Unveiling a Novel Insulator-to-Metal Transition in La_(N)iO_(4+δ):Challenging High-Temperature Superconductivity Claimed for Single-Layer Lanthanum Nickelates

La_(2)NiO_(4)has a similar structure to La_(2)CuO_(4)and was proposed as a high-temperature superconductor based on magnetic-moment measurements decades ago.Nevertheless,with the exception for electrical resistance drop behavior of about 4 orders of magnitude that is claimed to originate from the superconductivity ever observed in Sr-doped La_(N)iO_(4),most electrical data reported to date in La_(N)iO_(4)system exhibit a trivial insulating ground state.Here,we definitively identify the similar electrical resistance drop behavior of more than 3 orders of magnitude in La_(2)NiO_(4+δ).However,our extensive investigations reveal that this phenomenon is a novel insulatorto-metal transition,distinct from superconductivity.Intriguingly,compared to the weak magnetic-field effects,pressure can significantly suppress the transition and transform from the metallic to an insulating ground state,accompanied by an isostructural phase transition.Our work not only elucidates the fundamental properties of the metallic conducting ground state in La_(N)iO_(4)+δ,but also critically challenges the notion of superconductivity in single-layer lanthanum nickelates.

Thoracic spine infection caused by Pseudomonas fluorescens:A case report and review of literature

BACKGROUND The clinical incidence of spinal infection is gradually increasing,and its onset is insidious,easily leading to missed diagnosis and misdiagnosis,which may lead to serious complications such as nervous system dysfunction,spinal instability and/or deformity,and cause a huge burden on society and families.Early identification of the causative agent and precision medicine will greatly reduce the suffering of patients.At present,the main pathogenic bacteria that cause spinal infection are Staphylococcus aureus,Streptococcus,Pneumococcus,Escherichia coli,and Klebsiella.There are no reports of spinal infection caused by Pseudomonas fluorescens.CASE SUMMARY We report a 32-year-old female patient with spinal infection.She presented with flank pain,initially thought to be bone metastases or bone tuberculosis,and had a family background of tumors.Her clinical features and changes in imaging and laboratory tests led to the suspicion of thoracic spine infection.Histopathology of the lesion showed inflammation,tissue culture of the lesion was negative several times,and the possible pathogen-Pseudomonas fluorescens was found after gene sequencing of the lesion.The patient recovered completely after a full course of antibiotic treatment.CONCLUSION This report increases the range of pathogens involved in spinal infections,highlights the unique advantages of gene sequencing technology in difficult-todiagnose diseases,and validates conservative treatment with a full course of antibiotics for spinal infections without complications.

Nonlinear coupling modeling and dynamics analysis of rotating flexible beams with stretching deformation effect

Dynamic coupling modeling and analysis of rotating beams based on the nonlinear Green-Lagrangian strain are introduced in this work.With the reservation of the axial nonlinear strain,there are more coupling terms for axial and transverse deformations.The discretized dynamic governing equations are obtained by using the finite element method and Lagrange’s equations of the second kind.Time responses are conducted to compare the proposed model with other previous models.The stretching deformation due to rotating motion is observed and calculated by special formulations under dynamic equilibrium.The stretching deformation and the change of the associated equilibrium position are taken into account to analyze the free vibration and frequency response of the rotating beams.Analytical and numerical comparisons show that the proposed model can provide reliable results,while the previous models may lead to imprecise results,especially in high-speed conditions.

Ionic Liquid Engineering in Perovskite Photovoltaics

Over the past decade,perovskite photovoltaics have approached other currently available technologies and proven to be the most prospective type of solar cells.Although the many-sided research in this very active field has generated consistent results with regard to their undisputed consistently increasing power conversion efficiency,it also produced several rather contradictory opinions.Among other important details,debate surrounding their proneness to surface degradation and poor mechanical robustness,as well as the environmental footprint of this materials class,remains a moot point.The application of ionic liquids appears as one of the potential remedies to some of these challenges due to their high conductivity,the opportunities for chemical"tuning"of the structure,and relatively lower environmental footprint.This article provides an overview,classification,and applications of ionic liquids in perovskite solar cells.We summarize the use and role of ionic liquids as versatile additives,solvents,and modifiers in perovskite precursor solution,in charge transport layer,and in interfacial and stability engineering.Finally,challenges and the future prospects for the design and/or selection of ionic liquids with a specific profile that meets the requirements for next-generation highly efficient and stable perovskite solar cells are proposed.

