumors (GISTs) are... To the Editor: Neurofibromatosis type 1 (NFI) is one of the most common autosomal dominant inherited disorders with a prevalence of approximately 1 in 3000 individuals, Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. Studies have suggested that NF 1 associated GISTs (NF 1-GISTs) manifest at younger ages than sporadic GISTs. 展开更多
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