期刊文献+
共找到9篇文章
< 1 >
每页显示 20 50 100
A novel flexible nerve guidance conduit promotes nerve regeneration while providing excellent mechanical properties
1
作者 Tong Li Quhan Cheng +11 位作者 Jingai Zhang Boxin Liu Yu Shi Haoxue Wang lijie huang Su Zhang Ruixin Zhang Song Wang Guangxu Lu Peifu Tang Zhongyang Liu Kai Wang 《Neural Regeneration Research》 SCIE CAS 2025年第7期2084-2094,共11页
Autografting is the gold standard for surgical repair of nerve defects>5 mm in length;however,autografting is associated with potential complications at the nerve donor site.As an alternative,nerve guidance conduit... Autografting is the gold standard for surgical repair of nerve defects>5 mm in length;however,autografting is associated with potential complications at the nerve donor site.As an alternative,nerve guidance conduits may be used.The ideal conduit should be flexible,resistant to kinks and lumen collapse,and provide physical cues to guide nerve regeneration.We designed a novel flexible conduit using electrospinning technology to create fibers on the innermost surface of the nerve guidance conduit and employed melt spinning to align them.Subsequently,we prepared disordered electrospun fibers outside the aligned fibers and helical melt-spun fibers on the outer wall of the electrospun fiber lumen.The presence of aligned fibers on the inner surface can promote the extension of nerve cells along the fibers.The helical melt-spun fibers on the outer surface can enhance resistance to kinking and compression and provide stability.Our novel conduit promoted nerve regeneration and functional recovery in a rat sciatic nerve defect model,suggesting that it has potential for clinical use in human nerve injuries. 展开更多
关键词 aligned fibers anti-kinking helical fibers nerve guidance conduit nerve regeneration peripheral nerve injury topological guidance
下载PDF
Brain Encoding and Decoding in fMRI with Bidirectional Deep Generative Models 被引量:2
2
作者 Changde Du Jinpeng Li +1 位作者 lijie huang Huiguang He 《Engineering》 SCIE EI 2019年第5期948-953,共6页
Brain encoding and decoding via functional magnetic resonance imaging(fMRI)are two important aspects of visual perception neuroscience.Although previous researchers have made significant advances in brain encoding and... Brain encoding and decoding via functional magnetic resonance imaging(fMRI)are two important aspects of visual perception neuroscience.Although previous researchers have made significant advances in brain encoding and decoding models,existing methods still require improvement using advanced machine learning techniques.For example,traditional methods usually build the encoding and decoding models separately,and are prone to overfitting on a small dataset.In fact,effectively unifying the encoding and decoding procedures may allow for more accurate predictions.In this paper,we first review the existing encoding and decoding methods and discuss the potential advantages of a“bidirectional”modeling strategy.Next,we show that there are correspondences between deep neural networks and human visual streams in terms of the architecture and computational rules.Furthermore,deep generative models(e.g.,variational autoencoders(VAEs)and generative adversarial networks(GANs))have produced promising results in studies on brain encoding and decoding.Finally,we propose that the dual learning method,which was originally designed for machine translation tasks,could help to improve the performance of encoding and decoding models by leveraging large-scale unpaired data. 展开更多
关键词 BRAIN encoding and DECODING Functional magnetic resonance imaging DEEP neural networks DEEP GENERATIVE models Dual learning
下载PDF
Four-inch high quality crack-free AlN layer grown on a hightemperature annealed AlN template by MOCVD 被引量:2
3
作者 Shangfeng Liu Ye Yuan +13 位作者 Shanshan Sheng Tao Wang Jin Zhang lijie huang Xiaohu Zhang Junjie Kang Wei Luo Yongde Li Houjin Wang Weiyun Wang Chuan Xiao Yaoping Liu Qi Wang Xinqiang Wang 《Journal of Semiconductors》 EI CAS CSCD 2021年第12期57-61,共5页
