Research on the Status Quo and High-Quality Development of Sino-Foreign Cooperative Education in China

Faced with unprecedented changes in the world,China has chosen to continue expanding its opening-up and actively cooperate with other countries.Internationalization of education is one of the important directions for the future development of universities.Since the reform and opening-up,a series of Sino-foreign cooperative education policies have been successively released,forming a relatively systematic and complete policy system.Under the promotion of policies,Chinese universities actively engage in Sino-foreign cooperative education,with increasingly frequent educational exchanges and a clear trend towards internationalization.The scale of Sino-foreign cooperative education is also constantly expanding.It is worthy to explore how to draw on advanced teaching experience from overseas,continue to promote Sino-foreign cooperative education,and improve the quality of Sino-foreign cooperative education.

A Review of Device-Free Indoor Positioning for Home-Based Care of the Aged:Techniques and Technologies

With the development of urbanization,the problem of neurological diseases brought about by population aging has gradually become a social problem of worldwide concern.Aging leads to gradual degeneration of the central nervous system,shrinkage of brain tissue,and decline in physical function in many elderlies,making them susceptible to neurological diseases such as Alzheimer’s disease(AD),stroke,Parkinson’s and major depressive disorder(MDD).Due to the influence of these neurological diseases,the elderly have troubles such as memory loss,inability to move,falling,and getting lost,which seriously affect their quality of life.Tracking and positioning of elderly with neurological diseases and keeping track of their location in real-time are necessary and crucial in order to detect and treat dangerous and unexpected situations in time.Considering that the elderly with neurological diseases forget to wear a positioning device or have mobility problems due to carrying a positioning device,device-free positioning as a passive positioning technology that detects device-free individuals is more suitable than traditional active positioning for the home-based care of the elderly with neurological diseases.This paper provides an extensive and in-depth survey of device-free indoor positioning technology for home-based care and an in-depth analysis of the main features of current positioning systems,as well as the techniques,technologies andmethods they employ,fromthe perspective of the needs of the elderly with neurological conditions.Moreover,evaluation criteria and possible solutions of positioning techniques for the home-based care of the elderly with neurological conditions are proposed.Finally,the opportunities and challenges for the development of indoor positioning technology in 6G mobile networks for home-based care of the elderly with neurological diseases are discussed.This review has provided comprehensive and effective tracking and positioning techniques,technologies and methods for the elderly,by which we can obtain the location information of the elderly in real-time and make home-based care more comfortable and safer for the elderly with neurological diseases.

The Reform Process of English Medium Instruction in Korean Higher Education

In the context of the internationalization of higher education,many non-English speaking countries,from Europe to Asia,are promoting English as a medium of instruction(EMI).The EMI in South Korea started earlier and developed rapidly under the promotion.From the initial“Study Abroad in Korea Plan”to the World Class University(WCU)and Brain Korea 21st century(BK21)PLUS programs,with the support and guidance of the government,South Korea’s higher education has made significant progress,with the global top 100 universities in QS increasing from 1 to 6 in South Korea.

Exploring Bilingual Instruction for Intermediate Microeconomics in the Context of Sino-Foreign Collaborative Education

With the establishment of intermediate microeconomics courses in an increasing number of economics majors at universities,its importance is becoming more prominent.This article analyzes the current situation and existing problems of bilingual teaching in intermediate microeconomics.It also proposes improvement suggestions for bilingual teaching in intermediate microeconomics under Sino-foreign collaborative education,addressing aspects such as teaching mode innovation,teaching team building,bilingual teaching differentiation,and diverse process assessments.

Research on Blended Teaching Design Based on Deep Learning

In recent years,the blended teaching model in Chinese universities has developed rapidly,breaking through the time and space constraints of the teaching process and enriching teaching resources.The emergence of different teaching platforms has also actively promoted the modern development of education.However,there is still room for continuous optimization and development of blended learning,and issues such as some students’inability to effectively utilize online resources,inability to conduct in-depth learning,lack of thinking training,and insufficient ability cultivation and improvement require resolution.This article fully utilizes the basic concepts of deep learning in the existing blended teaching mode,proposes a blended teaching design based on deep learning,and enriches the existing student assessment and evaluation methods,thereby improving the teaching effectiveness of existing blended teaching,deepening the achievements of teaching reform,and improving teaching quality.

