Comparison of debris flow susceptibility assessment methods:support vector machine,particle swarm optimization,and feature selection techniques

The selection of important factors in machine learning-based susceptibility assessments is crucial to obtain reliable susceptibility results.In this study,metaheuristic optimization and feature selection techniques were applied to identify the most important input parameters for mapping debris flow susceptibility in the southern mountain area of Chengde City in Hebei Province,China,by using machine learning algorithms.In total,133 historical debris flow records and 16 related factors were selected.The support vector machine(SVM)was first used as the base classifier,and then a hybrid model was introduced by a two-step process.First,the particle swarm optimization(PSO)algorithm was employed to select the SVM model hyperparameters.Second,two feature selection algorithms,namely principal component analysis(PCA)and PSO,were integrated into the PSO-based SVM model,which generated the PCA-PSO-SVM and FS-PSO-SVM models,respectively.Three statistical metrics(accuracy,recall,and specificity)and the area under the receiver operating characteristic curve(AUC)were employed to evaluate and validate the performance of the models.The results indicated that the feature selection-based models exhibited the best performance,followed by the PSO-based SVM and SVM models.Moreover,the performance of the FS-PSO-SVM model was better than that of the PCA-PSO-SVM model,showing the highest AUC,accuracy,recall,and specificity values in both the training and testing processes.It was found that the selection of optimal features is crucial to improving the reliability of debris flow susceptibility assessment results.Moreover,the PSO algorithm was found to be not only an effective tool for hyperparameter optimization,but also a useful feature selection algorithm to improve prediction accuracies of debris flow susceptibility by using machine learning algorithms.The high and very high debris flow susceptibility zone appropriately covers 38.01%of the study area,where debris flow may occur under intensive human activities and heavy rainfall events.

Study of the OPG/RANKL/RANK signaling pathway in mice treated with sepsis-related acute kidney injury

Objective:The objective of this study was to investigate the alterations and potential implications of the Osteoprotegerin(OPG)/Receptor Activator of Nuclear Factor-kappa B Ligand(RANKL)/Receptor Activator of Nuclear Factor-kappa B(RANK)signaling pathway factors in a murine model of sepsis-associated acute kidney injury(SA-AKI).This research aimed to offer novel insights into the mechanistic exploration of SA-AKI.Methods:The SA-AKI model group(CLP group)was established through cecal ligation and puncture surgery(CLP),while the control group consisted of sham-operated animals(Sham group)subjected only to laparotomy without cecal ligation and puncture.Blood samples were collected 24 h post-surgery,and murine kidney tissues were harvested upon euthanasia.Serum levels of Serum Creatinine(Scr)and Blood Urea Nitrogen(BUN)were quantified using assay kits.Furthermore,serum levels of interleukin-6(IL-6),tumor necrosis factor-alpha(TNF-α),and interleukin-1 beta(IL-1β)were assessed through enzyme-linked immunosorbent assay(ELISA).Renal tissue pathological alterations were examined employing hematoxylin-eosin staining(HE),and the mRNA and protein levels of OPG,RANKL,and RANK in murine kidney tissues were determined via reverse transcription-quantitative polymerase chain reaction(RT-qPCR)and Western blotting.Results:Comparative analysis revealed that,in comparison to the Sham group,the CLP group demonstrated a significant elevation in the levels of Scr,BUN,IL-6,TNF-α,and IL-1β,with statistically significant disparities(all P<0.05).Histopathological examination of the CLP group's kidneys unveiled glomerular congestion,edema,partial ischemic wrinkling,enlargement of interstitial spaces,the presence of necrotic epithelial cells in select renal tubules,tubular luminal dilation,varying degrees of interstitial edema,and infiltration by a limited number of inflammatory cells.In parallel,relative to the Sham group,the CLP group exhibited substantial upregulation in mRNA expression of OPG and RANK in renal tissues,while RANKL mRNA expression experienced marked downregulation,with statistically significant distinctions(all P<0.05).Moreover,in comparison with the Sham group,the CLP group demonstrated an elevation in protein expression of OPG and RANK in kidney tissues,whereas RANKL protein expression displayed significant downregulation,with statistically significant differences(all P<0.05).Conclusion:In a murine sepsis model,augmented expression of OPG and RANK,coupled with diminished RANKL expression,suggests the potential involvement of the OPG/RANKL/RANK signaling pathway in the pathophysiological progression of SA-AKI.

