Metallogenic Epoch of Nonferrous Metallic and Silver Deposits in the Jiaodong Peninsula, China and its Geological Significance

As China＇s most important gold-producing district, the Jiaodong Peninsula also contains copper, lead-zinc, molybdenum （tungsten）, and other nonferrous metal ore deposits, but the space-time and genetic relationships with gold deposits remain uncertain. To investigate the temporal relationship between these nonferrous metal and gold ore deposits, We collected the samples from a number of nonferrous metallic and silver deposits and metallogenetic rock bodies in the eastern Jiaodong Peninsula for isotopic dating. The results show that the Re-Os isotopic model ages of the Lengjia molybdenum deposit in Rongcheng range from 114.5 ± 1.8 Ma to 112.6 ± 1.5 Ma, with an average age of 113.6 ± 1.6 Ma; the LA-ICP-MS ^206pb/^238U ages of 33 zircons in the sericitization porphyritic monzogranite that hosts the Tongjiazhuang silver deposit in Rongcheng range between 122 Ma and 109 Ma, with a weighted mean age of 116.04 ± 0.95 Ma; the LA-ICP-MS ^206pb/^238U ages of 31 zircons in the copper metallogenic pyroxene monzodiorite that hosts the Kuangbei copper deposit in Rongcheng range from 126 Ma to 106 Ma, with a weighted mean age of 116.6 ± 1.7 Ma; and the LA-ICP-MS ^206pb/^238U ages of 19 zircons in the pyroxene monzodiorite surrounding the Dadengge gold and multimetal deposit in Weihai range from 113 Ma to 110 Ma, with a weighted mean age of 111.7 ± 0.6 Ma. All these results indicate that the metallogenic ages of the silver and nonferrous metallic deposits in the Jiaodong Peninsula are in a limited range from 118 Ma to 111 Ma. Previous studies have demonstrated that the isotopic ages of gold deposits in the Jiaodong Peninsula range from 123 Ma to 110 Ma, while Weideshanian magmatism occurred between 126 Ma to 108 Ma. Both these ranges are grossly consistent with the metallogenic ages of silver and nonferrous metallic deposits in this study, suggesting that the large-scale mineralization occurred in the Early Cretaceous when magmatic activities were strong. This epoch may be linked to the lithosphere thinning and the thermo-upwelling extension in eastern China at that time. In addition, field investigation also shows that gold and nonferrous metallic deposits are distributed nearby the Weideshanian granite, with the nonferrous metallic deposits lying within or surrounding the granite pluton and the gold deposits outside the granite pluton. We propose the following mineralization scenario： In the Early Cretaceous, an intensive lithospheric extension induced partial melting and degassing of the metasomatized lithospheric mantle, which resulted in the formation of mantle-derived fluids enriched in metal elements. During the rapid process of magma ascent and intrusion, crust-derived fluids were activated by the magmatic thermal dome and served to further extract ore-forming materials from the crust. These fluids may have mixed with the mantle-derived fluid to form a crust-mantle mixing-type ore-forming fluid. The high-temperature conditions in the center or in contact with the granitic magmatic thermal dome would have been favorable for the formation of porphyry-type, skarn-type, and hydrothermal-vein-type ores, thus forming a series of Mo（W）, Cu, and Pb-Zn deposits in the mid-eastern Jiaodong Peninsula. In contrast, the medium- to low-temperature conditions in the periphery of the magmatic thermal dome would have favored the deposition of gold （silver） ores under the appropriate physiochemical and structural conditions. The metaliogenic epoch of the molybdenum, copper, and silver deposits, and their spatio-temporal and genetic relations to the gold deposits, as demonstrated in this study, not only provide important insights to the study of regional metallogeny, our understanding of the metallogenesis of the Jiaodong type gold deposit, and the geodynamic background of the large-scale mineralization in the Jiaodong Peninsula, but also have practical value in guiding the mineral exploration.

