In recent years,more and more reports have been reported on the extracellular role of vitamin D signaling pathway.Studies have shown that both genomic and non-genomic effects of vitamin D signaling pathway are involve...In recent years,more and more reports have been reported on the extracellular role of vitamin D signaling pathway.Studies have shown that both genomic and non-genomic effects of vitamin D signaling pathway are involved in calcium homeostasis,skeletal effects,cell proliferation,differentiation,oxidative stress,angiogenesis,inflammatory response,immune regulation,production and recognition of antimicrobial peptides to varying degrees.This paper reviews the research progress of key genes such as GC,CYP2R1,CYP24A1,CYP27B1,VDR and RXRαin vitamin D receptor signaling pathway,in order to understand the physiological and pathological mechanisms of this pathway more accurately and comprehensively,and lay a foundation for further research.展开更多
应用微波、紫外线、γ射线辐照三种物理技术降解苦荞饭中黄曲霉毒素B1(AFB1),采用高效液相色谱法测定AFB1的含量。试验考察了微波功率、微波时间、紫外照射时间、紫外照射高度、γ射线辐照剂量对其降解效率的影响。结果表明,苦荞饭中AFB...应用微波、紫外线、γ射线辐照三种物理技术降解苦荞饭中黄曲霉毒素B1(AFB1),采用高效液相色谱法测定AFB1的含量。试验考察了微波功率、微波时间、紫外照射时间、紫外照射高度、γ射线辐照剂量对其降解效率的影响。结果表明,苦荞饭中AFB1降解率依次为γ射线辐照>紫外降解>微波降解,γ射线在辐照剂量为20 k Gy时,降解率分别为33.6%±1.5%(污染剂量7.5μg/kg)、35.1%±1.7%(污染剂量30μg/kg)、45.7%±1.3%(污染剂量60μg/kg)。与单独降解技术相比,将任意两种或者三种降解技术联合后,其降解率均显著增加(P<0.05),微波+紫外线+γ射线辐照三种技术联合降解率可达51.9%±0.9%(污染剂量7.5μg/kg)、66.5%±0.7%(污染剂量30μg/kg)、71.5%±0.9%(污染剂量60μg/kg)。三种物理降解技术对于苦荞饭中低剂量的AFB1污染有一定的应用价值。展开更多
基金National Natural Science Foundation of China(No.81860551)Key Research and Development Project of Hainan Province(No.ZDYF2018156)。
文摘In recent years,more and more reports have been reported on the extracellular role of vitamin D signaling pathway.Studies have shown that both genomic and non-genomic effects of vitamin D signaling pathway are involved in calcium homeostasis,skeletal effects,cell proliferation,differentiation,oxidative stress,angiogenesis,inflammatory response,immune regulation,production and recognition of antimicrobial peptides to varying degrees.This paper reviews the research progress of key genes such as GC,CYP2R1,CYP24A1,CYP27B1,VDR and RXRαin vitamin D receptor signaling pathway,in order to understand the physiological and pathological mechanisms of this pathway more accurately and comprehensively,and lay a foundation for further research.
文摘应用微波、紫外线、γ射线辐照三种物理技术降解苦荞饭中黄曲霉毒素B1(AFB1),采用高效液相色谱法测定AFB1的含量。试验考察了微波功率、微波时间、紫外照射时间、紫外照射高度、γ射线辐照剂量对其降解效率的影响。结果表明,苦荞饭中AFB1降解率依次为γ射线辐照>紫外降解>微波降解,γ射线在辐照剂量为20 k Gy时,降解率分别为33.6%±1.5%(污染剂量7.5μg/kg)、35.1%±1.7%(污染剂量30μg/kg)、45.7%±1.3%(污染剂量60μg/kg)。与单独降解技术相比,将任意两种或者三种降解技术联合后,其降解率均显著增加(P<0.05),微波+紫外线+γ射线辐照三种技术联合降解率可达51.9%±0.9%(污染剂量7.5μg/kg)、66.5%±0.7%(污染剂量30μg/kg)、71.5%±0.9%(污染剂量60μg/kg)。三种物理降解技术对于苦荞饭中低剂量的AFB1污染有一定的应用价值。
