This paper addresses a multi-agent scheduling problem with uniform parallel machines owned by a resource agent and competing jobs with dynamic arrival times that belong to different consumer agents.All agents are self...This paper addresses a multi-agent scheduling problem with uniform parallel machines owned by a resource agent and competing jobs with dynamic arrival times that belong to different consumer agents.All agents are self-interested and rational with the aim of maximizing their own objectives,resulting in intense resource competition among consumer agents and strategic behaviors of unwillingness to disclose private information.Within the context,a centralized scheduling approach is unfeasible,and a decentralized approach is considered to deal with the targeted problem.This study aims to generate a stable and collaborative solution with high social welfare while simultaneously accommodating consumer agents’preferences under incomplete information.For this purpose,a dynamic iterative auction-based approach based on a decentralized decision-making procedure is developed.In the proposed approach,a dynamic auction procedure is established for dynamic jobs participating in a realtime auction,and a straightforward and easy-to-implement bidding strategy without price is presented to reduce the complexity of bid determination.In addition,an adaptive Hungarian algorithm is applied to solve the winner determination problem efficiently.A theoretical analysis is conducted to prove that the proposed approach is individually rational and that the myopic bidding strategy is a weakly dominant strategy for consumer agents submitting bids.Extensive computational experiments demonstrate that the developed approach achieves high-quality solutions and exhibits considerable stability on largescale problems with numerous consumer agents and jobs.A further multi-agent scheduling problem considering multiple resource agents will be studied in future work.展开更多
A novel dual-band ISGW cavity filter with enhanced frequency selectivity is proposed in this paper by utilizing a multi-mode coupling topology.Its cavity is designed to control the number of modes,and then the ports a...A novel dual-band ISGW cavity filter with enhanced frequency selectivity is proposed in this paper by utilizing a multi-mode coupling topology.Its cavity is designed to control the number of modes,and then the ports are determined by analyzing the coupling relationship between these selected modes.By synthesizing the coupling matrix of the filter,a nonresonating node(NRN)structure is introduced to flexibly tune the frequency of modes,which gets a dualband and quad-band filtering response from a tri-band filter no the NRN.Furthermore,a frequency selective surface(FSS)has been newly designed as the upper surface of the cavity,which significantly improves the bad out-of-band suppression and frequency selectivity that often exists in most traditional cavity filter designs and measurements.The results show that its two center frequencies are f01=27.50 GHz and f02=32.92GHz,respectively.Compared with the dual-band filter that there is no the FSS metasurface,the out-of-band suppression level is improved from measured 5 dB to18 dB,and its finite transmission zero(FTZ)numbers is increased from measured 1 to 4 between the two designed bands.Compared with the tri-band and quadband filter,its passband bandwidth is expanded from measured 1.17%,1.14%,and 1.13% or 1.31%,1.50%,0.56%,and 0.57% to 1.71% and 1.87%.In addition,the filter has compact,small,and lightweight characteristics.展开更多
Tomato(Solanum lycopersicum)is among the most important vegetables across the world,but cold stress usually affects its yield and quality.The wild tomato species Solanum habrochaites is commonly utilized as rootstock ...Tomato(Solanum lycopersicum)is among the most important vegetables across the world,but cold stress usually affects its yield and quality.The wild tomato species Solanum habrochaites is commonly utilized as rootstock for enhancing resistance against abiotic stresses in cultivated tomato,especially cold resistance.However,the underlying molecular mechanism remains unclear.In this research,we confirmed that S.habrochaites rootstock can improve the cold tolerance of cultivated tomato scions,as revealed by growth,physiological,and biochemical indicators.Furthermore,transcriptome profiling indicated significant differences in the scion of homo-and heterografted seedlings,including substantial changes in jasmonic acid(JA)biosynthesis and signaling,which were validated by RT–qPCR analysis.S.habrochaites plants had a high basal level of jasmonate,and cold stress caused a greater amount of active JA-isoleucine in S.habrochaites heterografts.Moreover,exogenous JA enhanced while JA inhibitor decreased the cold tolerance of tomato grafts.The JA biosynthesis-defective mutant spr8 also showed increased sensitivity to cold stress.All of these results demonstrated the significance of JA in the cold tolerance of grafted tomato seedlings with S.habrochaites rootstock,suggesting a future direction for the characterization of the natural variation involved in S.habrochaites rootstock-mediated cold tolerance.展开更多
S Background Music therapy is a promising complementary intervention for addressing various mental health conditions.Despite evidence of the beneficial effects of music,the acoustic features that make music effective ...S Background Music therapy is a promising complementary intervention for addressing various mental health conditions.Despite evidence of the beneficial effects of music,the acoustic features that make music effective in therapeutic contexts remain elusive.Aims This study aimed to identify and validate distinctive acoustic features of healing music.Methods We constructed a healing music dataset(HMD)based on nominations from related professionals and extracted 370 acoustic features.Healing-distinctive acoustic features were identified as those that were(1)independent from genre within the HMD,(2)significantly different from music pieces in a classical music dataset(CMD)and(3)similar to pieces in a five-element music dataset(FEMD).We validated the identified features by comparing jazz pieces in the HMD with a jazz music dataset(JMD).We also examined the emotional properties of the features in a Chinese affective music system(CAMS).Results The HMD comprised 165 pieces.Among all the acoustic features,74.59%shared commonalities across genres,and 26.22%significantly differed between the HMD classical pieces and the CMD.The equivalence test showed that the HMD and FEMD did not differ significantly in 9.46%of the features.The potential healing-distinctive acoustic features were identified as the standard deviation of the roughness,mean and period entropy of the third coefficient of the mel-frequency cepstral coefficients.In a three-dimensional space defined by these features,HMD's jazz pieces could be distinguished from those of the JMD.These three features could significantly predict both subjective valence and arousal ratings in the CAMS.Conclusions The distinctive acoustic features of healing music that have been identified and validated in this study have implications for the development of artificial intelligence models for identifying therapeutic music,particularly in contexts where access to professional expertise may be limited.This study contributes to the growing body of research exploring the potential of digital technologies for healthcare interventions.展开更多
