Aim： To evaluate the effect of testosterone （T） on adiponectin serum levels in transsexual female patients. Methods： We measured adiponectin, leptin, luteinizing hormone and follicle stimulating hormone, T, estrad...Aim： To evaluate the effect of testosterone （T） on adiponectin serum levels in transsexual female patients. Methods： We measured adiponectin, leptin, luteinizing hormone and follicle stimulating hormone, T, estradiol, lipid profile, biochemical parameters and body composition in 16 transsexual female patients at baseline and after 6 months of T treatment （100 mg Testoviron Depot/10 days, i.m.）. Results： Adiponectin levels were 16.9 ± 7.3 mg/mL at baseline and 13.5 ± 7.4 mg/mL at month 6 of T treatment （P 〈 0.05）. Leptin and high-density lipoprotein cholesterol decreased significantly, whereas body mass index, waist circumference and lean body mass increased significantly after 6 months of T treatment. No changes in insulin or Homeostasis Model Assessment were detected. Conclusion： T can significantly reduce adiponectin serum levels in transsexual female patients.展开更多
文摘Aim： To evaluate the effect of testosterone （T） on adiponectin serum levels in transsexual female patients. Methods： We measured adiponectin, leptin, luteinizing hormone and follicle stimulating hormone, T, estradiol, lipid profile, biochemical parameters and body composition in 16 transsexual female patients at baseline and after 6 months of T treatment （100 mg Testoviron Depot/10 days, i.m.）. Results： Adiponectin levels were 16.9 ± 7.3 mg/mL at baseline and 13.5 ± 7.4 mg/mL at month 6 of T treatment （P 〈 0.05）. Leptin and high-density lipoprotein cholesterol decreased significantly, whereas body mass index, waist circumference and lean body mass increased significantly after 6 months of T treatment. No changes in insulin or Homeostasis Model Assessment were detected. Conclusion： T can significantly reduce adiponectin serum levels in transsexual female patients.
