改进哈里斯鹰算法的仓储机器人路径规划研究

为提高静态环境下仓储移动机器人路径规划效率,解决传统哈里斯鹰(Harris Hawks optimization, HHO)算法在路径规划中存在收敛速度慢且易陷入局部最优的问题,提出了一种基于Tent混沌映射融合柯西反学习变异的哈里斯鹰优化算法(HHO algorithmbasedon Tentchaotic mapping hybrid Cauchy mutation and inverse learning, TCLHHO)。通过Tent混沌映射增加种群多样性,以提高算法的收敛速度;提出指数型的猎物逃逸能量更新策略,以平衡算法的全局搜索和局部开发能力;通过柯西反学习变异策略对最优个体进行扰动,扩大算法的搜索范围,增强全局搜索能力。根据真实仓储环境搭建二维栅格环境模型,并在Matlab中进行仿真对比实验。结果表明:该算法的规划速度、最优路径长度以及最优路径转折次数较对比算法具有较好的效果,验证了应用于智能仓储环境下改进的HHO路径规划问题的可行性和鲁棒性。

炎症和免疫指标对乙型肝炎病毒感染相关慢加急性肝衰竭预后判断价值研究进展

乙型肝炎病毒感染相关慢加急性肝衰竭(hepatitis B virus-related acute-on-chronic liver failure,HBV-ACLF)是在慢性乙型肝炎病毒感染导致的慢性肝病基础上,短期内出现急性肝功能失代偿的临床综合征。HBV-ACLF具有病情进展迅速、治疗效果差、死亡率高的特点。炎症和免疫应答是HBV-ACLF发生、发展及产生多器官、组织损伤的重要原因。本文对超敏C反应蛋白、降钙素原、白细胞介素类、淋巴细胞亚群类、趋化因子等炎症指标,以及超敏C反应蛋白/白蛋白比值、中性粒细胞/淋巴细胞比值、血小板/白细胞比值等多因素指标在HBV-ACLF病情及预后判断中的应用进行综述,发现动态观察炎症和免疫相关指标对HBV-ACLF预后判断、治疗方式选择等具有指导意义,且多因素指标判断HBV-ACLF患者预后的灵敏度及特异度优于单因素指标。炎症和免疫指标对HBV-ACLF患者预后判断具有指导意义。

甲胎蛋白在乙型肝炎病毒感染相关慢加急性肝衰竭诊治中的价值

乙型肝炎病毒感染相关慢加急性肝衰竭(hepatitis B virus infection-related acute liver failure,HBV-ACLF)是在乙型肝炎病毒(hepatitis B virus,HBV)感染导致的慢性肝炎和终末期肝病基础上发生的以肝脏功能急性衰竭为特征的临床综合征,是中国最主要的肝衰竭类型,短期死亡率极高。基础研究发现甲胎蛋白(alpha fetoprotein,AFP)水平与HBV-ACLF短期预后相关,可用于预测肝衰竭患者的短期预后。临床研究发现由中性粒细胞、乙型肝炎病毒表面抗原和AFP组成的NHA-ACLF模型,由总胆红素、年龄、血肌酐、国际标准化比值和AFP组成的TACIA评分模型,含AFP的人工肝支持系统-预后模型(APM)以及AFP的四分位数分层等对HBV-ACLF短期预后预测价值优于单用AFP。

《动物试验设计与数据分析》课程案例库建设与应用

《动物试验设计与数据分析》课程教学内容具有概念多,理论复杂,内容抽象的特点,针对目前该课程课堂教学以理论为主,与实际应用结合不够紧密,缺乏贯穿整个课程的案例资源的教学现状,本文从编写合适的教学案例、组织学生对案例进行演练、对案例教学进行恰当的评价总结入手,对动物试验设计与数据分析这门课程进行了案例式教学的应用与探索。教学案例库的建设和应用,是将教学理论知识与实践相结合,降低学生学习难度的重要措施,同时能提高学生发现问题、分析问题、解决问题的能力。

