Background Perivesical fat invasion is considered as an important prognostic factor for bladder cancer. However, the predictive role of perivesical fat invasion in invasive bladder cancer prognosis has never been repo...Background Perivesical fat invasion is considered as an important prognostic factor for bladder cancer. However, the predictive role of perivesical fat invasion in invasive bladder cancer prognosis has never been reported in Chinese patients. The aim of the study was to assess the predictive value of perivesical fat invasion for prognoses of T2 and T3 bladder cancer in Chinese patients. Methods One hundred and fifty-one patients who underwent radical cystectomy for pT2-3NOM0 invasive bladder cancer from 2001 to 2007 were studied. Cancer-specific survival rate （CSS） and recurrence-free survival rate （RFS） were compared between the pT2 and pT3 patient groups. Other clinicopathological parameters were also retrospectively analyzed by univariate and multivariate analyses to identify the independent predictor for the prognoses of this cohort. Results Average patient age at surgery was 58 years. Ninety （60.3%） patients had grade I and II disease. During follow-up （median 66 months）, 27 patients （17.9%） had tumor recurrence and 18 （11.9%） died of bladder cancer. In the univariate analysis, the CSS and RFS curves between T2 and T3 patients showed no significant difference （P=-0.756 and 0.354, respectively）. Multivariate Cox regression showed that histological classification and grade were independent predictors for CSS, while grade was the sole independent predictor for RFS. Conclusions For this group of Chinese patients, perivesical fat invasion did not demonstrate a statistically significant difference in prognosis between T2 and T3 patients. Nontransitional cell carcinoma （non-TCC） and high-grade patients had short CSS, and patients with high-qrade tumor had higher recurrent risk.展开更多
Background Bladder recurrent disease is still a challenge in the treatment of upper tract urothelial carcinoma （UTUC）. This controlled study aims to investigate the efficacy of early clipping of the distal ureter pr...Background Bladder recurrent disease is still a challenge in the treatment of upper tract urothelial carcinoma （UTUC）. This controlled study aims to investigate the efficacy of early clipping of the distal ureter prior to nephroureterectomy （NU） to prevent bladder recurrence after UTUC.展开更多
Pelvic recurrence of urothelial carcinoma after radical cystectomy is considered infrequent but the prognosis is poor. The incidence of pelvic recurrence after radical cystectomy was 4%-19%, depending on the clinical ...Pelvic recurrence of urothelial carcinoma after radical cystectomy is considered infrequent but the prognosis is poor. The incidence of pelvic recurrence after radical cystectomy was 4%-19%, depending on the clinical stage of the bladder malignancy]＇2 Pelvic recurrences usually occur within the first 2-3 years, and most of the patients die within 15 months after diagnosis of the recurrence.l＇3＇4 The treatment for pelvic recurrence was combined systemic chemotherapy, with a median survival period of 4-7monthsY Here we report a long-term survival case who received intra-arterial chemotherapy as a mono-therapy for pelvic recurrence, which developed 9 months after radical cystectomy.展开更多
文摘Background Perivesical fat invasion is considered as an important prognostic factor for bladder cancer. However, the predictive role of perivesical fat invasion in invasive bladder cancer prognosis has never been reported in Chinese patients. The aim of the study was to assess the predictive value of perivesical fat invasion for prognoses of T2 and T3 bladder cancer in Chinese patients. Methods One hundred and fifty-one patients who underwent radical cystectomy for pT2-3NOM0 invasive bladder cancer from 2001 to 2007 were studied. Cancer-specific survival rate （CSS） and recurrence-free survival rate （RFS） were compared between the pT2 and pT3 patient groups. Other clinicopathological parameters were also retrospectively analyzed by univariate and multivariate analyses to identify the independent predictor for the prognoses of this cohort. Results Average patient age at surgery was 58 years. Ninety （60.3%） patients had grade I and II disease. During follow-up （median 66 months）, 27 patients （17.9%） had tumor recurrence and 18 （11.9%） died of bladder cancer. In the univariate analysis, the CSS and RFS curves between T2 and T3 patients showed no significant difference （P=-0.756 and 0.354, respectively）. Multivariate Cox regression showed that histological classification and grade were independent predictors for CSS, while grade was the sole independent predictor for RFS. Conclusions For this group of Chinese patients, perivesical fat invasion did not demonstrate a statistically significant difference in prognosis between T2 and T3 patients. Nontransitional cell carcinoma （non-TCC） and high-grade patients had short CSS, and patients with high-qrade tumor had higher recurrent risk.
基金This study was supported by a grant from-the National Natural Science Foundation of China （No. 81072101/H1619）.
文摘Background Bladder recurrent disease is still a challenge in the treatment of upper tract urothelial carcinoma （UTUC）. This controlled study aims to investigate the efficacy of early clipping of the distal ureter prior to nephroureterectomy （NU） to prevent bladder recurrence after UTUC.
文摘Pelvic recurrence of urothelial carcinoma after radical cystectomy is considered infrequent but the prognosis is poor. The incidence of pelvic recurrence after radical cystectomy was 4%-19%, depending on the clinical stage of the bladder malignancy]＇2 Pelvic recurrences usually occur within the first 2-3 years, and most of the patients die within 15 months after diagnosis of the recurrence.l＇3＇4 The treatment for pelvic recurrence was combined systemic chemotherapy, with a median survival period of 4-7monthsY Here we report a long-term survival case who received intra-arterial chemotherapy as a mono-therapy for pelvic recurrence, which developed 9 months after radical cystectomy.
