IPACK阻滞与LIA在膝关节矫形术的应用效果比较

目的:比较腘动脉与膝关节后囊间隙(IPACK)阻滞与关节周围局部浸润镇痛(LIA)在膝关节矫形术后镇痛中的效果。方法:招募60例膝关节矫形术患者,随机分为IPACK阻滞组(I组)和LIA组(L组)。I组行IPACK阻滞,L组行LIA。记录疼痛评分、满意度评分、主动屈膝最大角度、步行距离、镇痛补救率和不良事件发生情况。结果:与L组比较,8h(T2)时点I组静态疼痛评分降低,差异有统计学意义(Z=-2.171,P<0.05);与L组比较,T2,24h(T3)时点I组动态疼痛评分降低,差异有统计学意义(Z=-1.277、-2.841,P<0.05);与L组比较,I组羟考酮应用率降低,差异有统计学意义(χ^(2)=6.667,P<0.05);与L组比较,I组术后2~3d患者主动屈膝最大角度增加,差异有统计学意义(Z=-2.088、-2.426,P<0.05)。结论:IPACK阻滞较LIA更适合于膝关节矫形术后镇痛。

PCV4 Cap抗体ELISA检测方法的建立及血清流行病学调查

旨在建立一种猪圆环病毒4(porcine circovirus type 4, PCV4)Cap蛋白间接ELISA抗体检测方法,对猪群中PCV4抗体进行检测,并与以往的关于PCV4血清流行病学的调查结果进行对比研究,从而更全面地了解PCV4在猪群中的感染和流行情况。本研究利用原核表达系统成功表达PCV4 Cap蛋白,对反应条件进行优化,建立了基于PCV4 Cap蛋白的间接ELISA方法。采用建立的ELISA方法对中国18个省份的不同阶段的2 298份猪血清样本进行检测,以调查中国猪群中PCV4的血清学流行情况。同时将Cap-ELISA检测方法与之前建立的Rep-ELISA进行对比,平行检测845份血清样本。结果显示,在18个省份中,17个省的血清样本中检测到PCV4抗体。PCV4总血清阳性率为34.94%,母猪和育肥猪阳性率分别为59.95%和31.64%,仔猪阳性率为21.14%,保育猪中检出的阳性率最低,为4.20%。两种方法共同检测845份血清样本,符合率为82.84%,其中Cap-ELISA检测总阳性率为31.83%,Rep-ELISA检测总阳性率为35.03%。研究表明,PCV4在中国广泛传播,不同年龄阶段的猪只均能感染。Cap-ELISA和Rep-ELISA两种方法一致性高,从抗体消长规律来分析,两种方法都说明猪群感染PCV4主要在育肥猪和母猪阶段。本研究提供了中国PCV4的最新血清流行病学特征和PCV4在不同阶段猪群中的感染情况,进一步证实了PCV4在我国猪群中有一定的感染率,其危害值得进一步研究和关注。

艾灸对佐剂性关节炎大鼠滑膜组织Beclin-1、LC3-Ⅱ表达的影响

目的观察艾灸对类风湿关节炎(rheumatoid arthritis,RA)大鼠炎症因子白细胞介素-2(interleukin-2,IL-2)及滑膜细胞中自噬相关因子Beclin-1、微管相关蛋白1轻链3-Ⅱ(microtubule-associated protein1 light chain 3-Ⅱ,LC3-Ⅱ)表达的影响,探索艾灸治疗RA的作用机制。方法将36只雄性SD大鼠随机分为空白组、模型组、甲氨蝶呤组、艾灸组,每组9只。采用弗氏完全佐剂造模法制备RA大鼠模型。造模成功后艾灸组予艾灸足三里、关元,每次20 min,每天1次;甲氨蝶呤组予甲氨蝶呤0.35 mg/kg灌胃,每周2次。空白组、模型组、甲氨蝶呤组每天给予艾灸组大鼠同样时长及强度的捆绑。每组均干预3周。观察大鼠一般情况,采用足趾容积测量仪检测大鼠左后肢足趾容积,ELISA法检测血清中IL-2含量,Western blot检测大鼠踝关节滑膜组织中Beclin-1、LC3-Ⅱ蛋白相对表达量。结果与模型组比较,甲氨蝶呤组及艾灸组精神一般,反应尚可,体质量恢复,较活跃,摄食、饮水尚可,足部肿胀、红肿缓解,其局部炎症及全身多发性关节炎情况均轻于模型组。与空白组比较,模型组大鼠于造模后第3、10、17、24天足趾容积明显增大(P<0.01),结合一般情况,提示模型制备成功;甲氨蝶呤组、艾灸组足趾容积于第24天增大(P<0.05)。与模型组比较,甲氨蝶呤组造模后第17、24天足趾容积降低(P<0.05,P<0.01),艾灸组第10、17、24天足趾容积明显降低(P<0.01)。干预3周后,与空白组比较,模型组血清中IL-2含量明显升高(P<0.01),滑膜组织Beclin-1、LC3-Ⅱ蛋白表达量明显上升(P<0.01);与模型组比较,甲氨蝶呤组、艾灸组血清中IL-2含量降低(P<0.05),艾灸组滑膜组织Beclin-1、LC3-Ⅱ蛋白表达量下降(P<0.05)。结论艾灸能改善RA大鼠关节肿胀,降低IL-2含量,其作用机制可能是通过调节自噬因子Beclin-1、LC3-Ⅱ蛋白表达量有关。

