We propose a one–step smoothing Newton method for solving the non-linearcomplementarity problem with P 0–function (P_0–NCP) based on the smoothing symmetric perturbedFisher function (for short, denoted as the SSPF...We propose a one–step smoothing Newton method for solving the non-linearcomplementarity problem with P 0–function (P_0–NCP) based on the smoothing symmetric perturbedFisher function (for short, denoted as the SSPF–function). The proposed algorithm has to solve onlyone linear system of equations and performs only one line search per iteration. Without requiringany strict complementarity assumption at the P_0–NCP solution, we show that the proposed algorithmconverges globally and superlinearly under mild conditions. Furthermore, the algorithm has localquadratic convergence under suitable conditions. The main feature of our global convergence resultsis that we do not assume a priori the existence of an accumulation point. Compared to the previousliteratures, our algorithm has stronger convergence results under weaker conditions.展开更多
SKG mouse,as a model of spontaneous rheumatoid arthritis (RA) bred recent years,is similar to the patients with RA.We analyzed the clonotypes of T cell infiltrating into joints of SKG mice in initial stage and late st...SKG mouse,as a model of spontaneous rheumatoid arthritis (RA) bred recent years,is similar to the patients with RA.We analyzed the clonotypes of T cell infiltrating into joints of SKG mice in initial stage and late stage of RA by using reverse transcriptase-polymerase chain reaction (RT-PCR) and subsequent single-strand conformation polymorphism (SSCP).The results indicated that the percentages of clonotypes TCR Vβ2 and Vβ8.2 of T cell clonotypes increased obviously to 72.3% and 60.2%,respectively.Mice number with identical TCR Vβ2 and Vβ8.2 clonotypes also clearly increased in late stage of disease to 100% and 75%,respectively. These results mean that T cells with TCR Vβ2 and Vβ8.2 clonotypes probably play an important role in RA progression of SKG mouse.Sequencing of the extracted DNA verified that common bands on SSCP gel were derived from the same T cell clones among samples from different joints.The results we obtained implied that RT-PCR/SSCP method was a sensitive and credible method for analyzing T cell clonotypes.When the T cells of SKG mouse were adoptively transferred to a nude mouse,it was verified that the T cells infiltrating into joints were related to morbid formation of RA.Cellular & Molecular Immunology.2004;1(4):300-303.展开更多
基金This work is partly supported by the National Natural Science Foundation of China(Grant,Nos.10271002,10201001)
文摘We propose a one–step smoothing Newton method for solving the non-linearcomplementarity problem with P 0–function (P_0–NCP) based on the smoothing symmetric perturbedFisher function (for short, denoted as the SSPF–function). The proposed algorithm has to solve onlyone linear system of equations and performs only one line search per iteration. Without requiringany strict complementarity assumption at the P_0–NCP solution, we show that the proposed algorithmconverges globally and superlinearly under mild conditions. Furthermore, the algorithm has localquadratic convergence under suitable conditions. The main feature of our global convergence resultsis that we do not assume a priori the existence of an accumulation point. Compared to the previousliteratures, our algorithm has stronger convergence results under weaker conditions.
文摘SKG mouse,as a model of spontaneous rheumatoid arthritis (RA) bred recent years,is similar to the patients with RA.We analyzed the clonotypes of T cell infiltrating into joints of SKG mice in initial stage and late stage of RA by using reverse transcriptase-polymerase chain reaction (RT-PCR) and subsequent single-strand conformation polymorphism (SSCP).The results indicated that the percentages of clonotypes TCR Vβ2 and Vβ8.2 of T cell clonotypes increased obviously to 72.3% and 60.2%,respectively.Mice number with identical TCR Vβ2 and Vβ8.2 clonotypes also clearly increased in late stage of disease to 100% and 75%,respectively. These results mean that T cells with TCR Vβ2 and Vβ8.2 clonotypes probably play an important role in RA progression of SKG mouse.Sequencing of the extracted DNA verified that common bands on SSCP gel were derived from the same T cell clones among samples from different joints.The results we obtained implied that RT-PCR/SSCP method was a sensitive and credible method for analyzing T cell clonotypes.When the T cells of SKG mouse were adoptively transferred to a nude mouse,it was verified that the T cells infiltrating into joints were related to morbid formation of RA.Cellular & Molecular Immunology.2004;1(4):300-303.
