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Photobiomodulation inhibits the expression of chondroitin sulfate proteoglycans after spinal cord injury via the Sox9 pathway 被引量:1
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作者 Zhihao Zhang Zhiwen Song +12 位作者 liang luo Zhijie Zhu Xiaoshuang Zuo Cheng Ju Xuankang Wang Yangguang Ma Tingyu Wu Zhou Yao Jie Zhou Beiyu Chen Tan Ding Zhe Wang Xueyu Hu 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第1期180-189,共10页
Both glial cells and glia scar greatly affect the development of spinal cord injury and have become hot spots in research on spinal cord injury treatment.The cellular deposition of dense extracellular matrix proteins ... Both glial cells and glia scar greatly affect the development of spinal cord injury and have become hot spots in research on spinal cord injury treatment.The cellular deposition of dense extracellular matrix proteins such as chondroitin sulfate proteoglycans inside and around the glial scar is known to affect axonal growth and be a major obstacle to autogenous repair.These proteins are thus candidate targets for spinal cord injury therapy.Our previous studies demonstrated that 810 nm photo biomodulation inhibited the formation of chondroitin sulfate proteoglycans after spinal cord injury and greatly improved motor function in model animals.However,the specific mechanism and potential targets involved remain to be clarified.In this study,to investigate the therapeutic effect of photo biomodulation,we established a mouse model of spinal cord injury by T9 clamping and irradiated the injury site at a power density of 50 mW/cm~2 for 50 minutes once a day for 7 consecutive days.We found that photobiomodulation greatly restored motor function in mice and down regulated chondroitin sulfate proteoglycan expression in the injured spinal cord.Bioinformatics analysis revealed that photobiomodulation inhibited the expression of proteoglycan-related genes induced by spinal cord injury,and versican,a type of proteoglycan,was one of the most markedly changed molecules.Immunofluorescence staining showed that after spinal cord injury,versican was present in astrocytes in spinal cord tissue.The expression of versican in primary astrocytes cultured in vitro increased after inflammation induction,whereas photobiomodulation inhibited the expression of ve rsican.Furthermore,we found that the increased levels of p-Smad3,p-P38 and p-Erk in inflammatory astrocytes were reduced after photobiomodulation treatment and after delivery of inhibitors including FR 180204,(E)-SIS3,and SB 202190.This suggests that Sma d 3/Sox9 and MAP K/Sox9 pathways may be involved in the effects of photobiomodulation.In summary,our findings show that photobiomodulation modulates the expression of chondroitin sulfate proteoglycans,and versican is one of the key target molecules of photo biomodulation.MAPK/Sox9 and Smad3/Sox9 pathways may play a role in the effects of photo biomodulation on chondroitin sulfate proteoglycan accumulation after spinal cord injury. 展开更多
关键词 chondroitin sulfate proteoglycans Erk MAPK P38 PHOTOBIOMODULATION principal component analysis SMAD3 SOX9 spinal cord injury VERSICAN
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Atomic-iodine-substituted polydiacetylene nanospheres with boosted intersystem crossing and nonradiative transition through complete radiative transition blockade for ultraeffective phototherapy
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作者 Dan Zhao Lingling Zhang +6 位作者 Mingming Yin Zhenyan He Fang Fang Minle Zhan Sidan Tian Fanling Meng liang luo 《Aggregate》 EI CAS 2024年第5期287-296,共10页
The energy dissipation pathways of a photosensitizer for phototherapies,including photodynamic therapy(PDT)and photothermal therapy(PTT),compete directly with that of itsfluorescence(FL)emission.Enriching heavy atoms o... The energy dissipation pathways of a photosensitizer for phototherapies,including photodynamic therapy(PDT)and photothermal therapy(PTT),compete directly with that of itsfluorescence(FL)emission.Enriching heavy atoms on theπ-conjugated systems and aggregation-caused quenching are two effective methods to turn off the FL emission of photosensitizers,which is expected to boost the inter-system crossing(for PDT)and nonradiative transition(for PTT)of photosensitizers for maximized phototherapeutic efficacy.Following this approach,an all-iodine-substituted polydiacetylene aggregate poly(diiododiacetylene)(PIDA)has been developed,which shows a superior near infrared absorption(ε_(808nm)=26.1 g^(-1) cm^(-1) L)with completely blocked FL,as well as high efficiency of reactive oxygen species generation(nearly 45 folds of indocyanine green)and photothermal conversion(33.4%).To make the insolublefibrillar PIDA aggregates favorable for systemic administration,they are converted into nanospheres through a pre-polymerization morphology transformation strategy.The in vivo study on a 4T1 tumor-bearing mouse model demonstrates that PIDA nanospheres can almost eliminate the tumor entirely in 16 days and prolong the survival time of mice to over 60 days,validating their effective phototherapeutic response through the strategy of inhibiting FL for boosted intersystem crossing and nonradiative transition. 展开更多