In this paper,an integrated substrate gap waveguide(ISGW)filtering antenna is proposed at millimeter wave band,whose surface wave and spurious modes are simultaneously suppressed.A secondorder filtering response is ob...In this paper,an integrated substrate gap waveguide(ISGW)filtering antenna is proposed at millimeter wave band,whose surface wave and spurious modes are simultaneously suppressed.A secondorder filtering response is obtained through a coupling feeding scheme using one uniform impedance resonator(UIR)and two stepped-impedance resonators(SIRs).To increase the stopband width of the antenna,the spurious modes are suppressed by selecting the appropriate sizes of the ISGW unit cell.Furthermore,the ISGW is implemented to improve the radiation performance of the antenna by alleviating the propagation of surface wave.And an equivalent circuit is investigated to reveal the working principle of ISGW.To demonstrate this methodology,an ISGW filtering antenna operating at a center frequency of 25 GHz is designed,fabricated,and measured.The results show that the antenna achieves a stopband width of 1.6f0(center frequency),an out-of-band suppression level of 21 dB,and a peak realized gain of 8.5 dBi.展开更多
Past hydroclimatic conditions in southern China are poorly constrained owing to the lack of high-resolution marine-sediment records. In this study, we present high-resolution geochemical and grain-size records of mari...Past hydroclimatic conditions in southern China are poorly constrained owing to the lack of high-resolution marine-sediment records. In this study, we present high-resolution geochemical and grain-size records of marine sediments from the coastal shelf of the northern South China Sea to investigate regional hydrological variations.Results suggest a warm and humid climate during the interval 9 200–7 600 cal a BP, followed by a cold and dry climate from 7 600 cal a BP to 6 500 cal a BP, and progressive humidification during the period 6 500–6 200 cal a BP.A prominent hydrological anomaly occurred during 7 600–6 500 cal a BP. This abrupt event corresponds closely to tropical Pacific and interhemispheric temperature gradients, suggesting that moisture variations in southern China may have been driven by interhemispheric and zonal Pacific temperature gradients via modulation of the intensity and location of the West Pacific subtropical high.展开更多
[Objectives]This study was conducted to explore the feasibility of planting pepino(Solanum muricatum Ait.)in Qinghai Province,and to understand the cultivation quality and yield in various areas of Qinghai.[Methods]Wi...[Objectives]This study was conducted to explore the feasibility of planting pepino(Solanum muricatum Ait.)in Qinghai Province,and to understand the cultivation quality and yield in various areas of Qinghai.[Methods]With small fruit type of pepino as the material,four areas in eastern Qinghai were selected to determine the agronomic traits,yield and quality indexes of pepino.[Results]Under the same cultivation conditions,there were some differences in the cultivation status of pepino,but overall,pepino fruit had higher quality.Various physiological indexes were correlated with quality and yield.[Conclusions]This study clarified the specific cultivation situation of pepino in Qinghai Province,and evaluated the quality and yield of pepino,providing strong data support for the promotion and planting of pepino in various regions in the future.展开更多
State-of-the-art technologies such as the Internet of Things(IoT),cloud computing(CC),big data analytics(BDA),and artificial intelligence(AI)have greatly stimulated the development of smart manufacturing.An important ...State-of-the-art technologies such as the Internet of Things(IoT),cloud computing(CC),big data analytics(BDA),and artificial intelligence(AI)have greatly stimulated the development of smart manufacturing.An important prerequisite for smart manufacturing is cyber-physical integration,which is increasingly being embraced by manufacturers.As the preferred means of such integration,cyber-physical systems(CPS)and digital twins(DTs)have gained extensive attention from researchers and practitioners in industry.With feedback loops in which physical processes affect cyber parts and vice versa,CPS and DTs can endow manufacturing systems with greater efficiency,resilience,and intelligence.CPS and DTs share the same essential concepts of an intensive cyber-physical connection,real-time interaction,organization integration,and in-depth collaboration.However,CPS and DTs are not identical from many perspectives,including their origin,development,engineering practices,cyber-physical mapping,and core elements.In order to highlight the differences and correlation between them,this paper reviews and analyzes CPS and DTs from multiple perspectives.展开更多
Background:The chemoresistance of prostate cancer(PCa)is invariably associated with the aggressiveness and metastasis of this disease.New emerging evidence indicates that the epithelial-to-mesenchymal transition(EMT)m...Background:The chemoresistance of prostate cancer(PCa)is invariably associated with the aggressiveness and metastasis of this disease.New emerging evidence indicates that the epithelial-to-mesenchymal transition(EMT)may play pivotal roles in the development of chemoresistance and metastasis.As a hallmark of EMT,E-cadherin is suggested to be a key marker in the development of chemoresistance.However,the molecular mechanisms underlying PCa chemoresistance remain unclear.The current study aimed to explore the association between EMT and chemoresistance in PCa as well as whether changing the expression of E-cadherin would affect PCa chemoresistance.Methods:Parental PC3 and DU145 cells and their chemoresistant PC3-Tx R and DU145-Tx R cells were analyzed.PC3-Tx R and DU145-Tx R cells were transfected with E-cadherin-expressing lentivirus to overexpress E-cadherin;PC3 and DU145 cells were transfected with small interfering RNA to silence E-cadherin.Changes of EMT phenotype-related markers and signaling pathways were assessed by Western blotting and quantitative real-time polymerase chain reaction.Tumor cell migration,invasion,and colony formation were then evaluated by wound healing,transwell,and colony formation assays,respectively.The drug sensitivity was evaluated using MTS assay.Results:Chemoresistant PC3-Tx R and