Appendiceal intussusception complicated by adenocarcinoma of the cecum:A case report

BACKGROUND Appendiceal intussusception is a pathological condition in which the appendix is inverted into the cecum,which may cause symptoms that resemble those of other gastrointestinal disorders and may induce intestinal obstruction.The rarity of this case presentation is the co-occurrence of appendiceal intussusception and cecal adenocarcinoma,a combination that to our knowledge has not previously been reported in the medical literature.This case provides new insights into the complexities of diagnosing and managing overlapping pathologies.CASE SUMMARY A 25-year-old woman presented with persistent periumbilical pain and bloody stools.An initial biopsy showed cecal cancer;however,subsequent colonoscopy and computed tomography findings raised the suspicion of appendiceal intussus-ception,which was later confirmed postoperatively.This unique case was charac-terized by a combination of intussusception and adenocarcinoma of the cecum.The intervention included a laparoscopic right hemicolectomy,which led to the histopathological diagnosis of mucinous adenocarcinoma with appendiceal intussusception.The patient recovered well postoperatively and was advised to initiate adjuvant chemotherapy.This case highlights not only the importance of considering appendiceal intussusception in the differential diagnosis,but also the possibility of appendicitis and the atypical presentation of neoplastic lesions.CONCLUSIONS Physicians should consider the possibility of appendiceal intussusception in cases of atypical appendicitis,particularly when associated with neoplastic presentation.

Rockburst criterion and evaluation method for potential rockburst pit depth considering excavation damage effect

Excavation-induced disturbances in deep tunnels will lead to deterioration of rock properties and formation of excavation damaged zone(EDZ).This excavation damage effect may affect the potential rockburst pit depth.Taking two diversion tunnels of Jinping II hydropower station for example,the relationship between rockburst pit depth and excavation damage effect is first surveyed.The results indicate that the rockburst pit depth in tunnels with severe damage to rock masses is relatively large.Subsequently,the excavation-induced damage effect is characterized by disturbance factor D based on the Hoek-Brown criterion and wave velocity method.It is found that the EDZ could be further divided into a high-damage zone(HDZ)with D=1 and weak-damage zone(WDZ),and D decays from one to zero linearly.For this,a quantitative evaluation method for potential rockburst pit depth is established by presenting a three-element rockburst criterion considering rock strength,geostress and disturbance factor.The evaluation results obtained by this method match well with actual observations.In addition,the weakening of rock mass strength promotes the formation and expansion of potential rockburst pits.The potential rockburst pit depth is positively correlated with HDZ and WDZ depths,and the HDZ depth has a significant contribution to the potential rockburst pit depth.

睡眠剥夺对面孔情绪加工的影响——认知神经科学的视角

面部表情是社会互动和情绪感染的重要形式,准确的面部情绪加工有助于做出合适的社会行为.睡眠缺乏会影响面孔情绪加工的不同方面,损伤面孔情绪分类和模糊情绪评级,并减弱记忆的巩固效果.以往研究通过不同类型的剥夺操作,为整夜睡眠、快速眼动(REM)睡眠和非快速眼动(NREM)睡眠在面孔情绪加工中的作用提供了依据.综合已有证据,面孔情绪加工异常可能是REM阶段特异性依赖的,体现在杏仁核、前额叶、脑岛及前扣带等脑区的皮层活动及睡眠阶段γ和θ等脑电活动.应加强睡眠阶段或组合在面孔情绪加工中的机制探讨,有望未来基于面孔情绪加工,更好地实现对睡眠相关疾病的诊断及治疗效果的预测.

