反义长链非编码RNA(long non coding RNA,lncRNA)是一类全新的RNA分子,在包括肿瘤的发生和发展在内的众多生命活动中发挥着重要作用。多种反义lncRNA在肿瘤患者组织中特异性表达,并且和患者的临床资料密切相关,是一种潜在的肿瘤分子标...反义长链非编码RNA(long non coding RNA,lncRNA)是一类全新的RNA分子,在包括肿瘤的发生和发展在内的众多生命活动中发挥着重要作用。多种反义lncRNA在肿瘤患者组织中特异性表达,并且和患者的临床资料密切相关,是一种潜在的肿瘤分子标志物。Lnc RNA可以通过miRNA海绵和RBP结合等方式参与基因的调控,在肿瘤的细胞周期、凋亡、血管生成、侵袭与转移等过程中发挥重要功能。进一步研究反义lncRNA在肿瘤中的作用机制,对深入了解恶性肿瘤的病因发病学和RNA语言具有重要理论意义;同时,反义lncRNA作为分子标志或者潜在的靶点,在恶性肿瘤的早期诊断、疗效判断、预后预测,乃至基因治疗等方面也将具有广阔的临床应用前景。展开更多
套细胞淋巴瘤(mantle cel l lymphoma,MCL)是一种具有独特生物学特征的非霍奇金B细胞淋巴瘤(non-Hodgkin l ymphoma,NHL),其特征是标志性易位t(11;14)(q13;q32)和细胞周期蛋白D1(cyclinD1)的过度表达。MCL的分子遗传学改变包括频繁的继...套细胞淋巴瘤(mantle cel l lymphoma,MCL)是一种具有独特生物学特征的非霍奇金B细胞淋巴瘤(non-Hodgkin l ymphoma,NHL),其特征是标志性易位t(11;14)(q13;q32)和细胞周期蛋白D1(cyclinD1)的过度表达。MCL的分子遗传学改变包括频繁的继发性细胞遗传学异常和少数基因的反复突变,如CCND1,SOX11等。本文对MCL近年来在分子遗传学方面的研究进展,包括细胞循环周期失调、DNA损伤应答改变以及其他相关基因的异常改变作一综述。展开更多
This paper analysis the developing of expendable conductivity temperature depth measuring system(XCTD)and introduce its principle of measuring about temperature,salinity and depth of ocean.Some key techniques are put ...This paper analysis the developing of expendable conductivity temperature depth measuring system(XCTD)and introduce its principle of measuring about temperature,salinity and depth of ocean.Some key techniques are put forward.According to the real needs of XCTD,conductivity sensor with high sensitivity is designed by principle of electromagnetic induce,the ocean conductivity from induced electromotive force has been calculated.Adding temperature correction circuit would help to reduce error of conductivity measurement because of sharply changing temperature.Advanced temperature measuring circuit of high precision and the constant current source is used to weaken effect of self-heating of resistance and fluctuation of the source.On respect of remote data transmission,LVDS is a good choice for the purpose of guarantee the quality of data transmitted and the transmission distance is reaching to thousand meters in the seawater.Modular programming method is also brought into this research aimed at improve the stability,reliability and maintainability of the whole measuring system.In February,2015,the trials in South China Sea demonstrate that the developed XCTD realize effective measurement at a speed of 6 knots and detection depth at 800 m.The consistency coefficient of the acquired data is greater than 0.99 and the success rate of probe launching is above 90%.展开更多
Aiming at the problem of insufficient consideration of the correlation between components in the prediction of the remaining life of mechanical equipment,the method of remaining life prediction that combines the self-...Aiming at the problem of insufficient consideration of the correlation between components in the prediction of the remaining life of mechanical equipment,the method of remaining life prediction that combines the self-attention mechanism with the long short-term memory neural network(LSTM-NN)is proposed,called Self-Attention-LSTM.First,the auto-encoder is used to obtain the component-level state information;second,the state information of each component is input into the self-attention mechanism to learn the correlation between components;then,the multi-component correlation matrix is added to the LSTM input gate,and the LSTM-NN is used for life prediction.Finally,combined with the commercial modular aero-propulsion system simulation data set(C-MAPSS),the experiment was carried out and compared with the existing methods.Research results show that the proposed method can achieve better prediction accuracy and verify the feasibility of the method.展开更多
Background Noise is widespread occupational hazard in iron and steel industry. Overhead-traveling cranes are widely used in this industry, but few studies characterized the overhead-traveling crane drivers＇ noise exp...Background Noise is widespread occupational hazard in iron and steel industry. Overhead-traveling cranes are widely used in this industry, but few studies characterized the overhead-traveling crane drivers＇ noise exposure level so far. In this study, we assessed and characterized personal noise exposure levels of overhead-traveling crane drivers in two steel-rolling mills.Methods One hundred and twenty-four overhead-traveling crane drivers, 76 in the cold steel-rolling mill and 48 in the hot steel-rolling mill, were enrolled in the study. Personal noise dosimeters （AIHUA Instruments Model AWA5610e, Hangzhou, China） were used to collect full-shift noise exposure data from all the participants. Crane drivers carried dosimeters with microphones placed near their collars during the work shifts. Work logs had been taken by the drivers simultaneously. Personal noise exposure data were divided into segments based on lines in which they worked. All statistical analyses were done using SPSS 13.0.Results The average personal noise exposure （LAeq.8h） of overhead-traveling crane drivers in the hot steel-rolling mills （（85.03±2.25） dB（A）） was higher than that in the cold one （（83.05±2.93） dB（A）, P〈0.001）. There were 17 overhead traveling cranes in the hot steel-rolling mill and 24 cranes in the cold one, of which carrying capacities varied from 15 tons to 100 tons. The average noise exposure level based on different lines in the hot and cold steel-rolling mills were （85.2±2.61） dB（A） and （83.3±3.10） dB（A） respectively （P=-0.001）, which were similar to the average personal noise exposure in both mills. The noise exposure levels were different among different lines （P=-0.021）. Conclusion Noise exposure levels, depending upon background noise levels and the noise levels on the ground, are inconstant. As the noise exposure levels are above the 85 dB（A） criteria, these drivers should be involved in the Hearing Conservation Program to protect their hearing.展开更多