DU145-Tx R cells exhibited an invasive and metastatic phenotype that associated with EMT,including the down-regulation of E-cadherin and up-regulation of Vimentin,Snail,and N-cadherin,comparing with that of parental PC3 and DU145 cells.When E-cadherin was overexpressed in PC3-Tx R and DU145-Tx R cells,the expression of Vimentin and Claudin-1 was down-regulated,and tumor cell migration and invasion were inhibited.In particular,the sensitivity to paclitaxel was reactivated in E-cadherin-overexpressing PC3-Tx R and DU145-Tx R cells.When E-cadherin expression was silenced in parental PC3 and DU145 cells,the expression of Vimentin and Snail was up-regulated,and,particularly,the sensitivity to paclitaxel was decreased.Interestingly,Notch-1 expression was up-regulated in PC3-Tx R and DU145-Tx R cells,whereas the E-cadherin expression was down-regulated in these cells comparing with their parental cells.The use ofγ-secretase inhibitor,a Notch signaling pathway inhibitor,significantly increased the sensitivity of chemoresistant cells to paclitaxel.Conclusion:The down-regulation of E-cadherin enhances PCa chemoresistance via Notch signaling,and inhibiting the Notch signaling pathway may reverse PCa chemoresistance.展开更多
1.Introduction The aim of intelligent manufacturing is to establish flexible and adaptive manufacturing operations locally or globally by using integrated information technology(IT)and artificial intelligence(AI)that ...1.Introduction The aim of intelligent manufacturing is to establish flexible and adaptive manufacturing operations locally or globally by using integrated information technology(IT)and artificial intelligence(AI)that can combine advanced computing power with manufacturing equipment.Intelligent manufacturing depends on the timely acquisition,distribution,and utilization of real-time data from both machines and processes on manufacturing shop floors[1]and even across product life-cycles.Effective information sharing can improve production quality,reliability,resource efficiency,and the recyclability of end-of-life products.Intelligent manufacturing built on digitalization is also intended to be more sustainable and to contribute to the factories of the future.However,intelligent manufacturing depends extensively on AI.To better grasp the future of intelligent manufacturing,it is necessary to understand AI.This paper provides the author’s perspective on AI from intelligence science to intelligent manufacturing.展开更多
BACKGROUND: Tongxinluo has been clinically proven to be effective in improving memory and cognitive function in patients with post-stroke vascular dementia. Is the mechanism related to the deposition of beta-amyloid ...BACKGROUND: Tongxinluo has been clinically proven to be effective in improving memory and cognitive function in patients with post-stroke vascular dementia. Is the mechanism related to the deposition of beta-amyloid peptide (A β ) in hippocampus? OBJECTIVE: To observe the effect of Tongxinluo on cognitive impairment in a mouse model with vascular dementia and the changes of A β deposition and β -secretase 1 (BACE1) expression. DESIGN: Randomized controlled study. SETTING: State Key Laboratory of Pharmaceutical Biotechnology of Nanjing University and Affiliated Drum Tower Hospital of Nanjing University Medical School. MATERIALS: The experiment was carried out in the State Key Laboratory of Pharmaceutical Biotechnology of Nanjing University and Affiliated Drum Tower Hospital of Nanjing University Medical School from March 2006 to January 2007. A total of 36 healthy Kunming mice, 18 of each gender, were chosen. The study was conducted in accordance with the National Regulations of Experimental Animal Administration, and all animal experiments were approved by the Committee of Experimental Animal Administration of Nanjing University. Tongxinluo was provided by Shijiazhuang Yiling Pharmaceutical Co., Ltd. METHODS: All mice were randomly divided into 6 groups, including naive control (n=6), sham-operated control (n=6) and experimental groups treated with different doses of Tongxinluo (0.2, 0.4, and 0.6 g/kg/d; n=6 for each group) or vehicle (n=6). Five groups were subjected to bilateral common carotid arteries (2-VO) occlusion to produce a vascular dementia model (no occlusion was performed in sham-operated group). The mice in the Tongxinluo treatment groups were intragastricly administered daily with a Tongxinluo suspension (40 g/L in distilled water) at doses of 0.2, 0.4 or 0.6 g/kg/d from day 1 to day 30 post-surgery. The animals in vehicle, sham-operated and naive groups were administered an equal volume of distilled water. MAIN OUTCOME MEASURES: ①Escape latency time determined in all groups of mice before and after 2-VO occlusion by Morris water maze. ②Changes in BACEI mRNA expression in the hippocampi of mice among the six groups by RT-PCR assay, and BACEI and A β protein expression in the hippocampi of mice by Western blot. RESULTS: All 36 mice were involved in the final analysis.① No difference was detected in escape latency time to a hidden platform among all groups in water maze test before surgery (P 〉 0.05) At 30 days after 2-VO occlusion, the vehicle animals exhibited a significantly longer latency in finding the hidden platform compared to that of sham-operated and naive animals (P 〈 0.01). The prolonged escape latency was significantly reduced by oral administration of 0.4 g or 0.6 kg/day (P 〈 0.01, P 〈 0.05). BACEI mRNA and protein expression in vehicle animals were much higher than in sham-operated and naive animals (P 〈 0.01). The ischemia-induced increases in BACE1 mRNA and protein level were attenuated by all three doses of Tongxinluo treatment (P 〈 0.01), and the 0.4 g/kg/d treatment was the most effective. A β protein expression in vehicle animals after 2-VO occlusion were much higher than in sham-operated and naive animals (P 〈 0.01). 2-VO occlusion-induced A β generation was significantly attenuated by all doses of Tongxinluo treatment, with the most effective dose being 0.4 g/kg/d (P 〈 0.01). CONCLUSION: BACE1 mRNA levels and protein levels of BACEI and A β are reduced in the hippocampi of vascular dementia model mice by all three doses of Tongxinluo treatment, with the most effective dose being 0.4 g/kg/d. The results suggest that inhibition of post-ischemia BACEI expression and A β generation in brain might underlie Tongxinluo's effects in improving cognitive impairment.展开更多