MetaOracle:A High-Throughput Decentralized Oracle for Web 3.0-Empowered Metaverse

Recent rapid advancements in communication technology have brought forth the era of Web 3.0,representing a substantial transformation in the Internet landscape.This shift has led to the emergence of various decentralized metaverse applications that leverage blockchain as their underlying technology to enable users to exchange value directly from point to point.However,blockchains are blind to the real world,and smart contracts cannot directly access data from the external world.To address this limitation,the technology of oracles has been introduced to provide real-world data for smart contracts and other blockchain applications.In this paper,we focus on mitigating the risks associated with oracles providing corrupt or incorrect data.We propose a novel Web 3.0 architecture for the Metaverse based on the multiidentifier network(MIN),and its decentralized blockchain oracle model called Meta Oracle.The experimental results show that the proposed scheme can achieve minor time investment in return for significantly more reliable data and increased throughput.

Visible-Light-Sensitive SrCO3/AgI Hybrids for Tetracycline Degradation

The SrCO3/AgI photocatalysts were prepared via a co-precipitation method by using SrCO3 as a co-photocatalyst and AgI as a photo sensitizer.X-ray diffraction,field emission scanning electron microscope,X-ray photoelectron spectrometer,UV-vis diffuse reflectance spectroscopy and electrochemical impedance spectroscope were used to analyze the structure,micro-morphology,chemical compositions,optical properties and photo-generated carrier behaviors of the as-prepared samples,respectively.The photocatalytic degradation mechanism of the as-developed composites was also proposed.Analysis results show SrCO3,an insulator,can improve the photocatalytic performances and recyclability of AgI for degrading tetracycline under visible light.As the theoretical molar ratio of Sr(NO3)2 to AgNO3 increases,the degradation efficiency of the hybrids first increases and then descends.When the theoretical molar ratio of that is 1:1,it acquires the maximum of 66.6% within 8 min.This is higher than 32.0% of pure AgI and 34.0% of SrCO3.Moreover,after three times degradations it is 63.0%,which is higher than 13.6% of AgI.The improvement of the photocatalytic performance of the sample is attributed to the construction of hybrids.The main activated species in catalysis process are superoxide radicals.

Structure, Formation, Properties, and Application of Calcium and Magnesium Silicate Hydrates System—A Review

In order to expand the advantages of strong durability and high compressive strength of calcium silicate hydrates(C-S-H),at the same time to make up for the poor early mechanical strength of magnesium silicate hydrates (M-S-H),we present the features and advantages of C-S-H and M-S-H and a comprehensive review of the progress on CaO-MgO-SiO_(2)-H_(2)O.Moreover,we systematically describe natural calcium and magnesium silicate minerals and thermodynamic properties of CaO-MgO-SiO_(2)-H_(2)O.The effect of magnesium on C-S-H and calcium on M-S-H is summarized deeply;the formation and structural feature of CaO-MgO-SiO_(2)-H_(2)O is also explained in detail.Finally,the development of calcium and magnesium silicate hydrates in the future is pointed out,and the further research is discussed and estimated.

Chemical-bonds Conjugated SnO2/AgIO4 Hybrids for Degradation of High Concentration Rhodamin B under Visible Light Illumination

SnO2/AgIO4 hybrids were fabricated by an in-situ synthetic method at room temperature. The structure, morphology, light response range, separation efficiency of the electron-hole pairs and elements of the as-synthesized samples were characterized by adopting X-ray diffraction, scanning electron microscopy, UV-Vis diffuse reflectance spectroscopy, electrochemical impedance spectroscopy and X-ray photoelectron spectroscopy, respectively. The synergistically photocatalytic degradation mechanism of the as-synthesized composites was also proposed. The experimental results reveal that under the visible light irradiation the as-synthesized SnO2/AgIO4 hybrids can enhance the photocatalytic degradation efficiency of rhodamine B compared to pure samples. With increasing the molar ratios of AgIO4 to SnO2, it displays the trend of first increasing and then decreasing. When it is 1:2 in 150 min, the as-prepared hybrids have the highest degradation efficiency of 93.1%, which increases by 6550.0%, 30.5%, and 1505.0% compared to those of pure SnO2, AgIO4, and TiO2(P25), respectively. Moreover, the Sn-O-Ag cross-linking bonds are formed at the interfaces of SnO2 and AgIO4. In addition, superoxide anion radicals and holes play a major role in the process of photodegradation.

