数字化时代高校就业指导服务模式的新路径探索

随着云计算和数字化技术的飞速发展,高校就业指导工作的工作理念也在不断创新,面对与日俱增的大学毕业生数量,高校亟需探索利用新媒体和数字化技术开展新型就业指导模式,以提供更加便捷的就业指导服务。基于此,通过调查问卷和走访相关单位的方式,总结当前高校就业指导服务存在的主要问题,分析数字化对毕业生就业指导工作开展的主要优势,深入探讨数字化就业指导平台数据分析的主要内容,从加强就业课程体系建设、明确就业指导服务目标、扩充就业指导师资队伍,以及推进就业服务客户端建设和数字化就业指导平台的优化设计几个方面,提出改进数字化毕业生就业指导工作的新措施,着重提出利用大数据分析技术来掌控就业市场的趋势和需求,为毕业生提供个性化的就业建议;同时,探索利用数字化平台加强毕业生与用人单位之间的联系,促进信息交流、招聘活动的新路径。从而得出以下启示:高校的就业指导部门应高度重视数字化应用平台建设,大力提升就业指导服务的质量和效果,更好地帮助学生成功就业,为国家输送更多更好的创新型人才。

Wang Jimin(王吉民)and History of Chinese Medicine(《中国医史》)

Wang Jimin was not only a distinguished medical historian in modem China and an academician of the International Academy of the History of Science but also an originator of the first Museum of Chinese Medical[History and of the Chinese Medical History Society.This study briefly introduces Wang’s family academic history,his groundbreaking achievements in studies on medical history and the first monograph of History of Chinese Medicine(English edition)in China.It also reviews the foundation of the first Museum of Chinese Medical History.

木材变磁铁创新趣味科研技能训练的探索与实践

高校是培养有见识、独立思考能力和创新意识专业人才的摇篮。通过木材变磁铁的科研技能训练课程实验,提升了学生综合运用所学知识开展科学研究的能力。本实验内容不但使学生了解木材的相关知识,而且锻炼了学生独立操作科研仪器和分析谱图的能力,打开了学生在科研领域的新视野,激发了学生热爱学习和科学研究的内在动力。

Neural stem cell-derived exosomes regulate cell proliferation,migration,and cell death of brain microvascular endothelial cells via the miR-9/Hes1 axis under hypoxia

Background:Our previous study found that mouse embryonic neural stem cell(NSC)-derived exosomes(EXOs)regulated NSC differentiation via the miR-9/Hes1 axis.However,the effects of EXOs on brain microvascular endothelial cell(BMEC)dysfunction via the miR-9/Hes1 axis remain unknown.Therefore,the current study aimed to determine the effects of EXOs on BMEC proliferation,migration,and death via the miR-9/Hes1 axis.Methods:Immunofluorescence,quantitative real-time polymerase chain reaction,cell counting kit-8 assay,wound healing assay,calcein-acetoxymethyl/propidium iodide staining,and hematoxylin and eosin staining were used to determine the role and mechanism of EXOs on BMECs.Results:EXOs promoted BMEC proliferation and migration and reduced cell death under hypoxic conditions.The overexpression of miR-9 promoted BMEC prolifera-tion and migration and reduced cell death under hypoxic conditions.Moreover,miR-9 downregulation inhibited BMEC proliferation and migration and also promoted cell death.Hes1 silencing ameliorated the effect of amtagomiR-9 on BMEC proliferation and migration and cell death.Hyperemic structures were observed in the regions of the hippocampus and cortex in hypoxia-induced mice.Meanwhile,EXO treatment improved cerebrovascular alterations.Conclusion:NSC-derived EXOs can promote BMEC proliferation and migra-tion and reduce cell death via the miR-9/Hes1 axis under hypoxic conditions.Therefore,EXO therapeutic strategies could be considered for hypoxia-induced vascular injury.

Genome-wide association study of grain micronutrient concentrations in bread wheat

Bread wheat(Triticum aestivum)is a staple food crop worldwide.The genetic dissection of important nutrient traits is essential for the biofortification of wheat to meet the nutritional needs of the world's growing population.Here,45,298 single-nucleotide polymorphisms(SNPs)from 55K chip arrays were used to genotype a panel of 768 wheat cultivars,and a total of 154 quantitative trait loci(QTLs)were detected for eight traits under three environments by genome-wide association study(GWAS).Three QTLs(qMn-3B.1,qFe-3B.4,and qSe-3B.1/qFe-3B.6)detected repeatedly under different environments or traits were subjected to subsequent analyses based on linkage disequilibrium decay and the P-values of significant SNPs.Significant SNPs in the three QTL regions formed six haplotypes for qMn-3B.1,three haplotypes for qFe-3B.4,and three haplotypes for qSe-3B.1/qFe-3B.6.Phenotypic analysis revealed significant differences among haplotypes.These results indicated that the concentrations of several nutrient elements have been modified during the domestication of landraces to modern wheat.Based on the QTL regions,we identified 15 high-confidence genes,eight of which were stably expressed in different tissues and/or developmental stages.TraesCS3B02G046100 in qMn-3B.1 and TraesCS3B02G199500 in qSe-3B.1/qFe-3B.6 were both inferred to interact with metal ions according to the Gene Ontology(GO)analysis.TraesCS3B02G199000,which belongs to qSe-3B.1/qFe-3B.6,was determined to be a member of the WRKY gene family.Overall,this study provides several reliable QTLs that may significantly affect the concentrations of nutrient elements in wheat grain,and this information will facilitate the breeding of wheat cultivars with improved grain properties.