Anthropogenic architectures have a significant impact to the environment. The Three Gorges Dam(TGD),as the largest dam in the world, is a typical example, and has influenced the mass anomalies transported by the flow ...Anthropogenic architectures have a significant impact to the environment. The Three Gorges Dam(TGD),as the largest dam in the world, is a typical example, and has influenced the mass anomalies transported by the flow downstream in the Yangtze River since June 2003. However, the evidence of TGD influence on downstream mass transportation is not documented. In this study, we analyze the monthly gravity solutions from GRACE to investigate the downstream mass variations of Yangtze River. From our results,the considerable mass loss is detected in the downstream of TGD. By comparing our estimations with the in situ water level data of TGD, we find that the mass variations derived from GRACE at Datong station decreases shortly after the impoundment of TGD. This confirms a strong connection between them.Furthermore, by comparing with the in situ sediment load and river discharge at Yichang and Datong gauging stations, we find that the sediment load data shows a similar mass loss signature while the river discharge of both stations has stay at a relative stable level. This indicates that further study is still needed to understand the mechanism better.展开更多
Ultrasonic extraction conditions of polyphenols from the needles of black pine(Pinus thunbergii) were optimized by single factors analysis and Box-Behnken experiment design. The results showed that both of ethanol con...Ultrasonic extraction conditions of polyphenols from the needles of black pine(Pinus thunbergii) were optimized by single factors analysis and Box-Behnken experiment design. The results showed that both of ethanol concentration and ultrasonic time had a significant effect on polyphenol extraction, and there was significant interaction between any two variables in the three parameters of ethanol concentration, ultrasonic temperature and ultrasonic time. The optimal parameters for polyphenol extraction were the ethanol concentration of 52.67%, ultrasonic temperature at 49.21 ℃and ultrasonic time of 30.76 min. Under these conditions, the actual content of polyphenols was close to the predicted value. Therefore, the process can be used to extract polyphenols from black pine needles.展开更多
1.Introduction The real question is not whether machines think but whether men do.Burrhus Frederic Skineer Dedicated manufacturing systems are fading out as future manufacturing(i.e.,Industry 4.0[1])demands ultra-flex...1.Introduction The real question is not whether machines think but whether men do.Burrhus Frederic Skineer Dedicated manufacturing systems are fading out as future manufacturing(i.e.,Industry 4.0[1])demands ultra-flexible smart manufacturing systems that can self-adapt to production process changes resulting from the varied batch sizes of personalized products[2–4].The manufacturing shop-floor can become an unstructured environment where manufacturing systems and processes change their configurations dynamically via adaptive near-real-time decision-making.One emerging trend to make manufacturing flexible and reconfigurable is to introduce collaborative machines that work alongside humans with high productivity[5-7].展开更多
Topography and soil factors are known to play crucial roles in the species composition of plant communities in subtropical evergreen-deciduous broadleaved mixed forests.In this study,we used a systematic quantitative ...Topography and soil factors are known to play crucial roles in the species composition of plant communities in subtropical evergreen-deciduous broadleaved mixed forests.In this study,we used a systematic quantitative approach to classify plant community types in the subtropical forests of Hubei Province(central China),and then quantified the relative contribution of drivers responsible for variation in species composition and diversity.We classified the subtropical forests in the study area into 12 community types.Of these,species diversity indices of three communities were significantly higher than those of others.In each community type,species richness,abundance,basal area and importance values of evergreen and deciduous species were different.In most community types,deciduous species richness was higher than that of evergreen species.Linear regression analysis showed that the dominant factors that affect species composition in each community type are elevation,slope,aspect,soil nitrogen content,and soil phosphorus content.Furthermore,structural equation modeling analysis showed that the majority of variance in species composition of plant communities can be explained by elevation,aspect,soil water content,litterfall,total nitrogen,and total phosphorus.Thus,the major factors that affect evergreen and deciduous species distribution across the 12 community types in subtropical evergreendeciduous broadleaved mixed forests include elevation,slope and aspect,soil total nitrogen content,soil total phosphorus content,soil available nitrogen content and soil available phosphorus content.展开更多
Nb-Tihot-rolled TRIP-assisted steel with high plasticity and appropriate volume percentage of retained austenite based on fine ferrite grain have been developed in the experiment. The test results showed that niobium ...Nb-Tihot-rolled TRIP-assisted steel with high plasticity and appropriate volume percentage of retained austenite based on fine ferrite grain have been developed in the experiment. The test results showed that niobium tend to exist in solution state in matrix with less precipitation, and niobium-titanium could be precipitated in form of (Nb, Ti)C or (Nb, Ti) (C, N), which play an important role in increasing yield strength (from 495 MPa to 610 MPa). Besides, the retained austenite had a positive effect on improving the plasticity by transformation into martensite during tensile deformation.展开更多
Multiple cropping index(MCI)is a very important indicator in crop production and agricultural intensification,which represents the utilizing degree of agriculture resources at time scale and the effective utilization ...Multiple cropping index(MCI)is a very important indicator in crop production and agricultural intensification,which represents the utilizing degree of agriculture resources at time scale and the effective utilization situation of arable land.The objective of this paper is monitoring multiple cropping index of Henan province of China according to the time series of MODIS(Moderate-Resolution Imaging Spectroradiometer)EVI(Enhanced Vegetation Index)after Savitzky-Golay filter processing from the year 2006 to 2011.The results revealed that this method could provide an effective way to monitor multiple cropping index,and the method of no additional authentication data is independent and reliable.The result was accurate and stable,the slope of linear regression of the multiple cropping index between the statistical results and the remote sensing results was 1.0136(R2=0.779).The precision of sample areas validation was 97.91%.Suggesting that the time series MODIS-EVI which after Savitzky-Golay filtering processed,could provide an effective way to extract spatial information of multiple cropping index for management department of agriculture.展开更多
基金supported by the National Natural Science Foundation of China(51975482)the China Scholarship Council.