关键词 blockedfluorescence emission heavy atom effect morphology transformation PHOTOTHERAPY polydi-acetylene aggregate
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Ankylosing spondylitis coexisting with Clonorchis sinensis infection: A case report
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作者 Tian-Xin Yi Wei Liu +2 位作者 Wen-Fei Leng Xiao-Chuan Wang liang luo 《World Journal of Clinical Cases》 SCIE 2024年第5期1018-1024,共7页
BACKGROUND Ankylosing spondylitis(AS)is a chronic immune-mediated inflammatory disease.The prevailing theory links AS onset to infections in susceptible individuals.Furthermore,infections may impair the immune respons... BACKGROUND Ankylosing spondylitis(AS)is a chronic immune-mediated inflammatory disease.The prevailing theory links AS onset to infections in susceptible individuals.Furthermore,infections may impair the immune responses.Numerous studies have investigated links between AS and various infections-bacterial,viral,fungal,and other microorganism infections.However,limited attention has been given to the association between AS and Clonorchis sinensis(C.sinensis)infection.CASE SUMMARY A 27-year-old male with a 10-yr history of AS presented to our hospital with inflammatory lower back pain as the primary manifestation.Ten years ago,the patient had achieved a stable condition after treatment with biological agents.However,he experienced a recurrence of lumbosacral pain with an unexplained cause 10 d before hospital admission.A lumbosacral magnetic resonance imaging(MRI)scan revealed bone marrow edema in the left sacroiliac joint,and laboratory indicators were elevated.Moreover,the presence of C.sinensis eggs was detected in the stool.The patient was prescribed praziquantel,resulting in the disap-pearance of C.sinensis eggs in subsequent routine stool tests and relief from lumbosacral pain.A follow-up MRI scan performed after 4 months revealed a reduction in bone marrow edema around the left sacroiliac joint.CONCLUSION C.sinensis infections could potentially trigger the exacerbation of AS.Clinicians should pay attention to investigating the presence of infections.INTRODUCTION Ankylosing spondylitis(AS)is a chronic inflammatory and rheumatic disease resulting from an imbalance between innate and acquired immune responses[1].While it can affect any part of the spine,its primary symptoms are persistent back pain and stiffness in the lower back and pelvis.The prevalence of AS per 10000 individuals is 23.8 in Europe,31.9 in North America,16.7 in Asia,10.2 in Latin America,and 7.4 in Africa[2].Infections commonly occur in the first 3 months and may act as potential triggers for the first symptoms of AS,often manifesting as gastrointestinal,urinary tract,and respiratory infections of microbiological origin[3,4].Clonorchis sinensis(C.sinensis)infection is a severe parasitic disease affecting millions globally,especially prevalent in China,South Korea,the Far East of Russia,and Vietnam,with an estimated 15 million cases[5].Transmission occurs through the consumption of undercooked freshwater fish containing metacercariae.Adult C.sinensis parasites then establish themselves within the human hepatobiliary system[6].C.sinensis infection triggers the activation of sphingosine 1-phosphate receptor 2,leading to the injury and fibrosis of the hepatobiliary[7].Recent research in a rat model found that C.sinensis infection increases the risk of hepatocellular carcinoma by stimulating hepatic progenitor cell proliferation[8].Complications of C.sinensis infection include cholestasis,cholangitis,biliary system fibrosis,and in severe cases,the development of cholangiocarcinoma[9].Consequently,the primary preventive measure is to abstain from consuming raw or undercooked freshwater fish.Praziquantel is the recommended and effective treatment for this infection[10].While there is existing literature on the coexistence of AS and parasitic infections,there is limited research specifically addressing the simultaneous presence of AS and C.sinensis infection.This case report details a rare scenario of AS coexisting with C.sinensis infection,underscoring the potential impact of C.sinensis infection on AS disease activity. 展开更多
关键词 Ankylosing spondylitis Clonorchis sinensis Parasites INFECTION Case report
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Association between Low Ambient Temperature and the Severity of Acute Ischemic Stroke
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作者 Xinyi Huang Liming Shu +5 位作者 Su Xiao Qiuhong Jiang Shiliang Yang Hualiang liang Hua Hong liang luo 《Journal of Clinical and Nursing Research》 2024年第5期83-94,共12页