LIBRA技术理论及其在史料图像资源中的应用

数字人文致力于数字技术与人文研究的深度融合,新技术的不断涌现,推动着数字人文的发展与变革。文章从众多的数字技术中凝练出五类最常用的关键性技术,形成LIBRA技术体系,主要包括关联数据(Linked Data)、国际图像互操作框架(IIIF)、大数据(Big Data)、资源描述框架(RDF)和人工智能(AI)。其中,资源描述框架和关联数据作为语义网的核心技术已在数字人文领域盛行多年;国际图像互操作框架作为新兴的技术已成为文化遗产机构开展图像资源研究的主流方案;大数据和人工智能技术已引起了人类社会的剧变,强大的算力和智能的算法赋予人文研究新的范式和新的视野。可以说,LIBRA已成为或将成为数字人文建设的核心技术框架,并会得到越来越多的重视和应用。在案例部分,文章从知识组织模型、数据存储模型和动态文本识别三方面探讨了LIBRA技术在构建多维度图像智慧系统中的深度应用。随着技术的发展变化,LIBRA并非一成不变,新技术也会补充和重塑LIBRA体系,以助力中国数字人文的建设与腾飞。

睡眠对儿童血清Leptin、Ghrelin及血脂水平影响的前瞻性研究

目的探讨儿童睡眠时间、睡眠质量对外周血清Leptin、Ghrelin及血脂水平的影响。方法利用前瞻性研究设计,在2016、2018年对宁波市象山县某中学学生开展睡眠问卷调查和体检,分析364例12~13岁初中学生不同睡眠时长、不同睡眠质量的血清Leptin、Ghrelin及血脂水平前后2年的变化情况,利用协方差分析方法分析睡眠对血清Leptin、Ghrelin及血脂水平的影响。结果协方差分析结果发现,去除基线水平影响后,不同睡眠时间的TC、Leptin水平仍有统计学差异(P<0.05)、不同睡眠时间的TG、LDL-C水平差异也有边缘统计学意义(P=0.053;P=0.051),该结果表明,中学生睡眠时间不足可能会升高TC、LDL-C、TG水平而降低Leptin水平。结论中学生睡眠时间不足(<9 h)与2年后TC、LDL-C、TG水平升高、Leptin水平下降有关,睡眠不足可能通过改变摄食和代谢的有关激素Leptin水平进一步影响血脂水平。

Willis覆膜支架治疗颈内动脉病变的疗效分析

目的探讨Willis覆膜支架治疗颈内动脉颅内段病变的安全性及有效性。方法回顾性分析2015年1月至2018年5月采用Willis覆膜支架治疗的16例颈内动脉病变者的临床资料。结果 16例,颈内动脉海绵窦瘘3例,颈内动脉岩骨段夹层动脉瘤并破裂出血3例,颈内动脉眼段动脉瘤破裂出血2例,颈内动脉虹吸部动脉瘤破裂出血8例。Willis覆膜支架成功治疗16例颈内动脉颅内段病变。术后随访3~6个月,1例术后6个月载瘤动脉轻度狭窄;1例术后3个月患侧颈内动脉闭塞,1例术后残留微小内漏3个月随访造影时内漏消失;16例GOS评分5分。结论 Willis覆膜支架能够安全有效地治疗颈内动脉颅内段病变,但需要更远期随访。

Method and application of knowledge organization system for S&T literature

In the big data environment, the construction of massive S&T literature data resources needs intelligent technical assistance. With a focus on comparing the domestic and foreign knowledge organization systems and their applications, this article analyzes and summarizes the gaps in related researches and applications at home and abroad. A knowledge organization system framework for S&T literature data resources is presented in the article. Starting from the basic element of knowledge organization system, it also proposes and designs terminology-based analysis methods and technologies for S&T literature. Based on this framework, it proposes ideas and develops corresponding software tool to carry out relevant experiments. It gives an overview of theories and technologies method for future research.