基于生物信息学方法设计鼠伤寒沙门氏菌OmpC-FliC多表位疫苗

为了设计鼠伤寒沙门氏菌OmpC-FliC多表位疫苗,试验在NCBI网站的Protein数据库中获取OmpC和FliC蛋白的氨基酸序列,采用Expasy服务器分析其理化性质,通过在线工具AllerTopV.2.0和Vexijen分析其抗原性和致敏性,应用NPS~@服务器分析二级结构,应用IEDB在线工具分析OmpC和FliC的B、T细胞表位。选取优势表位设计鼠伤寒沙门氏菌OmpC-FliC多表位疫苗,对其理化性质、抗原性、致敏性及三级结构进行预测。结果表明:OmpC和FliC均是亲水性蛋白,无致敏性,抗原性较高;OmpC和FliC蛋白均筛选出3个B细胞优势表位,2个细胞毒性T细胞(CTL细胞)优势表位,1个辅助T细胞(Th细胞)优势表位。设计的多表位疫苗为亲水性的稳定蛋白,抗原性预测的分数为1.1422分,且为非致敏原,预测三级结构模型的可信度大。说明鼠伤寒沙门氏菌OmpC-FliC多表位疫苗对动物无致敏性,且具有良好的抗原性。

不同Mg/Li比对粉末冶金Al-Mg-Li合金显微组织及力学性能的影响

采用粉末冶金工艺和热挤压方法制备了Al-Mg-Li合金,并通过金相显微镜、扫描电子显微镜、透射电子显微镜和拉伸试验机对合金的微观组织、断口形貌和力学性能进行了分析。研究了不同Mg/Li比(1.3、1.8、2.5)对合金在烧结态、挤压态和T6热处理态下的微观组织和力学性能的影响。结果显示,随着Mg/Li比的增加,烧结态合金的相对密度增加,表明Mg元素对烧结过程具有促进作用。对于挤压态Al-Mg-Li合金,随着Mg/Li比的增加,合金中含Mg的析出相逐渐增多,并聚集在晶界附近,力学性能得到了很大提高,抗拉强度由285 MPa增加至407 MPa。经T6热处理后,Al-Mg-Li合金的第二相主要由δ′相和T相组成,其中δ′相是主要的强化相,均匀分布在铝基体中,而T相在晶界处呈链状分布。研究表明,提高Mg/Li比可以提高Al-Mg-Li合金的抗拉强度和屈服强度,但延伸率可能会有所下降。T6热处理后Al-5Mg-2Li合金可达到抗拉强度532 MPa、屈服强度473 MPa、延伸率4.5%。