改良格拉斯哥预后评分和全身免疫炎症指数在宫颈癌患者预后预测中的价值

目的:探讨改良格拉斯哥预后评分(mGPS)和全身免疫炎症指数(SII)在宫颈癌患者预后预测中的价值。方法:回顾2010年-2017年我院的宫颈癌患者143例,收集完整病历并随访至2023年6月30日,采用Kaplan-Meier法绘制生存曲线,Log-rank检验和Cox回归分析影响患者预后的因素。结果:患者3年和5年生存率分别为85.31%和66.43%。受试者工作曲线(ROC)显示:mGPS、SII、白蛋白(ALB)、淋巴细胞(LYM)、中性粒细胞(NEU)和C反应蛋白(CRP)预测患者预后的曲线下面积分别为0.821、0.867、0.875、0.885、0.835和0.696,最佳截断值分别为0.5分、34.65 g/L、1.38×10^(9)/L、5.55×10^(9)/L、7.25 mg/L和475×10^(9)/L。Cox回归分析显示:mGPS、SII和FIGO分期是宫颈癌患者预后的影响因素,其HR分别为2.484(GPS=1)、7.096(mGPS=2)、0.121、9.507(FIGO为Ⅲ期)和23.715(FIGO为Ⅳ期)(P<0.05)。结论:mGPS、SII和FIGO分期是宫颈癌患者预后的重要预测因子。

宫颈刮片BHLHE22/CDO1和COL2A1基因甲基化检测在早期子宫内膜癌筛查中的作用

目的探讨宫颈刮片BHLHE22/CDO1和COL2A1基因甲基化检测在早期子宫内膜癌筛查中的作用。方法选取徐州市妇幼保健院2022年2月—2024年5月行宫腔镜下诊断性刮宫排除子宫内膜病变的患者78例,妇科检查时进行宫颈刮片细胞采集,并进行BHLHE22/CDO1和COL2A1基因甲基化检测。同时收集患者的基本临床资料及三维能量多普勒超声下子宫内膜血流指数(FI)、血管化指数(VI)、血管化-血流指数(VFI)等资料。以宫腔镜手术获得的组织病理学结果为金标准,利用单因素logistic回归模型分析子宫内膜癌的影响因素,采用受试者工作特征(ROC)曲线下面积(AUC)分析相关基因甲基化检测联合或不联合子宫内膜血流指标对早期子宫内膜癌的筛查价值。结果患者年龄、体重指数、VI、FI、VFI、BHLHE22/CDO1基因甲基化高风险是子宫内膜癌的影响因素(P<0.05)。宫颈刮片相关基因甲基化检测筛查子宫内膜癌的AUC为0.926(0.846~1.000),其敏感度和特异度分别为90.48%、94.74%。子宫内膜血流指标VFI联合宫颈刮片相关基因甲基化检测可提高敏感度至100%,但特异度降至68.42%。结论宫颈刮片BHLHE22/CDO1和COL2A1基因甲基化检测筛查子宫内膜癌的准确性较高,联合子宫内膜血流指标可以增加筛查的敏感度,但也降低了筛查的特异度,增加了有创操作的风险。

基于OBE理念的药学本科毕业论文指导与实践

目的以学生为中心开展药学专业本科毕业论文指导工作。方法毕业论文开展前,学生先在老师实验室实习二学期;论文题目确定后,学生通过查阅文献自己设计实验方案,并进行实验;课题结束后,学生先草拟出论文提纲,随后完成论文的撰写。导师在论文开展过程中起启发、指导和帮助作用。结果基于OBE理念的本科毕业论文指导形式,有助于调动药学专业学生的主观能动性,提高学生创造性和解决问题的能力。结论不断创新毕业论文指导模式,使学生成为课题的主人,是培养新时代“德、理、技、创”优秀生物医药技术人才的需要。

分析化学实验教学模式改革探索

分析化学实验是药学专业重要的基础课程,具有较强的实践性和应用性。总结目前分析化学实验课教学现状,探索该实验课的教学改革,提出课前视频学习结合线下预习的方法,采用以问题为导向和实验操作相结合的教学模式,增加学生自主设计实验的参与度,并将思政元素融入教学中,建立科学合理的考评方法。通过教学改革,培养学生学习能力和创新思维,提高当代大学生综合能力。