A crosstalk-free dual-mode sweat sensing system for naked-eye sweat loss quantification via changes in structural reflectance

Sweat loss monitoring is important for understanding the body’s thermoregulation and hydration status,as well as for comprehensive sweat analysis.Despite recent advances,developing a low-cost,scalable,and universal method for the fabrication of colorimetric microfluidics designed for sweat loss monitoring remains challenging.In this study,we propose a novel laserengraved surface roughening strategy for various flexible substrates.This process permits the construction of microchannels that show distinct structural reflectance changes before and after sweat filling.By leveraging these unique optical properties,we have developed a fully laser-engraved microfluidic device for the quantification of naked-eye sweat loss.This sweat loss sensor is capable of a volume resolution of 0.5µL and a total volume capacity of 11µL,and can be customized to meet different performance requirements.Moreover,we report the development of a crosstalk-free dual-mode sweat microfluidic system that integrates an Ag/AgCl chloride sensor and a matching wireless measurement flexible printed circuit board.This integrated system enables the real-time monitoring of colorimetric sweat loss signals and potential ion concentration signals without crosstalk.Finally,we demonstrate the potential practical use of this microfluidic sweat loss sensor and its integrated system for sports medicine via on-body studies.

Shikimic acid accelerates phase change and flowering in Chinese jujube

The juvenile-to-adult phase change with first flowering as the indicator plays a crucial role in the lifecycle of fruit trees. However, the molecular mechanisms underlying phase change in fruit trees remain largely unknown. Shikimic acid (ShA) pathway is a main metabolic pathway closely related to the synthesis of hormones and many important secondary metabolites participating in plant phase change. So,whether ShA regulates phase change in plants is worth clarifying. Here, the distinct morphological characteristics and the underlying mechanisms of phase change in jujube (Ziziphus jujuba Mill.), an important fruit tree native to China with nutritious fruit and outstanding tolerance abiotic stresses, were clarified. A combined transcriptome and metabolome analysis found that ShA is positively involved in jujube(Yuhong’×Xing 16’) phase change. The genes in the upstream of ShA synthesis pathway (ZjDAHPS, ZjDHQS and ZjSDH), the contents of ShA and the downstream secondary metabolites like phenols were significantly upregulated in the phase change period. Further, the treatment of spraying exogenous ShA verified that ShA at a very low concentration (60 mg·L^(-1)) can substantially speed up the phase change and flowering of jujube and other tested plants including Arabidopsis, tomato and wheat. The exogenous ShA (60 mg·L^(-1)) treatment in jujube seedlings could increase the accumulation of endogenous ShA, enhance leaf photosynthesis and the synthesis of phenols especially flavonoids and phenolic acids, and promote the expression of genes (ZjCOs, ZjNFYs and ZjPHYs) involved in flowering pathway. Basing on above results, we put forward a propose for the underlying mechanism of ShA regulating phase change, and a hypothesis that ShA could be considered a phytohormone-like substance because it is endogenous, ubiquitous, movable and highly efficient at very low concentrations. This study highlights the critical role of ShA in plant phase change and its phytohormone-like properties.

Phase equilibrium data prediction and process optimizationin butadiene extraction process

In response to the lack of reliable physical parameters in the process simulation of the butadiene extraction,a large amount of phase equilibrium data were collected in the context of the actual process of butadiene production by acetonitrile.The accuracy of five prediction methods,UNIFAC(UNIQUAC Functional-group Activity Coefficients),UNIFAC-LL,UNIFAC-LBY,UNIFAC-DMD and COSMO-RS,applied to the butadiene extraction process was verified using partial phase equilibrium data.The results showed that the UNIFAC-DMD method had the highest accuracy in predicting phase equilibrium data for the missing system.COSMO-RS-predicted multiple systems showed good accuracy,and a large number of missing phase equilibrium data were estimated using the UNIFAC-DMD method and COSMO-RS method.The predicted phase equilibrium data were checked for consistency.The NRTL-RK(non-Random Two Liquid-Redlich-Kwong Equation of State)and UNIQUAC thermodynamic models were used to correlate the phase equilibrium data.Industrial device simulations were used to verify the accuracy of the thermodynamic model applied to the butadiene extraction process.The simulation results showed that the average deviations of the simulated results using the correlated thermodynamic model from the actual values were less than 2%compared to that using the commercial simulation software,Aspen Plus and its database.The average deviation was much smaller than that of the simulations using the Aspen Plus database(>10%),indicating that the obtained phase equilibrium data are highly accurate and reliable.The best phase equilibrium data and thermodynamic model parameters for butadiene extraction are provided.This improves the accuracy and reliability of the design,optimization and control of the process,and provides a basis and guarantee for developing a more environmentally friendly and economical butadiene extraction process.

