Intervention Effect of Lower Limb Rehabilitation Robot with Task-Oriented Training on Stroke Patients and Its Influence on KFAROM Score

Objective: To explore the effect of lower limb rehabilitation robot combined with task-oriented training on stroke patients and its influence on KFAROM score. Methods: 100 stroke patients with hemiplegia admitted to our hospital from January 2023 to December 2023 were randomly divided into two groups, the control group (50 cases) was given task-oriented training assisted by nurses, and the observation group (50 cases) was given lower limb rehabilitation robot with task-oriented training. Lower limb balance, lower limb muscle strength, motor function, ankle function, knee flexion range of motion and walking ability were observed. Results: After treatment, the scores of BBS, quadriceps femoris and hamstrings in the observation group were significantly higher than those in the control group (P Conclusion: In the clinical treatment of stroke patients, the combination of task-oriented training and lower limb rehabilitation robot can effectively improve the lower limb muscle strength, facilitate the recovery of balance function, and have a significant effect on the recovery of motor function, which can improve the walking ability of stroke patients and the range of motion of knee flexion, and achieve more ideal therapeutic effectiveness.

WNT7A promotes tumorigenesis of head and neck squamous cell carcinoma via activating FZD7/JAK1/STAT3 signaling

Wnt signaling are critical pathway involved in organ development, tumorigenesis, and cancer progression. WNT7A, a member of the Wnt family, remains poorly understood in terms of its role and the underlying molecular mechanisms it entails in head and neck squamous cell carcinoma (HNSCC). According to the Cancer Genome Atlas (TCGA), transcriptome sequencing data of HNSCC, the expression level of WNT7A in tumors was found to be higher than in adjacent normal tissues, which was validated using Real-time RT-PCR and immunohistochemistry. Unexpectedly, overexpression of WNT7A did not activate the canonical Wnt-β-catenin pathway in HNSCC. Instead, our findings suggested that WNT7A potentially activated the FZD7/JAK1/STAT3 signaling pathway, leading to enhanced cell proliferation, self-renewal, and resistance to apoptosis. Furthermore, in a patient-derived xenograft (PDX) tumor model, high expression of WNT7A and phosphorylated STAT3 was observed, which positively correlated with tumor progression.These findings underscore the significance of WNT7A in HNSCC progression and propose the targeting of key molecules within the FZD7/JAK1/STAT3 pathway as a promising strategy for precise treatment of HNSCC.

Mechanism of Camellia nitidissima Chi in Treating Premature Ovarian Failure Based on Network Pharmacology and Molecular Docking

[Objectives]This study was conducted to explore active components and molecular biological mechanisms of Camellia nitidissima Chi in the treatment of premature ovarian failure(POF).[Methods]The active components and corresponding targets of C.nitidissima Chi were retrieved through literature and the TCMSP database.POF-related disease targets were identified using the OMIM and Genecards databases.A PPI network was constructed using the STRING database and Cytoscape 3.10.2.A herb-active component-target-pathway network diagram was also constructed with Cytoscape 3.10.2.The CytoNCA plugin was used to screen out the top five core targets and core active components.GO and KEGG enrichment analyses of the intersecting targets were performed using DAVID.Finally,molecular docking was conducted using Auto Dock to verify the interaction between core targets and active components,and visualization was done using PyMol.[Results]A total of 26 active components and 461 targets of C.nitidissima Chi were identified,with 154 intersecting targets related to POF.The core components of the herb included 1,1'-bi-2-naphthol,3',4-O-dimethylcedrusin,eriodictyol,quercetin,and vanillin.The PPI network revealed that the main targets were epidermal growth factor receptor(EGFR),protein kinase B1(AKT1),proto-oncogene Src(SRC),hypoxia-inducible factor 1α(HIF1A),and estrogen receptor 1(ESR1).KEGG enrichment analysis revealed 10 pathways closely related to POF,mainly involving the PI3K-Akt signaling pathway,chemical carcinogenesis-reactive oxygen species,endocrine resistance,and the HIF-1 signaling pathway.Molecular docking results showed that the core active components had strong binding activity with the targets.[Conclusions]C.nitidissima Chi has multi-component,multi-target,and multi-pathway characteristics in the comprehensive treatment of POF,providing informational support for its clinical application.