Objective:To explore the relationships among ambient temperature,ischemic stroke severity,and blood pressure.Methods:Meteorological data(2005–2015)were collected from the Guangzhou Meteorological Data Service.Ischemi... Objective:To explore the relationships among ambient temperature,ischemic stroke severity,and blood pressure.Methods:Meteorological data(2005–2015)were collected from the Guangzhou Meteorological Data Service.Ischemic stroke patients from the Department of Neurology of the First Affiliated Hospital,Sun Yat-sen University were retrospectively evaluated,each winter from 2005 to 2015.Patient demographics,baseline measurements,and National Institute of Health Stroke Scale(NIHSS)score were evaluated.Results:Three hundred sixty-two patients were included.The median latency from symptom onset to admission was 2 d(IQR:1–3 d).During recruitment,the highest and lowest temperatures were 39℃and 1.3℃,respectively.Hypertension was the most common comorbidity(75.1%).NIHSS scores at admission and discharge were higher in the cold-exposed group than in the controls regardless of the average temperature at admission.In addition,systolic and diastolic blood pressure values at admission were higher in the cold-exposed group than in the controls.When stratified by hypertensive status,the average and minimum temperatures at admission were negatively associated with systolic and diastolic blood pressure values in hypertensive patients.Reductions in the average and minimum temperatures at symptom onset were associated with more severe stroke.Conclusion:Ischemic stroke patients with symptom onset in winter had higher systolic blood pressure values and more serious neurologic deficits upon admission. 展开更多
关键词 Low ambient temperature STROKE Blood pressure SEVERITY
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Analysis of DNA Methylation Changes during the Late Fruit Development Stage in Luotian Persimmon
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作者 Shuzhen WANG liang luo +4 位作者 Qiu JIN Lang JIN Konghua TAN Chunjun LIU Weibin JIN 《Agricultural Biotechnology》 CAS 2017年第4期6-9,共4页
Persimmon ( Diospyros kaki Thunb. ) , a member of Ebenaceae family, is known as "woody grain" and "iron-stem crop". However, the epigenetie research has been rarely reported. In this study, tannin content in lat... Persimmon ( Diospyros kaki Thunb. ) , a member of Ebenaceae family, is known as "woody grain" and "iron-stem crop". However, the epigenetie research has been rarely reported. In this study, tannin content in late fruit development periods was determined. Moreover, the MSAP (methylation-sensitive amplified polymorphism) method was used to analyze methylation profile, and 13 primer combinations were selected. In total, 5 differential fragments were cloned and sequenced. This research would be helpful for further gene cloning, research on deastringency mechanism, as well as molecular breeding of D. kaki. 展开更多
关键词 "Luotiantianshi persimmon" Methylation-sensitive amplified polymorphism EPIGENETICS TANNINS
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“FD工艺”对酱香型白酒堆积过程的影响 被引量:6
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作者 梁泺 范宏筠 +4 位作者 税梁扬 张煜亮 周帅 李丽 冯治平 《食品工业科技》 CAS 北大核心 2023年第4期181-188,共8页
为探究酱香型白酒酿造堆积过程中酒醅堆各位点发酵状态及细菌群落结构的变化规律,将“FD工艺”应用于酱香型白酒第二轮次酒生产堆积发酵过程,对堆积过程中的酒醅理化因子和细菌群落变化进行探索和研究。结果表明:相较于传统酒醅堆积发... 为探究酱香型白酒酿造堆积过程中酒醅堆各位点发酵状态及细菌群落结构的变化规律,将“FD工艺”应用于酱香型白酒第二轮次酒生产堆积发酵过程,对堆积过程中的酒醅理化因子和细菌群落变化进行探索和研究。结果表明:相较于传统酒醅堆积发酵而言,“FD工艺”处理后的酒醅酸度能够有效降低,酸度下降了1.72 mmol/10 g,同时能有效控制酒醅中水分含量,使水分含量保持在±0.8%;“FD工艺”能有效促进淀粉转化(增加转化了0.76%),同时酒醅中还原糖含量也增加(增长了0.46%);酒醅细菌群落Shannon指数、Sobs指数和Ace指数显著(P<0.05)增加;“FD工艺”处理后的酒醅微生物属分类水平的丰富度和多样性明显增加,有利于好氧菌属如芽孢杆菌属Bacillus、高温放线菌属Thermoactinomyces等微生物生长。综上,“FD工艺”能改善堆积发酵过程中酒醅发酵不均的情况,酒醅细菌群落丰富度和多样性均明显增加,有利于优势好氧及耐高温细菌群落的生长。 展开更多
关键词 酱香型白酒 堆积发酵 FD工艺 高通量测序 细菌群落结构
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Photobiomodulation provides neuroprotection through regulating mitochondrial fission imbalance in the subacute phase of spinal cord injury 被引量:2
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作者 Xin Li Xuan-Kang Wang +14 位作者 Zhi-Jie Zhu Zhuo-Wen liang Peng-Hui Li Yang-Guang Ma Tan Ding Kun Li Xiao-Shuang Zuo Cheng Ju Zhi-Hao Zhang Zhi-Wen Song Hui-Lin Quan Jia-Wei Zhang liang luo Zhe Wang Xue-Yu Hu 《Neural Regeneration Research》 SCIE CAS CSCD 2023年第9期2005-2010,共6页
Increasing evidence indicates that mitochonarial lission imbalance plays an important role in derayed neuronal cell death. Our previous study round that photo biomodulation improved the motor function of rats with spi... Increasing evidence indicates that mitochonarial lission imbalance plays an important role in derayed neuronal cell death. Our previous study round that photo biomodulation improved the motor function of rats with spinal cord injury.However,the precise mechanism remains unclear.To investigate the effect of photo biomodulation on mitochondrial fission imbalance after spinal cord injury,in this study,we treated rat models of spinal co rd injury with 60-minute photo biomodulation(810 nm,150 mW) every day for 14 consecutive days.Transmission electron microscopy results confirmed the swollen and fragmented alte rations of mitochondrial morphology in neurons in acute(1 day) and subacute(7 and 14 days) phases.Photo biomodulation alleviated mitochondrial fission imbalance in spinal cord tissue in the subacute phase,reduced neuronal cell death,and improved rat posterior limb motor function in a time-dependent manner.These findings suggest that photobiomodulation targets neuronal mitochondria,alleviates mitochondrial fission imbalance-induced neuronal apoptosis,and thereby promotes the motor function recovery of rats with spinal cord injury. 展开更多
