Two new sesqulterpenoid glucosides, namely α-hydroxycostic acid 6-β-D-glucopyranoside (compound 1) and 11 βH-11,13-dlhydrodehydrocostuslactone 8α-O-(6'-acetyl)-β-D-glucopyranoside (compound 2), along with ...Two new sesqulterpenoid glucosides, namely α-hydroxycostic acid 6-β-D-glucopyranoside (compound 1) and 11 βH-11,13-dlhydrodehydrocostuslactone 8α-O-(6'-acetyl)-β-D-glucopyranoside (compound 2), along with 11 known sesqulterpenoids (compounds 3-13) were isolated from the aerial parts of Saussurea involucrate (Kar. et Kir.) Sch.- BIp. The structures of the new sesquiterpenoid glucosides were established by one- and two-dimensional nuclear magnetic resonance and mass spectrometry analysis.展开更多
Two novel 27-norergostanol steroids, panthogenins A (1) and B (2), possessing unusual rings E and F featuring a ketal moiety at C-25 were isolated from rhizomes ofDioscorea panthaica. Their structures and relative...Two novel 27-norergostanol steroids, panthogenins A (1) and B (2), possessing unusual rings E and F featuring a ketal moiety at C-25 were isolated from rhizomes ofDioscorea panthaica. Their structures and relative configurations were elucidated by extensive spectroscopic methods including 1D and 2D NMR techniques, and the structure of panthogenin A was further confirmed by X-ray crystallography. Both compounds showed potent in vitro insulin sensitizing activity.展开更多
Two new eupodienone lignans, named gymnothelignan T (1) and gymnothelignan U (2) were isolated from the whole plants of endemic medicinal plant of Gymnotheca chinensis (Saururaceae). The structures of the new co...Two new eupodienone lignans, named gymnothelignan T (1) and gymnothelignan U (2) were isolated from the whole plants of endemic medicinal plant of Gymnotheca chinensis (Saururaceae). The structures of the new compounds were elucidated by means of HRMS, 1D and 2D NMR. Compound I was tested for cytotoxic activity in HCT15, HCT116, A549, MCF-7 and HepG2 cells and exhibited no appreciable activity against these tested cell lines with IC50 values above 50 μmol/L.展开更多
Two novel 2,5-diphenyl oxazole derivatives,named gymnothecaoxazoles A(1) and B(2),were isolated from the whole parts of endemic medicinal plant of Gymnotheca chinensis(Saururaceae).The structures of the new comp...Two novel 2,5-diphenyl oxazole derivatives,named gymnothecaoxazoles A(1) and B(2),were isolated from the whole parts of endemic medicinal plant of Gymnotheca chinensis(Saururaceae).The structures of the new compounds were elucidated by extensive NMR and MS data,and the structure of compound 1was further confirmed by X-ray crystal diffraction analysis.展开更多
Two new oleanane-type triterpenoid saponins, gymnemoside-W1 and W2, together with seven known compounds were isolated from the leaves of Gymnema sylvestre R. Br. By means of spectral and chemical analysis, the structu...Two new oleanane-type triterpenoid saponins, gymnemoside-W1 and W2, together with seven known compounds were isolated from the leaves of Gymnema sylvestre R. Br. By means of spectral and chemical analysis, the structures of the new compounds were elucidated as 16 β-hydroxyl olean-12-en-3-O-[β-D-glucopyranosyl (1 →6)- β-D-glucopyranosyl]-28-O-β-D-glucopyranoside(1) and 16 β,21 β,28-trihydroxyl-olean-12-ene-3-O-glucoronopyranoside (2). The EtOH/H2O extracts of this plant were shown to be able to inhibit glucose absorption in rats.展开更多
In a novel procedure, human serum albumin timctionalized magnetic nanoparticles ( HSA-MNPS ) were used to selectively extract nine flavonoids in the extract of Ginkgo biloba leaves. The chemical structures of those ...In a novel procedure, human serum albumin timctionalized magnetic nanoparticles ( HSA-MNPS ) were used to selectively extract nine flavonoids in the extract of Ginkgo biloba leaves. The chemical structures of those flavonoids were characterized with high performance liquid chromatography coupled with mass spectrometry (HPLC-MS). The selective extraction with HSA-MNPs coupled with structural elucidation with HPLC-MS shows powerful potential for analysis of bioactive components in traditional Chinese medicines.展开更多
Two new biphenyl butyl neolignan derivatives,named gymnothebutyllignans A(1) and B(2),were isolated from the whole parts of endemic medicinal plant of Gymnotheca involucrata(Saururaceae).The structures of the ne...Two new biphenyl butyl neolignan derivatives,named gymnothebutyllignans A(1) and B(2),were isolated from the whole parts of endemic medicinal plant of Gymnotheca involucrata(Saururaceae).The structures of the new compounds were elucidated by extensive NMR and MS data,and the absolutely configuration of compound 1 was confirmed by X-ray crystal diffraction analysis.展开更多
Two new cyclic diarylheptanoids named ostryopsitrienol(1) and ostryopsitriol(2),together with six known compounds,were isolated from the stems of endemic medicinal plant of Ostryopsis nobilis (Betulaceae).The st...Two new cyclic diarylheptanoids named ostryopsitrienol(1) and ostryopsitriol(2),together with six known compounds,were isolated from the stems of endemic medicinal plant of Ostryopsis nobilis (Betulaceae).The structures of the new compounds were elucidated by means of HRMS,~1D NMR,~2D NMR and X-ray crystallography analysis.展开更多
基金Supported by the National Natural Science Foundation of China (30450005).