Learning algorithm and application of quantum BP neural networks based on universal quantum gates

A quantum BP neural networks model with learning algorithm is proposed. First, based on the universality of single qubit rotation gate and two-qubit controlled-NOT gate, a quantum neuron model is constructed, which is composed of input, phase rotation, aggregation, reversal rotation and output. In this model, the input is described by qubits, and the output is given by the probability of the state in which （1） is observed. The phase rotation and the reversal rotation are performed by the universal quantum gates. Secondly, the quantum BP neural networks model is constructed, in which the output layer and the hide layer are quantum neurons. With the application of the gradient descent algorithm, a learning algorithm of the model is proposed, and the continuity of the model is proved. It is shown that this model and algorithm are superior to the conventional BP networks in three aspects： convergence speed, convergence rate and robustness, by two application examples of pattern recognition and function approximation.

Ant colony optimization algorithm and its application to Neuro-Fuzzy controller design

An adaptive ant colony algorithm is proposed based on dynamically adjusting the strategy of updating trail information. The algorithm can keep good balance between accelerating convergence and averting precocity and stagnation. The results of function optimization show that the algorithm has good searching ability and high convergence speed. The algorithm is employed to design a neuro-fuzzy controller for real-time control of an inverted pendulum. In order to avoid the combinatorial explosion of fuzzy rules due tσ multivariable inputs, a state variable synthesis scheme is employed to reduce the number of fuzzy rules greatly. The simulation results show that the designed controller can control the inverted pendulum successfully.

End-to-end rate-based congestion control with random loss:convergence and stability

The convergence and stability analysis for two end-to-end rate-based congestion control algorithms with unavoidable random loss in packets are presented, which can be caused by, for example, errors on wireless links. The convergence rates of these two algorithms are analyzed by linearizing them around their equilibrium points, since they are globally stable and can converge to their unique equilibrium points. Some sufficient conditions for local stability in the presence of round-trip delay are obtained based on the general Nyquist criterion of stability. The stability conditions can be considered to be more general. If random loss in the first congestion control algorithm is not considered, they reduce to the local stability conditions which have been obtained in some literatures. Furthermore, sufficient conditions for local stability of a new congestion control algorithm have also been obtained if random loss is not considered in the second congestion control algorithm.

Convergence and stability of the Newton-Like algorithm with estimation error in optimization flow control

The Newton-Like algorithm with price estimation error in optimization flow control in network is analyzed. The estimation error is treated as inexactness of the gradient and the inexact descent direction is analyzed. Based on the optimization theory, a sufficient condition for convergence of this algorithm with bounded price estimation error is obtained. Furthermore, even when this sufficient condition doesn＇t hold, this algorithm can also converge, provided a modified step size, and an attraction region is obtained. Based on Lasalle＇s invariance principle applied to a suitable Lyapunov function, the dynamic system described by this algorithm is proved to be global stability if the error is zero. And the Newton-Like algorithm with bounded price estimation error is also globally stable if the error satisfies the sufficient condition for convergence. All trajectories ultimately converge to the equilibrium point.

LA-ICPMS Zircon U-Pb Age of the Zhongchaye Vermiculite Deposit in Laiwu,Shandong Province

Objective The Zhongchaye vermiculite deposit is located north of Laiwu.Tectonically,it belongs to the Luxi Block,west of the Tan-Lu fault zone(Fig.1a).The crystalline basement of this area consists of the Neoarchean Taishan Group and Paleoproterozoic Granitoid.The overlying strata are mainly Paleozoic carbonate rocks,Mesozoic clastic rocks。