化学螺栓抗拔承载力理论与试验研究

【目的】研究锚固于混凝土中的化学螺栓抗拔承载力及其对应理论计算方法。【方法】基于四线性黏结-滑移本构模型,考虑化学螺栓与混凝土界面的残余摩擦强度,对螺栓与混凝土间的黏结受力过程进行分析,推导了化学螺栓在受拉状态下的荷载-位移曲线的解析方程,同时设计并进行了化学螺栓的直接拉拔试验,用以检验理论方法的可靠性。【结果】随着化学螺栓锚固深度增加,锚固体破坏模式逐渐从复杂破坏(混合破坏)转变为螺栓被拉断的单一破坏。与当前常用的三线性黏结-滑移模型计算结果和试验值的标准误差相比,基于四线性黏结-滑移模型计算结果与试验值的标准误差更小,说明本文的理论公式可以更准确地反映在拉拔荷载作用下的螺栓荷载-位移的变化趋势。【结论】研究结论可为采用化学螺栓锚固的构件拉拔受力分析提供对应的理论参考。

高速机械粉磨对油基钻屑灰渣活性的影响

对油基钻屑灰渣进行了高速机械粉磨处理,研究了粉磨时间(0~7 min)对灰渣粒径分布和比表面积的影响,分析了掺灰渣胶砂试件的力学性能,并进行了XRD、SEM、FTIR微观分析。结果表明:与未粉磨处理的灰渣相比,粉磨3 min灰渣的粒径分布范围缩小至1.220~40.100μm,D50降低了60.9%,比表面积增大了27.6%;与其他粉磨时间的灰渣相比,用粉磨3 min的灰渣等质量取代30%水泥所制备的胶砂试件的28 d抗压强度最高,28 d抗折强度也较高;适宜的粉磨时间能够促进灰渣中的活性Si O2、Al2O3等与水泥水化产物Ca(OH)2发生二次水化反应,生成C-S-H凝胶和AFt,提高胶砂结构的密实度。

铝酸盐水泥结合莫来石不定形浇注料耐高温性能研究

采用不同类型的铝酸盐水泥与电熔莫来石制成莫来石不定形耐火浇注料,研究了在不同温度煅烧后的线变化率、显气孔率、体积密度、力学性能及荷重软化温度的变化,采用XRD、SEM及EDS对物相组成及微观形貌进行分析。结果表明,线变化率在不同温度煅烧后均呈收缩的趋势,显气孔率随煅烧温度升高不断增大,体积密度随煅烧温度升高先减小而后增大;莫来石质浇注料经不同高温煅烧后,其抗折强度随温度升高不断提高,抗压强度随温度升高不断降低;使用CA80水泥、CA70水泥制备的耐火浇注料荷重软化温度最高,分别为1462、1442℃。

Simultaneous removal of sulfur dioxide and nitrogen oxide from flue gas by phosphorus sludge:The performance and absorption mechanism

Developing low-cost and green simultaneous desulfurization and denitrification technologies is of great significance for sulfur dioxide(SO_(2))and nitrogen oxide(NO_(x))emission control at low temperatures,especially for small and medium-sized coal-fired boilers and furnaces.Herein,phosphorus sludge,an industrial waste from the production process of yellow phosphorus,has been developed to simultaneously eliminate SO_(2)and NO_(x)from coal-fired flue gas.The key factors affecting the experimental results indicate that desulfurization and denitrification efficiency of over 95%can be achieved at a low temperature of 55℃.Further,the absorption mechanism was investigated by characterizing the solid and liquid phases of the phosphorus sludge during the absorption process.The efficient removal of SO_(2)is attributed to the abundance of iron(Fe^(3+))and manganese(Mn^(2+))in the absorbent.SO_(2)can be rapidly catalyzed and converted to SO_(4)^(2-)by them.The key to NOx removal is the oxidation of NO toward watersoluble high-valent nitrogen oxides by oxidizing reactive substances induced via yellow phosphorus,which are then absorbed by water and converted to NO_(3)^(-).Meanwhile,yellow phosphorus is oxidized to phosphoric acid(H_(3)PO_(4)).The spent absorption slurry can be reused through wet process phosphoric acid production,as it contains sulfuric acid(H_(2)SO_(4)),nitric acid(HNO_(3)),and H_(3)PO_(4).Accordingly,this is a technology with broad application prospects.