Strategies for China’s Response to and Improvement of Third-Party Funding in International Investment Arbitration

China should prioritize the establishment and enhancement of a third-party funding system.It should actively refine the existing arbitration rules,addressing any loopholes in the current regulatory framework.Comprehensive measures should be implemented to regulate third-party funding,aligning with international trends.This is crucial not only to safeguard the foreign investment of the Chinese government and enterprises but also to position China as a globally influential arbitration center.

A MXene-Based Bionic Cascaded-Enzyme Nanoreactor for Tumor Phototherapy/Enzyme Dynamic Therapy and Hypoxia-Activated Chemotherapy

The enzyme-mediated elevation of reactive oxygen species(ROS)at the tumor sites has become an emerging strategy for regulating intracellular redox status for anticancer treatment.Herein,we proposed a camouflaged bionic cascaded-enzyme nanoreactor based on Ti_(3)C_(2)nanosheets for combined tumor enzyme dynamic therapy(EDT),phototherapy and deoxygenation-activated chemotherapy.Briefly,glucose oxidase(GOX)and chloroperoxidase(CPO)were chemically conjugated onto Ti_(3)C_(2)nanosheets,where the deoxygenation-activated drug tirapazamine(TPZ)was also loaded,and the Ti_(3)C_(2)-GOX-CPO/TPZ(TGCT)was embedded into nanosized cancer cell-derived membrane vesicles with high-expressed CD47(m_eTGCT).Due to biomimetic membrane camouflage and CD47 overexpression,m_eTGCT exhibited superior immune escape and homologous targeting capacities,which could effectively enhance the tumor preferential targeting and internalization.Once internalized into tumor cells,the cascade reaction of GOX and CPO could generate HClO for efficient EDT.Simultaneously,additional laser irradiation could accelerate the enzymic-catalytic reaction rate and increase the generation of singlet oxygen(~1O_(2)).Furthermore,local hypoxia environment with the oxygen depletion by EDT would activate deoxygenation-sensitive prodrug for additional chemotherapy.Consequently,m_eTGCT exhibits amplified synergistic therapeutic effects of tumor phototherapy,EDT and chemotherapy for efficient tumor inhibition.This intelligent cascaded-enzyme nanoreactor provides a promising approach to achieve concurrent and significant antitumor therapy.

教育新基建背景下区域教育信息化发展趋势和路径

教育新基建背景下,区域教育信息化发展面临发展策略、教育管理信息化转型、数字资源共建共享、创新应用方式转变等新趋势。文章在分析浙江省近年来教育信息化建设实践应用的基础上,提出区域教育信息化发展的四条路径:一是树立教育数字化改革的战略思维,二是推动区域教育数字基座一体化建设,三是将数字赋能组织创新作为首要任务,四是以场景化策略推动教育教学应用创新,以期为各地区域性推进教育新基建和教育信息化发展提供借鉴。

Preliminary Study on Broadband Resonance of Shaking Table Based on the Compressibility of Gas

In order to improve the performance of the shaking table,a vibration-enhanced shaking table which exploited broadband resonance was constructed.The broadband resonance was realized by an adjustable stiffness mechanism which exploited gas compressibility.Different from the traditional device,a gas filled cylinder(GFC)was mounted between the shake table and the exciter,and a pressure regulator was designed to regulate the gas pressure of the GFC.The natural frequency of the designed shaking table can be adjusted based on the compressibility of gas during the test.The principle of stiffness adjustment was theoretically analyzed and a series of experiments were carried out to investigate the effects of regulating the natural frequency.The experimental results indicate that the amplitude can be twice amplified and the natural frequency can be regulated between 2 0 Hz and 6 0 Hz.