文摘This paper addresses a multi-agent scheduling problem with uniform parallel machines owned by a resource agent and competing jobs with dynamic arrival times that belong to different consumer agents.All agents are self-interested and rational with the aim of maximizing their own objectives,resulting in intense resource competition among consumer agents and strategic behaviors of unwillingness to disclose private information.Within the context,a centralized scheduling approach is unfeasible,and a decentralized approach is considered to deal with the targeted problem.This study aims to generate a stable and collaborative solution with high social welfare while simultaneously accommodating consumer agents’preferences under incomplete information.For this purpose,a dynamic iterative auction-based approach based on a decentralized decision-making procedure is developed.In the proposed approach,a dynamic auction procedure is established for dynamic jobs participating in a realtime auction,and a straightforward and easy-to-implement bidding strategy without price is presented to reduce the complexity of bid determination.In addition,an adaptive Hungarian algorithm is applied to solve the winner determination problem efficiently.A theoretical analysis is conducted to prove that the proposed approach is individually rational and that the myopic bidding strategy is a weakly dominant strategy for consumer agents submitting bids.Extensive computational experiments demonstrate that the developed approach achieves high-quality solutions and exhibits considerable stability on largescale problems with numerous consumer agents and jobs.A further multi-agent scheduling problem considering multiple resource agents will be studied in future work.
基金supported by the National key research and development program of China(No.2021YFB2900401)by the National Natural Science Foundation of China(No.61861046)+1 种基金the key Natural Science Foundation of shenzhen(No.JCYJ20220818102209020)the key research and development program of shenzhen(No.ZDSYS20210623091807023)。
文摘A novel dual-band ISGW cavity filter with enhanced frequency selectivity is proposed in this paper by utilizing a multi-mode coupling topology.Its cavity is designed to control the number of modes,and then the ports are determined by analyzing the coupling relationship between these selected modes.By synthesizing the coupling matrix of the filter,a nonresonating node(NRN)structure is introduced to flexibly tune the frequency of modes,which gets a dualband and quad-band filtering response from a tri-band filter no the NRN.Furthermore,a frequency selective surface(FSS)has been newly designed as the upper surface of the cavity,which significantly improves the bad out-of-band suppression and frequency selectivity that often exists in most traditional cavity filter designs and measurements.The results show that its two center frequencies are f01=27.50 GHz and f02=32.92GHz,respectively.Compared with the dual-band filter that there is no the FSS metasurface,the out-of-band suppression level is improved from measured 5 dB to18 dB,and its finite transmission zero(FTZ)numbers is increased from measured 1 to 4 between the two designed bands.Compared with the tri-band and quadband filter,its passband bandwidth is expanded from measured 1.17%,1.14%,and 1.13% or 1.31%,1.50%,0.56%,and 0.57% to 1.71% and 1.87%.In addition,the filter has compact,small,and lightweight characteristics.
基金the National Key Research and Development Program of China (2021YFB1715700)the National Natural Science Foundation of China (62103046)+2 种基金the Beijing Institute of Technology Research Fund Program for Young Scholarsthe Chinese Academy of Sciences and University of Chinese Academy of Sciences for funding the research (Y92902MED2, E1E90808, and E0E90804)the Fundamental Research Funds for the Central Universities (E1E40805)。
基金This research was supported by the National Key Research and Development Program(2019YFD1001900,2022YFE0100900)the Natural Science Foundation of Hubei Province(2019CFA017).
文摘Tomato(Solanum lycopersicum)is among the most important vegetables across the world,but cold stress usually affects its yield and quality.The wild tomato species Solanum habrochaites is commonly utilized as rootstock for enhancing resistance against abiotic stresses in cultivated tomato,especially cold resistance.However,the underlying molecular mechanism remains unclear.In this research,we confirmed that S.habrochaites rootstock can improve the cold tolerance of cultivated tomato scions,as revealed by growth,physiological,and biochemical indicators.Furthermore,transcriptome profiling indicated significant differences in the scion of homo-and heterografted seedlings,including substantial changes in jasmonic acid(JA)biosynthesis and signaling,which were validated by RT–qPCR analysis.S.habrochaites plants had a high basal level of jasmonate,and cold stress caused a greater amount of active JA-isoleucine in S.habrochaites heterografts.Moreover,exogenous JA enhanced while JA inhibitor decreased the cold tolerance of tomato grafts.The JA biosynthesis-defective mutant spr8 also showed increased sensitivity to cold stress.All of these results demonstrated the significance of JA in the cold tolerance of grafted tomato seedlings with S.habrochaites rootstock,suggesting a future direction for the characterization of the natural variation involved in S.habrochaites rootstock-mediated cold tolerance.
基金supported by the National Natural Science Foundation of China(62101324)the Shanghai Sailing Program(20YF1442000)+2 种基金the Academic Leader of the Health Discipline of Shanghai Municipal Health Commission(2022XD025)the Qihang Program of Shanghai Mental Health Center(2020-QH-01)the Hospital Program of Shanghai Mental Health Center(2020-YJ01)。
文摘S Background Music therapy is a promising complementary intervention for addressing various mental health conditions.Despite evidence of the beneficial effects of music,the acoustic features that make music effective in therapeutic contexts remain elusive.Aims This study aimed to identify and validate distinctive acoustic features of healing music.Methods We constructed a healing music dataset(HMD)based on nominations from related professionals and extracted 370 acoustic features.Healing-distinctive acoustic features were identified as those that were(1)independent from genre within the HMD,(2)significantly different from music pieces in a classical music dataset(CMD)and(3)similar to pieces in a five-element music dataset(FEMD).We validated the identified features by comparing jazz pieces in the HMD with a jazz music dataset(JMD).We also examined the emotional properties of the features in a Chinese affective music system(CAMS).Results The HMD comprised 165 pieces.Among all the acoustic features,74.59%shared commonalities across genres,and 26.22%significantly differed between the HMD classical pieces and the CMD.The equivalence test showed that the HMD and FEMD did not differ significantly in 9.46%of the features.The potential healing-distinctive acoustic features were identified as the standard deviation of the roughness,mean and period entropy of the third coefficient of the mel-frequency cepstral coefficients.In a three-dimensional space defined by these features,HMD's jazz pieces could be distinguished from those of the JMD.These three features could significantly predict both subjective valence and arousal ratings in the CAMS.Conclusions The distinctive acoustic features of healing music that have been identified and validated in this study have implications for the development of artificial intelligence models for identifying therapeutic music,particularly in contexts where access to professional expertise may be limited.This study contributes to the growing body of research exploring the potential of digital technologies for healthcare interventions.
