Fine mapping and characterization of stripe rust resistance gene YrAYH in near-isogenic lines derived from a cross involving wheat landrace Anyuehong

Stripe rust,caused by Puccinia striiformis f.sp.tritici(Pst),is a devastating disease in wheat worldwide.Discovering and characterizing new resistance genes/QTL is crucial for wheat breeding programs.In this study,we fine-mapped and characterized a stripe rust resistance gene,YRAYH,on chromosome arm 5BL in the Chinese wheat landrace Anyuehong(AYH).Evaluations of stripe rust response to prevalent Chinese Pst races in near-isogenic lines derived from a cross of Anyuehong and Taichung 29 showed that YrAYH conferred a high level of resistance at all growth stages.Fine mapping using a large segregating population of 9748 plants,narrowed the YRAYH locus to a 3.7 Mb interval on chromosome arm 5BL that included 61 annotated genes.Transcriptome analysis of two NIL pairs identified 64 upregulated differentially expressed genes(DEGs)in the resistant NILs(NILs-R).Annotations indicated that many of these genes have roles in plant disease resistance pathways.Through a combined approach of fine-mapping and transcriptome sequencing,we identified a serine/threonine-protein kinase SRPK as a candidate gene underlying YrAYH.A unique 25 bp insertion was identified in the NILs-R compared to the NILs-S and previously published wheat genomes.An InDel marker was developed and co-segregated with YrAYH.Agronomic trait evaluation of the NILs suggested that YrAYH not only reduces the impact of stripe rust but was also associated with a gene that increases plant height and spike length.

四逆汤饼灸对兔膝骨关节炎软骨中Caveolin-1/p38 MAPK信号通路蛋白表达的影响

目的探讨四逆汤饼灸治疗膝骨关节炎(KOA)的作用机制。方法取新西兰兔50只,随机分为对照组、模型组、p38 MAPK抑制剂(抑制剂)组、四逆汤饼灸组、四逆汤饼灸联合p38 MAPK抑制剂(联合)组,每组10只。除对照组外,其他组采用右后肢膝关节伸直位石膏管型固定制备兔KOA模型。对照组、模型组不予治疗;抑制剂组于关节腔内注射p38 MAPK抑制剂TAK-715,1次/d,治疗2周;四逆汤饼灸组取鹤顶、内外膝眼穴位予以四逆汤饼灸治疗,1次/d,治疗2周;联合组于关节腔内注射p38 MAPK抑制剂TAK-715,并在鹤顶、内外膝眼穴位予以四逆汤饼灸治疗,1次/d,治疗2周。采用HE染色观察软骨病理变化,免疫组织化学染色法和蛋白质印迹法(Western blot)检测软骨组织中Caveolin-1、p38 MAPK、MMP-13蛋白的表达。结果HE染色结果显示,模型组软骨表面明显粗糙,破坏严重,细胞排列紊乱,Mankin’s评分明显升高;抑制剂组、四逆汤饼灸组及联合组软骨表面较光滑,软骨细胞分布较均匀,Mankin’s评分降低。免疫组化与Western blot结果显示,与对照组比较,模型组软骨组织中Caveolin-1、p38 MAPK、MMP-13的表达均升高(P均<0.05);与模型组比较,抑制剂组、四逆汤饼灸组及联合组软骨组织中Caveolin-1、p38MAPK、MMP-13的表达均降低(P均<0.05)。结论四逆汤饼灸能延缓KOA软骨的进一步破坏,其机制可能与抑制Caveolin-1/p38 MAPK信号通路蛋白的表达有关。

构建服务全民终身学习的多元职业教育体系

我国经济发展已由高速增长阶段转向高质量发展阶段,职业教育中职业技能人才的培养要瞄准技术变革和战略性新兴产业优化升级的方向,加快完成以公共实训机构、职业院校、职业培训机构和行业企业为载体的多元职业教育体系构建,从而形成具有终身学习特征的职业技能人才多维培养通道。为了让职业教育有力推动经济高质量发展,增强职业教育与战略性新兴产业需求的适应性,需要注重职业技能人才培养与新时代的产业发展相契合,优化职业教育类型定位,构建符合战略性新兴产业特征的终身学习职业教育体系,为各领域职业技能人才储备提供长期性和可持续性保障。

Effect of Jianpi Shengxue Tablet on Iron Metabolism and Nutritional Status in Patients with Renal Anemia:A Prospective,Randomized,Open,Parallel Controlled and Multicenter Clinical Study