口蹄疫病毒O型全自动磁微粒CLIA抗体定量检测方法的建立

【背景】口蹄疫(foot and mouth disease,FMD)是由口蹄疫病毒引起的一种急性、热性、烈性传染病,疫苗接种是预防临床口蹄疫的有效措施。免疫抗体水平监测则是评估疫苗免疫效果、制定免疫程序的重要依据,是免疫工作和疫情防控必不可少的关键环节,因此建立高效、快速、全自动的抗体检测方法具有重要意义。【目的】基于磁微粒(micromagnetic particles,MPs)化学发光免疫分析技术(CLIA),建立一种新型、全自动、可定量的口蹄疫病毒O型抗体检测方法,为口蹄疫免疫监测和疫情防控提供技术支撑。【方法】使用纳米材料磁微粒为固相载体和分离载体包被捕获抗体,用碱性磷酸酶(alkaline phosphatase,ALP)标记检测抗体,经过条件优化建立了一种新型磁微粒CLIA检测方法(magnetic particle chemiluminescence immunoassay,MP-CLIA)。本方法首先加入磁微粒-兔抗偶联物(magnetic particle-polyclonal antibodies,MPs-p Abs)、待测样本、口蹄疫病毒O型抗原,37℃孵育;再加入适量酶标抗体(ALP-p Abs),37℃孵育;最后加入化学发光底物AMPPD,检测相对发光强度(relative light unit,RLU)。研究通过检测标准品拟合标准曲线,并应用受试者工作特征曲线(receiver operating characteristic,ROC)确定检测方法的判定标准;利用质控样本进行方法学评价,同时检测田间样本,并和液相阻断ELISA(LPB-ELISA)比对,验证临床检测效果。【结果】优化后最佳反应条件为磁微粒浓度0.25 mg·m L^(-1)、口蹄疫病毒O型抗原1﹕1000稀释、酶标抗体1﹕2000稀释、加样量20μL。整个检测过程均在全自动化学发光免疫分析仪中完成,反应时间20 min,在抗体含量0—1280 U(效价0—1﹕2048)范围内标准曲线R2>0.99,可进行定量检测。该方法敏感性为94.66%;特异性为97.10%,检测口蹄疫A型、Asia I型血清型特异性为97.14%,与塞内卡病毒(SVV)、猪繁殖与呼吸综合征病毒(PRRSV)、牛流行热病毒(BEFV)、猪圆环病毒2型(PCV2)、羊痘病毒(QRFV)、小反刍兽疫病毒(PPRV)抗体阳性血清无交叉反应;重复检测变异系数CV值<10%;田间样本检测结果与LPB-ELISA符合率为94.69%,定量结果相关系数R2为0.8473,P<0.0001,相关性显著。【结论】建立的MP-CLIA方法耗时短、操作简便,配套国产全自动化学发光仪,可进行全自动化检测,是一种新型、高效的口蹄疫病毒O型抗体定量检测方法,本方法对应的试剂盒已经完成中试生产和临床检测试验,在全国不同区域试用效果较好,具有较高的临床应用价值。

基于Simulink空载高速转向工况车身运动特性分析

针对某矿用汽车悬挂进行分析,获取转向时的侧倾运动中心;对空载高速转向时,车身运动的关键特征参数进行分析,获取特征参数数学模型;采用Simulink搭建空载高速转向时的车身运动控制模型,并与车辆多体动力学模型联合开展运动特性分析;选取稳态回转工况,对转向特性进行分析,获取侧倾角、侧倾位移等参数的变化规律;将转向角与理论分析结果进行对比,并对比转向角偏差,以验证模型的准确性。结果可知:车身在高速工况转向,由于侧倾效应,外侧悬挂出现跳动,叠加了侧倾转角;侧倾运动对转角特性影响较大,分析模型与理论值基本一致,误差值小于5%;对转角偏差影响也较大,不考虑此部分的影响时,偏差增加了近20%。在精细化设计分析时,需要考虑此部分因素的影响。

猪圆环病毒2型感染性克隆的构建及拯救病毒的双抗体夹心ELISA鉴定

旨在构建猪圆环病毒2型(PCV2)感染性克隆,并利用双抗体夹心ELISA对拯救病毒进行鉴定。通过PCR从阳性病料中扩增出PCV2两种基因型2b与2d的全基因组DNA,并分别克隆入pMD-19T载体,获得2个重组质粒,命名为p19T-PCV2b与p19T-PCV2d。利用SacⅡ酶切获得l 767 bp的PCV2全基因组,并在体外分别用T4连接酶连接而环化,将环状基因组转染至PK-15细胞,传至P6代,利用间接免疫荧光试验(IFA)对拯救病毒进行鉴定,结果表明PCV2b与PCV2d感染性克隆可拯救出病毒。利用PCV2单克隆抗体(单抗)作为捕获抗体,用辣根过氧化酶(HRP)标记的PCV2多抗作为检测抗体,建立检测PCV2病毒粒子的双抗体夹心ELISA方法,用于PCV2拯救病毒的鉴定。将该检测方法与IFA和半数组织细胞感染量(TCID_(50))结果进行对比分析,结果显示,ELISA检测值与Image-J所计算的IFA荧光强度及TCID_(50)的相关系数分别达到0.7和0.8以上,说明该方法与IFA及TCID_(50)检测结果均具有较强的一致性,可以用于PCV2拯救病毒的快速鉴定。