In this work,based on physical vapor deposition and high-temperature annealing(HTA),the 4-inch crack-free high-quality AlN template is initialized.Benefiting from the crystal recrystallization during the HTA process,t... In this work,based on physical vapor deposition and high-temperature annealing(HTA),the 4-inch crack-free high-quality AlN template is initialized.Benefiting from the crystal recrystallization during the HTA process,the FWHMs of X-ray rocking curves for(002)and(102)planes are encouragingly decreased to 62 and 282 arcsec,respectively.On such an AlN template,an ultra-thin AlN with a thickness of~700 nm grown by MOCVD shows good quality,thus avoiding the epitaxial lateral over-growth(ELOG)process in which 3-4μm AlN is essential to obtain the flat surface and high crystalline quality.The 4-inch scaled wafer provides an avenue to match UVC-LED with the fabrication process of traditional GaN-based blue LED,therefore significantly improving yields and decreasing cost. 展开更多
关键词 ALN high temperature annealing MOCVD
下载PDF
Structure and luminescence of α-plane GaN on γ-plane sapphire substrate modified by Si implantation
4
作者 lijie huang Lin Li +13 位作者 Zhen Shang Mao Wang Junjie Kang Wei Luo Zhiwen Liang Slawomir Prucnal Ulrich Kentsch Yanda Ji Fabi Zhang Qi Wang Ye Yuan Qian Sun Shengqiang Zhou Xinqiang Wang 《Chinese Physics B》 SCIE EI CAS CSCD 2021年第5期63-68,共6页
We show the structural and optical properties of non-polar a-plane GaN epitaxial films modified by Si ion implantation.Upon gradually raising Si fluences from 5×10^(13)cm^(-2)to 5×10^(15)cm^(-2),the n-type d... We show the structural and optical properties of non-polar a-plane GaN epitaxial films modified by Si ion implantation.Upon gradually raising Si fluences from 5×10^(13)cm^(-2)to 5×10^(15)cm^(-2),the n-type dopant concentration gradually increases from 4.6×10^(18)cm^(-2)to 4.5×10^(20)cm^(-2),while the generated vacancy density accordingly raises from 3.7×10^(13)cm^(-2)to 3.8×10^(15)cm^(-2).Moreover,despite that the implantation enhances structural disorder,the epitaxial structure of the implanted region is still well preserved which is confirmed by Rutherford backscattering channeling spectrometry measurements.The monotonical uniaxial lattice expansion along the a direction(out-of-plane direction)is observed as a function of fluences till 1×10^(15)cm^(-2),which ceases at the overdose of 5×10^(15)cm^(-2)due to the partial amorphization in the surface region.Upon raising irradiation dose,a yellow emission in the as-grown sample is gradually quenched,probably due to the irradiation-induced generation of non-radiative recombination centers. 展开更多
关键词 ion implantation GAN DEFECTS
下载PDF
觉知压力在护理实习生自我导向学习能力与择业效能感间的中介作用 被引量:26
5
作者 程秋泓 张红梅 +5 位作者 张盼盼 石志宜 黄丽洁 郭瑞 张钦 蒋秋焕 《中华护理杂志》 CSCD 北大核心 2019年第6期908-912,共5页
目的评估护理实习生自我导向学习能力、觉知压力与择业效能感之间的关系。方法采用择业效能感量表、自我导向学习能力量表和觉知压力量表,对河南省某三级甲等医院的923名护理实习生进行调查。结果自我导向学习能力对择业效能感具有直接... 目的评估护理实习生自我导向学习能力、觉知压力与择业效能感之间的关系。方法采用择业效能感量表、自我导向学习能力量表和觉知压力量表,对河南省某三级甲等医院的923名护理实习生进行调查。结果自我导向学习能力对择业效能感具有直接正向预测作用(r=0.503,P<0.01),觉知压力是自我导向学习能力与择业效能感的中介变量,中介效应占总效应的21.60%。结论临床护理教育者应重视护理实习生临床实习期自我导向学习能力的培养、压力的监测与干预,以增强其择业信心,提高择业效能感。 展开更多
关键词 护理实习生 择业效能感 自我导向学习能力 觉知压力 中介作用
原文传递
脉冲激光对选区激光熔融Ti6Al4V钛合金表面质量及变形量的影响 被引量:6
6
作者 郭庆丰 张政 +1 位作者 黄李杰 林文雄 《激光与光电子学进展》 CSCD 北大核心 2020年第21期204-211,共8页
分别采用脉冲激光和连续激光作为选区激光熔融工艺的热源,研究了不同激光平均功率和脉冲占空比对Ti6Al4V钛合金试样致密度、表面粗糙度和显微组织等参数的影响。实验结果表明,相比连续激光,脉冲占空比为60%~70%的脉冲激光可以显著提高... 分别采用脉冲激光和连续激光作为选区激光熔融工艺的热源,研究了不同激光平均功率和脉冲占空比对Ti6Al4V钛合金试样致密度、表面粗糙度和显微组织等参数的影响。实验结果表明,相比连续激光,脉冲占空比为60%~70%的脉冲激光可以显著提高试样的表面质量,表面粗糙度最低为3.6μm,使试样晶粒宽度由(1.14±0.23)μm减小到(0.85±0.18)μm,且能有效消除连续激光加工时因热应力累积导致的翘曲变形。 展开更多
关键词 激光器与激光光学 激光材料加工 选区激光熔融工艺 脉冲激光 致密度 表面粗糙度 变形量
原文传递
表面具有非交联结构糖蛋白识别位点的分子印迹聚合物微球的可控制备 被引量:1
7
作者 黄丽洁 郑从光 张会旗 《科学通报》 EI CAS CSCD 北大核心 2019年第13期1407-1417,共11页