Objective This study aimed to analyze the clinical efficacy of the Jianpi Shengxue tablet for treating renal anemia.Methods A total of 200 patients with renal anemia from December 2020 to December 2022 were enrolled and randomly divided into two groups.Patients in the control group were treated with polysaccharide-iron complex,and those in the experimental group were administered Jianpi Shengxue tablet.After 8 weeks of continuous treatment,the therapeutic outcomes regarding anemia were compared between the two groups.Results After treatment,the red blood cell(RBC)count,hematocrit(HCT),reticulocyte percentage(RET),ferritin(SF),serum iron(SI),transferrin saturation(TSAT),and serum albumin(ALB)all increased(P<0.01),and the clinical symptom score and total iron binding capacity decreased(P<0.01)in the experimental group.Moreover,the improvements in RBC,HCT,RET,SF,SI,TAST,ALB,and clinical symptoms(fatigue,anorexia,dull skin complexion,numbness of hands and feet)in the experimental group were significantly greater than those in the control group(P<0.05).The total effective rate for treating renal anemia was significantly higher in the experimental group than in the control group(P<0.01).Conclusion The Jianpi Shengxue tablet demonstrates efficacy in treating renal anemia,leading to significant improvements in the laboratory examination results and clinical symptoms of patients with renal anemia.

Preparation Process and Quality Standard of Rougan Huaxian Ointment

[Objectives] To establish the preparation process and quality standard of Rougan Huaxian ointment.[Methods] The L_(9)(3^(4)) orthogonal test was employed to optimize the preparation process by considering the multiplication of water addition, extraction time, and extraction frequency as influencing factors. The dry paste yield was utilized as the evaluation criterion, in conjunction with the actual production conditions. Thin layer chromatography was employed to identify Radix Astragali, Lycii Fructus, Herba Dendrobii, and Rhizoma Polygoni Cuspidati. Ethanol served as the solvent for the determination of ethanol-soluble extractives using the cold immersion method.[Results] The preparation process was conducted as follows: the specified quantity of medicinal materials was combined with water for extraction purposes, performed in two separate stages. In each stage, eight times the amount of water was added. The first extraction lasted for 1.5 h, while the second extraction was completed in 1.0 h. The resulting liquid was then concentrated into a thick paste with a relative density ranging from 1.25 to 1.30 at a temperature of 60 ℃. The thin-layer chromatography analysis of Radix Astragali, Lycii Fructus, Herba Dendrobii, and Rhizoma Polygoni Cuspidati demonstrated distinct spots, effective separation, and the absence of interference from negative samples. Additionally, the ethanol-soluble extractives yielded a minimum of 8.0% in terms of dry weight.[Conclusions] The preparation process for Rougan Huaxian ointment is both stable and feasible. Furthermore, the quality standards established for this preparation are unique and reproducible, thereby facilitating effective quality control.

温针灸干预慢性疲劳综合征大鼠骨骼肌PINK1/Parkin通路的变化

背景:研究发现慢性疲劳综合征患者线粒体的功能异常,给予辅酶后可改善症状,温针灸是治疗该病的重要方法之一,但其作用机制尚不明确。目的:采用温针灸干预慢性疲劳综合征大鼠骨骼肌PINK1/Parkin通路,明确温针灸对慢性疲劳综合征的治疗机制。方法:将32只雄性SD大鼠适应性喂养3 d后随机分为正常组、模型组、温针灸组和辅酶组,每组各8只,除正常组外,其余各组大鼠以游泳力竭、慢性束缚及禁食多因素方法制备慢性疲劳综合征模型。造模成功后正常组、模型组大鼠采取相同固定及灌胃操作,温针灸组大鼠选用关元、中脘、足三里(双)穴进行治疗,1次/d,进针后将艾柱置于针柄点燃,每次治疗3壮,共15 min;辅酶组按照1 mg/kg进行灌胃,1次/d,共治疗14 d。记录实验期间各组大鼠体质量、力竭游泳时间及治疗期间的食物利用率。治疗结束后,取各组大鼠双侧腓肠肌,苏木精-伊红染色法观察各组大鼠腓肠肌病理形态,透射电镜观察各组大鼠腓肠肌线粒体形态结构及自噬体,免疫组化法检测各组大鼠骨骼肌中微管相关蛋白1轻链3(microtubule associated protein 1 light chain 3,LC3)Ⅱ蛋白表达水平,Western blot法检测各组骨骼肌中PINK1、Parkin、LC3蛋白的表达。结果与结论:①与正常组相比,模型组腓肠肌细胞核固缩、凝聚,数目增多,细胞排列紊乱,腓肠肌纤维排列紧密;温针灸组和辅酶组腓肠肌纤维排列间隙较模型组增加,细胞核减少,细胞排列较模型组整齐。②与正常组比较,模型组骨骼肌线粒体肿胀、融合及空泡化,线粒体膜断裂,基质较多溶解,嵴断裂、消失;存在自噬现象。与模型组比较,温针灸组及辅酶组线粒体数量增多,排列相对整齐,线粒体空泡化及线粒体嵴断裂情况改善,膜结构相对完整;存在自噬现象。③与正常组相比,模型组骨骼肌中PINK1蛋白表达上调(P<0.05)、而Parkin、LC3Ⅱ、LC3Ⅱ/Ⅰ蛋白的表达稍有上调(P>0.05);与模型组相比,温针灸组和辅酶组骨骼肌中PINK1、Parkin、LC3Ⅱ、LC3Ⅱ/Ⅰ蛋白表达明显上调(P<0.05),温针灸组蛋白表达上调更为显著。④结果说明,温针灸可能通过激活PINK1/Parkin通路,上调LC3Ⅱ表达,形成线粒体自噬体,促进降解受损线粒体的相关内容物,改善线粒体质量,从而发挥治疗慢性疲劳综合征的作用。