MDT+Sandwich教学法在本科内科学教学中的应用

目的探讨多学科诊疗(MDT)+“三明治”教学法(Sandwich教学法)与传统的以学科为基础的教学法在本科内科学教学中的应用效果。方法选取五年制临床医学专业60名本科生为研究对象,随机分为对照组(n=30)和试验组(n=30)。对照组采用传统的以学科为基础的教学法,试验组采用MDT+Sandwich教学法,课程结束后比较两组教学效果。结果试验组理论考试、临床技能操作考核成绩及课堂教学效果均优于对照组。结论在内科学教学中引入MDT+Sandwich教学法,能够更好地培养学生分析和解决临床问题能力。

Efficacy and safety of Lianhuaqingwen capsules in high-risk common type COVID-19 pneumonia:A multicenter retrospective study

Objective:To evaluate the clinical safety and efficacy of Lianhuaqingwen(LHQW)capsules in patients with high-risk common type COVID-19 pneumonia.Methods:A retrospective multicenter study on 383 high-risk common type COVID-19 pneumonia cases was conducted.Patients were categorized as the standard treatment(SDT)group(n=168)and the LHQW+SDT group(n=215).The primary endpoint was the rate of symptom(fever,fatigue,coughing)recovery and the secondary endpoints included the time to symptom recovery,the proportion of patients with improvement in chest CT images,the proportion of patients with clinical cure,the timing and rate of negative conversion of SARS-CoV-2 RNA assay.Results:The recovery rate was significantly higher in the LHQW+SDT group as compared with the SDT group(89.7%vs.72.0%,P<0.01).The combined use of LHQW+SDT also showed shorter time for symptom recovery,as well as shorter time for individual symptom of fever,fatigue and coughing recovery than use of SDT alone.A higher proportion of patients in the LHQW+SDT group with improvements in chest CT images and clinical cure(77.7%vs.57.1%,P<0.01)but the proportion of patients deteriorating to severe cases(1%vs.25%,P<0.01)in this group was significant lower than those in the SDT group.No significant difference in negative conversion rate of viral assay results was observed(76.8%vs.75.0%,P>0.05).No serious adverse events were reported.Conclusions:LHQW capsules could be recommended to ameliorate clinical symptoms and reduce the rate of deteriorating to severe cases for high-risk common type COVID-19 pneumonia.

A Fixed-Point Fast Sweeping WENO Method with Inverse Lax-Wendroff Boundary Treatment for Steady State of Hyperbolic Conservation Laws

Fixed-point fast sweeping WENO methods are a class of efficient high-order numerical methods to solve steady-state solutions of hyperbolic partial differential equations(PDEs).The Gauss-Seidel iterations and alternating sweeping strategy are used to cover characteristics of hyperbolic PDEs in each sweeping order to achieve fast convergence rate to steady-state solutions.A nice property of fixed-point fast sweeping WENO methods which distinguishes them from other fast sweeping methods is that they are explicit and do not require inverse operation of nonlinear local systems.Hence,they are easy to be applied to a general hyperbolic system.To deal with the difficulties associated with numerical boundary treatment when high-order finite difference methods on a Cartesian mesh are used to solve hyperbolic PDEs on complex domains,inverse Lax-Wendroff(ILW)procedures were developed as a very effective approach in the literature.In this paper,we combine a fifthorder fixed-point fast sweeping WENO method with an ILW procedure to solve steadystate solution of hyperbolic conservation laws on complex computing regions.Numerical experiments are performed to test the method in solving various problems including the cases with the physical boundary not aligned with the grids.Numerical results show highorder accuracy and good performance of the method.Furthermore,the method is compared with the popular third-order total variation diminishing Runge-Kutta(TVD-RK3)time-marching method for steady-state computations.Numerical examples show that for most of examples,the fixed-point fast sweeping method saves more than half CPU time costs than TVD-RK3 to converge to steady-state solutions.

Active components of Bupleuri Radix in the treatment of schizophrenia analyzed by network pharmacology and clinical verification