关键词 low-level laser therapy MITOCHONDRIA mitochondrial dynamics mitochondrial fission imbalance NEURON PHOTOBIOMODULATION secondary injury spinal cord injury
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An Interpretable CNN for the Segmentation of the Left Ventricle in Cardiac MRI by Real-Time Visualization 被引量:1
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作者 Jun Liu Geng Yuan +2 位作者 Changdi Yang Houbing Song liang luo 《Computer Modeling in Engineering & Sciences》 SCIE EI 2023年第5期1571-1587,共17页
The interpretability of deep learning models has emerged as a compelling area in artificial intelligence research.The safety criteria for medical imaging are highly stringent,and models are required for an explanation... The interpretability of deep learning models has emerged as a compelling area in artificial intelligence research.The safety criteria for medical imaging are highly stringent,and models are required for an explanation.However,existing convolutional neural network solutions for left ventricular segmentation are viewed in terms of inputs and outputs.Thus,the interpretability of CNNs has come into the spotlight.Since medical imaging data are limited,many methods to fine-tune medical imaging models that are popular in transfer models have been built using massive public Image Net datasets by the transfer learning method.Unfortunately,this generates many unreliable parameters and makes it difficult to generate plausible explanations from these models.In this study,we trained from scratch rather than relying on transfer learning,creating a novel interpretable approach for autonomously segmenting the left ventricle with a cardiac MRI.Our enhanced GPU training system implemented interpretable global average pooling for graphics using deep learning.The deep learning tasks were simplified.Simplification included data management,neural network architecture,and training.Our system monitored and analyzed the gradient changes of different layers with dynamic visualizations in real-time and selected the optimal deployment model.Our results demonstrated that the proposed method was feasible and efficient:the Dice coefficient reached 94.48%,and the accuracy reached 99.7%.It was found that no current transfer learning models could perform comparably to the ImageNet transfer learning architectures.This model is lightweight and more convenient to deploy on mobile devices than transfer learning models. 展开更多
关键词 Interpretable graphics training VISUALIZATION image segmentation left ventricle CNNS global average pooling
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Halogen chlorine triggered oxygen vacancy-rich Ni(OH)_(2) with enhanced reaction kinetics for pseudocapacitive energy storage 被引量:1
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作者 Jiangyu Hao Lijin Yan +6 位作者 liang luo Qiaohui Liu Youcun Bai Yuying Han Yang Zhou Xuefeng Zou Bin Xiang 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2023年第7期296-306,I0007,共12页
Two-dimensional (2D)Ni(OH)_(2) nanosheets can theoretically expose their active sites of 100%.Whereas,their intrinsic easy accumulation and low conductivity lead to weak and unsustainable reaction kinetics.Herein,we p... Two-dimensional (2D)Ni(OH)_(2) nanosheets can theoretically expose their active sites of 100%.Whereas,their intrinsic easy accumulation and low conductivity lead to weak and unsustainable reaction kinetics.Herein,we propose a novel halogen chlorine-triggered electrochemical etching strategy to controllably manage the reaction kinetics of 2D Ni(OH)_(2) nanosheets(EE/Cl-Ni(OH)_(2)).It is found that halogen chlorine doping can adjust the interlamellar spacing flexibly and promote the lattice oxygen activation to achieve controlled construction of superficial oxygen defects at the adjustable voltage.The optimal EE/Cl-Ni(OH)_(2) electrode exhibits a high rate capability and excellent specific capacity of 206.9 mA h g^(-1) at 1 A g^(-1) in a three-electrode system,which is more than twice as high as the pristine Ni(OH)_(2).Furthermore,EE/Cl-Ni(OH)_(2) cathode and FeOOH@rGO anode are employed for developing an aqueous Ni-Fe battery with an excellent energy density of 83 W h kg^(-1),a high power density of 17051 W kg^(-1),and robust durability over 20,000 cycles.This strategy exploits a fresh channel for the ingenious fabrication of highefficiency and stable nickel-based deficiency materials for energy storage. 展开更多
