Colon cancer(CRC)is one of the most common malignancies globally,ranking third in terms of new cancer cases and second as a cause of cancer deaths[1].In recent 30 years,the incidence and mortality rates of CRC in Chin...Colon cancer(CRC)is one of the most common malignancies globally,ranking third in terms of new cancer cases and second as a cause of cancer deaths[1].In recent 30 years,the incidence and mortality rates of CRC in China have been increasing,gradually exceeding the global levels[2].Due to the fact that most CRC patients are diagnosed at the advanced stage,the treatment of this disease is challenging and often ineffective.Therefore,prevention and early diagnosis of CRC are crucial.展开更多
Sepsis is a life-threatening multiple organ dysfunction syndrome caused by the imbalance of the immune response to infection,featuring complex and variable conditions,and is one of the leading causes of mortality in I...Sepsis is a life-threatening multiple organ dysfunction syndrome caused by the imbalance of the immune response to infection,featuring complex and variable conditions,and is one of the leading causes of mortality in ICU patients.Lung injury is a common organ damage observed in sepsis patients.Macrophages and Th17 cells,as crucial components of innate and adaptive immunity,play pivotal roles in the development of sepsis-induced acute lung injury(ALI).This review summarizes the alterations and mechanisms of macrophages and Th17 cells in sepsis-induced ALI.By focusing on the“cross-talk”between macrophages and Th17 cells,this review aims to provide a solid theoretical foundation for further exploring the therapeutic targets of traditional Chinese medicine formulas in the treatment of sepsis complicated with ALI,thereby offering insights and guidance for the clinical application of traditional Chinese medicine in managing sepsis-associated ALI.展开更多
Non-alcoholic fatty liver disease(NAFLD),also known as MAFLD,is a chronic liver disease characterized by dyslipidemia and excessive steatosis in hepatocytes[1].With the acceleration of urbanization,the problems of phy...Non-alcoholic fatty liver disease(NAFLD),also known as MAFLD,is a chronic liver disease characterized by dyslipidemia and excessive steatosis in hepatocytes[1].With the acceleration of urbanization,the problems of physical activity reduction and nutritional imbalance are becoming increasingly prominent.The prevalence of NAFLD has reached 25%globally[2],and it is also showing a trend of continuous growth and younger onset ag[3].Although numerous studies have confirmed that the pathogenesis of NAFLD may be related to genetic susceptibility,gene polymorphism,intestinal microenvironment disorder,insulin resistance,and other factors[4],the"two-hit"theory also reveals the mechanism of the occurrence of some NAFLD,there is still a lack of effective and stable drugs that can inhibit the progression of NAFLD to liver fibrosis and even liver cancer in the treatment of NAFLD[5].展开更多
基金This study is supported by National Natural Science Foundation of China(82374320,82060864).
文摘Colon cancer(CRC)is one of the most common malignancies globally,ranking third in terms of new cancer cases and second as a cause of cancer deaths[1].In recent 30 years,the incidence and mortality rates of CRC in China have been increasing,gradually exceeding the global levels[2].Due to the fact that most CRC patients are diagnosed at the advanced stage,the treatment of this disease is challenging and often ineffective.Therefore,prevention and early diagnosis of CRC are crucial.
基金supported by the National Natural Science Foundation of China(No.82104581,No.82060864).
文摘Sepsis is a life-threatening multiple organ dysfunction syndrome caused by the imbalance of the immune response to infection,featuring complex and variable conditions,and is one of the leading causes of mortality in ICU patients.Lung injury is a common organ damage observed in sepsis patients.Macrophages and Th17 cells,as crucial components of innate and adaptive immunity,play pivotal roles in the development of sepsis-induced acute lung injury(ALI).This review summarizes the alterations and mechanisms of macrophages and Th17 cells in sepsis-induced ALI.By focusing on the“cross-talk”between macrophages and Th17 cells,this review aims to provide a solid theoretical foundation for further exploring the therapeutic targets of traditional Chinese medicine formulas in the treatment of sepsis complicated with ALI,thereby offering insights and guidance for the clinical application of traditional Chinese medicine in managing sepsis-associated ALI.
文摘Non-alcoholic fatty liver disease(NAFLD),also known as MAFLD,is a chronic liver disease characterized by dyslipidemia and excessive steatosis in hepatocytes[1].With the acceleration of urbanization,the problems of physical activity reduction and nutritional imbalance are becoming increasingly prominent.The prevalence of NAFLD has reached 25%globally[2],and it is also showing a trend of continuous growth and younger onset ag[3].Although numerous studies have confirmed that the pathogenesis of NAFLD may be related to genetic susceptibility,gene polymorphism,intestinal microenvironment disorder,insulin resistance,and other factors[4],the"two-hit"theory also reveals the mechanism of the occurrence of some NAFLD,there is still a lack of effective and stable drugs that can inhibit the progression of NAFLD to liver fibrosis and even liver cancer in the treatment of NAFLD[5].