The principle and amelioration of lithium plating in fast-charging lithium-ion batteries

Fast charging is restricted primarily by the risk of lithium(Li)plating,a side reaction that can lead to the rapid capacity decay and dendrite-induced thermal runaway of lithium-ion batteries(LIBs).Investigation on the intrinsic mechanism and the position of Li plating is crucial to improving the fast rechargeability and safety of LIBs.Herein,we investigate the Li plating behavior in porous electrodes under the restricted transport of Li^(+).Based on the theoretical model,it can be concluded that the Li plating on the anodeseparator interface(ASI)is thermodynamically feasible and kinetically advantageous.Meanwhile,the prior deposition of metal Li on the ASI rather than the anode-current collector interface(ACI)is verified experimentally.In order to facilitate the transfer of Li^(+)among the electrode and improve the utilization of active materials without Li plating,a bilayer asymmetric anode composed of graphite and hard carbon(GH)is proposed.Experimental and simulation results suggest that the GH hybrid electrode homogenizes the lithiated-rate throughout the electrode and outperforms the pure graphite electrode in terms of the rate performance and inhibition of Li plating.This work provides new insights into the behavior of Li plating and the rational design of electrode structure.

Accurate estimation of Li/Ni mixing degree of lithium nickel oxide cathode materials

Li/Ni mixing negatively influences the discharge capacity of lithium nickel oxide and high-nickel ternary cathode materials.However,accurately measuring the Li/Ni mixing degree is difficult due to the preferred orientation of labbased XRD measurements using Bragg–Brentano geometry.Here,we find that employing spherical harmonics in Rietveld refinement to eliminate the preferred orientation can significantly decrease the measurement error of the Li/Ni mixing ratio.The Li/Ni mixing ratio obtained from Rietveld refinement with spherical harmonics shows a strong correlation with discharge capacity,which means the electrochemical capacity of lithium nickel oxide and high-nickel ternary cathode can be estimated by the Li/Ni mixing degree.Our findings provide a simple and accurate method to estimate the Li/Ni mixing degree,which is valuable to the structural analysis and screening of the synthesis conditions of lithium nickel oxide and high-nickel ternary cathode materials.

新形势下当前地质矿产勘查及找矿技术分析

随着科技的不断进步和智能化、信息化以及环保理念的发展,新一代地质勘查技术和方法应运而生。这对于保障国家和全球能源安全、推动工业化和现代化进程具有重要意义。在全球化和科技高度发展的新形势下,地质矿产勘查的技术和方法也在不断改进和发展。面对资源枯竭、生态环境破坏等多重压力,如何合理、高效地进行地质矿产勘查已成为当今地勘工作面临的重要任务。

Mechanism study on the influence of surface properties on the synthesis of dimethyl carbonate from CO_(2)and methanol over ceria catalysts

The direct synthesis of dimethyl carbonate(DMC)from CO_(2)and methanol has attracted much attention as an environmentally benign and alternative route for conventional routes.Herein,a series of cerium oxide catalysts with various textural features and surface properties were prepared by the one-pot synthesis method for the direct DMC synthesis from CO_(2)and methanol,and the structure-performance relationship was investigated in detail.Characterization results revealed that both of surface acid-base properties and the oxygen vacancies contents decreased with the rising crystallinity at increasingly higher calcination temperature accompanied by an unexpectedly volcano-shaped trend of DMC yield observed on the catalysts.In situ diffuse reflectance infrared Fourier transform spectroscopy(DRIFTS)studies indicated that the adsorption rate of methanol is slower than that of CO_(2)and the methanol activation state largely influences the formation of key intermediate.Although the enhanced surface acidity-basicity and oxygen vacancies brought by low-temperature calcination could facilitate the activation of CO_(2),the presence of excess strongly basic sites on low-crystallinity sample was detrimental to DMC synthesis due to the preferred formation of unreactive mono/polydentate carbonates as well as the further impediment of methanol activation.Moreover,with the use of 2-cyanopyridine as a dehydration reagent,the DMC synthesis was found to be both influenced by the promotion from the rapid in situ removal of water and the inhibition from the competitive adsorption of hydration products on the same active sites.

