Successful conversion of advanced gastric cancer treated by immunotherapy combined with chemotherapy: A case report

Gastric cancer is one of the most common malignant tumors,for patients with advanced gastric cancer,the traditional treatment is mainly chemotherapy or combined targeted therapy;however,these have not achieved ideal efficacy.However,with the continuous deepening of research on molecular targeted drugs and immunosuppressants,the treatment of advanced gastric cancer patients has made new progress,and some new technologies have also been continuously emerged and applied,which brings hope for the treatment of advanced gastric cancer.Recently,several multicenter randomized controlled phase III studies on immunotherapy for advanced gastric cancer yielded encouraging results,demonstrating its superior efficacy in the treatment of advanced gastric cancer.However,prospective data to support the acceptance of surgery and the R0 removal rate following conversion therapy with immune checkpoint inhibitors are lacking.In this study,a 58-year-old woman with advanced gastric cancer and positive PD-L1 expression,negative HER-2 expression,and microsatellite stable status received immunochemotherapy combined with traditional Chinese medicine to achieve R0 resection and satisfactory efficacy.

Efficacy and safety of Huaiqihuang granule as adjuvant treatment for primary nephrotic syndrome in children: a meta-analysis and systematic review

Background Huaiqihuang(HQH)granule is a traditional Chinese herbal complex that has been used as an adjuvant treatment in clinics for the primary nephrotic syndrome(PNS)for many years.However,the effectiveness and safety of HQH have not been systematically discussed.This review aimed to evaluate the effectiveness and safety of HQH in paediatric patients with PNS.Methods The following databases were searched from inception to Mar 2019:MEDLINE,Cochrane Library,EMBASE,CNKI,Wanfang Database,the Chinese Scientific Journal Database and the Chinese biomedical literature service system.All the randomized controlled trials(RCTs)eligible for inclusion were included.The primary outcomes were relapse,infection,remission and adverse events.The secondary outcomes included serum immunoglobulin levels(IgA,IgG or IgM),T-lymphocyte subtype(CD3+,CD4+,CD8+,CD4+/CD8+),IL-10,TNF-α,TNF-γ,total cholesterol and time of proteinuria turning negative.Results Fourteen RCTs(885 patients)were identified.Treatment with HQH reduced the chance of relapse[relative risk(RR):0.47;95%CI:0.34,0.66;P<0.001]and infections(RR:0.47;95%Cl:0.35,0.62;P<0.001).No significant difference was found in adverse events.HQH also increased the serum levels of IgA[weighted mean difference(WMD):0.40;95%Cl:0.20,0.60;P<0.001]and IgG(WMD:1.58;95%Cl:1.38-1.78;P<0.001),as well as CD4+[standard mean difference(SMD):0.90;95%Cl:0.12-1.68;P=0.02],CD3+(WMD:4.04;95% CI:3.27-4.82;P<0.001),and the CD4^(+)/CD8^(+)ratio(WMD:0.31;95% CI:0.21-0.41;P<0.001),but decreased the level of CD8+cells(WMD:-3.39;95% CI:-5.73-1.05;P=0.004).No statistically significant difference was found in IgM(WMD:0.05;95% CI:-0.13,0.24;P=0.57).Conclusions HQH could reduce the rate of relapse and the frequency of infection in children with PNS.No apparent adverse effects were found.Moreover,the beneficial influence of HQH may act through immunomodulation.Additional multi-center,large-sample,high-quality studies are needed to confirm the effectiveness and safety of HQH.

Rice SUVH Histone Methyltransferase Genes Display Specific Functions in Chromatin Modification and Retrotransposon Repression

Histone lysine methylation plays an important role in heterochromatin formation and reprogramming of gene expression. SET-domain-containing proteins are shown to have histone lysine methyltransferase activities. A large number of SET-domain genes are identified in plant genomes. The function of most SET-domain genes is not known. In this work, we studied the 12 rice （Oryza sativa） homologs of Su（var）3-9, the histone H3 lysine 9 （H3K9） methyltransferase identified in Drosophila. Several rice SUVHs （i.e. SDG714, SDG727, and SDG710） were found to have an antagonistic func- tion to the histone H3K9 demethylase JMJ706, as down-regulation of these genes could partially complement the jmj706 phenotype and reduced histone H3K9 methylation. Down-regulation of a rice Su（var）3-9 homolog （SUVH）, namely SDG728, decreased H3K9 methylation and altered seed morphology. Overexpression of the gene increased H3K9 methylation. SDG728 and other SUVH genes were found to be involved in the repression of retrotransposons such as Tos17 and a Tyl-copia element. Analysis of histone methylation suggested that SDG728-mediated H3K9 methylation may play an important role in retrotransposon repression.