关键词 Ni(OH)_(2) Electrochemical etching Lattice defects High energy density Ni-Fe battery
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Intelligent Identification over Power Big Data:Opportunities,Solutions,and Challenges
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作者 liang luo Xingmei Li +4 位作者 Kaijiang Yang Mengyang Wei Jiong Chen Junqian Yang liang Yao 《Computer Modeling in Engineering & Sciences》 SCIE EI 2023年第3期1565-1595,共31页
The emergence of power dispatching automation systems has greatly improved the efficiency of power industry operations and promoted the rapid development of the power industry.However,with the convergence and increase... The emergence of power dispatching automation systems has greatly improved the efficiency of power industry operations and promoted the rapid development of the power industry.However,with the convergence and increase in power data flow,the data dispatching network and the main station dispatching automation system have encountered substantial pressure.Therefore,themethod of online data resolution and rapid problemidentification of dispatching automation systems has been widely investigated.In this paper,we performa comprehensive review of automated dispatching of massive dispatching data from the perspective of intelligent identification,discuss unresolved research issues and outline future directions in this area.In particular,we divide intelligent identification over power big data into data acquisition and storage processes,anomaly detection and fault discrimination processes,and fault tracing for dispatching operations during communication.A detailed survey of the solutions to the challenges in intelligent identification over power big data is then presented.Moreover,opportunities and future directions are outlined. 展开更多
关键词 Data acquisition data storage anomaly detection service fault-tolerant scheduling
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A Double-Weighted Deterministic Extreme Learning Machine Based on Sparse Denoising Autoencoder and Its Applications
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作者 liang luo Bolin Liao +1 位作者 Cheng Hua Rongbo Lu 《Journal of Computer and Communications》 2022年第11期138-153,共16页
Extreme learning machine (ELM) is a feedforward neural network-based machine learning method that has the benefits of short training times, strong generalization capabilities, and will not fall into local minima. Howe... Extreme learning machine (ELM) is a feedforward neural network-based machine learning method that has the benefits of short training times, strong generalization capabilities, and will not fall into local minima. However, due to the traditional ELM shallow architecture, it requires a large number of hidden nodes when dealing with high-dimensional data sets to ensure its classification performance. The other aspect, it is easy to degrade the classification performance in the face of noise interference from noisy data. To improve the above problem, this paper proposes a double pseudo-inverse extreme learning machine (DPELM) based on Sparse Denoising AutoEncoder (SDAE) namely, SDAE-DPELM. The algorithm can directly determine the input weight and output weight of the network by using the pseudo-inverse method. As a result, the algorithm only requires a few hidden layer nodes to produce superior classification results when classifying data. And its combination with SDAE can effectively improve the classification performance and noise resistance. Extensive numerical experiments show that the algorithm has high classification accuracy and good robustness when dealing with high-dimensional noisy data and high-dimensional noiseless data. Furthermore, applying such an algorithm to Miao character recognition substantiates its excellent performance, which further illustrates the practicability of the algorithm. 展开更多
关键词 Extreme Learning Machine Sparse Denoising Autoencoder Pseudo-Inverse Method Miao Character Recognition
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Recent progress on nanoparticle-based drug delivery systems for cancer therapy 被引量:11
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作者 Yanru Xin Mingming Yin +2 位作者 Liyuan Zhao Fanling Meng liang luo 《Cancer Biology & Medicine》 SCIE CAS CSCD 2017年第3期228-241,共14页
The development of cancer nanotherapeutics has attracted great interest in the recent decade. Cancer nanotherapeutics have overcome several limitations of conventional therapies, such as nonspecific biodistribution, p... The development of cancer nanotherapeutics has attracted great interest in the recent decade. Cancer nanotherapeutics have overcome several limitations of conventional therapies, such as nonspecific biodistribution, poor water solubility, and limited bioavailability. Nanoparticles with tuned size and surface characteristics are the key components of nanotherapeutics, and are designed to passively or actively deliver anti-cancer drugs to tumor cells. We provide an overview of nanoparticle-based drug delivery methods and cancer therapies based on tumor-targeting delivery strategies that have been developed in recent years. 展开更多