基金This work was supported by the National Key research and development program of China(No.2021YFB 2900401)the national natural science foundation of China(No.62361057,No.61861046)+1 种基金the key natural science foundation of Shenzhen(No.JCYJ20220818102209020)the key research and development program of Shenzhen(No.ZDSYS20210623091807023).
文摘In this paper,an integrated substrate gap waveguide(ISGW)filtering antenna is proposed at millimeter wave band,whose surface wave and spurious modes are simultaneously suppressed.A secondorder filtering response is obtained through a coupling feeding scheme using one uniform impedance resonator(UIR)and two stepped-impedance resonators(SIRs).To increase the stopband width of the antenna,the spurious modes are suppressed by selecting the appropriate sizes of the ISGW unit cell.Furthermore,the ISGW is implemented to improve the radiation performance of the antenna by alleviating the propagation of surface wave.And an equivalent circuit is investigated to reveal the working principle of ISGW.To demonstrate this methodology,an ISGW filtering antenna operating at a center frequency of 25 GHz is designed,fabricated,and measured.The results show that the antenna achieves a stopband width of 1.6f0(center frequency),an out-of-band suppression level of 21 dB,and a peak realized gain of 8.5 dBi.
基金The National Natural Science Foundation of China under contract No. 42001078the College Student Innovation and Training Project of Guangdong Ocean University under contract No. S20211056601+3 种基金the Guangdong Natural Science Foundation of China under contract No. 2021A1515011157the Innovative Team Project of Guangdong Universities under contract No.2019KCXTF021the First-class Discipline Plan of Guangdong Province under contract Nos 080503032101 and 231420003the Marine Science Research Team Project of Guangdong Ocean University under contract No. 002026002004。
文摘Past hydroclimatic conditions in southern China are poorly constrained owing to the lack of high-resolution marine-sediment records. In this study, we present high-resolution geochemical and grain-size records of marine sediments from the coastal shelf of the northern South China Sea to investigate regional hydrological variations.Results suggest a warm and humid climate during the interval 9 200–7 600 cal a BP, followed by a cold and dry climate from 7 600 cal a BP to 6 500 cal a BP, and progressive humidification during the period 6 500–6 200 cal a BP.A prominent hydrological anomaly occurred during 7 600–6 500 cal a BP. This abrupt event corresponds closely to tropical Pacific and interhemispheric temperature gradients, suggesting that moisture variations in southern China may have been driven by interhemispheric and zonal Pacific temperature gradients via modulation of the intensity and location of the West Pacific subtropical high.
基金Supported by Science and Technology Demonstration of Rural Revitalization in Jianzha County(2023-NK-X01)。
文摘[Objectives]This study was conducted to explore the feasibility of planting pepino(Solanum muricatum Ait.)in Qinghai Province,and to understand the cultivation quality and yield in various areas of Qinghai.[Methods]With small fruit type of pepino as the material,four areas in eastern Qinghai were selected to determine the agronomic traits,yield and quality indexes of pepino.[Results]Under the same cultivation conditions,there were some differences in the cultivation status of pepino,but overall,pepino fruit had higher quality.Various physiological indexes were correlated with quality and yield.[Conclusions]This study clarified the specific cultivation situation of pepino in Qinghai Province,and evaluated the quality and yield of pepino,providing strong data support for the promotion and planting of pepino in various regions in the future.
基金This work is financially supported by the National Key Research and Development Program of China(2016YFB1101700)the National Natural Science Foundation of China(51875030)the Academic Excellence Foundation of BUAA for PhD Students.
文摘State-of-the-art technologies such as the Internet of Things(IoT),cloud computing(CC),big data analytics(BDA),and artificial intelligence(AI)have greatly stimulated the development of smart manufacturing.An important prerequisite for smart manufacturing is cyber-physical integration,which is increasingly being embraced by manufacturers.As the preferred means of such integration,cyber-physical systems(CPS)and digital twins(DTs)have gained extensive attention from researchers and practitioners in industry.With feedback loops in which physical processes affect cyber parts and vice versa,CPS and DTs can endow manufacturing systems with greater efficiency,resilience,and intelligence.CPS and DTs share the same essential concepts of an intensive cyber-physical connection,real-time interaction,organization integration,and in-depth collaboration.However,CPS and DTs are not identical from many perspectives,including their origin,development,engineering practices,cyber-physical mapping,and core elements.In order to highlight the differences and correlation between them,this paper reviews and analyzes CPS and DTs from multiple perspectives.
