The zircon SHRIMP dating of the Zhangtiantang granite gave an age of 159±7 Ma.,which shows that the granite was produced at the early Late Jurassic.The Ar-Ar plateau ages of biotite and K-feldspar from the Zhangt...The zircon SHRIMP dating of the Zhangtiantang granite gave an age of 159±7 Ma.,which shows that the granite was produced at the early Late Jurassic.The Ar-Ar plateau ages of biotite and K-feldspar from the Zhangtiantang pluton are 153.2±1.1 Ma and 135.8±1.2 Ma,respectively.The Ar-Ar anti-isochrone ages of biotite and K-feldspar are 152.5±1.7Ma and 135.4±2.7Ma,respectively.The ages represent the isotopic closure ages of minerals in the pluton.The Zhangtiantang granites are regarded as peraluminous crust-derived type granites to possess the typical geochemical characteristics of calc-alkaline rocks on continental margin,with enriched Si,K,Al(average value of A/CNK as 1.18),HREE,Rb,U,and Th,heavily depleted V,Cr,Co,Ni,Ti,Nb-Ta,Zr,Sr,P,and Ba,strongly negative Eu and common corundum normative(average value of C as 1.84).The εNd(t) values of the Zhangtiantang granite are-5.84 to-7.79,and t2DM values are 1.69 to 1.83 Ga,which indicates partial melting of continental-crust metamorphic sedimentary rocks during the Middle Proterozoic.The cooling history of the Zhangtiantang granitic pluton indicates that the cooling velocity of pluton was faster(about 67℃ /Ma) from zircon(158 Ma) to biotite(152 Ma),and was slower(about12℃ /Ma) from biotite(152.5 Ma) to K-feldspar(135.8 Ma).It can be deduced that the temporal gap(about 10 Ma) between the granite formmation and W-Sn mineralization in South China may be related to ordinary magma-hydrothermal processes by the variational cooling curve of the pluton.The Zhangtiantang pluton was formed in a compressive setting,with differentiation evolution and mineralization occurring in a relative relaxation setting.展开更多
Tβ4 plays an important role in the control of actin polymerization in eukaryotic cells.While its effect in multiple organs and diseases has being widely investigated,lttle is known about its influence on Alzheimer...Tβ4 plays an important role in the control of actin polymerization in eukaryotic cells.While its effect in multiple organs and diseases has being widely investigated,lttle is known about its influence on Alzheimer's disease and the possible mechanisms.Thus,we aimed to evaluate the effects and mechanisms of T94 on glial polarization and cognitive performance in APP/PS1 transgenic mice.Morris water maze test were conducted to assess memory in APP/PS1 mice.Thioflavin S staining,IHC/IF,ELISA,and immunoblotting were performed to explore Aβaccumulation,glial polarization and TLR4/NF-rB axis.We demonstrated that over expression of T94 alone alleviated Aβaccumulation of APP/PS1 mice,reversed microglia and astrocyte polarization and cognitive behavior performance.In addition,Tβ4 could downregulate both TLR4/MyD88/NF-xB p65 and p52 dependent inflammatory pathway.While combination drug of TLR4 antagonist or NF-rB p65 inhibitor exerted no further effects.展开更多
长江将大量泥沙排入东海,对杭州湾的沉积演变产生重大影响,但长江型碎屑对杭州湾不同时期、不同位置的贡献差异缺乏研究。通过分析杭州湾舟山海域水下钻孔(HZW1907孔)沉积物中有机、无机元素地球化学特征,对杭州湾沉积过程中的水体古盐...长江将大量泥沙排入东海,对杭州湾的沉积演变产生重大影响,但长江型碎屑对杭州湾不同时期、不同位置的贡献差异缺乏研究。通过分析杭州湾舟山海域水下钻孔(HZW1907孔)沉积物中有机、无机元素地球化学特征,对杭州湾沉积过程中的水体古盐度、源区风化过程、沉积物组成与来源和长江–杭州湾–东海陆架沉积系统进行研究,并基于稀土元素组成的两端元混合模型,定量探讨长江泥沙对杭州湾不同位置沉积的贡献程度差异。结果表明,杭州湾湾口从晚更新世以来,经历了冰期的下切河谷深切、河谷充填和河谷埋藏3个阶段演化过程,相应发育了河床相(约33.9~23.7kaBP)、河漫滩相(约23.7~12.0kaBP)、古河口湾相(约12.0~9.0 ka BP)、浅海相(约9.0~4.0 ka BP)和现代河口湾相(约4.0 ka BP至今);沉积物的Ga/Rb和K_(2)O/Al_(2)O_(3)关系揭示了中国东部在33.9 ka BP以来经历了冷干–暖湿的气候变化;TS和TOC的变化反映了淡水–不稳定淡水、海水混合–稳定海水的沉积水体演替,与东海陆架一致。晚更新世期间,杭州湾地区发育的河床相、河漫滩相沉积物源区主要来自钱塘江流域,显示长英质火成岩的特征;全新世以来的古河口湾相、浅海相和现代河口湾相沉积物为钱塘江型碎屑与长江型碎屑的混合,显示中基性火成岩的特征,湾口受到长江物质的影响更强。以长江和钱塘江流域(Gd/Yb)_(UCC)为端元的模拟结果显示,杭州湾湾口与湾顶受到长江物质影响差异较大,古河口湾相时期,长江供给杭州湾湾口沉积物约78%,湾顶约39%;浅海相时期,长江供给杭州湾地区超过80%的碎屑,湾口、湾顶无明显差别;现代河口湾相时期,长江供给湾口沉积物约76%,湾顶约22%。该模拟方法在长江向杭州湾输送的碎屑分析中具有定量化的作用,并有望适用于其他沿海陆架河流系统。展开更多