阿那亚艺术中心

如恩设计受开发商阿那亚Aranya之邀,在其开发的秦皇岛黄金海岸社区内设计一座艺术中心,业主的远见卓识为项目的设计赋予了充分的构思空间,如恩也希望借此契机,尝试突破艺术中心与公共空间的固有定义。阿那亚社区整体强调重新找回人的情感价值,以及与环境的和谐互融。因而,除了满足艺术展陈的功能外,如恩在建筑内部设计了一个环形的庭院,作为社区居民的公共活动空间。

Development and preclinical evaluation of multifunctional hydrogel for precise thermal protection during thermal ablation

Image-guided thermal ablation(TA),which is less invasive,has been widely applied for treating various kinds of tumors.However,TA still poses the potential risk of thermal damage to sensitive tissue nearby.Therefore,an adjunctive thermoprotective hydrodissection technique with constant injection of 5%glucose(5%Glu)has currently been adopted for clinical application,but this may be hazardous to humans.In this study,a multifunctional hyaluronic acid-based hydrogel(HA-Dc)was developed for hydrodissection.Compared with 5%Glu(the most clinically used solution)and the previously reported F127 hydrogel,the HA-Dc hydrogel was studied in vitro in a porcine liver model and in vivo in a rabbit model and showed good injectability and better tissue retention,stability,and thermoprotective properties throughout the TA procedure.Furthermore,in the preclinical evaluation in a Macaca fascicularis(M.fascicularis)model,HA-Dc showed excellent performance in terms of stricter neuroprotection compared with 5%Glu.In addition,the HA-Dc hydrogel with good biocompatibility and controllable degradation behavior in vivo could be a promising platform for thermal protection during clinical TA procedures.

A novel two-dimensional nanoheterojunction via facilitating electron–hole pairs separation for synergistic tumor phototherapy and immunotherapy

Nanomaterial-mediated phototherapy in tumor treatment has been developed rapidly in the past few years due to its noninvasive character.However,the low energy conversion efficiency and high recombination rate of the photo-triggered electron–hole pairs of single nano-agent limit the phototherapy efficiency.Herein,we constructed a novel two-dimensional nanoheterojunction MoS_(2)-Ti_(3)C_(2)(MT),which allowed a high photothermal conversion efficiency(59.1%)as well as an effective separation of photo-triggered electron–hole pairs for reactive oxygen species(ROS)generation under single 808 nm laser irradiation.Upon the modification of the mitochondrial targeted molecule(3-proxycarboxylic)triphenyl phosphine bromide(TPP)and 4T1 cell membrane,m@MoS_(2)-Ti_(3)C_(2)/TPP(m@MTT)could effectively target to the tumor cell and further locate to the mitochondria to amplify tumor-specific oxidative stress,which not merely effectively inhibits the local tumor growth but also induces tumor immunogenic cell death(ICD)for activating antitumor immune response.Additionally,cytosine guanine dinucleotide(CPG),as a Toll-like receptor 9(TLR9)agonist,was further introduced to the system to boost adaptive immune responses,resulting in improved level of cytotoxic T cells as well as a decrease in the number of regulatory T cells.In vivo antitumor mechanism studies demonstrated that not only the primary and distant tumors in 4T1 bearing-tumor mice model were significantly inhibited,but also the lung metastasis of tumor was effectively suppressed.Therefore,this work revealed the ROS generation mechanism of MT nanoheterojunction and provided a novel strategy to fabricate a biomedically applicable MT nanoheterojunction for tumor treatment.

Piezocatalytic performance of Fe_(2)O_(3)−Bi_(2)MoO_(6) catalyst for dye degradation

A Fe_(2)O_(3)−Bi_(2)MoO_(6) heterojunction was synthesized via a hydrothermal method.Scanning electron microscopy,transmission electron microscopy,energy-dispersive X-ray,powder X-ray diffraction,Fourier transform infrared spectroscopy and ultra-violet−visible near-infrared spectrometry were performed to measure the structures,morphologies and optical properties of the as-prepared samples.The various factors that affected the piezocatalytic property of composite catalyst were studied.The highest rhodamine B degradation rate of 96.6%was attained on the 3% Fe_(2)O_(3)−Bi_(2)MoO_(6) composite catalyst under 60 min of ultrasonic vibration.The good piezocatalytic activity was ascribed to the formation of a hierarchical flower-shaped microsphere structure and the heterostructure between Fe_(2)O_(3) and Bi_(2)MoO_(6),which effectively separated the ultrasound-induced electron–hole pairs and suppressed their recombination.Furthermore,a potential piezoelectric catalytic dye degradation mechanism of the Fe_(2)O_(3)−Bi_(2)MoO_(6) catalyst was proposed based on the band potential and quenching effect of radical scavengers.The results demonstrated the potential of using Fe_(2)O_(3)−Bi_(2)MoO_(6) nanocomposites in piezocatalytic applications.

