Retrospective Study Immune function status of postoperative patients with colon cancer for predicting liver metastasis

BACKGROUND Colon cancer(CC)has a high incidence rate.Radical resection is the main treatment method for CC;however,liver metastasis(LM)often occurs post-surgery.The liver contains both innate and adaptive immune cells that monitor and remove abnormal cells and pathogens.Before LM,tumor cells secrete cytokines and exosomes to adjust the immune microenvironment of the liver,thus forming an inhibitory immune microenvironment for colonization by circulating tumor cells.This indicates that the immune state of patients with CC plays a crucial role in the occurrence and progression of LM.AIM To observe and analyze the relationship between immune status and expression of tumor factors in patients with LM of CC,and to provide a scientific interven-tion method for promoting the patient prognosis.METHODS A retrospective analysis was performed.The baseline data of 100 patients with CC and 100 patients with CC who suffered from postoperative LM and were admitted to our hospital from May 2021 to May 2023 were included in the non-occurrence and occurrence groups,respectively.The immune status of the pa-tients and the expression of tumor factor-related indicators in the two groups were compared,and the predictive value of the indicators for postoperative LM in patients with CC was analyzed.RESULTS Compared with the non-occurrence group,the expression of serum carcinoem-bryonic antigen(CEA),CA19-9,CA242,CA72-4 and CA50 in patients in the occurrence group were significantly higher,while the expression of CD3+,CD4+,CD8+,natural killer(NK)and CD4+/CD25 in patients in the occurrence group were significantly lower(P<0.05).No significant difference was observed in other baseline data between groups(P>0.05).Multivariate logistic regression model analysis revealed that the expressions of CEA,CA19-9,CA242,CA72-4,CA50,CD3+,CD4+,CD8+,NK,and CD4+/CD25 were associated with the LM in patients with CC.High expressions of serum CEA,CA19-9,CA242,CA72-4 and CA50,and low expressions of CD3+,CD4+,CD8+,NK,and CD4+/CD25 in patients with CC were risk factors for LM(OR>1,P<0.05).The receiver operating characteristic curve showed that the area under curve for CEA,CA19-9,CA242,CA72-4,CA50,CD3+,CD4+,CD8+,NK,and CD4+/CD25 in the prediction of LM in patients with CC were all>0.80,with a high predictive value.CONCLUSION The expression of tumor factors and immune state-related indices in patients with CC is closely associated with the occurrence of LM.

Notch signaling mediated by TGF-β/Smad pathway in concanavalin A-induced liver fibrosis in rats

AIM To explore the exact interaction between Notch and transforming growth factor(TGF)-β signaling in liver fibrosis. METHODS We established a rat model of liver fibrosis induced by concanavalin A. Peripheral blood mononuclear cells(PBMCs) were isolated from the modeled rats, and cultured with γ-secretase inhibitor DAPT and TGF-β inhibitor for 24 h. The m RNA levels of Notch and TGF-β signaling were detected by quantitative real-time polymerase chain reaction. Expression of Notch and TGF-β proteins was analyzed by western blotting.RESULTS Compared to control rats, Notch and TGF-β signaling was activated in PBMCs of model rats. Administration of DAPT and TGF-β inhibitor suppressed Notch and TGF-β signal transducer in PBMCs of model rats. DAPT reduced m RNA and protein expression of TGF-β signaling, such as TGF-β1 and Smad3. TGF-β inhibitor also downregulated Notch1, Hes1 and Hes5, and m RNA and protein expression of the Notch signaling pathway.CONCLUSION Notch and TGF-β signaling play a role in liver fibrosis. TGF-β signaling upregulates Notch signaling, which promotes TGF-β signaling.

如何“后继有人”?——基于身份视角的家族企业接班人培养策略组态研究

接班人的有效培养是家族企业顺利传承乃至持续发展的关键。现有研究多关注接班人“向外行动”能力的提升,却忽略了其改变自己内在世界的“向内行动”能力,亦忽略了家族企业代际互动的复杂情境。鉴于此,本文基于身份理论,以形成“合格接班人身份”为培养目标,构建了“赋权-赋能”的接班人培养影响因素分析框架,用fsQCA方法对家族企业接班人培养策略的有效性进行组态研究。发现:(1)单一策略并不构成有效培养家族企业接班人的必要条件;(2)三类组态构成了“殊途同归”的家族企业接班人有效培养路径,包括双重赋能主导型、赋权主导的学习支持驱动型、赋能赋权联动型。本文引入身份理论和组态视角,探究多种培养策略耦合对接班人培养效果的影响,丰富了家族企业代际传承的理论和实践。

On the Prescription Translation of Traditional Chinese Medicine

Traditional Chinese Medicine(TCM)is an essential legacy of Chinese culture,which makes a great contribution to China and the world's medical fields.To make it accepted by more people from different countries,the translation of TCM becomes important.As an important branch of TCM,the study of prescription promotes the development of TCM,and its translation is also significant.However,there are various problems in TCM prescription translation and there are few standards in TCM translation.Thus,this research uses Christiane Nord's"Functionality plus Loyalty"Translation Theory to analyze the TCM prescription translation.Based on characteristics of prescription formation,the paper applies Christiane Nord's"Functionality plus Loyalty"theory to TCM prescription translation.It draws a conclusion that TCM prescription translation can be done according to"Functionality plus Loyalty"theory,and there are three ways of prescription names translation.They are literal translation,free translation and transliteration.