基于RClimDex模型的1961-2020年遂宁地区极端降水变化特征

文章采用1961-2020年遂宁3个国家站日降水量资料,基于RClimDex模型的4种极端降水指数,利用线性回归、R/S分析、M-K突变检验、滑动t检验及小波分析方法研究遂宁1961-2020年极端降水变化特征。文章计算了遂宁极端降水阈值、极端降水频次及极端降水强度,并详细分析了四种极端降水指数的趋势、周期及突变检验,以期对业务人员研究极端降水有所帮助。

超声辅助酸浸废旧LiCoO_(2)正极材料反应过程优化

采用超声辅助酸浸回收废旧锂离子电池正极材料LiCoO_(2)中的Co,实现有价金属的高效浸出。研究超声功率等浸出条件对Co的浸出效率的影响并用响应面分析法探究浸出条件因素的交互作用,实现浸出反应过程优化。实验结果表明,在反应温度为60℃,反应时间为60 min,超声功率为250 W的条件下,Co的浸出率为97.31%;反应时间,反应温度和超声功率三个实验因素对反应过程的影响程度顺序依次为反应温度>反应时间>超声功率;反应温度和反应时间的交互作用在Co的浸出过程中最为显著,反应温度和超声功率之间的交互作用次之,超声功率和反应时间之间的交互作用最弱。

Paradigm for Determining the Optimal Ultradeep and Superthick Saline Aquifer for High-TDS Mine Water Geological Storage

Saline aquifers are the most popular waste and CO_(2)injection and storage reservoirs worldwide.This project proposes that several optimal injection positions should be investigated as hydraulic pressure-focused positions,in order to relieve the high demands of pump performance.The comprehensive indices(F_(i))representing the injectivity of different burial depths were obtained by using information entropy,based on the mercury injection experimental data of 13 rock samples.The results demonstrated that the burial depths of No.4,No.1 and No.2 in the Liujiagou Formation were the most suitable positions for hydraulic focused injection,which means the upper 30 m thickness could be regarded as the hydraulic focused range in the saline aquifer with an average thickness of 400 m.In addition,some laboratory experiments and in situ tests were carried out for the purpose of certifying and analyzing results,including SEM,XRD,brittleness index and logging.The results suggested that the rock samples at the No.4,No.1 and No.2 burial depth ranges have loose microstructure,weak cementation,as well as dual pores and fractures.The lithology is mainly quartz and feldspar,but the clay mineral content is high(10%-25%),which is positive for dissolution.The lithology is suitable for hydraulic fracturing to form extended cracks and micro-fissures during high-TDS(total dissolved solids)mine water injection,because of the high brittleness index.Finally,a theoretical and technical framework for high-TDS mine water injection was established,based on operating pilot engineering.Some theoretical defects and drawbacks learned from the field practices were summarized and solutions proposed.The research in this study could provide guidance and a paradigm for the inexpensive treatment of high-TDS mine water by injection and storage.

Research status and application of artificial intelligence large models in the oil and gas industry

This article elucidates the concept of large model technology,summarizes the research status of large model technology both domestically and internationally,provides an overview of the application status of large models in vertical industries,outlines the challenges and issues confronted in applying large models in the oil and gas sector,and offers prospects for the application of large models in the oil and gas industry.The existing large models can be briefly divided into three categories:large language models,visual large models,and multimodal large models.The application of large models in the oil and gas industry is still in its infancy.Based on open-source large language models,some oil and gas enterprises have released large language model products using methods like fine-tuning and retrieval augmented generation.Scholars have attempted to develop scenario-specific models for oil and gas operations by using visual/multimodal foundation models.A few researchers have constructed pre-trained foundation models for seismic data processing and interpretation,as well as core analysis.The application of large models in the oil and gas industry faces challenges such as current data quantity and quality being difficult to support the training of large models,high research and development costs,and poor algorithm autonomy and control.The application of large models should be guided by the needs of oil and gas business,taking the application of large models as an opportunity to improve data lifecycle management,enhance data governance capabilities,promote the construction of computing power,strengthen the construction of“artificial intelligence+energy”composite teams,and boost the autonomy and control of large model technology.