关键词 NANOPARTICLES NANOMEDICINE drug delivery tumor targeting cancer therapy
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Effect of directional solidification process on microstructure and stress rupture property of a hot corrosion resistant single crystal superalloy 被引量:7
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作者 liang luo Cheng-bo Xiao +2 位作者 Jing-yang Chen Qing Li Sheng-long Dai 《China Foundry》 SCIE 2019年第1期8-13,共6页
The influences of different directional solidification processes, i.e., the high rate solidification(HRS) and liquid metal cooling(LMC), on microstructure and stress rupture property of DD488 alloy were investigated. ... The influences of different directional solidification processes, i.e., the high rate solidification(HRS) and liquid metal cooling(LMC), on microstructure and stress rupture property of DD488 alloy were investigated. The DD488 alloy was directional solidified by both HRS and LMC processes. The microstructure and stress rupture properties at 980 ℃/250 MPa were investigated by using optical microscopy(OM), scanning electron microscopy(SEM), electron microprobe analyzer(EPMA), transmission electron microscopy(TEM) and stress rupture testing. The results indicated that the LMC process refined the primary dendrite arm and decreased the microporosity volume fraction and solidification segregations of Cr and Co in as-cast DD488 alloy. After standard heat treatment of 1,260 ℃/4 h, AC(air cooling) + 1,080 ℃/4 h, AC + 870 ℃/24 h, AC, the γ′ morphology in LMC alloy was more cuboidal than that in HRS alloy, and the γ′ volume fraction of LMC alloy was higher than that of HRS alloy. The stress rupture life at 980 ℃/250 MPa of HRS alloy was 76.8 h, and it increased to 110.0 h in LMC al oy. The LMC process increased the stress rupture life due to the higher γ′ volume fraction, more perfect rafting structure and finer interfacial dislocation networks. 展开更多
关键词 DD488 SUPERALLOY liquid metal COOLING high rate SOLIDIFICATION MICROSTRUCTURE PROPERTY
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Fructo-oligosaccharide intensifies visceral hypersensitivity and intestinal inflammation in a stress-induced irritable bowel syndrome mouse model 被引量:5
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作者 Bin-Rui Chen Li-Jun Du +5 位作者 Hui-Qin He John J Kim Yan Zhao Ya-Wen Zhang liang luo Ning Dai 《World Journal of Gastroenterology》 SCIE CAS 2017年第47期8321-8333,共13页
AIM To determine whether fructo-oligosaccharide(FOS) affects visceral sensitivity, inflammation, and production of intestinal short-chain fatty acids(SCFA) in an irritable bowel syndrome(IBS) mouse model.METHODS Mice ... AIM To determine whether fructo-oligosaccharide(FOS) affects visceral sensitivity, inflammation, and production of intestinal short-chain fatty acids(SCFA) in an irritable bowel syndrome(IBS) mouse model.METHODS Mice were randomly assigned to daily oral gavage of saline solution with or without FOS(8 g/kg body weight) for 14 d. Mice were further assigned to receive either daily one-hour water avoidance stress(WAS) or sham-WAS for the first 10 d. After 2 wk, visceral sensitivity was measured by abdominal withdrawal reflex in response to colorectal distension and mucosal inflammation was evaluated. Gas chromatography, real-time reverse transcription PCR, and immunohistochemistry assays were used to quantify cecal concentrations of SCFA, intestinal cytokine expression, and number of intestinal mast cells per high-power field(HPF), respectively.RESULTS Mice subjected to WAS exhibited visceral hypersensitivity and low-grade inflammation. Among mice subjected to WAS, FOS increased visceral hypersensitivity and led to higher cecal concentrations of acetic acid(2.49 ± 0.63 mmol/L vs 1.49 ± 0.72 mmol/L, P < 0.05), propionic acid(0.48 ± 0.09 mmol/L vs 0.36 ± 0.05 mmol/L, P < 0.01), butyric acid(0.28 ± 0.09 mmol/L vs 0.19 ± 0.003 mmol/L, P < 0.05), as well as total SCFA(3.62 ± 0.87 mmol/L vs 2.27 ± 0.75 mmol/L, P < 0.01) compared to saline administration. FOS also increased ileal interleukin(IL)-23 mR NA(4.71 ± 4.16 vs 1.00 ± 0.99, P < 0.05) and colonic IL-1β mR NA(2.15 ± 1.68 vs 0.88 ± 0.53, P < 0.05) expressions as well as increased mean mast cell counts in the ileum(12.3 ± 2.6 per HPF vs 8.3 ± 3.6 per HPF, P < 0.05) and colon(6.3 ± 3.2 per HPF vs 3.4 ± 1.2 per HPF, P < 0.05) compared to saline administration in mice subjected to WAS. No difference in visceral sensitivity, intestinal inflammation, or cecal SCFA levels was detected with or without FOS administration in mice subjected to sham-WAS.CONCLUSION FOS administration intensifies visceral hypersensitivity and gut inflammation in stress-induced IBS mice, but not in the control mice, and is also associated with increased intestinal SCFA production. 展开更多