冻融循环作用对东北农田黑土团聚体及有机碳的影响

为研究冻融循环作用对东北农田黑土土壤团聚体及结合碳的影响,本研究以黑龙江省海伦市农田黑土为研究对象,利用室内培养试验研究了-9、-18、-26℃3个温度下冻融频次对农田黑土团聚体及有机碳含量的影响。结果表明:随着冻融循环次数的增加,1~0.5 mm和0.25~0.053 mm团聚体含量在3种冻融温度下均发生了显著变化(P<0.05)。与冻融循环1次相比,在相同温度下冻融循环17次后1~0.5 mm团聚体含量在-9、-18、-26℃下分别降低了68.53%、10.91%和40.96%,0.25~0.053 mm团聚体含量分别升高了10.93%、40.89%和99.72%。在-9℃下土壤团聚体分形维数显著升高(P<0.05),由2.09增加到2.74,在-18、-26℃下则变化幅度较小,分别变化了0.1和0.05。土壤团聚体结合碳随着冻融频次的增加没有出现显著的变化(P>0.05),在-18℃和-26℃下,<0.053 mm团聚体有逐渐降低的趋势,在冻融循环17次后分别降低了10.31%和13.73%。冻融作用会显著降低东北农田黑土土壤团聚体的稳定性,冻融作用会显著降低1~0.5 mm团聚体含量并提高0.25~0.053 mm团聚体含量(P<0.05);冻融次数和冻融温度均是影响土壤团聚体稳定性的重要因素。

铜绿假单胞菌Gxun-2产铁载体发酵条件优化及其抑菌效果

鉴定铜绿假单胞菌(Pseudomonas aeruginosa)Gxun-2分泌铁载体类型,确定其最佳发酵工艺条件,同时考察铁载体发酵液对植物病原菌拮抗效果,为该菌株在农业中的应用提供理论依据。本试验先用铬天青(chrome azurol sulfonate,CAS)平板和全波段紫外光吸收法对P.aeruginosa Gxun-2产铁载体进行定性和定量分析,进一步通过单因素、Plackett-Burman及正交试验相结合的方法对其产铁载体培养基及培养条件进行了优化,最后利用平板对峙法测定产铁载体发酵液对香蕉枯萎病病原菌尖孢镰刀菌(Fusarium oxysporum f.sp.cubense,FOC)的拮抗效果。结果表明,菌株Gxun-2所产铁载体类型为异羟肟酸型,确定产铁载体最佳发酵工艺为:琥珀酸钠2 g/L、甘油10 g/L、硫酸铵1 g/L,初始pH6.8、温度35℃、接种量1%(v/v)、装液量140 mL/250 mL;在此条件下,菌株Gxun-2产铁载体活性单位(Su)达到81.20%±0.24%,较优化前提高了82.84%±0.82%,对FOC的抑菌率达70.60%±1.87%,较优化前提高了52.68%±4.23%。

基于CiteSpace和VOSviewer分析fMRI在认知功能研究中的应用

目的了解功能磁共振成像(Function Magnetic Resonance Imaging,fMRI)在认知功能领域的研究进展、热点趋势以及未来发展方向。方法检索2012—2022年CNKI和Web of Science数据库中关于fMRI在认知功能研究中应用的中英文文献。借助CiteSpace和VOSviewer软件对发文的国家、作者合作关系、发文机构、被引频次和关键词进行可视化分析。结果CNKI文献纳入研究1220篇,发文量逐年增长,合作团体较少,机构内部合作紧密,发文量最高的机构是首都医科大学宣武医院;关键词“低频振幅”“功能连接”出现的频次较高,研究集中于糖尿病、抑郁症、痴呆等疾病,主要关注注意力、记忆、短时记忆、执行功能等认知功能。Web of Science文献纳入研究10056篇,文献中作者形成多个合作团体,团体之间合作紧密,发文量最高的机构是Harvard Medical School,关键词“functional connectivity”“brain network”“default mode network”等出现频次较高,研究集中于阿尔茨海默病、轻度认知障碍等疾病,主要关注注意力、工作记忆、情景记忆以及执行功能。结论中文和英文文献中对于fMRI在认知功能中的研究热度保持稳定,已对多种疾病展开认知功能研究。