Proactive Caching at the Wireless Edge:A Novel Predictive User Popularity-Aware Approach

Mobile Edge Computing(MEC)is a promising technology that provides on-demand computing and efficient storage services as close to end users as possible.In an MEC environment,servers are deployed closer to mobile terminals to exploit storage infrastructure,improve content delivery efficiency,and enhance user experience.However,due to the limited capacity of edge servers,it remains a significant challenge to meet the changing,time-varying,and customized needs for highly diversified content of users.Recently,techniques for caching content at the edge are becoming popular for addressing the above challenges.It is capable of filling the communication gap between the users and content providers while relieving pressure on remote cloud servers.However,existing static caching strategies are still inefficient in handling the dynamics of the time-varying popularity of content and meeting users’demands for highly diversified entity data.To address this challenge,we introduce a novel method for content caching over MEC,i.e.,PRIME.It synthesizes a content popularity prediction model,which takes users’stay time and their request traces as inputs,and a deep reinforcement learning model for yielding dynamic caching schedules.Experimental results demonstrate that PRIME,when tested upon the MovieLens 1M dataset for user request patterns and the Shanghai Telecom dataset for user mobility,outperforms its peers in terms of cache hit rates,transmission latency,and system cost.

TP53基因突变急性髓系白血病患者临床及分子生物学特征分析

目的:分析TP53基因突变急性髓系白血病(acute myeloid leukemia,AML)患者临床及分子生物学特征。方法:回顾性分析2017年7月至2023年5月就诊于徐州医科大学附属淮安医院256例初发AML患者临床资料,均行聚合酶链式反应(polymerase chain reaction,PCR)结合一代测序技术检测,统计TP53基因突变频率,分析TP53基因突变患者临床、实验室特征、分子学特征、核型特征及总生存期。结果:TP53基因突变频率为7.8%;TP53基因突变组年龄、世界卫生组织(WHO)分型,白细胞(white blood cell,WBC)计数和骨髓原始细胞与TP53基因无突变组具有显著性差异(P<0.05);TP53基因突变组中检测出BCR-ABL、NPM1突变、CEBPA突变、RUNX1-RUNX1T1、MLL相关融合基因、FLT3-ITD突变及CBFβ-MYH11突变分子学异常发生率与TP53基因无突变组无显著性差异(P>0.05);TP53基因突变组中单体核型、复杂核型、异常核型、-17/17p-、-7/7q-和-3/3q-检出率与TP53基因无突变组具有显著性差异(P<0.05);TP53基因无突变组总生存期显著优于TP53基因突变组患者(P<0.05);单因素和多因素Cox回归分析结果显示,WBC和TP53基因突变均为AML患者的独立影响因素(均P<0.05)。TP53基因突变AML患者具有一定临床及分子生物学特征,伴有TP53基因突变患者生存预后不佳。

