Effect of Yishen Qiqiao Fang on dopamine content in serum and cerebrospinal fluid of patients in persistent vegetative statec

BACKGROUND： It has been demonstrated that the attack of persistent vegetative state is associated with the damaged neuron, which produces dopamine, and nervous pathway, the reduce of dopamine or malfunction of dopamine.OBJECTIVE： To observe the effect of self-made traditional Chinese medicine （TCM） Yishen Qiqiao Fang,which has the functions of supplementing qi and nourishing blood, resolving phlegm by promoting blood circulation, restoring consciousness and inducing resuscitation, on the contents of dopamine in serum and cerebrospinal fluid of patients in persistent vegetative state.DESIGN： An open randomized controlled clinical trial.SETTINGS： Nanjing University of Traditional Chinese Medicine, Nanjing Zijin Hospital.PARTICIPANTS： Thirty-eight inpatients of persistent vegetative state were selected from the Department of Neurology, Nanjing Zijin Hospital from August 2005 to November 2006. The patients were diagnosed according to the diagnostic standards set by the summary of a meeting for specialists in Nanjing. Informed contents were obtained from their relatives. According to the order of admission, the enrolled patients were divided into control group （n =20） and TCM treated group （n =20）.METHODS： In the control group, the patients were treated with routine treatments for the symptoms. In the TCM treated group, the patients were treated with Yishen Qiqiao Fang besides the same treatments in the control group. TCM dispensing granules： each bag of mongolian milkvetch root, Chinese angelica and peach seed equaled to 10 g crude drug respectively; each bag of grassleaf sweetflag rhizome and dahurian angelica root equaled to 6 g crude drug respectively; Musk 0.05 g. The daily dosage for adults： 4 bags of mongolian milkvetch root, 2 bags of Chinese angelica, 0.05 g musk, 1 bag of peach seed, 2 bags of grassleaf sweetflag rhizome and 2 bags of dahurian angelica root, which should be given though nasal feeding or gastrostogavage before breakfast and supper every day, the course lasted for 2 months. The contents of dopamine in serum and cerebrospinal fluid were determined with enzyme immunoassay analyzer before and after treatment in both groups.MAIN OUTCOME MEASURES： Contents of dopamine in serum and cerebrospinal fluid before and after treatment in both groups.RESULTS： Totally 38 patients of persistent vegetative state were enrolled, 33 of them were involved in the final analysis of results, and the other 5 missed. The contents of dopamine in serum and cerebrospinal fluid had no obvious differences between the two groups both before and after treatment （P〉0.05）. In the control group, the contents of dopamine in serum and cerebrospinal fluid had no obvious differences before and after treatment （P〉0.05）. In the TCM treated group, the contents of dopamine in serum and cerebrospinal fluid after treatment were obviously higher than those before treatment （t =2.174, 2.485, P〈0.05）.CONCLUSION： Yishen Qiqiao Fang can significantly increase the contents of dopamine in serum and cerebrospinal fluid of patients in persistent vegetative state, which may be one of the mechanisms for ameliorating persistent vegetative state.

Structure and frustrated magnetism of the two-dimensional triangular lattice antiferromagnet Na_(2)BaNi(PO_(4))_(2)

A new frustrated triangular lattice antiferromagnet Na_(2)BaNi(PO_(4))_(2) was synthesized by high temperature flux method.The two-dimensional triangular lattice is formed by the Ni^(2+)ions with S=1.Its magnetism is highly anisotropic with the Weiss constants θCW=6.615 K(H||c)and43.979 K(H⊥c).However,no magnetic ordering is present down to 0.3 K,reflecting strong geometric spin frustration.Our heat capacity measurements show substantial residual magnetic entropy existing below 0.3 K at zero field,implying the presence of low energy spin excitations.These results indicate that Na_(2)BaNi(PO_(4))_(2) is a potential spin liquid candidate with spin-1.