基金supported by National Natural Science Foundation of China(NSFC)Key Project(No.81130046)NSFC(Nos.81272415 and 81171993)+1 种基金Guangxi Key Projects(No.2013GXNSFEA053004)Youth Science Foundation of Guangxi Medical University(No.GXMUYSF201539)
文摘Background:The chemoresistance of prostate cancer(PCa)is invariably associated with the aggressiveness and metastasis of this disease.New emerging evidence indicates that the epithelial-to-mesenchymal transition(EMT)may play pivotal roles in the development of chemoresistance and metastasis.As a hallmark of EMT,E-cadherin is suggested to be a key marker in the development of chemoresistance.However,the molecular mechanisms underlying PCa chemoresistance remain unclear.The current study aimed to explore the association between EMT and chemoresistance in PCa as well as whether changing the expression of E-cadherin would affect PCa chemoresistance.Methods:Parental PC3 and DU145 cells and their chemoresistant PC3-Tx R and DU145-Tx R cells were analyzed.PC3-Tx R and DU145-Tx R cells were transfected with E-cadherin-expressing lentivirus to overexpress E-cadherin;PC3 and DU145 cells were transfected with small interfering RNA to silence E-cadherin.Changes of EMT phenotype-related markers and signaling pathways were assessed by Western blotting and quantitative real-time polymerase chain reaction.Tumor cell migration,invasion,and colony formation were then evaluated by wound healing,transwell,and colony formation assays,respectively.The drug sensitivity was evaluated using MTS assay.Results:Chemoresistant PC3-Tx R and DU145-Tx R cells exhibited an invasive and metastatic phenotype that associated with EMT,including the down-regulation of E-cadherin and up-regulation of Vimentin,Snail,and N-cadherin,comparing with that of parental PC3 and DU145 cells.When E-cadherin was overexpressed in PC3-Tx R and DU145-Tx R cells,the expression of Vimentin and Claudin-1 was down-regulated,and tumor cell migration and invasion were inhibited.In particular,the sensitivity to paclitaxel was reactivated in E-cadherin-overexpressing PC3-Tx R and DU145-Tx R cells.When E-cadherin expression was silenced in parental PC3 and DU145 cells,the expression of Vimentin and Snail was up-regulated,and,particularly,the sensitivity to paclitaxel was decreased.Interestingly,Notch-1 expression was up-regulated in PC3-Tx R and DU145-Tx R cells,whereas the E-cadherin expression was down-regulated in these cells comparing with their parental cells.The use ofγ-secretase inhibitor,a Notch signaling pathway inhibitor,significantly increased the sensitivity of chemoresistant cells to paclitaxel.Conclusion:The down-regulation of E-cadherin enhances PCa chemoresistance via Notch signaling,and inhibiting the Notch signaling pathway may reverse PCa chemoresistance.
文摘1.Introduction The aim of intelligent manufacturing is to establish flexible and adaptive manufacturing operations locally or globally by using integrated information technology(IT)and artificial intelligence(AI)that can combine advanced computing power with manufacturing equipment.Intelligent manufacturing depends on the timely acquisition,distribution,and utilization of real-time data from both machines and processes on manufacturing shop floors[1]and even across product life-cycles.Effective information sharing can improve production quality,reliability,resource efficiency,and the recyclability of end-of-life products.Intelligent manufacturing built on digitalization is also intended to be more sustainable and to contribute to the factories of the future.However,intelligent manufacturing depends extensively on AI.To better grasp the future of intelligent manufacturing,it is necessary to understand AI.This paper provides the author’s perspective on AI from intelligence science to intelligent manufacturing.
基金the NatureScience Foundation of Jiangsu Province, No.BK2005002the International Cooperation Program and talented manprogram of Jiangsu Provinceof China, No. BZ2006045,06-B-002
文摘BACKGROUND: Tongxinluo has been clinically proven to be effective in improving memory and cognitive function in patients with post-stroke vascular dementia. Is the mechanism related to the deposition of beta-amyloid peptide (A β ) in hippocampus? OBJECTIVE: To observe the effect of Tongxinluo on cognitive impairment in a mouse model with vascular dementia and the changes of A β deposition and β -secretase 1 (BACE1) expression. DESIGN: Randomized controlled study. SETTING: State Key Laboratory of Pharmaceutical Biotechnology of Nanjing University and Affiliated Drum Tower Hospital of Nanjing University Medical School. MATERIALS: The experiment was carried out in the State Key Laboratory of Pharmaceutical Biotechnology of Nanjing University and Affiliated Drum Tower Hospital of Nanjing University Medical School from March 2006 to January 2007. A total of 36 healthy Kunming mice, 18 of each gender, were chosen. The study was conducted in accordance with the National Regulations of Experimental Animal Administration, and all animal experiments were approved by the Committee of Experimental Animal Administration of Nanjing University. Tongxinluo was provided by Shijiazhuang Yiling Pharmaceutical Co., Ltd. METHODS: All mice were randomly divided into 6 groups, including naive control (n=6), sham-operated control (n=6) and experimental groups treated with different doses of Tongxinluo (0.2, 0.4, and 0.6 g/kg/d; n=6 for each group) or vehicle (n=6). Five groups were subjected to bilateral common carotid arteries (2-VO) occlusion to produce a vascular dementia model (no occlusion was performed in sham-operated group). The mice in the Tongxinluo treatment groups were intragastricly administered daily with a Tongxinluo suspension (40 g/L in distilled water) at doses of 0.2, 0.4 or 0.6 g/kg/d from day 1 to day 30 post-surgery. The animals in vehicle, sham-operated and naive groups were administered an equal volume of distilled water. MAIN OUTCOME MEASURES: ①Escape latency time determined in all groups of mice before and after 2-VO occlusion by Morris water maze. ②Changes in BACEI mRNA expression in the hippocampi of mice among the six groups by RT-PCR assay, and BACEI and A β protein expression in the hippocampi of mice by Western blot. RESULTS: All 36 mice were involved in the final analysis.① No difference was detected in escape latency time to a hidden platform among all groups in water maze test before surgery (P 〉 0.05) At 30 days after 2-VO occlusion, the vehicle animals exhibited a significantly longer latency in finding the hidden platform compared to that of sham-operated and naive animals (P 〈 0.01). The prolonged escape latency was significantly reduced by oral administration of 0.4 g or 0.6 kg/day (P 〈 0.01, P 〈 0.05). BACEI mRNA and protein expression in vehicle animals were much higher than in sham-operated and naive animals (P 〈 0.01). The ischemia-induced increases in BACE1 mRNA and protein level were attenuated by all three doses of Tongxinluo treatment (P 〈 0.01), and the 0.4 g/kg/d treatment was the most effective. A β protein expression in vehicle animals after 2-VO occlusion were much higher than in sham-operated and naive animals (P 〈 0.01). 2-VO occlusion-induced A β generation was significantly attenuated by all doses of Tongxinluo treatment, with the most effective dose being 0.4 g/kg/d (P 〈 0.01). CONCLUSION: BACE1 mRNA levels and protein levels of BACEI and A β are reduced in the hippocampi of vascular dementia model mice by all three doses of Tongxinluo treatment, with the most effective dose being 0.4 g/kg/d. The results suggest that inhibition of post-ischemia BACEI expression and A β generation in brain might underlie Tongxinluo's effects in improving cognitive impairment.
