目的探讨GLP-1受体激动剂(司美格鲁肽)治疗具有胰岛素抵抗的多囊卵巢综合征(PCOS-IR)不孕患者临床疗效。方法选取60例胰岛素抵抗的PCOS-IR不孕症患者,随机分为观察组(应用司美格鲁肽治疗)和对照组(应用二甲双胍治疗),每组30例。比较治...目的探讨GLP-1受体激动剂(司美格鲁肽)治疗具有胰岛素抵抗的多囊卵巢综合征(PCOS-IR)不孕患者临床疗效。方法选取60例胰岛素抵抗的PCOS-IR不孕症患者,随机分为观察组(应用司美格鲁肽治疗)和对照组(应用二甲双胍治疗),每组30例。比较治疗前后两组患者血清中性激素、胰岛素、血糖、糖化血红蛋白指标变化情况,包括促卵泡刺激素(FSH)、黄体生成素(LH)、睾酮(T)、催乳素(PRL)、胰岛素(INS)、C-肽、空腹血糖(FPG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbAlc)水平,评估用药的有效性。结果治疗前,两组患者性激素、胰岛素、血糖、糖化血红蛋白指标比较差异均无统计学意义(P>0.05);治疗后,两组患者相关指标FPG、FINS、HDMA-IR及HbAlc显著降低(P<0.05)。结论司美格鲁肽能够显著改善PCOS合并IR患者胰岛素抵抗及糖代谢水平,并对改善患者排卵和调整受孕周期有显著疗效。展开更多
Jilin City is a typical river valley city in Northeast China.In this paper,the authors studied the spatial and temporal expansion characteristics of the built-up areas in Jilin City from 1990 to 2020 using the analysi...Jilin City is a typical river valley city in Northeast China.In this paper,the authors studied the spatial and temporal expansion characteristics of the built-up areas in Jilin City from 1990 to 2020 using the analysis of expansion speed and strength,fractal dimension,barycenter coordinate transfer index and sector analysis.The ultimate-goal is to analyze the driving and restrictive factors that affect the spatial expansion of river valley cities.The results indicate that(1)the expansion speed of urban land in Jilin City has been re-latively slow in the past 30 years,while only slightly faster in 2010–2020;(2)in the spatial dimension,Jilin City mainly expanded to the south,then to the west,and extensive expansion has resulted in complex mor-phology with little stability and compactness;(3)the expansion is affected by multiple factors,of which the positive factor is industrial development,while the restrictive factors include natural factors,population loss,etc.This study provides a case for the formulation of land use policies and land space planning in river valley cities.展开更多
文摘目的探讨GLP-1受体激动剂(司美格鲁肽)治疗具有胰岛素抵抗的多囊卵巢综合征(PCOS-IR)不孕患者临床疗效。方法选取60例胰岛素抵抗的PCOS-IR不孕症患者,随机分为观察组(应用司美格鲁肽治疗)和对照组(应用二甲双胍治疗),每组30例。比较治疗前后两组患者血清中性激素、胰岛素、血糖、糖化血红蛋白指标变化情况,包括促卵泡刺激素(FSH)、黄体生成素(LH)、睾酮(T)、催乳素(PRL)、胰岛素(INS)、C-肽、空腹血糖(FPG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbAlc)水平,评估用药的有效性。结果治疗前,两组患者性激素、胰岛素、血糖、糖化血红蛋白指标比较差异均无统计学意义(P>0.05);治疗后,两组患者相关指标FPG、FINS、HDMA-IR及HbAlc显著降低(P<0.05)。结论司美格鲁肽能够显著改善PCOS合并IR患者胰岛素抵抗及糖代谢水平,并对改善患者排卵和调整受孕周期有显著疗效。
基金Supported by Project of National Natural Science Foundation of China(No.42071255)。
文摘Jilin City is a typical river valley city in Northeast China.In this paper,the authors studied the spatial and temporal expansion characteristics of the built-up areas in Jilin City from 1990 to 2020 using the analysis of expansion speed and strength,fractal dimension,barycenter coordinate transfer index and sector analysis.The ultimate-goal is to analyze the driving and restrictive factors that affect the spatial expansion of river valley cities.The results indicate that(1)the expansion speed of urban land in Jilin City has been re-latively slow in the past 30 years,while only slightly faster in 2010–2020;(2)in the spatial dimension,Jilin City mainly expanded to the south,then to the west,and extensive expansion has resulted in complex mor-phology with little stability and compactness;(3)the expansion is affected by multiple factors,of which the positive factor is industrial development,while the restrictive factors include natural factors,population loss,etc.This study provides a case for the formulation of land use policies and land space planning in river valley cities.