医学本科生对老年痴呆症认识与态度的调查研究

目的:了解医学本科生对老年痴呆症的知识水平及态度,并分析知识掌握与态度之间的关系,为提升医学本科生对老年痴呆症的知识水平并增强其同理心提供参考依据。方法:采用分层抽样的方法选取石河子大学医学院486名本科生作为研究对象,采用一般资料调查量表、阿尔茨海默病知识量表(ADKS)以及痴呆态度量表(DAS)进行调查。结果:医学本科生ADKS总分(20.49±4.11)分,DAS总分(89.95±13.69)分,多元线性回归结果显示,专业、年级、是否有老年痴呆症家族史等是本科生ADKS得分的主要影响因素(均P<0.05),共解释变异量57.2%,性别、之前是否学习过老年痴呆症知识、是否有与老人同住的经历等是本科生DAS得分的主要影响因素(均P<0.05),共解释变异量46.7%。结论:医学本科生知识水平较高,说明其对老年痴呆相关知识掌握水平较高,但痴呆态度持中立,待提升。学校课程设置上可以根据态度情况做出适当修改,以提升医学本科生对于老年痴呆症病人治疗与照护的积极性。

基于射频技术的开关柜无源无线温度测量系统

配电开关柜安全运行对保障供电可靠性至关重要,配电开关设备的温度监测是前期状态判断和故障后期诊断的重要手段。文中研制了一套基于射频技术的开关柜无源无线温度测量系统,用于配电设备温度状态监测,通过无源无线的方式减少传感设备供电寿命问题、引线爬电问题及布线安装问题。对系统中传感器设备的传感、通讯、封装相关技术进行研究,对系统运行的工作流程进行设计。对系统进行实际运行环境测试和性能及功能测试,测试结果显示本系统适用于开关柜的温度监测,对智能配电网传感节点的智能化、无线化和自取能、自组网有着推动意义。

清热散结胶囊对流行性角结膜炎患者视力、泪膜稳定性及泪液蛋白水平的影响

目的:探讨清热散结胶囊对流行性角结膜炎患者视力、泪膜稳定性及泪液蛋白水平的影响。方法:随机将316例流行性角结膜炎患者纳入对照组和试验组,各158例。对照组给予更昔洛韦眼用凝胶进行治疗,试验组在此基础上加用清热散结胶囊,两组均治疗2周,并随访6个月。比较两组疗效、中医证候、眼表功能、视力情况、泪膜稳定性、泪液蛋白水平、不良反应及复发情况。结果:试验组治疗2周后的总有效率高于对照组(P<0.05)。治疗2周后与治疗前比,两组中医证候、眼表疾病指数(OSDI)、泪膜破裂时间(BUT)、泪液分泌量(SIT)、角膜荧光素染色(FL)评分降低,试验组更低(P<0.05);两组视力及泪液乳铁蛋白(LF)、总蛋白(TP)、分泌型免疫球蛋白A(sIgA)、溶菌酶(LZM)水平升高,试验组更高(P<0.05)。两组治疗期间的并发症总发生率比较无统计学差异(P>0.05);试验组随访期间的复发率为1.90%,低于对照组的12.03%(P<0.05)。结论:流行性角结膜炎患者经清热散结胶囊治疗后其泪液蛋白水平得到有效调节,中医证候、眼表功能、视力情况及泪膜稳定性得到有效改善,疗效提高,且复发风险降低,安全性良好。

基于HFSS的电连接器信号完整性仿真分析

针对高速传输电连接器存在特征阻抗偏小且不连续的问题,基于信号完整性理论提出了采用集总端口并设计测试夹具的优化方案,通过三维电磁仿真软件HFSS建立电连接器3D模型,设置终端驱动求解类型,给定材料属性,分配激励及边界条件,设置求解频率和扫频模式进行信号完整性仿真,分析其TDR特征阻抗、插入损耗、回波损耗、近端串扰、远端串扰等信号完整性参数。结果表明:电连接器在10 MHz~5 GHz频率范围内设置集总端口激励、设计仿真夹具的方式下,插入损耗为-12~-6 dB,回波损耗为-1.3~0 dB、近端串扰为-40 dB以下、远端串扰为-45 dB以下,符合HJ30J的标准要求;与波端口激励、无设计夹具仿真进行参数对比,串扰降低10 dB,TDR特征阻抗提升10Ω,性能参数得到提升。