Background:Bupleuri Radix is a common Chinese medicinal material in traditional Chinese medicine.Currently,the therapeutic effect of treating schizophrenia is relatively well understood.However,there are fewer studies examining the underlying mechanisms of its treatment.The objective of the study was to investigate the primary mechanisms of Bupleuri Radix in treating schizophrenia through network pharmacology and clinical validation.Method:Network pharmacology revealed possible molecular mechanisms,followed by clinical verification.Sixty-seven schizophrenia patients undergoing treatment at the Hunan Brain Hospital between October and November 2022 were recruited and randomly divided into the olanzapine group and the olanzapine+Bupleuri Radix group.Additionally,32 healthy people undergoing physical examinations during the same period were included as the control group.The patient’s positive and negative symptom scale scores were compared.qPCR was used to detect the mRNA expression levels of ESR1,mTOR,EIF4E,and SMAD4 in peripheral blood.Results:Through network pharmacological analysis,it was concluded in this study that Bupleuri Radix might regulate the mTOR,PI3K-Akt,and HIF-1 signaling pathways.Clinical experiments indicated that compared with before treatment,the positive and negative symptom scale scores and total scores of the two treatment groups were significantly decreased after treatment(P<0.01).In addition,the positive and negative symptom scale scores and total scores in the olanzapine+Bupleuri Radix group were significantly decreased(P<0.01)compared to the olanzapine group after treatment.Before treatment,ESR1 mRNA expression levels in peripheral blood were significantly higher in the two treatment groups than in the control group,whereas the mRNA expression levels of mTOR,EIF4E,and SMAD4 in peripheral blood were significantly lower(P<0.01).The mRNA expression levels of mTOR,EIF4E,and SMAD4 in peripheral blood were significantly higher after therapy than before treatment,whereas the mRNA expression levels of ESR1 in peripheral blood were significantly lower(P<0.01).After therapy,the olanzapine+Bupleuri Radix group’s mRNA expression levels of mTOR,EIF4E,and SMAD4 were significantly higher than those of the olanzapine group,whereas the mRNA expression levels of ESR1 were significantly lower(P<0.01).Conclusion:The mechanism of Bupleuri Radix’s therapeutic efficacy in schizophrenia may involve the up-regulation of mTOR,EIF4E,and SMAD4 mRNA expression and the down-regulation of ESR1 mRNA expression in peripheral blood.

高职院校《管理学基础》课程思政元素融入探究

《管理学基础》课程是高职院校财务管理、物流管理及市场营销等专业的专业核心课程。随着社会的不断发展,与之相关的教学内容、教学形式也需要不断更新,与时俱进。思政教育走进课堂,思政元素融入课程教学是教学理论改革的新创举,也是新时代提升高职教育质量、培养高素质人才的核心环节。从高职院校《管理学基础》课程教学内容常见问题出发,多角度分析问题产生的原因,进一步探寻思政元素融入《管理学基础》课程的必要性,并根据课程章节的核心内容提出《管理学基础》课程中思想政治元素的融入构想。

面向复杂施工环境的实时目标检测算法

针对施工环境下普遍存在的环境杂乱、目标被遮挡、目标尺度范围大、正负样本不平衡、现有检测算法实时性不足等问题,提出一种面向复杂施工环境的实时目标检测算法YOLO-C。将提取到的低层特征与高层特征相融合,增强网络全局感知能力;设计小目标检测层,提高算法对不同尺度目标的检测精度;设计通道-空间注意力(CSA)模块,增强目标特征,抑制背景特征;在损失函数部分,采用VariFocal Loss计算分类损失,解决正负样本不平衡问题;GhostConv作为基本卷积块构建GCSP(Ghost Cross Stage Partial)结构,降低参数量和计算量;针对复杂施工环境,构建混凝土施工现场目标检测数据集,在构建的数据集上与多个算法进行对比分析实验。实验结果表明,YOLO-C算法的检测精度更高,参数量更小,更适合复杂施工环境下的目标检测任务。

基于改进LinkNet的寒旱区遥感图像河流识别方法

为解决遥感图像河流精细化提取问题,提出一种改进LinkNet模型的分割网络(AFRLinkNet)。AFRLinkNet在LinkNet基础上引入了残差通道注意力结构、非对称卷积模块以及密集跳跃连接结构,并用视觉激活函数FReLU替换ReLU激活函数。残差通道注意力结构可以强化对分割任务有效的特征,以提高模型的分类能力,得到更多的细节信息。利用非对称卷积模块进行模型压缩和加速。使用FReLU激活函数提升网络提取遥感图像河流的精细空间布局。在寒旱区河流数据集上的实验结果表明,AFRLinkNet网络相较于FCN、UNet、ResNet50、LinkNet、DeepLabv3+网络交并比分别提高了26.4、22.7、17.6、12.0、9.7个百分点,像素准确率分别提高了25.9、22.5、13.2、10.5、7.3个百分点;引入非对称卷积模块后,交并比提高了5.1个百分点,像素准确率提高了2.9个百分点,在此基础上引入残差通道注意力结构之后,交并比又提高了2.2个百分点,像素准确率提高了2.3个百分点,证明了其对河流细节识别效果更好。