杜仲CONSTANS-like全基因组鉴定、系统进化及表达模式分析

【目的】揭示CONSTANS-like在杜仲Eucommia ulmoides基因组中的分布、结构特征及表达模式。【方法】利用生物信息学方法,对杜仲CONSTANS-like基因家族进行鉴定及理化性质、进化关系、基因结构、启动子元件和表达模式分析。【结果】杜仲基因组中共鉴定到8个EuCOLs基因,分别命名为EuCOL1~EuCOL8,氨基酸数目为315~469,理论等电点分布范围为5.10~6.47,分子量为35.21~52.65 kDa。亚细胞定位预测均定位在细胞核中,为亲水性蛋白,分布于8条染色体。系统进化分为2个亚家族(群组Ⅰ和群组Ⅲ),分别包含2和6个EuCOLs蛋白,同一亚家族基序具有相似性。EuCOLs基因结构简单,启动子中含有多个光周期响应元件。表达模式分析显示:EuCOLs在杜仲叶片发育中表达水平相对较低,EuCOL7在杜仲胶形成中表达量最高,各家族成员表达特征存在差异。蛋白互作预测显示:EuCOL7可与多个光周期响应蛋白互作。【结论】杜仲CONSTANS-like基因家族含有典型的CCT和B-box结构域,可能参与叶片发育及杜仲胶的形成。

黔北正安地区安场向斜奥陶系五峰组—志留系龙马溪组页岩气富集规律

四川盆地外缘黔北地区具有良好的页岩气勘探开发前景。基于测井、录井及分析化验等资料,对黔北正安地区安场向斜奥陶系五峰组—志留系龙马溪组页岩气储层特征及富集规律进行了分析。研究结果表明:①黔北正安地区安场向斜奥陶系五峰组—志留系龙马溪组岩性主要为硅质页岩与硅质岩,孔隙类型主要为有机孔隙及粒间孔、粒内溶孔、晶间孔等无机孔隙与页理缝和构造缝及微裂缝等。岩石中总有机碳(TOC)为0.34%~6.65%,平均为3.69%,纵向上自下而上总体呈先增大后减小的趋势,平面上在向斜核部的TOC含量较高,呈环带状向四周降低。岩心含气的质量体积为1.6~6.2 m^(3)/t,平均为3.9 m^(3)/t,龙马溪组总含气量垂向上随着深度的增加而增加,平面上从向斜中部向南北两端逐渐降低,从向斜核部向两翼逐渐降低。矿物脆性指数总体较高,具有很好的可压裂性。②研究区五峰组—龙马溪组为“陆棚边缘、改造残留、向斜浅埋”的独特地质背景,其有利的沉积环境及古生产力为页岩气富集成藏奠定了基础,良好的保存条件避免了页岩储层中天然气的大量逸散,上覆的新滩组盖层与下伏的宝塔组底板形成了“上盖下堵”的封堵组合。③盆外残余向斜页岩气在向斜中心明显富集,核部是页岩气聚集的有利位置,两翼低角度逆断层遮挡处也是页岩气的有利富集部位,微裂缝的发育有利于页岩气的聚集与稳产,因此中浅层残余向斜的井位部署应重点考虑“宽、缓、深”的核心部位。