MAN低速主机配置方案及机舱布置分析

为满足船东对MAN低速主机配置、机舱布置和船舶经济性的要求,分别对基于选择催化还原(Selective Catalytic Reduction,SCR)技术和废气再循环(Exhaust Gas Recirculation,EGR)技术的2种MAN低速主机配置方案的设计原理及辅助系统设计进行分析。从燃油、化学品消耗和机舱布置方面进行研究,为船东基于安装和运行成本考虑选择合适的减排技术方案提供参考。实例对比分析结果表明,虽然SCR配置方案的机舱布置相对困难,但目前其设备和燃油成本低于EGR配置方案,具有更好的经济性。随着燃油和设备价格的不断调整,可综合对比2种配置方案的经济性之后选择更优的方案。

焦家深部金矿床成矿流体来源:来自黄铁矿微量元素及S-He-Ar同位素的约束

焦家金矿是胶东蚀变岩型金矿的典型代表,金储量超过200t。矿体受焦家主干断裂控制,呈脉状产出,发育钾化、绢英岩化、硅化和碳酸盐化等蚀变,矿石中主要载金矿物为黄铁矿。热液成矿期主要可分为四个阶段:黄铁矿-石英阶段(i)、金-石英-黄铁矿阶段(ii)、金-石英-多金属硫化物阶段(iii)和石英-碳酸盐阶段(iv)。本文选取焦家金矿床深部I号主矿体为研究对象,采集了不同标高(-600^-1100m)的钻孔岩心样品,分析了黄铁矿的微量元素和S-He-Ar同位素组成,以此讨论成矿流体的组成、性质及来源。研究发现:焦家深部I号矿体黄铁矿呈浅黄色,强金属光泽,自形-半自形粒状结构,粒度50~1000μm,呈浸染状-细脉状分布于黄铁绢英岩化碎裂岩中,为第ii成矿阶段的产物。黄铁矿的稀土元素含量较低,ΣREE为3.27×10^-6~38.5×10^-6,富集轻稀土元素,δCe值为0.81~1.05,δEu值为0.67~1.43,Th/La、Nb/La比值均小于1,指示成矿流体为富Cl的还原性流体。Co/Ni比值介于0.54~1.57之间,平均值为0.99,与变质流体相近;Y/Ho比值在21.9~35.5之间,与地幔值(25~30)和中国东部大陆地壳值(20~35)接近,指示成矿流体与壳-幔相互作用有关。Y/Ho值、Zr/Hf值和Nb/Ta值变化范围较大,表明成矿热液体系发生了交代作用或有外来热液加入。与大陆地壳相比,黄铁矿富集Cu、Pb、Zn、Cd、Co、Ni等亲硫、铁族元素,亏损高场强元素。焦家深部金矿床黄铁矿的δ^34 S值介于7.5‰~9.8‰之间,平均值为8.7‰,低于浅部矿床δ^34 S值,呈现出由浅到深δ^34 S值逐渐降低的特点。胶东金矿硫同位素组成整体一致,绝大多数矿床δ^34 S值均为正值,变化范围主要集中在6‰~12‰,其来源与古老的变质基底岩系、中生代花岗岩以及幔源流体具有继承演化关系。δ^34 S值整体呈现出:石英脉型<硫化物石英脉型<蚀变岩型的变化规律,说明矿化类型的差异是造成硫同位素组成差别的最主要因素。黄铁矿的3 He/4 He值为1.6±0.1Ra^1.8±0.1Ra,40 Ar/36 Ar值为750~3106,均显示混合来源特征。幔源He所占比例为20%~22%,表明幔源流体可能参与了成矿过程。焦家金矿成矿与燕山晚期中国东部强烈的壳幔相互作用密切相关。