用于非线性非平稳船舶运动极短期预报的一种复合自回归经验模态分解支持向量机回归模型（英文）

目的:基于支持向量机回归(SVR)模型在非线时间序列的预测能力及经验模态分解(EMD)方法在处理非线性非平稳性的优势,提出一种复合自回归经验模态分解支持向量机回归(AR-EMDSVR)模型,提高非线性非平稳船舶运动极短期预报精度。创新点:1.研究非线性非平稳船舶运动的极短期预报问题,提出一种复合的预报方法;2.基于不同层次的预报模型和模型试验数据,分析非线性非平稳性对极短期预报精度的影响。方法:1.在SVR模型中引入基于自回归(AR)预报端点延拓的EMD方法,形成复合的AR-EMDSVR预报模型;2.基于集装箱船模水池试验运动数据将AR-EMD-SVR模型与AR、SVR和EMD-AR三种模型进行比较,分析非线性非平稳性对极短期预报的影响以及不同模型的预报性能。结论:1.AR-EMD方法能够有效的克服非平稳对极短期预报模型(AR和SVR)在精度上所带来的不良影响;2.基于船模试验数据的预报结果表明:相较于AR、SVR和EMD-AR三种预报模型,基于AR-EMD-SVR模型的非线性非平稳船舶运动极短期预报结果具有更高的精度。

Dent disease:classification,heterogeneity and diagnosis

Background Dent disease is a rare tubulopathy characterized by manifestations of proximal tubular dysfunction,which occurs almost exclusively in males.It mainly presents symptoms in early childhood and may progress to end-stage renal failure between the 3rd and 5th decades of human life.According to its various genetic basis and to clinical signs and symp-toms,researchers define two forms of Dent disease(Dent diseases 1 and 2)and suggest that these forms are produced by mutations in the CLCN5 and OCRL genes,respectively.Dent diseases 1 and 2 account for 60% and 15% of all Dent disease cases,and their genetic cause is generally understood.However,the genetic cause of the remaining 25% of Dent disease cases remains unidentified.Data sources All relevant peer-reviewed original articles published thus far have been screened out from PubMed and have been referenced.Results Genetic testing has been used greatly to identify mutation types of CLCN5 and OCRL gene,and next-generation sequencing also has been used to identify an increasing number of unknown genotypes.Gene therapy may bring new hope to the treatment of Dent disease.The abuse of hormones and immunosuppressive agents for the treatment of Dent disease should be avoided to prevent unnecessary harm to children.Conclusions The current research progress in classification,genetic heterogeneity,diagnosis,and treatment of Dent disease reviewed in this paper enables doctors and researchers to better understand Dent disease and provides a basis for improved prevention and treatment.

一种用于非线性非平稳波浪极短期预报的复合经验模态分解自回归模型（英文）

目的:相对于由能量平衡方程得到的数值预报模型和以神经网络为代表的非线性模型而言,自回归(AR)模型在波浪预报中具有计算效率高、自适应性强和建模所需的样本小等优点,但同时存在局限于平稳线性假设的缺陷。针对非线性非平稳波浪的极短期预报问题,提出一种复合的经验模态分解自回归预报模型,提高波浪预报精度。创新点:1.研究非线性非平稳波浪极短期预报问题,提出一种复合的预报方法;2.基于三个不同地理位置的海洋波浪实测数据对预测模型进行验证,并分析非线性非平稳性对波浪预报结果的影响。方法:1.在AR模型中引入经验模态分解(EMD)方法,形成复合的EMD-AR预报模型;2.分析实测波浪数据的非线性和非平稳性特点,并基于实测波浪数据获得AR模型和EMD-AR模型的预报结果;3.基于多种预报误差度量分析AR模型和EMD-AR模型的预报性能以及非线性非平稳性对波浪预报结果的影响。结论:1.波浪非线性和非平稳性会导致AR预报模型精度降低。预报误差中,幅值上的偏差主要由波浪的非线性引起,而相位上的偏差则是源于波浪的非平稳性;2.EMD方法能够有效地克服波浪非线性和非平稳性对AR模型在精度上所带来的不良影响,在精度上EMD-AR模型的预报结果较AR模型有较大提高。

Glomerular podocyte dysfunction in inherited renal tubular disease

Background Hereditary renal tubular disease can cause hypercalciuria,acid-base imbalance,hypokalemia,hypomagnesemia,rickets,kidney stones,etc.If these diseases are not diagnosed or treated in time,they can cause kidney damage and electrolyte disturbances,which can be detrimental to the maturation and development of the child.Glomerular involvement in renal tubular disease patients has only been considered recently.Methods We screened 71 papers(including experimental research,clinical research,etc.)about Dent's disease,Gitelman syndrome,and cystinosis from PubMed,and made reference.Results Glomerular disease was initially underestimated among the clinical signs of renal tubular disease or was treated merely as a consequence of the tubular damage.Renal tubular diseases affect glomerular podocytes through certain mechanisms resulting in functional damage,morphological changes,and glomerular lesions.Conclusions This article focuses on the progress of changes in glomerular podocyte function in Dent disease,Gitelman syndrome,and cystinosis for the purposes of facilitating clinically accurate diagnosis and scientific treatment and improving prognosis.

一种用于船舶纵-横联合减摇的预测控制器（英文）

目的:为提高船舶运动联合减摇效果,提出一种基于船舶运动及船舶水动力预报的联合减摇控制方法,并基于弱非线性二维半方法进行数值仿真,分析该控制方法的减摇控制效果。创新点:1.提出基于船舶运动预报和水动力预报的减摇方法,克服了控制时延对减摇效果的影响;2.基于弱非线性二维半方法进行船舶运动减摇数值仿真,验证了该方法能够实现良好的联合减摇控制效果。方法:1.在控制过程中基于极短期预报方法预报船舶运动姿态,并利用船舶运动方程预报水动力,将预报的水动力作为鳍角分配的依据;2.基于弱非线性二维半方法在时域内进行船舶运动减摇数值仿真,分析该控制方法在各种不同海况下的减摇控制效果。结论:1.弱非线性二维半方法在高速船舶的水动力预报中可以获得良好的效果;2.在各个不同海况下,本文提出的控制方法能够实现有效的联合减摇。