复杂地层对盾构泥水设备选型影响的研究

探讨了盾构泥水处理系统中标准贯入锤击数与液性指数的关系。通过对不同盾构隧道项目的粉质黏土和黏土进行数据分析,采用最小二乘法进行一元线性回归统计,揭示了两者之间的负相关关系。结果表明,3组数据呈中等程度相关,1组呈弱相关。研究证实,标准贯入锤击数越小,土质越软。但不同土层的线性拟合方程存在差异,因此,仅能定性判断土层的液性指数范围。

氧化石墨烯改性LiFePO_(4)正极材料的电化学性能

采用球磨法制备不同氧化石墨烯添加量的LiFePO_(4)/GO复合材料,研究氧化石墨烯添加量对LiFePO_(4)正极锂离子电池性能的影响。通过XRD、SEM、FTIR、XPS和相关的电化学方法研究了材料的物理和电化学性能。结果表明,球磨法制备LiFePO_(4)/GO复合材料不改变LiFePO_(4)的物性,与纯LiFePO_(4)相比,LiFePO_(4)/GO复合材料表现出更好的高倍率性能和循环稳定性。其中LiFePO_(4)与GO质量比为100∶1.25时,GO-1.25混合材料在0.5 C放电倍率下循环100次后显示出154.9 mAh/g的放电比容量,其容量保持率为98.7%。

血清Metrnl对类风湿关节炎患者颈动脉粥样硬化的诊断价值

目的探讨血清镍纹蛋白(Meteorin-like,Metrnl)对类风湿关节炎(rheumatoid arthritis,RA)并发颈动脉粥样硬化(carotid atherosclerosis,CAS)的诊断价值。方法RA患者66例为研究对象(RA组)、选取同期体检的健康志愿者22例为正常对照组(NC组),两组被检者的一般资料和实验室指标[类风湿因子(rheumatoid factor,RF)、抗环瓜氨酸多肽抗体(anti-cyclic citrullinated peptide,anti-CCP)、甘油三酯(triglyceride,TG)、总胆固醇(total cholesterol,TC)、高密度脂蛋白胆固醇(high-density lipoprotein cholesterol,HDL-C)和低密度脂蛋白胆固醇(low-density lipoprotein cholesterol,LDL-C)、白细胞介素-6(interleukin-6,IL-6)、C反应蛋白(C-reaction protein,CRP)、血细胞沉降率(erythrocyte sedimentation rate,ESR)],使用酶联免疫吸附法(ELISA)测定血清Metrnl水平;根据RA患者是否合并CAS分为RA未合并CAS(RA-nonCAS)组和RA合并CAS(RA-CAS)组,进行单因素及logistics回归分析RA患者发生CAS的影响因素,绘制受试者工作特征曲线(ROC)、并计算曲线下面积(AUC)评估Metrnl对RA合并CAS的诊断价值。结果RA患者血清RF、anti-CCP、IL-6、ESR及Metrnl表达水平较NC组明显升高,差异有统计学意义(P<0.05);单因素及logistics回归分析显示,血清CRP及Metrnl水平较RA-nonCAS组升高,差异有统计学意义(P<0.05);多因素logistics回归分析显示,血清Metrnl可能作为RA并发CAS的独立危险因素(OR=1.125,P<0.05),并对RA并发CAS有一定的诊断价值,AUC为0.872、最佳截断值为124.164μg/L。结论血清Metrnl可能作为RA合并CAS的诊断学指标。

新型波形沥青防水板屋面系统施工技术研究

以成都某项目新型波形沥青防水板屋面系统施工为例,重点介绍了波形沥青防水板在坡屋面系统的防水施工工艺、细部节点处理和质量控制措施。通过对各种施工参数的优化调整,提出了一套高效、科学的施工技术方案。该施工技术不但节约了施工成本和工期,而且确保了屋面防水、通风、隔热保温效果,施工质量易于保证。

