Immunoglobulin G-mediated food intolerance and metabolic syndrome influence the occurrence of reflux esophagitis in Helicobacter pylori-infected patients

BACKGROUND Reflux esophagitis has an increasing prevalence and complex and diverse symptoms.Identifying its risk factors is crucial to understanding the etiology,prevention,and management of the disease.The occurrence of reflux esophagitis may be associated with food reactions,Helicobacter pylori(H.pylori)infection,and metabolic syndromes.AIM To investigate the risk factors for reflux esophagitis and analyze the effects of immunoglobulin(Ig)G-mediated food intolerance,H.pylori infection,and metabolic syndrome on reflux esophagitis.METHODS Outpatients attending the Second Medical Center of the PLA General Hospital between 2017 and 2021 were retrospectively enrolled.The patients’basic information,test results,gastroscopy results,H.pylori test results,and IgG-mediated food intolerance results were collected.Multivariate logistic regression analysis was used to analyze risk factors for reflux esophagitis.Statistical mediation analysis was used to evaluate the effects of IgG-mediated food intolerance and metabolic syndrome on H.pylori infection affecting reflux esophagitis.RESULTS A total of 7954 outpatients were included;the prevalence of reflux esophagitis,IgG-mediated food intolerance,H.pylori infection,and metabolic syndrome were 20.84%,61.77%,35.91%,and 60.15%,respectively.Multivariate analysis showed that the independent risk factors for reflux esophagitis included IgG-mediated food intolerance(OR=1.688,95%CI:1.497-1.903,P<0.00001)and metabolic syndrome(OR=1.165,95%CI:1.030-1.317,P=0.01484),and the independent protective factor for reflux esophagitis was H.pylori infection(OR=0.400,95%CI:0.351-0.456,P<0.00001).IgG-mediated food intolerance had a partially positive mediating effect on H.pylori infection as it was associated with reduced occurrence of reflux esophagitis(P=0.0200).Metabolic syndrome had a partially negative mediating effect on H.pylori infection and reduced the occurrence of reflux esophagitis(P=0.0220).CONCLUSION Patients with IgG-mediated food intolerance and metabolic syndrome were at higher risk of developing reflux esophagitis,while patients with H.pylori infection were at lower risk.IgG-mediated food intolerance reduced the risk of reflux esophagitis pathogenesis in patients with H.pylori infection;however,metabolic syndrome increased the risk of patients with H.pylori infection developing reflux esophagitis.

过敏性哮喘急性发作患者血清淀粉样蛋白A的表达与影响因素分析

目的 分析过敏性哮喘患者血清淀粉样蛋白A(serum amyloid A,SAA的表达水平,探讨SAA与哮喘急性发作严重程度、过敏性哮喘生物标志物之间的相关性。方法 收集2018年1月至2019年12月在武汉大学中南医院呼吸与危重症医学科住院的哮喘患者信息,根据血清过敏原特异性IgE(sIgE)检测结果分为过敏性哮喘和非过敏性哮喘两组,比较两组患者SAA水平,分析SAA与过敏性哮喘患者的嗜酸性粒细胞(eosinophils,EOS)、总IgE及呼出气一氧化氮(fractional exhaled nitric oxide,FeNO)之间的相关性。利用Logistics回归分析SAA与过敏性哮喘表型之间的关系。结果共纳入127例哮喘急性发作患者,平均年龄(50.5±16.6)岁,女性69例(54.3%)。其中过敏性哮喘患者57例,非过敏性哮喘患者70例。过敏性哮喘患者SAA水平为(26.8±27.4)mg/L,显著高于非过敏性哮喘者(9.1±5.8)mg/L。重-危重度急性发作过敏性哮喘患者SAA水平为(55.0±16.4)mg/L,显著高于轻-中度急性发作过敏性哮喘患者(13.8±13.0)mg/L。过敏性哮喘患者SAA水平与尘螨s IgE等级之间呈正相关关系(r=0.398,P=0.044),与总IgE水平、FeNO及EOS%之间无明显相关性;SAA(OR=1.138,P <0.001)及总IgE(OR=1.015,P <0.001)水平可能是过敏性哮喘的预测因素。结论 过敏性哮喘患者SAA水平显著高于非过敏性哮喘患者,且与过敏原sIgE水平之间存在正相关关系,SAA可能有助于预测哮喘的临床表型。