基金supported by the Foundation of Geology Research Projects,funded by the Department of Science and Technology and International Cooperation,Chinese Geological Survey (Grant No. 1212010611805)
文摘The zircon SHRIMP dating of the Zhangtiantang granite gave an age of 159±7 Ma.,which shows that the granite was produced at the early Late Jurassic.The Ar-Ar plateau ages of biotite and K-feldspar from the Zhangtiantang pluton are 153.2±1.1 Ma and 135.8±1.2 Ma,respectively.The Ar-Ar anti-isochrone ages of biotite and K-feldspar are 152.5±1.7Ma and 135.4±2.7Ma,respectively.The ages represent the isotopic closure ages of minerals in the pluton.The Zhangtiantang granites are regarded as peraluminous crust-derived type granites to possess the typical geochemical characteristics of calc-alkaline rocks on continental margin,with enriched Si,K,Al(average value of A/CNK as 1.18),HREE,Rb,U,and Th,heavily depleted V,Cr,Co,Ni,Ti,Nb-Ta,Zr,Sr,P,and Ba,strongly negative Eu and common corundum normative(average value of C as 1.84).The εNd(t) values of the Zhangtiantang granite are-5.84 to-7.79,and t2DM values are 1.69 to 1.83 Ga,which indicates partial melting of continental-crust metamorphic sedimentary rocks during the Middle Proterozoic.The cooling history of the Zhangtiantang granitic pluton indicates that the cooling velocity of pluton was faster(about 67℃ /Ma) from zircon(158 Ma) to biotite(152 Ma),and was slower(about12℃ /Ma) from biotite(152.5 Ma) to K-feldspar(135.8 Ma).It can be deduced that the temporal gap(about 10 Ma) between the granite formmation and W-Sn mineralization in South China may be related to ordinary magma-hydrothermal processes by the variational cooling curve of the pluton.The Zhangtiantang pluton was formed in a compressive setting,with differentiation evolution and mineralization occurring in a relative relaxation setting.
文摘Tβ4 plays an important role in the control of actin polymerization in eukaryotic cells.While its effect in multiple organs and diseases has being widely investigated,lttle is known about its influence on Alzheimer's disease and the possible mechanisms.Thus,we aimed to evaluate the effects and mechanisms of T94 on glial polarization and cognitive performance in APP/PS1 transgenic mice.Morris water maze test were conducted to assess memory in APP/PS1 mice.Thioflavin S staining,IHC/IF,ELISA,and immunoblotting were performed to explore Aβaccumulation,glial polarization and TLR4/NF-rB axis.We demonstrated that over expression of T94 alone alleviated Aβaccumulation of APP/PS1 mice,reversed microglia and astrocyte polarization and cognitive behavior performance.In addition,Tβ4 could downregulate both TLR4/MyD88/NF-xB p65 and p52 dependent inflammatory pathway.While combination drug of TLR4 antagonist or NF-rB p65 inhibitor exerted no further effects.
文摘长江将大量泥沙排入东海,对杭州湾的沉积演变产生重大影响,但长江型碎屑对杭州湾不同时期、不同位置的贡献差异缺乏研究。通过分析杭州湾舟山海域水下钻孔(HZW1907孔)沉积物中有机、无机元素地球化学特征,对杭州湾沉积过程中的水体古盐度、源区风化过程、沉积物组成与来源和长江–杭州湾–东海陆架沉积系统进行研究,并基于稀土元素组成的两端元混合模型,定量探讨长江泥沙对杭州湾不同位置沉积的贡献程度差异。结果表明,杭州湾湾口从晚更新世以来,经历了冰期的下切河谷深切、河谷充填和河谷埋藏3个阶段演化过程,相应发育了河床相(约33.9~23.7kaBP)、河漫滩相(约23.7~12.0kaBP)、古河口湾相(约12.0~9.0 ka BP)、浅海相(约9.0~4.0 ka BP)和现代河口湾相(约4.0 ka BP至今);沉积物的Ga/Rb和K_(2)O/Al_(2)O_(3)关系揭示了中国东部在33.9 ka BP以来经历了冷干–暖湿的气候变化;TS和TOC的变化反映了淡水–不稳定淡水、海水混合–稳定海水的沉积水体演替,与东海陆架一致。晚更新世期间,杭州湾地区发育的河床相、河漫滩相沉积物源区主要来自钱塘江流域,显示长英质火成岩的特征;全新世以来的古河口湾相、浅海相和现代河口湾相沉积物为钱塘江型碎屑与长江型碎屑的混合,显示中基性火成岩的特征,湾口受到长江物质的影响更强。以长江和钱塘江流域(Gd/Yb)_(UCC)为端元的模拟结果显示,杭州湾湾口与湾顶受到长江物质影响差异较大,古河口湾相时期,长江供给杭州湾湾口沉积物约78%,湾顶约39%;浅海相时期,长江供给杭州湾地区超过80%的碎屑,湾口、湾顶无明显差别;现代河口湾相时期,长江供给湾口沉积物约76%,湾顶约22%。该模拟方法在长江向杭州湾输送的碎屑分析中具有定量化的作用,并有望适用于其他沿海陆架河流系统。