Function identification of miR159a,a positive regulator during poplar resistance to drought stress

Drought seriously affects the growth and development of plants.MiR159 is a highly conserved and abundant microRNA family that plays a crucial role in plant growth and stress responses.However,studies of its function in woody plants are still lacking.Here,the expression of miR159a was significantly upregulated after drought treatment in poplar,and the overexpression of miR159a(OX159a)significantly reduced the open area of the stomata and improved water-use efficiency in poplar.After drought treatment,OX159a lines had better scavenging ability of reactive oxygen species and damage of the membrane system was less than that in wild-type lines.MYB was the target gene of miR159a,as verified by psRNATarget prediction,RT-qPCR,degradome sequencing,and 5′rapid amplification of cDNA ends(5′RACE).Additionally,miR159a-short tandem target mimic suppression(STTM)poplar lines showed increased sensitivity to drought stress.Transcriptomic analysis comparing OX159a lines with wild-type lines revealed upregulation of a series of genes related to response to water deprivation and metabolite synthesis.Moreover,drought-responsive miR172d and miR398 were significantly upregulated and downregulated respectively in OX159a lines.This investigation demonstrated that miR159a played a key role in the tolerance of poplar to drought by reducing stomata open area,increasing the number and total area of xylem vessels,and enhancing water-use efficiency,and provided new insights into the role of plant miR159a and crucial candidate genes for the molecular breeding of trees with tolerance to drought stress.

PHASE TRANSFOR MATION INDUCED BY DEFORMATION IN TiAl(Cr)INTERMETALLICS AT ROOM TEMPERATURE

The phase transformation induced by deformation in TiAl(Cr) intermetallics at room temperature has been studied by means of TEM and HREM observations and nanoprobe analysis. The results showed that, twinning is a primary deformation mechanism at room temperature, when plastic deformation is small twinning takes place on {111} planes and when plastic deformation is great two sets twins takes place usually from intersection region, where the atomic structure changes to hexagonal structure with the composition of Ti 55.7 2Al 42.2 8Cr 1.7 .

Fabrication of Biomimetic Surface for Hydrophobic and Anti-icing Purposes via the Capillary Force Lithography

In this paper,inspired by lotus leaf surfaces,we fabricated biomimetic multi-scale micro-nano-structures by Two-Step Capillary Force Lithography(TS-CFL)and UV-assisted Capillary Force Lithography(UV-CFL).The experimental results indicated that TS-CFL was unfitted to fabricate large-area multi-scale micro-nano-structures.Conversely,UV-CFL can fabricate large-area multi-scale micro-nano-structures.We discussed the hydrophobic and anti-icing properties of the biomimetic surfaces fabricated by these two technologies.We found that small structures are significant for improving the hydrophobic anti-icing properties of single-structured or structureless surfaces.We believe that these results can complement the experimental details of both technologies and enable the development of more interesting micro-nano-structures biomimetic surfaces by both technologies in the future.

国家自然科学基金项目光学学科的科学问题属性剖析

国家自然科学基金委员会从2019年开始试点实行科学问题属性分类的项目资助导向,该项改革举措不仅为项目申请者规范了课题类别和撰写要点,还为项目评审专家明确了评审要点和评判标准,在项目遴选和资助管理过程中起到了积极引导作用。本文以数理科学部物理一处光学学科为例,分析了科学问题属性分类资助政策执行以来的现状,讨论了科学问题属性的特点以及在执行中存在的问题,并从申请者、评审专家和管理者多个视角对科学问题属性提出了一些建设性的意见,同时基于科学问题属性对光学学科的未来发展提出了建议。

Recent Advances in Graphitic Carbon Nitride-Based Chemiluminescence,Cataluminescence and Electrochemiluminescence

Graphitic carbon nitride(g-C3N4)has attracted considerable attention due to its special structure and properties,such as its good chemical and thermal stability under ambient conditions,low cost and non-toxicity,and facile synthesis.Recently,g-C3N4-based sensors have been demonstrated to be of high interests in the areas of sensing due to the unique optical,electronic and catalytic properties of g-C3N4.This review focuses on the most salient advances in luminescent sensors based on g-C3N4,chemiluminescence,cataluminescence and electrochemiluminescence methods are discussed.This review provides valuable information for researchers of related areas and thus may inspire the development of more practical and effective approaches for designing two-dimensional(2D)nanomaterial-assisted luminescent sensors.