Experimental Evaluation on Grinding Texture on Flank Face in Chamfer Milling of Stainless Steel

The surface quality of chamfer milling of stainless steel is closed related to the products of 3 C(Computer, Communication and Consumer electronics), where a cutter is a major part to achieve that. Targeting a high-quality cutter,an experimental evaluation is carried out on the influence of grinding texture of cutter flank face on surface quality.The mathematic models of chamfer cutter are established, and they are validated by a numerical simulation. Also the grinding data are generated by the models and tested by a grinding simulation for safety reasons. Then, a set of chamfer cutting tools are machined in a five-axis CNC grinding machine, and consist of five angles between the cutting edge and the grinding texture on the 1 st flank faces, i.e., 0°, 15°, 30°, 45° and 60°. Furthermore, the machined cutting tools are tested in a series of milling experiments of chamfer hole of stainless steel, where cutting forces and surface morphologies are measured and observed. The results show that the best state of both surface quality and cutting force is archived by the tool with 45° grinding texture, which can provide a support for manufacturing of cutting tool used in chamfer milling.

Polysaccharide extracts of Cirsium japonicum protect rat H9c2 myocardial cells from oxidative stress induced by hydrogen peroxide

Daji （Cirsium japonicum） has been applied against gastric disorders, lung diseases, and cardiovascular problems in thetraditional Chinese medicinal system. The present study was to investigate the protective effects of Daji （Cirsiumjaponicum） polysaccharide extracts （CJP） against hydrogen peroxide （H2O2） shock in rat H9c2 myocardial cells. First,CJP was isolated by hot water extraction and ethanol precipitation; it was then characterized by high performance liquidchromatography and infrared spectrum analysis. Rat H9c2 cells were subjected to H2O2 treatment to establish a cellinjury model. The 3- （4,5- dimethylthiazol- 2-yl）-2,5- diphenyltetrazolium bromide assay showed that CJP pretreatmentsignificantly ameliorated the H2O2 injury in a dose-dependent manner. Furthermore, the cell apoptosis induced by H2O2was markedly inhibited by CJP pretreatment, whereas the cleavage level of caspase-3, -8, and -9 was reduced. Inaddition, the p38 mitogen-activated protein kinase pathway might be involved in the protective effect of CJP onmyocardial cells. Therefore, we conclude that polysaccharide extracts of Daji （Cirsium japonicum） protect rat H9c2myocardial cells from oxidative stress induced by H2O2.

Effects of lipoic acid on oxidative stress and damages to sensory nerve subgroups in patients with diabetic peripheral neuropathy

Objective: To explore the effect of lipoic acid on oxidative stress and damages to sensory nerve subsets in patients with diabetic peripheral neuropathy. Methods: A total of 150 patients with diabetic peripheral neuropathy who had received treatment in the Hospital between January 2017 and July 2018 were selected. The patients were randomly divided into two groups, with 75 cases in each group. The control group was treated with Xueshuangtong Injection and Kallikrein, and the observation group was treated with lipoic acid plus medicines given to the control group. The nerve conduction velocity, blood pressure and blood glucose, serum lipids, and serum inflammatory factors were compared between the two groups. Results: The CPT values of the median nerve-ulnar nerves, bilateral superficial peroneal nerves and deep peroneal nerves in the observation group at 5 Hz, 250 Hz, and 2000 Hz were lower than those in the control group, and the difference was statistically significant. After treatment, the SOD in the observation group was higher than that in the control group, and the MDA and Hs-CRP were lower than those in the control group, where the difference was statistically significant. After treatment, the levels of blood pressure and blood glucose in the observation group were lower than those in the control group, and the difference was statistically significant. After treatment, LDL-C, TC, and TG in the observation group were lower than those in the control group, and HDL-C was higher than that in the control group. The difference was statistically significant. Conclusion: For patients with type 2 diabetes, lipoic acid can help improve the clinical treatment, which can improve the levels of blood glucose, blood pressure and blood lipid, increase nerve conduction velocity, and reduce the damage to sensory nerve subgroup.