老年人群骨关节疾病流行特征及其影响因素研究

背景骨关节疾病是老年人群常见、多发的慢性疾病,其与更高的死亡率、更多的致残率、功能状态的下降和较低的生命质量显著相关,产生巨大的疾病负担。目前尚无河南省该病流行情况及其影响因素的研究。目的了解河南省老年人群骨关节疾病流行特征及其影响因素,为其实施精准防控提供科学依据。方法采用多阶段随机整群抽样方法,通过调查问卷、医学体检、实验室检测等方法,获取2018年河南省≥18岁常住居民人口学特征、既往疾病史、身体活动及身体指标等,本研究纳入1055名≥60岁居民为研究对象。运用多因素Logistic回归分析探讨河南省不同特征老年人群骨关节疾病特征及其影响因素。结果2018年河南省老年人群骨关节疾病患病率(加权后)为28.13%(95%CI=28.10%~28.15%)。其中女性、城市、超重或肥胖、中心性肥胖、血脂异常或高脂血症、无吸烟史、有打鼾史、中等强度活动的老年人群骨关节疾病患病率更高(P<0.05)。多因素Logistic回归分析显示,男性(OR=0.717,95%CI=0.550~0.933,P=0.013)是老年人群骨关节疾病的保护因素;超重或肥胖(OR=1.329,95%CI=1.050~1.684,P=0.018)、中心性肥胖(OR=1.305,95%CI=1.047~1.626,P=0.018)是老年人群骨关节疾病的危险因素。结论河南省老年人群骨关节疾病与性别、BMI和中心性肥胖相关,应对老年人群中女性、超重或肥胖和中心性肥胖者开展针对性健康教育及综合干预。

发育性髋关节发育不良患者固液双相纤维增强软骨的力学性能

背景:发育性髋关节发育不良由于髋臼、股骨头存在结构、大小及方向等方面的畸形,患者长时间活动或站立会引起腹股沟疼痛,如果得不到有效的治疗,患者的正常活动将严重受限。目的:基于FEBio建立具有固液双相纤维增强软骨的球-窝髋关节有限元模型,探究发育性髋关节发育不良患者和正常人髋关节软骨的生物力学特性。方法:对1名发育性髋关节发育不良患者和1名正常志愿者进行髋关节建模,模型包含左盆骨、左股骨及附着其上的软骨。验证正常髋关节固液双相纤维增强软骨模型有效性后,建立髋关节发育不良患者髋关节有限元模型,对比两者在单腿站立时(2 130 N静态载荷)软骨的接触应力、流体压力、固相等效应力和流体支撑率的差异。结果与结论:(1)与正常髋关节相比,载荷加载完成后1 s(承载初期),发育性髋关节发育不良患者髋臼软骨出现明显的边缘接触,且峰值接触应力(3.86 MPa)和峰值流体压力(3.76 MPa)均大于正常髋关节软骨;(2)1 500 s(承载稳定)后,2个模型软骨峰值接触应力和峰值流体压力均减小,但发育性髋关节发育不良患者软骨接触位置由软骨边缘向中心移动,流体支撑率由97.41%下降到91.08%,正常髋关节软骨流体支撑率下降了0.58%,由95.24%下降到94.66%;(3)提示单腿站立生理载荷下,发育性髋关节发育不良患者软骨出现明显的边缘载荷,其峰值接触应力、流体压力和流体支撑率的下降幅度均大于正常软骨,考虑软骨的固液双相纤维增强特性对于评估髋关节发育不良患者髋关节软骨的生物力学性能、理解髋关节发育不良病理生理机制和制定术前计划具有重要的临床意义。

基于半划分调度的Linux实时调度算法改进

传统的多处理器实时任务调度算法分为划分调度算法和全局调度算法。近年来,半划分调度算法逐渐受到广泛关注,该算法综合全局调度和划分调度的行为特性,可以改善全局调度算法系统开销大和划分调度算法处理器利用率低的问题。Linux内核中已经实现了基于GEDF(Global Earliest Deadline First)算法的deadline调度器,但是对于多处理器处理器GEDF调度算法会产生Dhall效应。文章对Linux内核中实时调度算法做了改进;在EDF(Earliest Deadline First)算法的基础上,加入半划分调度的思想,在实时任务处理器利用率差别较大时也能成功调度,提高Linux实时任务可调度性的同时降低了上下文切换频率,从而降低了上下文切换带来的系统开销。