基于北斗卫星导航系统的全球铁路信号系统设想

近年来,我国经济和社会快速发展,这对铁路运输系统提出了全新要求,在此情境之下,以往传统的列车控制系统已经无法全面满足实际需求,因此基于北斗卫星导航系统的新型铁路信号系统应运而生。通过该系统对列车定位和运动状态感知,新型列车控制系统的自主性和灵活性得到极大提高,能够有效解决现阶段铁路运输所面临的多种难题。本文阐述了新型铁路信号系统中应用北斗的关键性技术,详细介绍了在实际铁路运营条件下,使用该技术的新型列车控制系统的现场演示结果,以说明通过使用北斗卫星导航系统以及相关解决方案实现的列车自主状态感知性能特征,揭示了此类关键技术在下一代列车控制系统和其他基于北斗系统的铁路设施中的巨大潜力。

数字化时代背景下虚拟仿真教学评价体系的构建与实践

本文探讨了数字化时代背景下虚拟仿真教学评价体系的构建与应用,旨在解决当前虚拟仿真教学中评价体系不完善的问题。通过设计一个科学、全面的数字化评价体系,显著提升了教学质量和学生的学习效果。研究结果显示,数字化评价体系在知识掌握、实践操作和创新能力等方面对学生的表现有显著提高。多维度的评价和实时反馈机制为教师提供了科学的教学指导,促进了学生的个性化学习和自主发展。数字化评价体系还增强了教学过程的透明度和互动性,使教学更加灵活和高效。学生反馈显示,该评价体系帮助他们更好地了解自身学习进度和不足,促进了持续改进和自主学习。

Human ACE2-Functionalized Gold“Virus-Trap”Nanostructures for Accurate Capture of SARS-CoV-2 and Single-Virus SERS Detection

The current COVID-19 pandemic urges the extremely sensitive and prompt detection of SARS-CoV-2 virus.Here,we present a Human Angiotensin-converting-enzyme 2(ACE2)-functionalized gold“virus traps”nanostructure as an extremely sensitive SERS biosensor,to selectively capture and rapidly detect S-protein expressed coronavirus,such as the current SARS-CoV-2 in the contaminated water,down to the single-virus level.Such a SERS sensor features extraordinary 106-fold virus enrichment originating from high-affinity of ACE2 with S protein as well as“virus-traps”composed of oblique gold nanoneedles,and 109-fold enhancement of Raman signals originating from multi-component SERS effects.Furthermore,the identification standard of virus signals is established by machine-learning and identification techniques,resulting in an especially low detection limit of 80 copies mL^(−1) for the simulated contaminated water by SARS-CoV-2 virus with complex circumstance as short as 5 min,which is of great significance for achieving real-time monitoring and early warning of coronavirus.Moreover,here-developed method can be used to establish the identification standard for future unknown coronavirus,and immediately enable extremely sensitive and rapid detection of novel virus.

Maize-legume intercropping promote N uptake through changing the root spatial distribution,legume nodulation capacity,and soil N availability

Legume cultivars affect N uptake,component crop growth,and soil physical and chemical characteristics in maize-legume intercropping systems.However,how belowground interactions mediate root growth,N fixation,and nodulation of different legumes to affect N uptake is still unclear.Hence,a two-year experiment was conducted with five planting patterns,i.e.,maize-soybean strip intercropping(IMS),maize-peanut strip intercropping(IMP),and corresponding monocultures(monoculture maize(MM),monoculture soybean(MS),and monoculture peanut(MP)),and two N application rates,i.e.,no N fertilizer(N-)and conventional N fertilizer(N+),to examine relationships between N uptake and root distribution of crops,legume nodulation and soil N availability.Results showed that the averaged N uptake per unit area of intercrops was significantly lower than the corresponding monocultures.Compared with the monoculture system,the N uptake of the intercropping systems increased by 31.7-45.4%in IMS and by 7.4-12.2%in IMP,respectively.The N uptake per plant of intercropped maize and soybean significantly increased by 61.6 and 31.8%,and that of intercropped peanuts significantly decreased by 46.6%compared with the corresponding monocultures.Maize and soybean showed asymmetrical distribution of roots in strip intercropping systems.The root length density(RLD)and root surface area density(RSAD)of intercropped maize and soybean were significantly greater than that of the corresponding monocultures.The roots of intercropped peanuts were confined,which resulted in decreased RLD and RSAD compared with the monoculture.The nodule number and nodule fresh weight of soybean were significantly greater in IMS than in MS,and those of peanut were significantly lower in IMP than in MP.The soil protease,urease,and nitrate reductase activities of maize and soybean were significantly greater in IMS and IMP than in the corresponding monoculture,while the enzyme activities of peanut were significantly lower in IMP than in MP.The soil available N of maize and soybean was significantly greater increased in IMS and IMP than in the corresponding monocultures,while that of IMP was significantly lower than in MP.In summary,the IMS system was more beneficial to N uptake than the IMP system.The intercropping of maize and legumes can promote the N uptake of maize,thus reducing the need for N application and improving agricultural sustainability.