GhIQD10 interacts with GhCaM7 to control cotton fiber elongation via calcium signaling

IQ67-domain(IQD)proteins function in plant defense and in organ development.The mechanisms by which they influence cotton fiber development are unknown.In the present study,GhIQD10 was expressed mainly in the transition period of cotton fiber development,and GhIQD10-overexpression lines showed shorter fibers.GhIQD10 interacted with GhCaM7 and the interaction was inhibited by Ca^(2+).In in vitro ovule culture,Ca^(2+)rescued the shorter-fiber phenotype of GhIQD10-overexpression lines,which were insensitive to the Ca^(2+)channel inhibitor verapamil and the Ca^(2+)pool release channel blocker 2-aminoethoxydiphenyl borate.We conclude that GhIQD10 affects cotton fiber elongation via Ca^(2+)signaling by interacting with GhCaM7.Brassinosteroid(BR)biosynthesis and signaling genes were up-regulated in GhIQD10-overexpression lines.Fiber development in these lines was not affected by epibrassinolide or the BR biosynthesis inhibitor brassinozole,indicating that the influence of GhIQD10 on fiber elongation was not associated with BR.

Adsorption structure of macrocyclic energetic molecule DOATF on Au(111)

Furazan macrocyclic compound 3,4:7,8:11,12:15,16-tetrafurazan-1,9-dioxazo-5,13-diazocyclohexadecane(DOATF)is an ideal energetic material with high heat of formation.Here,using scanning tunneling microscopy(STM)and noncontact atomic force microscopy(nc-AFM),we investigated the adsorption structure of DOATF molecules on Au(111)surface,which shows the four furanzan rings in the STM images and a bright protrusion off the center of the molecule in the nc-AFM images.Combined with density functional theory(DFT)calculations,we confirmed that the bright feature in the nc-AFM images is an N-O coordinate bond pointing upwards in one of the two azoxy groups;while the other N-O bond pointing towards the Au(111)surface.Our work contributes for a deeper understanding of the adsorption structure of macrocyclic compounds,which would promote the designing of DOATF-metal frameworks.

Fabrication of honeycomb AuTe monolayer with Dirac nodal line fermions

Two-dimensional honeycomb lattices show great potential in the realization of Dirac nodal line fermions(DNLFs).Here,we successfully synthesized a gold telluride(AuTe)monolayer by direct tellurizing an Au(111)substrate.Low energy electron diffraction measurements reveal that it is(2×2)AuTe layer stacked onto(3×3)Au(111)substrate.Moreover,scanning tunneling microscopy images show that the AuTe layer has a honeycomb structure.Scanning transmission electron microscopy reveals that it is a single-atom layer.In addition,first-principles calculations demonstrate that the honeycomb AuTe monolayer exhibits Dirac nodal line features protected by mirror symmetry,which is validated by angle-resolved photoemission spectra.Our results establish that monolayer AuTe can be a good candidate to investigate 2D DNLFs and provides opportunities to realize high-speed low-dissipation devices.

Online and Offline Integrated Teaching of Histology and Embryology Based on Concept of "Golden Course"

Taking construction of the online and offline integrated first-class undergraduate curriculum teaching modes of Histology and Embryology in Guangxi as an opportunity,under the guidance of student-centered teaching concept,efforts were made to innovate online and offline integrated teaching mode to overcome the shortcomings and dilemma of traditional Histology and Embryology teaching,with attention paid to the competence education in students including schematic knowledge,professional techniques,analytical thinking,and ideological and political theories,which would be of great significance for the cultivation of high-quality professionals specialized in traditional Chinese medicine.

矿渣基地聚物混凝土柱抗震性能研究

为了研究不同强度等级的矿渣基地聚物混凝土柱的抗震性能,设计了3个普通混凝土悬臂柱试件和3个矿渣基地聚物混凝土悬臂柱试件,通过低周反复荷载试验,对地聚物混凝土柱的破坏模式、裂缝发展、滞回性能、位移延性、耗能性能、刚度与强度退化和承载力等进行了评估,分析了混凝土种类、混凝土强度对试件抗震性能的影响。结果表明,在低周反复荷载作用下,与普通混凝土试件相比,矿渣基地聚物混凝土柱的抗震性能并未明显改善;提高地聚物混凝土强度会改变地聚物混凝土柱的破坏模式,从而对部分抗震性能(延性、耗能能力)产生不利的影响;验证表明《混凝土结构设计规范》(GB 50010—2010)中受弯承载力计算公式对于地聚物混凝土构件的计算结果偏小,拓展到工程应用中偏安全。

