Grooming is an innate behavior that serves multiple purposes and has a dual nature, reflecting both comfort and stress. Auto-grooming, in particular, is highly sensitive to stressors and can be influenced by natural a...Grooming is an innate behavior that serves multiple purposes and has a dual nature, reflecting both comfort and stress. Auto-grooming, in particular, is highly sensitive to stressors and can be influenced by natural and synthetic anxiolytics. Researchers believe that rodent grooming can be a valuable tool in translational neurobiological studies, specifically focusing on aberrant grooming, such as the syntactic chain of grooming, which can serve as an experimental model for certain human psycho-nervous disorders.展开更多
According to our research, the use of radon inhalation in experimental animals, particularly in genetically determined rats with epileptic seizures, altered all parameters of the epileptic seizure development picture,...According to our research, the use of radon inhalation in experimental animals, particularly in genetically determined rats with epileptic seizures, altered all parameters of the epileptic seizure development picture, namely the hidden period, the first and second wild jog duration after the audiogenic signal. On the third day, no response to the audiogenic signal was observed at all, and not even a single episode of tonic-clonic seizures. All mentioned suggest that radon inhalation could be used to treat epilepsy. Presented study is the first precedent of attempt R-Ho through inhalation for treatment of epileptic seizures in animal models with further translation to clinical study in humans through pilot phase II study. More profound and scientifically systematized approach is needed to determine uniqueness of Tskhaltubo water springs, great importance investigation of the mechanisms of radon effects on the excitatory and inhibitory functioning of CNS and further clinical studies to establish its effect on humans.展开更多
文摘Grooming is an innate behavior that serves multiple purposes and has a dual nature, reflecting both comfort and stress. Auto-grooming, in particular, is highly sensitive to stressors and can be influenced by natural and synthetic anxiolytics. Researchers believe that rodent grooming can be a valuable tool in translational neurobiological studies, specifically focusing on aberrant grooming, such as the syntactic chain of grooming, which can serve as an experimental model for certain human psycho-nervous disorders.
文摘According to our research, the use of radon inhalation in experimental animals, particularly in genetically determined rats with epileptic seizures, altered all parameters of the epileptic seizure development picture, namely the hidden period, the first and second wild jog duration after the audiogenic signal. On the third day, no response to the audiogenic signal was observed at all, and not even a single episode of tonic-clonic seizures. All mentioned suggest that radon inhalation could be used to treat epilepsy. Presented study is the first precedent of attempt R-Ho through inhalation for treatment of epileptic seizures in animal models with further translation to clinical study in humans through pilot phase II study. More profound and scientifically systematized approach is needed to determine uniqueness of Tskhaltubo water springs, great importance investigation of the mechanisms of radon effects on the excitatory and inhibitory functioning of CNS and further clinical studies to establish its effect on humans.