超声引导下腰方肌阻滞对腹腔镜子宫肌瘤剔除术患者镇静Ramsay评分、血清应激指标及苏醒质量的影响

目的:探讨超声引导下腰方肌阻滞(QLB)对腹腔镜子宫肌瘤剔除术(LM)患者Ramsay镇静评分、血清去甲肾上腺素(NE)水平及苏醒质量的影响.方法:选择2019年5月-2021年8月在本院行LM的患者104例,随机数字表法分为对照组(n=52)和观察组(n=52),均行全凭静脉麻醉,观察组先给予超声引导下QLB.比较两组手术前后不同时点血清应激指标皮质醇(Cor)、去甲肾上腺素(NE)水平、疼痛视觉模拟评分法(VAS)、镇静Ramsay评分、苏醒质量及不良反应发生率.结果:两组气腹后10min至术后24h血清Cor、NE水平均持续升高但观察组低于对照组(均P<0.05);两组术后6~24h静息状态下VAS评分先降低后升高,Ramsay评分逐渐升高,观察组术后6h、12h、24hVAS评分均低于对照组,Ramsay评分(2.32±0.56分、2.49±0.53分、2.64±0.46分)均高于对照组(1.57±0.42分、1.68±0.38分、1.82±0.43分)(均P<0.05);观察组呼之睁眼时间(6.69±0.83min)、拔管时间(8.17±1.14min)、苏醒时间(26.45±4.93min)均短于对照组(7.95±0.91min、9.35±1.68min、32.16±6.22min),术后不良反应发生率(5.8%)低于对照组(21.2%)(均P<0.05).结论:对LM患者实施超声引导下QLB,可明显提高镇痛镇静效果,减轻患者机体应激状况,改善术后苏醒质量且提高用药安全性.

异氟醚通过上调NMDA受体导致发育期大鼠海马神经元凋亡

目的探讨异氟醚麻醉对新生大鼠海马神经元N-甲基-D-天冬氨酸(NMDA)受体亚基及凋亡的影响。方法新生1d的SD大鼠36只,雌雄不拘,取海马组织进行原代培养。采用随机数字表法将培养海马神经元5d的培养皿随机分为三组:对照组(C组)、异氟醚组(I组)和AP5+异氟醚组(A组),每组12只。I组和A组培养的海马神经元放置在密闭箱中,吸入1.5%异氟醚和纯氧,吸入时间6h,C组不做任何处理。于异氟醚麻醉结束后2、4、6、24h(C组于相应时点),提取海马神经元总mRNA和总蛋白,采用RT-PCR法测定NR2A mRNA、NR2BmRNA和caspase-3mRNA的表达量,采用Westen blot法测定caspase-3蛋白含量。结果与C组比较,异氟醚麻醉结束后2、4和6hI组海马神经元NR2AmRNA和NR2BmRNA的表达量明显上调(P<0.05)。与C组和A组比较,I组异氟醚麻醉结束后2、4和6h海马神经元caspase-3mRNA的表达量、异氟醚麻醉后4和6h海马caspase-3蛋白含量明显升高(P<0.05)。结论吸入1.5%异氟醚可能通过上调新生大鼠海马神经元NMDA受体导致发育神经元凋亡,阻断NMDA受体可以预防异氟醚导致的发育期海马神经元凋亡。