慢性阻塞性肺疾病并发肺动脉高压患者外周血Apelin、NO、NOS水平的检测意义

目的探讨慢性阻塞性肺疾病(COPD)并发肺动脉高压、肺心病的患者外周血中Apelin、一氧化碳(NO)、一氧化碳合酶(NOS)的水平及其临床意义。方法选取2015年~2016年收治的COPD患者及同期查体的健康患者共120例,随机分为四组:单纯COPD组、COPD合并肺动脉高压组、COPD合并肺心病组、对照组,每组均30例。对比各组外周血的Apelin、NO、NOS的水平。结果单纯COPD组、COPD合并肺动脉高压组、COPD合并肺心病组的外周血的Apelin、NO、NOS水平,均显著低于对照组(P<0.05)。COPD合并肺动脉高压组、COPD合并肺心病组的外周血的Apelin、NO、NOS水平,均显著低于单纯COPD组(P<0.05)。COPD合并肺动脉高压组和COPD合并肺心病组的外周血Apelin和NO、Apelin和NOS、NO和NOS之间均有相关性(P<0.05)。结论 COPD患者,尤其是合并肺动脉高压、肺心病的患者中,Apelin、NOS、NO显著下降,提示三者在调节肺循环稳态方面可能具有特殊的生理病理意义。

电子束退火法制备Li-N共掺杂多晶ZnO薄膜

为研究电子束退火对Li-N共掺杂Zn O薄膜性能的影响,首先利用溶胶-凝胶旋涂法在p型Si(111)衬底上制备Li-N共掺杂的Zn O前驱膜,然后用电子束对前驱膜进行退火。退火时,电子束加速电压10 k V,退火时间5 min,聚焦束流123 m A,束流为0.7~1.9 m A,最后得到Li-N共掺杂的Zn O薄膜。XRD谱分析表明,当束流高于1.5 m A之后,薄膜为六方Zn O和立方Zn O的混合多晶薄膜,且有金属Zn生成,导致薄膜有较强的绿光发射。SEM图片分析显示,薄膜的晶粒尺寸随束流增加而增大,当束流高于1.5 m A后,晶粒尺寸变化不大,约为60 nm。光致发光(PL)谱和激光拉曼谱的分析结果证实Li、N元素已掺入Zn O晶格中,PL谱中观察到Li元素掺杂引起的紫光发射,拉曼散射光谱中观察到N替代O位的缺陷振动模式。

ASP rs2250656、LDLR rs1122608、LIPG rs2000813基因多态性与冠心病的相关性研究

目的探讨促酰化蛋白基因rs2250656位点、内皮酯酶基因rs2000813位点与低密度脂蛋白受体基因rs1122608位点多态性和冠心病的相关性。方法收集新疆医科大学第一附属医院收治的723例冠心病患者(观察组)以及756例非冠心病患者(对照组)。采用聚合酶链反应方法检测研究对象促酰化蛋白基因rs2250656位点、内皮酯酶基因rs2000813位点与低密度脂蛋白受体基因rs1122608位点的基因型,分析不同基因型与冠心病的关系。结果ASP rs2250656基因位点中,与TT基因型相比,携带CC基因型患者发生冠心病的风险是前者的1.847倍(OR=1.847,95%CI=0.766-1.223,P=0.025),内皮酯酶基因rs2000813以及低密度脂蛋白受体基因rs1122608与冠心病的发生未见明显关联性。结论促酰化蛋白基因rs2250656多态性和冠心病具有密切的关联,CC基因型是冠心病的一个重要的危险因素。