CBL教学法对产科实习考核促进作用的研究

目的:研究CBL教学法对产科实习生多模式出科考核的促进作用。方法:选择在我科实习的100名临床医学本科实习生作为研究对象,随机分为试验组和对照组,各50人。其中试验组按照CBL教学法进行临床实习,对照组按照传统带教模式进行临床实习。结果:3周实习后,试验组学生的Mini-CEX和DOPS出科考核成绩均明显高于对照组,差异有统计学意义(P<0.05),且学生满意度更高。结论:CBL教学法对产科实习生多模式出科考核成绩和学生满意程度均有促进作用。

石榴籽油不同极性部位的分离、纳米乳制备及生物学活性

目的将石榴籽油(pomegranate seed oil,PSO)分离为不同极性部位,并比较生物活性。方法采用硅胶柱层析法分离出PSO甘油三酯(pomegranate seed oil triglyceride,PSO-TG)和甘油二酯(pomegranate seed oil diglycerides,PSO-DG),用无水乙醇提取PSO,制得富含多酚的PSO(polyphenol enriched pomegranate seed oil,P-PSO);用自由基清除法考察各油的抗氧化活性;采用滤纸片法检测油的抗菌能力;将4种油制成纳米乳,考察各纳米乳对α-糖苷酶和α-淀粉酶的抑制活性。结果PSO、PSO-DG、PSO-TG和P-PSO的极性顺序为P-PSO>PSO-DG>PSO>PSO-TG;对DPPH自由基清除率为P-PSO>PSO-TG>PSO>PSO-DG;PSODG对枯草芽胞杆菌(Bacillus subtilis)的抑制活性显著高于其余3种油(P<0.05),PSO对少孢哈萨克斯坦酵母(Kazachstania exigua)有最强的抗菌作用;纳米乳对α-糖苷酶和α-淀粉酶的抑制作用为PSO-DG>PSO>P-PSO>PSO-TG。结论油的极性影响着其对细菌质膜和细胞壁的穿透能力,以及与酶的亲和作用,是油发挥生物活性的关键因素。

联合语义分割的自监督单目深度估计方法

研究深度估计和语义分割的图像之间的互利关系,提出了一种联合语义分割的自监督单目深度估计方法USegDepth.语义分割和深度估计任务通过共享编码器,实现语义引导.为了进一步提高编码器的跨多任务性能,设计了多任务特征提取模块,堆叠该模块构成共享编码器,解决有限感受野和缺乏跨通道交互导致的模型特征表示能力欠佳问题,进一步提升模型精度.同时,提出跨任务交互模块,通过双向的跨域信息交互细化特征表示,提升深度估计表现,特别是光度一致性监督有限的弱纹理区域和物体边界.通过在KITTI数据集上的训练和全面评估,实验结果显示所提的USegDepth模型方法的均方相对误差相比于SGDepth降低了0.176个百分点,在阈值为1.253的阈值精度达到了98.4%,证明了USegDepth在深度预测上具有较高的准确率.

护士长的患者安全态度现状及其影响因素

目的:了解护士长的患者安全态度现状及其影响因素,为医院制订相关安全管理策略提供参考。方法:采用便利抽样方法,于2021年7月至8月选取全国共40所医院的1048名护士长作为研究对象,采用一般资料调查表、中文修订版患者安全态度调查问卷(Chinese Version of Safety Attitude Questionnaire,C-SAQ)及护士职业价值观量表(Nurses’Profession Values Scale-revised,NPVS-R)对其进行问卷调查,以问卷星方式发放电子问卷。采用多元线性回归分析护士长的患者安全态度的影响因素。结果:护士长的患者安全态度总分为128.38±17.18,其中管理感知维度得分最高,工作条件维度得分最低;护士长的患者安全态度与其职业价值观呈正相关(r=0.608,P<0.01);多元线性回归结果显示:是否参加过护理安全培训、月收入、所在医院级别和职业价值观得分是护士长的患者安全态度的影响因素(均P<0.05)。结论:护士长的患者安全态度处于中上水平,仍有待进一步提升;护士长的患者安全态度影响因素与是否参加过护理安全培训、较高的月收入及职业价值观有关。医院管理者可通过向护士长提供护理安全培训、合理提高薪资待遇及提高护士长的职业价值观来促进其患者安全态度的提升,从而促进患者的安全。

我国特种食品产业现状与发展趋势

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