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益生菌单独用药和联合用药对比安慰剂治疗溃疡性结肠炎的疗效分析 被引量:3
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作者 冯丽伟 赵岳 《世界华人消化杂志》 CAS 2019年第6期367-375,共9页
背景临床工作中,常加用益生菌来治疗溃疡性结肠炎(ulcerative colitis,UC),但其在UC的治疗中到底发挥多大的作用、在哪一阶段起作用,目前尚无定论.目的采用Meta分析的方法比较益生菌与安慰剂在成人UC中的疗效及安全性.方法检索Pub Med, ... 背景临床工作中,常加用益生菌来治疗溃疡性结肠炎(ulcerative colitis,UC),但其在UC的治疗中到底发挥多大的作用、在哪一阶段起作用,目前尚无定论.目的采用Meta分析的方法比较益生菌与安慰剂在成人UC中的疗效及安全性.方法检索Pub Med, EMBASE, Cochrane Library,万方数据库,中国知网数据库中有关益生菌与安慰剂在UC治疗中的随机对照试验研究(randomized controlled trials,RCTs).结果 14项RCTs共计869例患者纳入本研究.其中,关于UC诱导缓解的研究有9项RCTs,关于维持治疗的有5项RCTs.比较其在UC诱导缓解中的作用,发现益生菌对比安慰剂的缓解率分别为45.5%、34.7%, RR=1.36,95%CI:1.11-1.66),二者有统计学意义(P=0.002),各研究之间不存在异质性(χ~2=11.81, P=0.16, I^2=32%);比较其在UC维持治疗中的作用,发现各研究间存在异质性(P=0.09, I^2=72%),进一步亚组分析发现,单独应用益生菌较单独应用安慰剂有效(P=0.004),而益生菌联合应用其他药物(5-ASA、美沙拉嗪、激素和硫唑嘌呤)与安慰剂联合其他药物相比,无统计学意义(P=0.95);比较益生菌与安慰剂在UC治疗中的安全性,发现二者副作用相近,分别为23.1%、15.3%,二者比较无统计学意义(P=0.86).结论在UC诱导缓解中,无论单独应用益生菌还是益生菌联合其他药物的作用比安慰剂效果好;在UC维持治疗中,单用益生菌的作用比安慰剂效果好,但合用其他药物时,益生菌无明显优势;二者在UC治疗中的安全性相近. 展开更多
关键词 益生菌 安慰剂 溃疡性结肠炎 Meta分析
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Effects of illness perception on negative emotions and fatigue in chronic rheumatic diseases:Rumination as a possible mediator
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作者 Yanxia Lu Xia Jin +3 位作者 li-wei feng CSK Tang Michelle Neo Roger C Ho 《World Journal of Clinical Cases》 SCIE 2022年第34期12515-12531,共17页
BACKGROUND Illness perception has long been hypothesized to be linked to psychological well-b eing in patients with rheumatic diseases,although substantial evidence is lacking,and the contribution of ruminative coping... BACKGROUND Illness perception has long been hypothesized to be linked to psychological well-b eing in patients with rheumatic diseases,although substantial evidence is lacking,and the contribution of ruminative coping style to this relationship is unclear.AIM To investigate the roles of illness perception and rumination in predicting fatigue and negative emotions in patients with chronic rheumatic diseases.METHODS Illness perception,rumination,fatigue and negative emotions(i.e.depression,anxiety and stress)were assessed by the Illness Perception Questionnaire-Revised,Stress Reactive Rumination Scale,Multidimensional Assessment of Fatigue,and the Depression,Anxiety and Stress Scale respectively.Multivariate regression analysis,the Sobel test,and the bootstrap were used to identify the mediating effect of rumination.RESULTS All five subscales of illness perception,including perceived illness identity,chronicity,cyclical nature,consequences and coherence of illness,were significantly associated with fatigue and negative emotions.In mediational analysis,rumination was found to mediate three components of illness perception(the identity,cyclical nature and consequences of illness)and negative emotions/fatigue.CONCLUSION Perceived identity,cyclical nature,and consequences of illness are significantly associated with fatigue and negative emotions in patients with chronic rheumatic diseases and these associations are mediated by rumination.Our findings suggest that psychological intervention should target rumination to improve physical and emotional well-being of patients with chronic rheumatic diseases. 展开更多
关键词 FATIGUE Illness perception Negative emotions Rheumatoid arthritis RUMINATION Systemic lupus erythematosus
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