A targeting black phosphorus nanoparticle based immune cells nanoregulator for photodynamic/photothermal and photo-immunotherapy

Photo-immunotherapy is a novel therapeutic approach against malignant tumors with minimal invasiveness.Herein,a targeting multifunctional black phosphorus(BP)nanoparticle,modified by PEGylated hyaluronic acid(HA),was designed for photothermal/photodynamic/photo-immunotherapy.In vitro and in vivo assays indicated that HA-BP nanoparticles possess excellent biocompatibility,stability,and sufficient therapeutic efficacy in the combined therapy of photothermal therapy(PTT)and photodynamic therapy(PDT)for cancer therapy.Moreover,the results of in vitro showed that HA-BP down-regulated the expression of CD206(M2 macrophage marker)by 42.3%and up-regulated the ratio of CD86(M1 macrophage marker)by 59.6%,indicating that HABP nanoparticles have functions in remodeling tumor associated macrophages(TAMs)phenotype(from protumor M2 TAMs to anti-tumor M1 macrophages).Fluorescence(FL)and photoacoustic(PA)multimodal imaging confirmed the selective accumulation of HA-BP in tumor site via both CD44^+mediated active targeting and passive EPR effect.In vitro and in vivo studies suggested that the combined therapy of PDT,PTT and immunotherapy using HA-BP could not only significantly inhibit original tumor but also induce immunogenic cell death(ICD)and release Damage-associated molecular patterns(DAMPs),which could induce maturation of dendritic cells(DCs)and activate effector cells that robustly evoke the antitumor immune responses for cancer treatment.This study expands the biomedical application of BP nanoparticles and displays the potential of modified BP as a multifunctional therapeutic platform for the future cancer therapy.

Ecotoxicological effects of waterborne PFOS exposure on swimming performance and energy expenditure in juvenile goldfish (Carassius auratus)

The potential risks of perfluorooctane sulfonate （PFOS） are of increasing ecological concern. Swimming performance is linked to the fitness and health of fish. However, the impacts of PFOS on swimming performance remain largely unknown. We investigated the ecotoxicological effects of acute exposure to PFOS on the swimming performance and energy expenditure of juvenile goldfish （Carassius auratus）. The fish were exposed to a range of PFOS concentrations （0, 0.5, 2, 8 and 32 mg/L） for 48 hr. The spontaneous swimming activity, fast-start swimming performance, critical swimming speed （Ucrit） and active metabolic rate （AMR） of the goldfish were examined after exposure to PFOS. PFOS exposure resulted in remarkable effects on spontaneous activity. Motion distance was reduced, and the proportion of motionless time increased with increasing concentrations of PFOS. However, no significant alterations in the fast-start performance-related kinematic parameters, such as latency time, maximum linear velocity, maximum linear acceleration or escape distance during the first 120 msec after stimulus, were observed after PFOS exposure. Unexpectedly, although PFOS exposure had marked influences on the swimming oxygen consumption rates and AMR of goldfish, the U crit of the goldfish was not significantly affected by PFOS. This may result in a noteworthy increase in the energetic cost of transport. The overall results indicate that, in contrast to spontaneous activity, underlying swimming capabilities are maintained in goldfish after short-term exposure to PFOS, but energy expenditure during the process of swimming is dramatically aggravated.