关键词 FRUCTO-OLIGOSACCHARIDE STRESS Irritable bowel syndrome Visceral hypersensitivity Intestinal inflammation Short chain fatty acids FODMAP
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Real-world cost-effectiveness associated with infliximab maintenance therapy for moderate to severe Crohn's disease in China 被引量:4
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作者 Ji-Hao Shi liang luo +6 位作者 Xiao-Li Chen Yi-Peng Pan Zhou Zhang Hao Fang Ying Chen Wen-Dong Chen Qian Cao 《World Journal of Gastroenterology》 SCIE CAS 2020年第41期6455-6474,共20页
BACKGROUND Infliximab was the first approved biologic treatment for moderate to severe Crohn's disease(MS-CD) in China. However, the cost-effectiveness of infliximab maintenance therapy(IMT) for MS-CD relative to ... BACKGROUND Infliximab was the first approved biologic treatment for moderate to severe Crohn's disease(MS-CD) in China. However, the cost-effectiveness of infliximab maintenance therapy(IMT) for MS-CD relative to conventional maintenance therapy remained unclarified.AIM To assess the cost-effectiveness of IMT for MS-CD in Chinese patients from the perspective of Chinese public insurance payer.METHODS A cohort of MS-CD patients managed in a Chinese tertiary care hospital was created to compare IMT with conventional maintenance therapy(CMT) for clinical outcomes and direct medical costs over a 1-year observation time using conventional regression analyses. A decision-analytic model with the generated evidence was constructed to assess the cost-effectiveness of IMT relative to CMT using reimbursed medical costs.RESULTS Based on the included 389 patients, IMT was associated with significantly higher disease remission chance [odds ratio: 4.060, P = 0.003], lower risk of developing new complications(odds ratio: 0.527, P = 0.010), higher utility value for quality of life(coefficient 0.822, P = 0.008), and lower total hospital costs related to disease management(coefficient-0.378, P = 0.008) than CMT. Base-case cost-effectiveness analysis estimated that IMT could cost Chinese health insurance payers $55260 to gain one quality-adjusted life year(QALY). The cost-effectiveness of IMT was mainly driven by the estimate of quality of life, treatment efficacy of maintenance therapy, mortality risk associated with active disease, and unit price of infliximab. The probability that IMT was cost-effective at a willingness-to-pay threshold of three times gross domestic product [2018 Chinese gross domestic product per capita(GDPPC)] was 86.4%.CONCLUSION IMT significantly improved real-world health outcomes and cost the Chinese public health insurance payers less than one GDPPC to gain one QALY in Chinese MS-CD patients. 展开更多
关键词 INFLIXIMAB Crohn's disease Maintenance therapy COST-EFFECTIVENESS OUTCOMES Direct medical costs
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Recent progress of nanotechnology-based theranostic systems in cancer treatments 被引量:3
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作者 Ying Xue Yuting Gao +1 位作者 Fanling Meng liang luo 《Cancer Biology & Medicine》 SCIE CAS CSCD 2021年第2期336-351,共16页
Theranostics that integrates therapy and diagnosis in one system to achieve accurate cancer diagnosis and treatment has attracted tremendous interest,and has been recognized as a potential breakthrough in overcoming t... Theranostics that integrates therapy and diagnosis in one system to achieve accurate cancer diagnosis and treatment has attracted tremendous interest,and has been recognized as a potential breakthrough in overcoming the challenges of conventional oncotherapy.Nanoparticles are ideal candidates as carriers for theranostic agents,which is attributed to their extraordinary physicochemical properties,including nanoscale sizes,functional properties,prolonged blood circulation,active or passive tumor targeting,specific cellular uptake,and in some cases,excellent optical properties that ideally meet the needs of phototherapy and imaging at the same time.Overall,with the development of nanotechnology,theranostics has become a reality,and is now in the transition stage of"bench to bedside."In this review,we summarize recent progress on nanotechnology-based theranostics,i.e.,nanotheranostics,that has greatly assisted traditional therapies,and has provided therapeutic strategies emerging in recent decades,as well as"cocktail"theranostics mixing various treatment modalities. 展开更多
关键词 THERANOSTICS cancer therapy DIAGNOSIS NANOPARTICLES NANOTECHNOLOGY
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Time-Programmed Delivery of Sorafenib and Anti-CD47 Antibody via a Double-Layer-Gel Matrix for Postsurgical Treatment of Breast Cancer 被引量:3
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作者 Liping Huang Yiyi Zhang +6 位作者 Yanan Li Fanling Meng Hongyu Li Huimin Zhang Jiasheng Tu Chunmeng Sun liang luo 《Nano-Micro Letters》 SCIE EI CAS CSCD 2021年第9期223-237,共15页