The potential of herbal drugs to treat heart failure:The roles of Sirt1/AMPK

Heart failure(HF)is a highly morbid syndrome that seriously affects the physical and mental health of patients and generates an enormous socio-economic burden.In addition to cardiac myocyte oxidative stress and apoptosis,which are considered mechanisms for the development of HF,alterations in cardiac energy metabolism and pathological autophagy also contribute to cardiac abnormalities and ultimately HF.Silent information regulator 1(Sirt1)and adenosine monophosphate-activated protein kinase(AMPK)are nicotinamide adenine dinucleotide(NAD+)-dependent deacetylases and phosphorylated kinases,respectively.They play similar roles in regulating some pathological processes of the heart through regulating targets such as peroxisome proliferator-activated receptorγcoactivator 1α(PGC-1α),protein 38 mitogen-activated protein kinase(p38 MAPK),peroxisome proliferator-activated receptors(PPARs),and mammalian target of rapamycin(mTOR).We summarized the synergistic effects of Sirt1 and AMPK in the heart,and listed the traditional Chinese medicine(TCM)that exhibit cardioprotective properties by modulating the Sirt1/AMPK pathway,to provide a basis for the development of Sirt1/AMPK activators or inhibitors for the treatment of HF and other cardiovascular diseases(CVDs).

N-glycan biosignatures as a potential diagnostic biomarker for earlystage pancreatic cancer

BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)has a poor prognosis,with a 5-year survival rate of less than 10%,owing to its late-stage diagnosis.Early detection of pancreatic cancer(PC)can significantly increase survival rates.AIM To identify the serum biomarker signatures associated with early-stage PDAC by serum N-glycan analysis.METHODS An extensive patient cohort was used to determine a biomarker signature,in-cluding patients with PDAC that was well-defined at an early stage(stages I and II).The biomarker signature was derived from a case-control study using a case-cohort design consisting of 29 patients with stage I,22 with stage II,4 with stage III,16 with stage IV PDAC,and 88 controls.We used multiparametric analysis to identify early-stage PDAC N-glycan signatures and developed an N-glycan sig-nature-based diagnosis model called the“Glyco-model”.RESULTS The biomarker signature was created to discriminate samples derived from patients with PC from those of controls,with a receiver operating characteristic area under the curve of 0.86.In addition,the biomarker signature combined with cancer antigen 19-9 could discriminate patients with PDAC from controls,with a receiver operating characteristic area under the curve of 0.919.Glyco-model demonstrated favorable diagnostic performance in all stages of PC.The diagnostic sensitivity for stage I PDAC was 89.66%.Core Tip:This study employed a patient cohort to investigate the N-glycan signature of early-stage pancreatic cancer(PC).Serum N-glycans analysis was conducted to identify the serum biomarker signature associated with early-stage pancreatic ductal adenocarcinoma(PDAC),resulting in the identification of nine early-stage PDAC N-glycan signatures.Subsequently,utilizing these biosignatures,a diagnostic model named the“Glyco-model”was developed,demonstrating promising diagnostic performance across all stages of PC.The study revealed that the diagnostic sensitivity for stage I PDAC was determined to be 89.66%.Consequently,this diagnostic model exhibits potential as a prospective strategy for the early detection of PDAC.

扶贫改革试验区对地方基本公共服务供给水平的影响研究——来自浙江省丽水市的经验证据

本文利用2013年浙江省丽水市实施的扶贫改革试验区这一外生冲击构造准自然实验,借助浙江省2007—2020年58个县域的面板数据,主要采用双重差分固定效应识别方法,评估、阐释试验区对地方基本公共服务供给水平的影响效果以及作用渠道。结果表明,试验区促使地方人均基本公共服务支出提升750元左右,所得结论在经过一系列不同形式的稳健性检验之后仍然成立。从动态效应来看,试验区对提升地方基本公共服务供给水平具有长时段的显著影响。作用渠道分析显示,试验区的设立促使地方政府承担较大的财政收支压力,并借助税收努力,同时通过财政预算结构调整,能够达到提高基本公共服务供给水平的目的。此外,试验区内部地区间具有的差异性特征对不同类别的基本公共服务供给也表现出一定的异质性影响。丽水市作为扶贫改革试验区的一个缩影,本文的研究有助于给政策制定者提供一个反馈的视角,同时也有助于为我国探寻构建适度普惠型社会福利的新路径提供经验借鉴。