基于DeepInsight和迁移学习的入侵检测技术

针对入侵检测研究中,入侵检测训练样本较少、样本不平衡等问题,本文提出一种基于DeepInsight和迁移学习的入侵检测方法 DI–TL–CNN (DeepInsight–transfer learning–convolutional neural network,DI–TL–CNN).分析采用DeepInsight方法将入侵数据转换为适合CNN模型输入的图像数据集的过程;研究基于VGG16模型的训练方法,并进一步利用迁移学习开展目标域入侵检测的过程.通过冻结和微调CNN模型中不同模块参数,比较研究了6种迁移方案,并基于数据集实验研究,获得优化方案.采用以UNSW-NB15为基础的不平衡数据集作为方法验证对象,进行网络的入侵检测分析,验证本文提出的DI–TL–CNN方法的正确性;进一步实验比较研究本文提出的方法与其他方法的检测性能,实验结果表明,DI–TL–CNN方法更加适用于样本较小和不平衡数据情况下的入侵检测,其准确率和召回率等性能指标均优于其他检测方法,具有良好的应用前景.

Dynamic simulation analysis of molten salt reactor-coupled air-steam combined cycle power generation system

A nonlinear dynamic simulation model based on coordinated control of speed and flow rate for the molten salt reactor and combined cycle systems is proposed here to ensure the coordination and stability between the molten salt reactor and power system.This model considers the impact of thermal properties of fluid variation on accuracy and has been validated with Simulink.This study reveals the capability of the control system to compensate for anomalous situations and maintain shaft stability in the event of perturbations occurring in high-temperature molten salt tank outlet parameters.Meanwhile,the control system’s impact on the system’s dynamic characteristics under molten salt disturbance is also analyzed.The results reveal that after the disturbance occurs,the controlled system benefits from the action of the control,and the overshoot and disturbance amplitude are positively correlated,while the system power and frequency eventually return to the initial values.This simulation model provides a basis for utilizing molten salt reactors for power generation and maintaining grid stability.

基于驾驶行为的快速路交织区发光标线效果评估

快速路交织区主动管控策略对提高快速路运行效率、改善行车环境、提升行车安全等具有重要意义。主动发光标线是一种新型道路交通安全主动管控设施,因其智能可控、虚实变换、应急预警等功能特点,越来越受到关注和逐步被推广应用。为探究发光标线这一新型道路标线在快速路交织区对行车安全的作用效果,从驾驶人角度出发,基于驾驶模拟试验,分析发光标线对驾驶行为的影响特征,评估发光标线作用效果。通过设计夜间环境下普通标线和发光标线两种驾驶模拟试验场景方案,获取驾驶行为数据,从行车安全性、舒适性和驾驶人操纵表现3方面选取速度标准差、横向偏移标准差、纵向加速度均方根值、加速度标准差、平均速度、油门功效6项指标构建评价指标体系。进一步分析各项指标在不同标线场景下的差异显著性及效应量水平,最后采用可拓物元方法构建综合评价模型,对比两种标线方案的作用效果。研究结果表明:发光标线对交织区及临近交织区路段驾驶行为特性具有较显著的影响,发光标线下驾驶人横向位置感知和操纵水平提升,车速调控能力提高,车辆行驶更加平稳。基于可拓物元模型综合评价结果表明,在快速路交织区及临近交织区路段发光标线作用效果均优于普通标线,有利于提升快速路交织区行车安全。

图腾柱功率因数校正器的二自由度控制分析

TPFC一般采用一自由度输出电压控制,在负载变化时输出电压动态特性较差,且启动过程存在明显超调。本文在推导TPFC双闭环控制结构基础上,引用了负载电流前馈控制和输出电压反馈补偿控制,构成两种二自由度(2DOF)控制结构。仿真分析表明,负载电流前馈型2DOF控制可以有效抑制负载变化引起的输出电压波动,但启动过程超调明显;输出电压反馈补偿型2DOF控制可以实现输出电压无超调启动,但是抑制负载变化的能力较差;综合负载电流前馈型和输出电压反馈补偿型的2DOF控制获得满意的输出电压控制效果,表现为启动过程无超调和变载过程无波动。

沉香药理作用概述及研究进展

目的本文在综述近年来沉香药理作用的基础上,通过CiteSpace分析2013年5月31日—2023年5月31日关于沉香(Aquilariae Lignum Resinatum)的发文趋势、作者及机构合作网络、研究现状、研究热点、发展趋势。方法检索中国知网(CNKI)2013年5月31日—2023年5月31日关于沉香的文献,使用CiteSpace软件对发文情况、作者及科研机构的合作网络、关键词、研究概况、研究趋势、研究热点进行关联或聚类分析,并绘制可视化图谱。结果纳入1133篇文献,年发文量呈现较为稳定的增长趋势;作者共现分析得出了以戴好富、魏建和、高晓霞为主的三大研究团队;机构合作网络密度为0.0046;形成了用药规律、沉香、化学成分、沉香四醇等共10个关键词聚类。结论目前关于沉香的研究还处于发展阶段,作者、机构较为松散,各地区需加强合作,为进一步研究提供基础。