文摘反义长链非编码RNA(long non coding RNA,lncRNA)是一类全新的RNA分子,在包括肿瘤的发生和发展在内的众多生命活动中发挥着重要作用。多种反义lncRNA在肿瘤患者组织中特异性表达,并且和患者的临床资料密切相关,是一种潜在的肿瘤分子标志物。Lnc RNA可以通过miRNA海绵和RBP结合等方式参与基因的调控,在肿瘤的细胞周期、凋亡、血管生成、侵袭与转移等过程中发挥重要功能。进一步研究反义lncRNA在肿瘤中的作用机制,对深入了解恶性肿瘤的病因发病学和RNA语言具有重要理论意义;同时,反义lncRNA作为分子标志或者潜在的靶点,在恶性肿瘤的早期诊断、疗效判断、预后预测,乃至基因治疗等方面也将具有广阔的临床应用前景。
文摘套细胞淋巴瘤(mantle cel l lymphoma,MCL)是一种具有独特生物学特征的非霍奇金B细胞淋巴瘤(non-Hodgkin l ymphoma,NHL),其特征是标志性易位t(11;14)(q13;q32)和细胞周期蛋白D1(cyclinD1)的过度表达。MCL的分子遗传学改变包括频繁的继发性细胞遗传学异常和少数基因的反复突变,如CCND1,SOX11等。本文对MCL近年来在分子遗传学方面的研究进展,包括细胞循环周期失调、DNA损伤应答改变以及其他相关基因的异常改变作一综述。
文摘This paper analysis the developing of expendable conductivity temperature depth measuring system(XCTD)and introduce its principle of measuring about temperature,salinity and depth of ocean.Some key techniques are put forward.According to the real needs of XCTD,conductivity sensor with high sensitivity is designed by principle of electromagnetic induce,the ocean conductivity from induced electromotive force has been calculated.Adding temperature correction circuit would help to reduce error of conductivity measurement because of sharply changing temperature.Advanced temperature measuring circuit of high precision and the constant current source is used to weaken effect of self-heating of resistance and fluctuation of the source.On respect of remote data transmission,LVDS is a good choice for the purpose of guarantee the quality of data transmitted and the transmission distance is reaching to thousand meters in the seawater.Modular programming method is also brought into this research aimed at improve the stability,reliability and maintainability of the whole measuring system.In February,2015,the trials in South China Sea demonstrate that the developed XCTD realize effective measurement at a speed of 6 knots and detection depth at 800 m.The consistency coefficient of the acquired data is greater than 0.99 and the success rate of probe launching is above 90%.
基金the National Natural Science Foundation of China(Nos.51875451 and 51834006)。
文摘Aiming at the problem of insufficient consideration of the correlation between components in the prediction of the remaining life of mechanical equipment,the method of remaining life prediction that combines the self-attention mechanism with the long short-term memory neural network(LSTM-NN)is proposed,called Self-Attention-LSTM.First,the auto-encoder is used to obtain the component-level state information;second,the state information of each component is input into the self-attention mechanism to learn the correlation between components;then,the multi-component correlation matrix is added to the LSTM input gate,and the LSTM-NN is used for life prediction.Finally,combined with the commercial modular aero-propulsion system simulation data set(C-MAPSS),the experiment was carried out and compared with the existing methods.Research results show that the proposed method can achieve better prediction accuracy and verify the feasibility of the method.
基金the grant from the National Natural Science Fundation of China(No.30271112 and No.30640085)
文摘Background Noise is widespread occupational hazard in iron and steel industry. Overhead-traveling cranes are widely used in this industry, but few studies characterized the overhead-traveling crane drivers＇ noise exposure level so far. In this study, we assessed and characterized personal noise exposure levels of overhead-traveling crane drivers in two steel-rolling mills.Methods One hundred and twenty-four overhead-traveling crane drivers, 76 in the cold steel-rolling mill and 48 in the hot steel-rolling mill, were enrolled in the study. Personal noise dosimeters （AIHUA Instruments Model AWA5610e, Hangzhou, China） were used to collect full-shift noise exposure data from all the participants. Crane drivers carried dosimeters with microphones placed near their collars during the work shifts. Work logs had been taken by the drivers simultaneously. Personal noise exposure data were divided into segments based on lines in which they worked. All statistical analyses were done using SPSS 13.0.Results The average personal noise exposure （LAeq.8h） of overhead-traveling crane drivers in the hot steel-rolling mills （（85.03±2.25） dB（A）） was higher than that in the cold one （（83.05±2.93） dB（A）, P〈0.001）. There were 17 overhead traveling cranes in the hot steel-rolling mill and 24 cranes in the cold one, of which carrying capacities varied from 15 tons to 100 tons. The average noise exposure level based on different lines in the hot and cold steel-rolling mills were （85.2±2.61） dB（A） and （83.3±3.10） dB（A） respectively （P=-0.001）, which were similar to the average personal noise exposure in both mills. The noise exposure levels were different among different lines （P=-0.021）. Conclusion Noise exposure levels, depending upon background noise levels and the noise levels on the ground, are inconstant. As the noise exposure levels are above the 85 dB（A） criteria, these drivers should be involved in the Hearing Conservation Program to protect their hearing.