A multi-agent architecture for scheduling in platform-based smart manufacturing systems

During the past years, a number of smart manufacturing concepts have been proposed, such as cloud manufacturing, Industry 4.0, and Industrial Internet. One of their common aims is to optimize the collaborative resource configuration across enterprises by establishing platforms that aggregate distributed resources. In all of these concepts, a complete manufacturing system consists of distributed physical manufacturing systems and a platform containing the virtual manufacturing systems mapped from the physical ones. We call such manufacturing systems platform-based smart manufacturing systems (PSMSs). A PSMS can therefore be regarded as a huge cyber-physical system with the cyber part being the platform and the physical part being the corresponding physical manufacturing system. A significant issue for a PSMS is how to optimally schedule the aggregated resources. Multi-agent technology provides an effective approach for solving this issue. In this paper we propose a multi-agent architecture for scheduling in PSMSs, which consists of a platform-level scheduling multi-agent system (MAS) and an enterprise-level scheduling MAS. Procedures, characteristics, and requirements of scheduling in PSMSs are presented. A model for sched-uling in a PSMS based on the architecture is proposed. A case study is conducted to demonstrate the effectiveness of the proposed architecture and model.

Enhancing the intrinsic properties of flower-like BiOI by S-doping toward excellent photocatalytic performances

A facile strategy was proposed to fabricate the S-doped flower-like BiOI microspheres(S-BiOI) for boosting the photocatalytic performance of BiOI via engineering the surface oxygen vacancy and exposed {001}crystal planes.The S-doping generated oxygen vacancies in BiOI lattice structure to create point defects and exposed {001} crystal planes,resulting in a decrease in bandgap and an enhancement in charges separation,which could significantly hasten the photocatalytic reaction.The concentration of CH_(4) N_(2) S was a key factor to promote the Cr(Ⅵ) reduction activities.The optimized S-BiOI_(1.25) presented a superior Cr(Ⅵ) removal efficiency of 100% for 60 min,which Cr(Ⅵ) reduction rate was 11.3 times higher than the pristine BiOI and still remained 97.5% Cr(Ⅵ) removal after 5 cycles.DFT calculation confirmed that the bandgap of the S-BiOI was narrowed compared to that of BiOI,but the S-BiOI still remained the intrinsic band structure of the pristine BiOI.

ARSlice:Head-Mounted Display Augmented with Dynamic Tracking and Projection

Computed tomography(CT)generates cross-sectional images of the body.Visualizing CT images has been a challenging problem.The emergence of the augmented and virtual reality technology has provided promising solutions.However,existing solutions suffer from tethered display or wireless transmission latency.In this paper,we present ARSlice,a proof-of-concept prototype that can visualize CT images in an untethered manner without wireless transmission latency.Our ARSlice prototype consists of two parts,the user end and the projector end.By employing dynamic tracking and projection,the projector end can track the user-end equipment and project CT images onto it in real time.The user-end equipment is responsible for displaying these CT images into the 3D space.Its main feature is that the user-end equipment is a pure optical device with light weight,low cost,and no energy consumption.Our experiments demonstrate that our ARSlice prototype provides part of six degrees of freedom for the user,and a high frame rate.By interactively visualizing CT images into the 3D space,our ARSlice prototype can help untrained users better understand that CT images are slices of a body.