文摘Two new sesqulterpenoid glucosides, namely α-hydroxycostic acid 6-β-D-glucopyranoside (compound 1) and 11 βH-11,13-dlhydrodehydrocostuslactone 8α-O-(6'-acetyl)-β-D-glucopyranoside (compound 2), along with 11 known sesqulterpenoids (compounds 3-13) were isolated from the aerial parts of Saussurea involucrate (Kar. et Kir.) Sch.- BIp. The structures of the new sesquiterpenoid glucosides were established by one- and two-dimensional nuclear magnetic resonance and mass spectrometry analysis.
基金Financial support from the National Natural Science Foundation of China (Nos.21072184,30973634 and 81173536)
文摘Two novel 27-norergostanol steroids, panthogenins A (1) and B (2), possessing unusual rings E and F featuring a ketal moiety at C-25 were isolated from rhizomes ofDioscorea panthaica. Their structures and relative configurations were elucidated by extensive spectroscopic methods including 1D and 2D NMR techniques, and the structure of panthogenin A was further confirmed by X-ray crystallography. Both compounds showed potent in vitro insulin sensitizing activity.
基金financially supported by the grant from the National Natural Sciences Foundation of China (No. 30973634)
文摘Two new eupodienone lignans, named gymnothelignan T (1) and gymnothelignan U (2) were isolated from the whole plants of endemic medicinal plant of Gymnotheca chinensis (Saururaceae). The structures of the new compounds were elucidated by means of HRMS, 1D and 2D NMR. Compound I was tested for cytotoxic activity in HCT15, HCT116, A549, MCF-7 and HepG2 cells and exhibited no appreciable activity against these tested cell lines with IC50 values above 50 μmol/L.
基金financially supported by grants from the National Natural Sciences Foundation (Nos. 21572219 and 21302180) of China
文摘Two novel 2,5-diphenyl oxazole derivatives,named gymnothecaoxazoles A(1) and B(2),were isolated from the whole parts of endemic medicinal plant of Gymnotheca chinensis(Saururaceae).The structures of the new compounds were elucidated by extensive NMR and MS data,and the structure of compound 1was further confirmed by X-ray crystal diffraction analysis.
文摘Two new oleanane-type triterpenoid saponins, gymnemoside-W1 and W2, together with seven known compounds were isolated from the leaves of Gymnema sylvestre R. Br. By means of spectral and chemical analysis, the structures of the new compounds were elucidated as 16 β-hydroxyl olean-12-en-3-O-[β-D-glucopyranosyl (1 →6)- β-D-glucopyranosyl]-28-O-β-D-glucopyranoside(1) and 16 β,21 β,28-trihydroxyl-olean-12-ene-3-O-glucoronopyranoside (2). The EtOH/H2O extracts of this plant were shown to be able to inhibit glucose absorption in rats.
基金Financial support from National Natural Science Foundation of China (Nos. 21072184 and 81173536)
文摘In a novel procedure, human serum albumin timctionalized magnetic nanoparticles ( HSA-MNPS ) were used to selectively extract nine flavonoids in the extract of Ginkgo biloba leaves. The chemical structures of those flavonoids were characterized with high performance liquid chromatography coupled with mass spectrometry (HPLC-MS). The selective extraction with HSA-MNPs coupled with structural elucidation with HPLC-MS shows powerful potential for analysis of bioactive components in traditional Chinese medicines.
基金financially supported by grants from the National Natural Sciences Foundation of China(No.31560102)
文摘Two new biphenyl butyl neolignan derivatives,named gymnothebutyllignans A(1) and B(2),were isolated from the whole parts of endemic medicinal plant of Gymnotheca involucrata(Saururaceae).The structures of the new compounds were elucidated by extensive NMR and MS data,and the absolutely configuration of compound 1 was confirmed by X-ray crystal diffraction analysis.
基金financially supported by the grants from the National Natural Sciences Foundation of China(No. 30973634)
文摘Two new cyclic diarylheptanoids named ostryopsitrienol(1) and ostryopsitriol(2),together with six known compounds,were isolated from the stems of endemic medicinal plant of Ostryopsis nobilis (Betulaceae).The structures of the new compounds were elucidated by means of HRMS,~1D NMR,~2D NMR and X-ray crystallography analysis.