Stability of the Stratification of Water Bodies in the North Passage of the Yangtze River Estuary Based on the EFDC Model

To study the stratified stability of a water column in the North Passage of the Yangtze River Estuary,a numerical model of the hydrodynamics of this estuary is established using the EFDC model.On the basis of EFDC results,this paper derives and pro-vides the discriminative index of water body stability caused by salinity and analyzes the along-range variation in water body strati-fication stability in the North Passage of the Yangtze River Estuary and the periodic variation at a key location(bend area)based on the simulation results of the numerical model.This work shows that the water body in the bend area varies between mixed and strati-fied types,and the vertical average flow velocity has a good negative correlation with the differential velocity between the surface and bottom layers of the water body.The model simulation results validate the formulae for the stratified stability discriminant during spring tides.

Transition metal coordination polymers with flexible dicarboxylate ligand:Synthesis,characterization,and photoluminescence property

Under solvothermal conditions,six new coordination polymers(CPs)[Mn(L)(phen)(H_(2)O)]_(n)(1),[Co(L)(phen)(H_(2)O)]_(n)(2),[Cu(L)(phen)(H_(2)O)]_(n)(3),[Zn_(2)(L)_(2)(phen)2(H_(2)O)]_(n)(4),[Zn(L)(phen)]_(n)(5),and[Cd(L)(phen)2]_(n)(6)were synthesized by reactions of dicarboxylate ligand 2,2'-(1,2-phenylenebis(methylene))bis(sulfanediyl)dinobutyric acid(H_(2)L)and 1,10-phenanthroline(phen)with the corresponding metal salts.Complexes 1-6 have been structurally characterized by single-crystal X-ray diffraction analyses,elemental analysis,IR,thermogravimetric analysis,and powder X-ray diffraction.The structures of 1-6 are 1D chains,which are further connected by hydrogen bonding interac-tions to form 3D supramolecular structures.Among them,1 and 2 are isomorphic with L2-of syn-conformation,while L2-shows anti-conformation in 3-6.In addition,the solid-state photoluminescence property of 4-6 was investigated.

Experimental Investigation on Vertical Hydraulic Transport of Ores in Deepsea Mining

Deepsea mining has been proposed since the 1960s to alleviate the lack of resources on land.Vertical hydraulic transport of collected ores from the seabed to the sea surface is considered the most promising method for industrial applications.In the present study,an indoor model test of the vertical hydraulic transport of particles was conducted.A noncontact optical method has been proposed to measure the local characteristics of the particles inside a vertical pipe,including the local concentration and particle velocity.The hydraulic gradient of ore transport was evaluated with various particle size distributions,particle densities,feeding concentrations and mixture flow velocities.During transport,the local concentration is larger than the feeding concentration,whereas the particle velocity is less than the mixture velocity.The qualitative effects of the local concentration and local fluid velocity on the particle velocity and slip velocity were investigated.The local fluid velocity contributes significantly to particle velocity and slip velocity,whereas the effect of the local concentration is marginal.A higher feeding concentration and mixture flow velocity result in an increased hydraulic gradient.The effect of the particle size gradation is slight,whereas the particle density plays a crucial role in the transport.

Dynamic Analysis of a 10 MW Floating Offshore Wind Turbine Considering the Tower and Platform Flexibility

Recently,semisubmersible floating offshore wind turbine technologies have received considerable attention.For the coupled simulation of semisubmersible floating offshore wind energy,the platform is usually considered a rigid model,which could affect the calculation accuracy of the dynamic responses.The dynamic responses of a TripleSpar floating offshore wind turbine equipped with a 10 MW offshore wind turbine are discussed herein.The simulation of a floating offshore wind turbine under regular waves,white noise waves,and combined wind-wave conditions is conducted.The effects of the tower and platform flexibility on the motion and force responses of the TripleSpar semisubmersible floating offshore wind turbine are investigated.The results show that the flexibility of the tower and platform can influence the dynamic responses of a TripleSpar semisubmersible floating offshore wind turbine.Considering the flexibility of the tower and platform,the tower and platform pitch motions markedly increased compared with the fully rigid model.Moreover,the force responses,particularly for tower base loads,are considerably influenced by the flexibility of the tower and platform.Thus,the flexibility of the tower and platform for the coupled simulation of floating offshore wind turbines must be appropriately examined.