骨植入材料表面微结构对MC3T3-E1成骨细胞成骨分化的影响

背景:骨植入材料表面微纳结构仿生设计可模拟人体天然骨组织中细胞外环境的结构,从而获得较为理想的骨整合功能,但骨植入材料表面微纳结构调控细胞功能及促进成骨的机制还有待进一研究。目的:分析钛片材料微结构表面对MC3T3-E1成骨细胞成骨分化的影响。方法:(1)在5 V或20 V恒定电压下,采用酸蚀和阳极氧化技术在钛片表面制备不同管径的纳米管阵列,分别记为R5组、R20组。检测纯钛片(未经酸蚀和阳极氧化处理)、R5组、R20组的表面形貌、粗糙度与亲水性。(2)将对数生长期的MC3T3-E1成骨细胞分别接种于纯钛片、R5组、R20组钛片表面,成骨诱导培养24 h后,采用RT-PCR检测与免疫荧光染色分析细胞机械敏感通道蛋白1的表达;加入含或不含机械敏感通道蛋白1激活剂Yada1的成骨诱导基,培养7 d后进行碱性磷酸酶染色,培养14 d后进行茜素红染色。结果与结论:(1)扫描电镜下可见纯钛片表面光滑,R5组、R20组钛片表面可见分布相对均匀且有序的纳米管阵列,平均直径分别约30 nm和100 nm,原子力显微镜进一步验证了扫描电镜观察结果。R5组钛片表面粗糙度大于纯钛片(P <0.05),水接触角小于纯钛片(P <0.05);R20组钛片表面粗糙度大于R5组(P<0.05),水接触角小于R5组(P<0.05)。(2)RT-PCR检测与免疫荧光染色显示,R5组细胞机械敏感通道蛋白1的表达高于纯钛片组(P <0.05),R20组细胞机械敏感通道蛋白1的表达高于R5组(P <0.05)。在成骨诱导条件下,与未加入Yada1情况相比,纯钛片组加入Yada1后的细胞碱性磷酸酶活性、钙化结节沉积均无明显变化,R5组、R20组加入Yada1后的细胞碱性磷酸酶活性、钙化结节沉积均显著增加(P <0.05);在加入或未加入Yada1情况下,R5组细胞碱性磷酸酶活性与钙化结节沉积均多于纯钛片组(P <0.05),R20组细胞碱性磷酸酶活性与钙化结节沉积均多于R5组(P <0.05)。(3)结果表明,钛片表面微结构可通过激活机械敏感通道蛋白1促进成骨细胞MC3T3-E1的成骨分化。

livin、LRH1、Ki-67在骨肉瘤中的表达及与预后的关系

目的探讨凋亡抑制蛋白生存蛋白(livin)、肝受体同系物1(LRH1)、Ki-67在骨肉瘤中的表达及与预后的关系。方法回顾性分析50例骨肉瘤患者的临床资料,收集手术切除后骨肉瘤患者的骨肉瘤组织标本50例及相应的癌旁正常组织标本50例,采用链霉菌抗生物素蛋白-过氧化物酶(SP)免疫组化法检测骨肉瘤组织和癌旁正常组织中livin、LRH1、Ki-67的表达情况,并根据预后情况将组织标本分为死亡组(n=15)和生存组(n=35)。分析骨肉瘤组织中livin、LRH1、Ki-67的表达与患者预后的关系。结果骨肉瘤组织中livin、LRH1、Ki-67的阳性表达率均明显高于癌旁正常组织,差异均有统计学意义(P﹤0.01)。死亡组骨肉瘤组织中livin、LRH1、Ki-67的阳性表达率均高于生存组骨肉瘤组织,差异均有统计学意义(P﹤0.05)。单因素分析结果显示:livin、LRH1、Ki-67的表达与骨肉瘤患者的死亡有关(P﹤0.01);多因素分析结果显示:livin、LRH1、Ki-67的表达是影响骨肉瘤患者死亡的独立影响因素。结论 livin、LRH1、Ki-67在骨肉瘤组织中的阳性率表达均较高,三者共同参与骨肉瘤的发生和发展。

基于RFB协议的Linux远程桌面程序的分析与研究

为基于国产平台研发安全可靠的远程桌面程序,对目前已有的各种远程桌面程序进行分析与研究,其中重点研究Linux平台上基于RFB协议的VNC程序。针对基于RFB协议的VNC程序,对其基本框架及工作流程进行分析与研究,重点研究图像消息的传输、屏幕变化的检测以及图像的压缩编码方式,针对目前国产化发展应用需求以及现状,为进一步提升VNC程序的性能,以满足国产信息系统的新需求,提出未来需改进的方向。

四位一体的土木工程专业课程思政教学改革实践

为了加强土木工程专业课程思政建设,进行了四位一体的土木工程专业课程思政教学改革。其总思路为“一主线、二导入、三抓手、四融合”,即以“解思政、融思政、强思政”为主线,以“强思政”作为教学目标,做好顶层设计,修订人才培养方案和课程大纲;以“解思政”“融思政”作为教学手段,做好思政元素的全面导入和有机融合;二导入是指从“人物”和“史政”两方面充分挖掘凝练课程思政内涵,导入思政元素,建立课程思政资源库;三抓手是指从教学方法、融合设计和考核评价入手,做好思政元素和专业知识的有机融合,进而实现“价值塑造、知识传授、能力培养、智慧启迪”的有机统一。经过实践取得了很好的育人成效。