基金support from the National Natural Science Foundation of China (41774094, 41704013 and 51809250)the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB23030100)
文摘Anthropogenic architectures have a significant impact to the environment. The Three Gorges Dam(TGD),as the largest dam in the world, is a typical example, and has influenced the mass anomalies transported by the flow downstream in the Yangtze River since June 2003. However, the evidence of TGD influence on downstream mass transportation is not documented. In this study, we analyze the monthly gravity solutions from GRACE to investigate the downstream mass variations of Yangtze River. From our results,the considerable mass loss is detected in the downstream of TGD. By comparing our estimations with the in situ water level data of TGD, we find that the mass variations derived from GRACE at Datong station decreases shortly after the impoundment of TGD. This confirms a strong connection between them.Furthermore, by comparing with the in situ sediment load and river discharge at Yichang and Datong gauging stations, we find that the sediment load data shows a similar mass loss signature while the river discharge of both stations has stay at a relative stable level. This indicates that further study is still needed to understand the mechanism better.
基金Supported by the Policy Guidance Plan of Jiangsu Province(Production and Research Cooperation)(BY2016061-27)National Spark Program(2015GA690284)College Students' Practice Innovation Training Program of Jiangsu Province(201711049094X,201811049048X)
文摘Ultrasonic extraction conditions of polyphenols from the needles of black pine(Pinus thunbergii) were optimized by single factors analysis and Box-Behnken experiment design. The results showed that both of ethanol concentration and ultrasonic time had a significant effect on polyphenol extraction, and there was significant interaction between any two variables in the three parameters of ethanol concentration, ultrasonic temperature and ultrasonic time. The optimal parameters for polyphenol extraction were the ethanol concentration of 52.67%, ultrasonic temperature at 49.21 ℃and ultrasonic time of 30.76 min. Under these conditions, the actual content of polyphenols was close to the predicted value. Therefore, the process can be used to extract polyphenols from black pine needles.
基金supported by grants from The University of Auckland FRDF New Staff Research Fund(3720540).
文摘1.Introduction The real question is not whether machines think but whether men do.Burrhus Frederic Skineer Dedicated manufacturing systems are fading out as future manufacturing(i.e.,Industry 4.0[1])demands ultra-flexible smart manufacturing systems that can self-adapt to production process changes resulting from the varied batch sizes of personalized products[2–4].The manufacturing shop-floor can become an unstructured environment where manufacturing systems and processes change their configurations dynamically via adaptive near-real-time decision-making.One emerging trend to make manufacturing flexible and reconfigurable is to introduce collaborative machines that work alongside humans with high productivity[5-7].
基金the National Natural Science Foundation of China(51809250)Hubei Provincial Natural Science Foundation for Innovation Groups(No.2019CFA019).
文摘Topography and soil factors are known to play crucial roles in the species composition of plant communities in subtropical evergreen-deciduous broadleaved mixed forests.In this study,we used a systematic quantitative approach to classify plant community types in the subtropical forests of Hubei Province(central China),and then quantified the relative contribution of drivers responsible for variation in species composition and diversity.We classified the subtropical forests in the study area into 12 community types.Of these,species diversity indices of three communities were significantly higher than those of others.In each community type,species richness,abundance,basal area and importance values of evergreen and deciduous species were different.In most community types,deciduous species richness was higher than that of evergreen species.Linear regression analysis showed that the dominant factors that affect species composition in each community type are elevation,slope,aspect,soil nitrogen content,and soil phosphorus content.Furthermore,structural equation modeling analysis showed that the majority of variance in species composition of plant communities can be explained by elevation,aspect,soil water content,litterfall,total nitrogen,and total phosphorus.Thus,the major factors that affect evergreen and deciduous species distribution across the 12 community types in subtropical evergreendeciduous broadleaved mixed forests include elevation,slope and aspect,soil total nitrogen content,soil total phosphorus content,soil available nitrogen content and soil available phosphorus content.
文摘Nb-Tihot-rolled TRIP-assisted steel with high plasticity and appropriate volume percentage of retained austenite based on fine ferrite grain have been developed in the experiment. The test results showed that niobium tend to exist in solution state in matrix with less precipitation, and niobium-titanium could be precipitated in form of (Nb, Ti)C or (Nb, Ti) (C, N), which play an important role in increasing yield strength (from 495 MPa to 610 MPa). Besides, the retained austenite had a positive effect on improving the plasticity by transformation into martensite during tensile deformation.
基金This work is supported by National Natural Science Foundation of China(Project No.518092509)Science and Technology Service Network Initiative(STS)of the Chinese Academy of Sciences(Project No.KFJ-STS-ZDTP-009)Open Foundation of The Ministry of Water Resources Key Laboratory of Soil and Water Loss Process and Control in the Loess Plateau(Project No.2017004).
文摘Multiple cropping index(MCI)is a very important indicator in crop production and agricultural intensification,which represents the utilizing degree of agriculture resources at time scale and the effective utilization situation of arable land.The objective of this paper is monitoring multiple cropping index of Henan province of China according to the time series of MODIS(Moderate-Resolution Imaging Spectroradiometer)EVI(Enhanced Vegetation Index)after Savitzky-Golay filter processing from the year 2006 to 2011.The results revealed that this method could provide an effective way to monitor multiple cropping index,and the method of no additional authentication data is independent and reliable.The result was accurate and stable,the slope of linear regression of the multiple cropping index between the statistical results and the remote sensing results was 1.0136(R2=0.779).The precision of sample areas validation was 97.91%.Suggesting that the time series MODIS-EVI which after Savitzky-Golay filtering processed,could provide an effective way to extract spatial information of multiple cropping index for management department of agriculture.