脂氧素A4对异氟烷所致老龄大鼠认知功能障碍的影响

目的观察脂氧素A4 (LXA4)对异氟烷麻醉诱发老龄大鼠促炎因子释放及认知功能障碍的影响。方法将120只雄性SD大鼠随机分成对照组(C组)、异氟烷组(I组)、LXA4+异氟烷组(L+I组)和LXA4组(L组)(n=30)。异氟烷麻醉开始前,L组和L+I组脑室注射0.3 nmol·L-1LXA4 5μL,C组和I组脑室注射等量0.9%氯化钠溶液。C组和L组大鼠以30%O2-70%N2混合气体处理6 h,I组和L+I组大鼠以1.4%异氟烷处理6 h。麻醉结束后测定动脉血气及血糖,麻醉后0,3,6,12和24 h监测海马肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)、白细胞介素1β(IL-1β)和核因子κB抑制因子α(IκBα)表达,每次5只。其余大鼠完全清醒后,饲养至麻醉后2周,Morris水迷宫实验检测空间学习和记忆能力,分离海马,Western Blotting检测IκBα表达水平。结果与C组比较,I组麻醉后0,3,6 h IL-1β和IL-6表达明显上调(P<0.05);麻醉后0,3,6,12 h TNF-α表达明显上调(P<0.05);麻醉后0,3,6 h IκBα表达下调(P<0.05)。与I组比较,L+I组麻醉后0,3,6 h TNF-α、IL-1β和IL-6表达下调,IκBα表达上调(P<0.05)。水迷宫实验训练第3天和第4天,与I组比较,L+I组大鼠定位平台时间缩短,在目标象限的时间百分比更高(P<0.05)。结论 LXA4可改善异氟烷麻醉所致的老年大鼠学习记忆功能障碍,其机制可能与抑制老年大鼠海马促炎因子释放有关。

影响高速离心风机现场动平衡试验若干问题的分析

本文对风机质量不平衡的原因与振动特征进行了介绍,说明了高速离心风机在动平衡试验过程中临时键相位置的确定原则,叙述了试验过程中的测量单位和动平衡计算方法。通过几起高速离心风机转子动平衡处理案例,总结了风机在不同状态下和不同类型风机影响系数的差异,研究结果对高速离心风机现场动平衡试验具有一定的指导意义。

不同麻醉方式对老年结直肠癌术患者肠道屏障功能及术后认知功能障碍的影响

目的:探究不同麻醉方式对老年结直肠癌术患者的肠道屏障功能及术后认知功能有无影响。方法:选取我院2018年3月至2021年3月收治的100例进行根治术的老年结直肠癌患者为研究对象,依照简单随机数字表法分为A组和B组,每组分别50例。B组患者采用全身麻醉,A组患者采用硬膜外复合全麻。观察比较其肠道屏障功能,术后认知功能障碍评分及麻醉效果评分。结果:从肠道屏障功能评分比较,术前两组患者血清二胺氧化酶、D-乳酸、内毒素水平比较差异无统计学意义(P>0.05);术后两组患者水平均显著下降且A组血清二胺氧化酶、D-乳酸、内毒素水平下降幅度大于B组(P<0.05)。从两组患者的术后认知功能障碍发生率比较,广义估计方程检验结果显示①组间比较结果:wald=8.366,P=0.004<0.05,组间比较具有统计学意义。与B组比较,A组概率为0.004。②重复测量时间比较结果:wald=11.540,P=0.003<0.05,组间比较具有统计学意义。不同麻醉方式患者不同时点认知功能发生情况存在差异。与T4比较,T2、T3分别为0.001、0.077。从两组患者的POCD发生率折线图可以看出,A组患者在T2~T4呈直线下降趋势,显著比B组患者下降快。从两组患者的手术麻醉效果上比较,A组患者麻醉时间、苏醒时间、拔管时间均少于B组患者,两组患者比较差异具有统计学意义(P<0.05)。结论:不同麻醉方式对老年结直肠癌术患者的肠道屏障功能和术后认知功能是有一定影响的,硬膜外复合全身麻醉的安全性更高,POCD的发生率更低,苏醒时间和拔管时间更短,对肠道屏障功能有改善作用。