N, P and K use efficiency and maize yield responses to fertilization modes and densities

Optimal planting density and proper fertilization method are important factors to improve maize yield and nutrient utilization. A two-year(2016 and 2017) field experiment was conducted with three plant densities(6.0, 7.5 and 9.0 plants m^-2) and three fertilization modes(no fertilizer, 0 F;one-off application of slow-released fertilizer, SF;twice application of conventional fertilizer, CF). Results indicated that the grain yields and N, P and K use efficiencies under SF with the optimal planting density(7.5 plants m^-2) were the highest among all the treatments in 2016 and 2017. Compared with CF, SF could increase post-silking dry matter accumulation and promote N, P and K uptake at pre-and post-silking stages;this treatment increased grain N, P and K concentrations and resulted in high N, P and K use efficiencies. Nutrient(N, P and K) absorption efficiencies and partial productivity, and nutrient(N and P) recovery efficiency in SF treatment were significantly higher than those in CF treatments under the planting density of 7.5 plants m^-2. Under both SF and CF conditions, the grain yield, total N accumulation and nutrient use efficiencies initially increased, peaked at planting density of 7.5 plants m^-2, and then decreased with increasing plant density. Based on the yield and nutrient use efficiency in two years, plant density of 7.5 plants m^-2 with SF can improve both the grain yield and N, P and K use efficiency of spring maize in Jiangsu Province, China.

Charge‑Transfer Resonance and Electromagnetic Enhancement Synergistically Enabling MXenes with Excellent SERS Sensitivity for SARS‑CoV‑2 S Protein Detection

The outbreak of coronavirus disease 2019 has seriously threatened human health.Rapidly and sensitively detecting SARSCoV-2 viruses can help control the spread of viruses.However,it is an arduous challenge to apply semiconductor-based substrates for virus SERS detection due to their poor sensitivity.Therefore,it is worthwhile to search novel semiconductor-based substrates with excellent SERS sensitivity.Herein we report,for the first time,Nb2C and Ta2C MXenes exhibit a remarkable SERS enhancement,which is synergistically enabled by the charge transfer resonance enhancement and electromagnetic enhancement.Their SERS sensitivity is optimized to 3.0×10^6 and 1.4×10^6 under the optimal resonance excitation wavelength of 532 nm.Additionally,remarkable SERS sensitivity endows Ta2C MXenes with capability to sensitively detect and accurately identify the SARS-CoV-2 spike protein.Moreover,its detection limit is as low as 5×10^−9 M,which is beneficial to achieve real-time monitoring and early warning of novel coronavirus.This research not only provides helpful theoretical guidance for exploring other novel SERS-active semiconductor-based materials but also provides a potential candidate for the practical applications of SERS technology.

288.15 K下硫酸盐溶液体系中章氏硼镁石转化规律研究

我国盐湖资源丰富,尤以柴达木盆地盐湖为代表,其卤水中富含硼、镁资源,但由于其结构复杂,在水溶液中存在过饱和现象,且不稳定、易转化,这使得其资源无法得到大规模、工业化的生产,严重限制了我国充沛的盐湖硼资源的开发和高值化利用。本文以288.15 K作为实验温度,对MgSO_(4)质量分数分别为5%、10%、20%、30%溶液中章氏硼镁石的转化规律进行了实验研究,有助于阐明盐湖镁硼酸盐形成过程机制,对于丰富盐湖硼酸盐化学、推动盐湖卤水合理开发利用意义重大。

甲状腺结节大小对超声引导下细针穿刺活检标本质量影响的研究

本研究旨在评估甲状腺结节大小对超声引导下细针穿刺活检(US-FNAB)标本质量的影响。回顾性分析由同一名超声医生独立完成的614例共733个甲状腺结节US-FNAB患者资料,根据甲状腺结节直径分为A组(<5 mm)、B组(5~10 mm)和C组(>10 mm),比较各组间标本不满意率。A组189个结节,不满意率为11.6%(22/189);B组397个结节,不满意率为10.8%(43/397);C组147个结节,不满意率为9.5%(14/147)。三组间US-FNAB标本不满意率比较差异均无统计学意义(P>0.05)。对于一名具有丰富操作经验的医生,甲状腺结节大小不会影响US-FNAB的标本质量。