锂离子电池储能系统火灾抑制仿真研究

由于锂离子储能系统火灾燃爆危险性大且实验成本高,因此基于模型对储能系统火灾特性及灭火性能模拟仿真研究具有重要意义。本文通过火灾动力学模拟(fire dynamics simulator,FDS)软件建立了20尺(1尺=0.333 m)储能集装箱的全尺寸仿真分析模型,研究了电池系统的火蔓延过程以及CO_(2)、H_(2)和CO等特征气体的扩散规律。结果表明,电池箱着火后,在火源中心位置H_(2)和CO浓度可达到1000 ppm(1 ppm=10-4%)以上,而在集装箱角落的浓度仅为24~183 ppm;水喷淋灭火系统降温效果明显,可以将火焰上部温度自791℃迅速降低至330℃以下;此外,水喷淋灭火系统会造成电池箱的不完全燃烧,导致局部区域可燃气体浓度上升。本文的结果旨在为锂离子电池储能系统的安全设计及火灾防控技术研究提供一种仿真分析方法。

AECOPD患者血清FOXM1和CCR5水平与肺功能及预后的预测价值研究

目的探讨叉头框蛋白M1(fork head box M1,FOXM1),CC趋化因子受体5(CC chemokine receptor 5,CCR5)对老年慢性阻塞性肺疾病急性加重期(acute exacerbation of chronic obstructive pulmonary disease,AECOPD)患者肺功能及预后的评估价值。方法选取2022年1月~2023年1月岳阳市人民医院收治的128例AECOPD患者作为急性加重期组,选择同期收治的135例稳定期COPD患者作为稳定期组,年龄、性别相仿的120例健康体检志愿者为对照组。采用酶联免疫吸附法(ELISA)检测血清中FOXM1和CCR5的表达水平,肺活量计检测肺功能指标。Pearson法分析AECOPD患者血清FOXM1,CCR5与肺功能指标的相关性;多因素Logistic回归分析筛选AECOPD患者预后影响因素,受试者工作特征(receiver operator characteristic,ROC)曲线分析FOXM1,CCR5水平对AECOPD患者预后不良的评估价值。结果AECOPD组患者和稳定期组患者血清中CCR5(49.36±12.31 ng/ml,34.25±8.87 ng/ml),FOXM1(40.21±10.74 pg/ml,23.38±5.77 pg/ml)水平较对照组(14.55±4.58 ng/ml,15.06±3.55 pg/ml)明显升高,FEV1(1.15±0.13 L,1.67±0.19 L),FVC(2.93±0.30 L,3.28±0.36 L),FEV1/FVC(39.25%±3.97%,50.91%±5.01%)较对照组(1.95±0.26 L,3.57±0.44 L,54.62%±5.20%)下降,差异具有统计学意义(F=111.034~641.907,均P<0.05)。血清FOXM1,CCR5水平随着肺功能分级加重而逐渐升高,肺功能指标FEV1,FVC水平随着肺功能分级加重而逐渐降低,差异具有统计学意义(F=31.27,49.37;42.72,29.48,均P<0.05)。血清FOXM1,CCR5表达与FEV1,FVC,FEV1/FVC呈负相关(r=-0.639~‐0.479,均P<0.05)。Logistic回归分析发现,CCR5[OR(95%CI):3.380(1.944~5.876)],FOXM1[OR(95%CI):5.711(3.175~10.273)],APACHEⅡ评分[OR(95%CI):2.132(1.243~3.60)],肺功能分级[OR(95%CI):2.017(1.007~4.037)]为预后不良发生的危险因素(均P<0.05),FEV1[OR(95%CI):0.649(0.441~0.955)],FVC[OR(95%CI):0.120(0.073~0.198)]为预后不良发生的保护因素(均P<0.05)。ROC曲线结果显示,血清FOXM1,CCR5水平预测AECOPD患者预后不良的曲线下面积(area under curve,AUC)分别为0.821,0.831,二者联合预测的AUC为0.895,高于单一指标检测(Z=2.800,2.654,均P<0.05)。结论FOXM1和CCR5在AECOPD患者血清中均呈高水平,早期检测二者可作为评估AECOPD患者肺功能及预后不良的血清标志物。