Accessibility and Fairness of Public Service Facilities from the Perspective of Supply and Demand Coordination: A Case Study of Old Urban Area of Guangzhou City

The accessibility and fairness of public service facilities are important manifestations of the convenience and equality of urban public service resource allocation.Optimizing the layout of urban public service facilities is an inevitable requirement for promoting the construction of people centered cities.This paper takes the old urban area of Guangzhou as the research area,measures the accessibility of multiple types of public service facilities based on an improved two-step floating catchment method,and combines Palma Ratio and location quotient methods to explore the fairness of urban public service facilities from two dimensions:social equity and spatial equity,with supply and demand relationship analysis as the main line.Research has shown that:①there is a significant spatial difference in the accessibility of public service facilities in the old urban areas of Guangzhou,and the comprehensive accessibility is generally higher in the central and southeastern regions of the old urban areas with fewer residential populations;②from the perspective of social equity,the resource allocation of public service facilities in the old urban areas of Guangzhou is in a seriously unfair state(with a fairness index of 2.99),and there are also varying degrees of unfairness within the streets;③from the perspective of spatial equity,the location quotient of public service facilities in the old urban areas of Guangzhou shows a pattern of multil center circles decreasing,indicating a significant spatial mismatch between the accessibility supply side of public service facilities and the demand side of the residential population.The research conclusion will provide scientific basis for optimizing the allocation of urban public service facilities and ensuring the equalization of public services.

碳化钛材料ELID磨削加工机理及工艺实验研究

碳化钛新型材料因高硬度、高耐磨性及高化学稳定性等特点被应用到金属复合材料制造以及表面喷涂等方面,其常规磨削方式存在加工效率低、表面质量差、成本高及磨具损耗大的问题。采用ELID磨削技术对碳化钛进行精密磨削加工实验,以二次通用旋转法设计实验,探究加工工艺参数对碳化钛样件表面粗糙度的影响规律。采用DPS软件对实验数据进行分析并建立数学模型,借助MATLAB软件计算出最佳理论工艺参数组合,通过实验对其进行修正和完善,得出实际最佳工艺参数组合为:砂轮进给量1μm,砂轮线速度30m/s,电解电流12.3A,电解间隙1.1mm。在此参数下对碳化钛进行ELID磨削加工,获得样件的表面粗糙度值为246nm,相比于常规磨削方式,样件的表面质量提高14.6%,加工时间缩短36.7%,砂轮损耗率降低53.2%,整体加工效率提高100%以上。

硬质合金立铣刀螺旋槽ELID精密成型磨削试验研究

制造立铣刀过程中,磨削螺旋槽是关键工序,采用传统树脂结合剂砂轮磨削螺旋槽存在让刀、刃宽尺寸偏差大、加工效率低等难题。采用ELID磨削技术对硬质合金立铣刀螺旋槽进行精密成型磨削试验,设计二次回归通用旋转组合实验法,探究磨削工艺参数对硬质合金立铣刀螺旋槽刃宽尺寸的影响规律,利用DPS软件统计实验数据并建立数学模型,通过MATLAB软件优化得出最佳工艺参数组合并进行试验验证。试验结果表明,采用砂轮转速3188.40r/min、砂轮进给量1300μm/s、电解电压85V、占空比42.37%的参数对螺旋槽进行ELID精密成型磨削加工,有效解决了让刀问题,与相同粒度的树脂砂轮比,生产效率提高25%,刃宽尺寸偏差范围降低8%,偏差值保持在6μm以内。

电火花—ELID磨削复合法加工铝基金刚石试验研究

采用电火花—ELID磨削复合法对铝基金刚石进行精密磨削加工试验,探究不同工艺参数对铝基金刚石加工表面质量的影响规律,并对工艺参数进行优化。试验结果表明,采用放电电流为16A、放电电压为90V、脉冲宽度为30μs、铜极转速为400r/min电火花加工工艺参数进行粗加工,采用电解电压为70V、占空比为60%、砂轮进给量为0.8μm/次、砂轮转速为2880r/min的ELID磨削工艺参数进行精密加工,可实现铝基金刚石材料的精密加工,并获得了表面粗糙度Ra=136nm的铝基金刚石加工样件。