将原子转移自由基沉淀聚合技术、表面锚定糖蛋白策略及表面引发的可控自由基聚合方法相结合,发展了一种简便高效地制备表面具有(由亲水性聚合物刷形成的)非交联结构糖蛋白(卵清蛋白(OVA))识别位点的分子印迹聚合物(MIP)微球的新方法.对... 将原子转移自由基沉淀聚合技术、表面锚定糖蛋白策略及表面引发的可控自由基聚合方法相结合,发展了一种简便高效地制备表面具有(由亲水性聚合物刷形成的)非交联结构糖蛋白(卵清蛋白(OVA))识别位点的分子印迹聚合物(MIP)微球的新方法.对所得具有不同非交联印迹壳层厚度的MIP微球的形貌、化学结构、表面亲水性及模板吸附性能进行了系统研究.结果表明,该方法可高效制备在水溶液中对OVA具有优异识别性能的MIPs.随着MIP微球表面亲水性聚合物刷的引入,其表面亲水性与水相分散稳定性明显提高;同时亲水性聚合物刷的长度亦对MIPs的模板吸附性能有显著影响:只有当亲水性聚合物刷长度与OVA粒径加上微球表面修饰的苯硼酸基的总长度相近时, MIP微球对OVA的吸附容量与专一性吸附方能达到最优;此外,该MIP还具有良好的OVA选择性. 展开更多
关键词 分子印迹聚合物 糖蛋白 表面锚定 可控表面印迹 亲水性聚合物刷 未交联的印迹位点
原文传递
A novel antibacterial biomaterial mesh coated by chitosan and tigecycline for pelvic floor repair and its biological performance 被引量:2
8
作者 Changyan Liang You Ling +2 位作者 Feng Wei lijie huang Xiaomao Li 《Regenerative Biomaterials》 SCIE 2020年第5期483-490,共8页
The biomaterials composed of mammalian extracellular matrix(ECM)have a great potential in pelvic floor tissue repair and functional reconstruction.However,bacterial infection does cause great damage to the repair func... The biomaterials composed of mammalian extracellular matrix(ECM)have a great potential in pelvic floor tissue repair and functional reconstruction.However,bacterial infection does cause great damage to the repair function of biomaterials which is the major problem in clinical utilization.Therefore,the development of biological materials with antimicrobial effect is of great clinical significance for pelvic floor repair.Chitosan/tigecycline(CS/TGC)antibacterial biofilm was prepared by coating CS/TGC nanoparticles on mammalian-derived ECM.Infrared spectroscopy,scanning electron microscopy,bacteriostasis circle assay and static dialysis methods were used to characterize the membrane.MTS assay kit and DAPI fluorescence staining were used to evaluate cytotoxicity and cell adhesion.The biocompatibility was assessed by subabdominal implantation model in goats.Subcutaneous antimicrobial test in rabbit back was used to evaluate the antimicrobial and repairing effects on the infected wounds in vivo.Infrared spectroscopy showed that the composite coating had been successfully modified.The antibacterial membrane retained the main structure of ECM multilayer fibers.In vitro release of biomaterials showed sustained release and stability.In vivo studies showed that the antibacterial biological membrane had low cytotoxicity,fast degradation,good compatibility,anti-infection and excellent repair ability. 展开更多
关键词 chitosan nanoparticles TIGECYCLINE extracellular matrix antibacterial membrane pelvic floor repair
原文传递
Artificial intelligence-based ultrasound imaging technologies for hepatic diseases 被引量:1
9
作者 Longfei Ma Rui Wang +6 位作者 Qiong He lijie huang Xingyue Wei Xu Lu Yanan Du Jianwen Luo Hongen Liao 《iLIVER》 2022年第4期252-264,共13页
Ultrasound(US)imaging is a non-invasive,real-time,economical,and convenient imaging modality that has been widely used in diagnosing and treating hepatic diseases.Artificial intelligence(AI)technology can predict or m... Ultrasound(US)imaging is a non-invasive,real-time,economical,and convenient imaging modality that has been widely used in diagnosing and treating hepatic diseases.Artificial intelligence(AI)technology can predict or make decisions based on the experience of clinical experts and knowledge obtained from training data.This technology can help clinicians improve the detection efficiency and evaluate hepatic diseases,promote clinical treatment of the liver,and predict the response of the liver after treatment.This review summarizes the current rapid development of US technology and related AI methods in the diagnosis and treatment of hepatic diseases.Covered topics include steatosis grading,fibrosis staging,detection of focal liver lesions,US image segmentation,multimodal image registration,and other applications.At present,the field of AI in US imaging is still in its early stages.With the future progress of AI technology,AI-based US imaging can further improve diagnosis,reduce medical costs,and optimize US-based clinical workflow.This technology has broad prospects for application to hepatic diseases. 展开更多
关键词 Artificial intelligence Ultrasound imaging Hepatic diseases Diagnosis and treatment
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部