The highly immunosuppressive microenvironment after surgery has a crucial impact on the recurrence and metastasis in breast cancer patients.Programmable delivery of immunotherapy-involving combinations through a singl... The highly immunosuppressive microenvironment after surgery has a crucial impact on the recurrence and metastasis in breast cancer patients.Programmable delivery of immunotherapy-involving combinations through a single drug delivery system is highly promising,yet greatly challenging,to reverse postoperative immunosuppression.Here,an injectable hierarchical gel matrix,composed of dual lipid gel(DLG)layers with different soybean phosphatidylcholine/glycerol dioleate mass ratios,was developed to achieve the time-programmed sequential delivery of combined cancer immunotherapy.The outer layer of the DLG matrix was thermally responsive and loaded with sorafenib-adsorbed graphene oxide(GO)nanoparticles.GO under manually controlled near-infrared irradiation generated mild heat and provoked the release of sorafenib first to reeducate tumor-associated macrophages(TAMs)and promote an immunogenic tumor microenvironment.The inner layer,loaded with anti-CD47 antibody(aCD47),could maintain the gel state for a much longer time,enabling the sustained release of aCD47 afterward to block the CD47-signal regulatory proteinα(SIRPα)pathway for a long-term antitumor effect.In vivo studies on 4T1 tumor-bearing mouse model demonstrated that the DLG-based strategy efficiently prevented tumor recurrence and metastasis by locally reversing the immunosuppression and synergistically blocking the CD47-dependent immune escape,thereby boosting the systemic immune responses. 展开更多
关键词 Hierarchical hydrogel SORAFENIB Postoperative immunosuppression reversal Tumor-associated macrophages Anti-CD47 antibody
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谷壳用量对多粮浓香型白酒机械化酿造过程的影响研究 被引量:3
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作者 周帅 杨明永 +11 位作者 范宏筠 税梁扬 袁思棋 张峰华 王浩杰 梁泺 张太坤 王程 薛江林 王燕 张世强 张煜亮 《酿酒科技》 2022年第9期60-64,共5页
在白酒机械化酿造生产过程中,通过改变多粮浓香型白酒谷壳的使用量,跟踪窖内糟醅的理化指标数据、出窖糟醅感官质量以及基酒品质,探讨不同白酒酿造过程中谷壳用量对多粮浓香型白酒热季停产后第一排投粮糟醅发酵的影响。结果表明,机械化... 在白酒机械化酿造生产过程中,通过改变多粮浓香型白酒谷壳的使用量,跟踪窖内糟醅的理化指标数据、出窖糟醅感官质量以及基酒品质,探讨不同白酒酿造过程中谷壳用量对多粮浓香型白酒热季停产后第一排投粮糟醅发酵的影响。结果表明,机械化生产中谷壳使用量为30%时对多粮浓香型白酒热季停产后头排投粮糟醅的发酵最为有利。 展开更多
关键词 多粮浓香型白酒 糟醅 谷壳用量 理化指标 机械化酿造
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Ergodicity recovery of random walk in heterogeneous disordered media 被引量:1
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作者 liang luo Ming Yi 《Chinese Physics B》 SCIE EI CAS CSCD 2020年第5期165-173,共9页
Significant and persistent trajectory-to-trajectory variance are commonly observed in particle tracking experiments,which have become a major challenge for the experimental data analysis.In this theoretical paper we i... Significant and persistent trajectory-to-trajectory variance are commonly observed in particle tracking experiments,which have become a major challenge for the experimental data analysis.In this theoretical paper we investigate the ergodicity recovery behavior,which helps clarify the origin and the convergence of trajectory-to-trajectory fluctuation in various heterogeneous disordered media.The concepts of self-averaging and ergodicity are revisited in the context of trajectory analysis.The slow ergodicity recovery and the non-Gaussian diffusion in the annealed disordered media are shown as the consequences of the central limit theorem in different situations.The strange ergodicity recovery behavior is reported in the quenched disordered case,which arises from a localization mechanism.The first-passage approach is introduced to the ergodicity analysis for this case,of which the central limit theorem can be employed and the ergodicity is recovered in the length scale of diffusivity correlation. 展开更多
关键词 anomalous diffusion random walk disordered systems non-Gaussian diffusion
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“FD工艺”对酱香型白酒堆积过程真菌群落结构和酒体品质的影响 被引量:2
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作者 税梁扬 梁泺 +6 位作者 周帅 杨明永 袁思棋 张峰华 王浩杰 张世强 范宏筠 《酿酒科技》 2022年第9期25-32,共8页
为探究酱香型白酒堆积过程中“FD工艺”对酒醅真菌群落结构的影响,将“FD工艺”应用于酱香型白酒第二轮次堆积发酵过程中。针对第二轮次堆积发酵的酒醅,收集“FD工艺”应用前后的酒醅样品,采用高通量测序技术对所有酒醅样品进行真菌群... 为探究酱香型白酒堆积过程中“FD工艺”对酒醅真菌群落结构的影响,将“FD工艺”应用于酱香型白酒第二轮次堆积发酵过程中。针对第二轮次堆积发酵的酒醅,收集“FD工艺”应用前后的酒醅样品,采用高通量测序技术对所有酒醅样品进行真菌群落结构分析。经“FD工艺”处理后的酒醅相关结果表明:(1)酒醅真菌群落Shannon指数、Sobs指数和Ace指数显著增加;(2)微生物门分类水平上,子囊菌门Ascomycota在两组样本中占绝对优势,相对丰度均超过99%,担子菌门Basidiomycota相对丰度有所增加;(3)微生物属分类水平上,酒醅有利于嗜热真菌属Thermomyces、嗜热子囊菌Thermoascus、毕赤酵母属Pichia、未分类的曲霉菌属unclassified_f_Aspergillaceae、曲霉菌属Aspergillus、复膜孢酵母属Saccharomycopsis、Kazachstania属、伊萨酵母属Issatchenkia、节担菌属Wallemia、假丝酵母属Candida、孢圆酵母属Torulaspora的生长;(4)“FD工艺”的酒醅出酒量大幅上升,基酒品质有所上升,主要酯类和醇类化合物,如乙酸乙酯和正丙醇含量有所增加。综上,酱香型白酒第二轮次堆积发酵过程经“FD工艺”处理后酒醅真菌群落多样性和丰富度均有明显增加,且有利于大部分真菌群落的生长,有效提高了出酒量和基酒的品质,为酱香型白酒堆积发酵新工艺改良提供了一定的理论依据。 展开更多
关键词 酱香型白酒 堆积发酵 “FD工艺” 高通量测序 真菌群落结构
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