Multiple stimuli-responsive nanosystem for potent,ROS-amplifying,chemo-sonodynamic antitumor therapy

Although sonodynamic therapy(SDT)is a promising non-invasive tumor treatment strategy due to its safety,tissue penetration depth and low cost,the hypoxic tumor microenvironment limits its therapeutic effects.Herein,we have designed and developed an oxygen-independent,ROS-amplifying chemo-sonodynamic antitumor therapy based on novel pH/GSH/ROS triple-responsive PEG-PPMDT nanoparticles.The formulated artemether(ART)/Fe_(3)O_(4)-loaded PEG-PPMDT NPs can rapidly release drug under the synergistic effect of acidic endoplasmic pH and high intracellular GSH/ROS levels to inhibit cancer cell growth.Besides,the ROS level in the NPs-treated tumor cells is magnified by ART via interactions with both Fe^(2+)ions formed in situ at acidic pH and external ultrasound irradiation,which is not affected by hypoxia tumor microenvironment.Consequently,the enriched intracellular ROS level can cause direct necrosis of ROS-stressed tumor cells and further accelerate the drug release from the ROS-responsive PEG-PPMDT NPs,achieving an incredible antitumor potency.Specifically,upon the chemo-sonodynamic therapy by ART/Fe_(3)O_(4)-loaded PEG-PPMDT NPs,all xenotransplants of human hepatocellular carcinoma(HepG2)in nude mice shrank significantly,and 40% of the tumors were completely eliminated.Importantly,the Fe3O4 encapsulated in the NPs is an efficient MRI contrast agent and can be used to guide the therapeutic procedures.Further,biosafety analyses show that the PEG-PPMDT NPs possess minimal toxicity to main organs.Thus,our combined chemo-sonodynamic therapeutic method is promising for potent antitumor treatment by controlled release of drug and facile exogenous generation of abundant ROS at target tumor sites.

选择性氧化HMF

近年来,利用储量丰富且可再生的生物质资源制备高附加值化学品和液体燃料是目前化学研究领域的热点之一,同时契合可持续发展的国家战略。5-羟甲基糠醛(HMF)是关键的生物质平台化合物之一,广泛应用于制备精细平台化合物、药物的中间体、聚合物的合成、液体燃料的前驱体等。因此,HMF的选择性氧化逐渐成为生物质领域的研究热点。本文主要介绍了近五年来关于HMF选择氧化制备DFF、FFCA、FDCA等生物质衍生物的研究,以及以HMF为中间体的生物质转化过程。关于对HMF进行选择性氧化,主要聚焦于以热催化和光催化两种途径。其中,以热催化的途径将HMF选择性氧化为DFF和FDCA研究较多,此途径下的催化体系主要介绍了贵金属和非贵金属两类;而在为数不多的光催化途径下,主要研究的催化体系是g-C3N4催化剂。最后,指出了目前HMF氧化反应研究存在的不足,并提出了可能解决的方法。

An integrative drug repositioning framework discovered a potential therapeutic agent targeting COVID-19

The global spread of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)requires an urgent need to find effective therapeutics for the treatment of coronavirus disease 2019(COVID-19).In this study,we developed an integrative drug repositioning framework,which fully takes advantage of machine learning and statistical analysis approaches to systematically integrate and mine large-scale knowledge graph,literature and transcriptome data to discover the potential drug candidates against SARS-CoV-2.Our in silico screening followed by wet-lab validation indicated that a poly-ADP-ribose polymerase 1(PARP1)inhibitor,CVL218,currently in Phase I clinical trial,may be repurposed to treat COVID-19.Our in vitro assays revealed that CVL218 can exhibit effective inhibitory activity against SARS-CoV-2 replication without obvious cytopathic effect.In addition,we showed that CVL218 can interact with the nucleocapsid(N)protein of SARS-CoV-2 and is able to suppress the LPS-induced production of several inflammatory cytokines that are highly relevant to the prevention of immunopathology induced by SARS-CoV-2 infection.

分享与共融——阿那亚艺术中心

由郭锡恩和胡如珊于2004年共同创立,是一家立足于中国上海的多元化建筑设计研究室。如恩设计提供国际化的建筑、室内、整体规划、平面以及产品设计服务。公司目前的项目分布在很多不同的国家,拥有来自全世界各地的员工,使用超过30种语言。不同文化背景组成了如恩的设计团队,正是团队的差异独特性增强了其设计理念:以全球化的观念结合多元、重叠的设计理念来创造一个新的建筑范例。