美容整形清创缝合术联合牛碱性成纤维细胞生长因子对颌面部外伤的治疗效果

目的分析颌面部外伤患者采取美容整形清创缝合术、牛碱性成纤维细胞生长因子共同治疗的预后情况。方法随机选取2021年1月—2023年2月滕州市中医医院收治的颌面部外伤患者100例作为研究对象,通过随机抽签方式分组,对照组50例使用美容整形清创缝合术,观察组50例使用美容整形清创缝合术联合牛碱性成纤维细胞生长因子,对比两组治疗效果。结果观察组临床总疗效为96.00%,高于对照组(80.00%),差异有统计学意义(χ^(2)=6.060,P<0.05);观察组术后3 d血清表皮生长因子高于对照组,且肿瘤坏死因子-α、白介素-6低于对照组,差异有统计学意义(P均<0.05);观察组术后瘢痕长度、愈合时间短于对照组,且双向瘢痕评分量表、温和华评分表低于对照组,差异有统计学意义(P均<0.05);观察组并发症发生率低于对照组,差异有统计学意义(P<0.05)。结论予以美容整形清创缝合术治疗颌面部外伤的同时,配合牛碱性成纤维细胞生长因子可以提高患者临床疗效,其恢复效果更好、并发症发生率更低,有助于改善各种临床指标。

新中国诞生的文物见证

中国人民政治协商会议第一届全体会议的代表签名册、两易其名的《中国人民政治协商会议共同纲领》、三个不同版本的《中央人民政府公告》、天安门广场升起的第一面五星红旗,这几组由中国国家博物馆馆藏的珍贵文物,承载着中国共产党和民主党派齐心协力筹建新中国的历史,记录了召开全国政协第一届全体会议、拟定《共同纲领》、修改《中央人民政府公告》、制定五星红旗的重要片段,见证了中华人民共和国的诞生。

强化护患沟通技巧对门诊导诊工作中纠纷事件发生的预防作用分析

目的探讨强化护患沟通技巧对门诊导诊工作中纠纷事件发生的预防作用。方法采用随机数字表法,选取2022年1月-2022年6月于郑州市金水区总医院就诊的40例患者作为对照组,采用常规导诊方案;另选取2022年7月-2022年12月于郑州市金水区总医院就诊的40例患者作为观察组,采用强化护患沟通技巧导诊方案。比较应用效果。结果观察组导诊时间短于对照组,准确率高于对照组纠纷事件发生率低于对照组,满意度优于对照组,差异均有统计学意义(P<0.05)。结论强化护患沟通技巧有助于提高满意度,缩短导诊时间,提高导诊准确率,降低纠纷事件发生情况。

Blind recognition of k/n rate convolutional encoders from noisy observation

Blind recognition of convolutional codes is not only essential for cognitive radio, but also for non-cooperative context. This paper is dedicated to the blind identification of rate k/n convolutional encoders in a noisy context based on Walsh-Hadamard transformation and block matrix (WHT-BM). The proposed algorithm constructs a system of noisy linear equations and utilizes all its coefficients to recover parity check matrix. It is able to make use of fault-tolerant feature of WHT, thus providing more accurate results and achieving better error performance in high raw bit error rate (BER) regions. Moreover, it is more computationally efficient with the use of the block matrix (BM) method. © 2017 Beijing Institute of Aerospace Information.

GSK3β inhibits epithelial-mesenchymal transition via the Wnt/β-catenin and PI3K/Akt pathways

AIM： To investigate the regulatory mechanism of glycogen synthase kinase 3β（GSK3β） in epithelialmesenchymal transition（EMT） process after proliferative vitreoretinopathy（PVR） induction. METHODS： Experimental PVR was induced by intravitreal injection of retinal pigment epithelium（RPE） cells in the eyes of rabbits. A PI3 K/Akt inhibitor（wortmannin） and a GSK3β inhibitor（Li Cl） were also injected at different time during PVR progress. Electroretinogram（ERG）, ocular fundus photographs, and B-scan ultrasonography were used to observe the PVR progress. Western blot test on the extracted retina were performed at 1, 2, 4 wk. The expression of the mesenchymal marker vimentin was determined by immunohistochemistry. Toxicity of wortmannin and Li Cl were evaluated by ERG and Td Tmediated d UTP nick-end labeling（TUNEL） assay. The vitreous was also collected for metabolomic analysis. RESULTS： Experimental PVR could significantly lead to EMT, along with the suppressed expression of GSK3β and the activation of Wnt/β-catenin and PI3 K/Akt pathways. It was verified that upregulating the expression of GSK3β could effectively inhibit EMT process by suppressing Wnt/β-catenin and PI3 K/Akt pathways. CONCLUSION： GSK3β effectively inhibits EMT via the Wnt/β-catenin and PI3 K/Akt pathways. GSK3β may be regarded as a promising target of experimental PVR inhibition.