Design method of extractant for liquid-liquid extraction based on elements and chemical bonds

In the petrochemical industry process, the relative volatility between the components to be separated is close to one or the azeotrope that systems are difficult to separate. Liquid-liquid extraction is a common and effective separation method, and selecting an extraction agent is the key to extraction technology research. In this paper, a design method of extractants based on elements and chemical bonds was proposed. A knowledge-based molecular design method was adopted to pre-select elements and chemical bond groups. The molecules were automatically synthesized according to specific combination rules to avoid the problem of “combination explosion” of molecules. The target properties of the extractant were set, and the extractant meeting the requirements was selected by predicting the correlation physical properties of the generated molecules. Based on the separation performance of the extractant in liquid-liquid extraction and the relative importance of each index, the fuzzy comprehensive evaluation membership function was established, the analytic hierarchy process determined the mass ratio of each index, and the consistency test results were passed. The results of case study based on quantum chemical analysis demonstrated that effective determination of extractants for the analysis of benzene-cyclohexane systems. The results unanimously prove that the method has important theoretical significance and application value.

MXene Sediment-Based Poly(vinyl alcohol)/Sodium Alginate Aerogel Evaporator with Vertically Aligned Channels for Highly Efficient Solar Steam Generation

Solar-driven interfacial evaporation from seawater is considered an effective way to alleviate the emerging freshwater crisis because of its green and environmentally friendly characteristics.However,developing an evaporator with high efficiency,stability,and salt resistance remains a key challenge.MXene,with an internal photothermal conversion efficiency of 100%,has received tremendous research interest as a photothermal material.However,the process to prepare the MXene with monolayer is inefficient and generates a large amount of“waste”MXene sediments(MS).Here,MXene sediments is selected as the photothermal material,and a three-dimensional MXene sediments/poly(vinyl alcohol)/sodium alginate aerogel evaporator with vertically aligned pores by directional freezing method is innovatively designed.The vertical porous structure enables the evaporator to improve water transport,light capture,and high evaporation rate.Cotton swabs and polypropylene are used as the water channel and support,respectively,thus fabricating a self-floating evaporator.The evaporator exhibits an evaporation rate of 3.6 kg m^(-2)h^(-1)under one-sun illumination,and 18.37 kg m^(-2)of freshwater is collected in the condensation collection device after 7 h of outdoor sun irradiation.The evaporator also displays excellent oil and salt resistance.This research fully utilizes“waste”MS,enabling a self-floating evaporation device for freshwater collection.

阿帕替尼治疗6例晚期难治性卵巢癌的临床观察

目的:观察甲磺酸阿帕替尼治疗常规治疗失败的晚期卵巢癌患者的临床疗效及不良反应。方法:选取天津医科大学第二医院2015年6月至2016年10月收治的6例常规治疗失败的晚期难治性卵巢癌患者,通过观察患者口服甲磺酸阿帕替尼后的影像学检查、NSE、CEA、CA125等肿瘤标记物的变化来评估近期疗效。结果:6例患者平均年龄为55(48~71)岁。中、低分化浆液性囊腺癌4例,交界性乳头状囊腺瘤癌变1例,透明细胞癌1例。6例接受甲磺酸阿帕替尼治疗的患者中,完全缓解(complete response,CR)0例,部分缓解(partial response,PR)2例,疾病稳定(stable disease,SD)1例,疾病进展(progressive disease,PD)3例。客观有效率(objective response rate,ORR)33%(2/6),疾病控制率(disease control rate,DCR)50%(3/6)。服药的所有患者安全性良好,主要不良反应为手足综合征与高血压,且程度较轻,经对症治疗后好转。结论:甲磺酸阿帕替尼治疗常规治疗失败的晚期难治性卵巢癌患者初步观察具有一定的疗效,且安全性良好。今后仍需进一步探索该药治疗卵巢癌的机制,为晚期卵巢癌患者寻求更为有效的治疗策略。

甲磺酸阿帕替尼靶向治疗转移性去势抵抗性前列腺癌的临床疗效观察

目的:评价甲磺酸阿帕替尼单药靶向治疗常规治疗失败的转移性去势抵抗性前列腺癌(metastatic castration-resistant prostate cancer,mCRPC)的近期疗效和不良反应。方法:收集天津医科大学第二医院2016年6月至2017年12月收治的25例常规治疗失败的mCRPC患者临床资料,观察口服甲磺酸阿帕替尼后的影像学检查,根据最新修订的实体瘤疗效评价标准(m-RECIST)、癌痛评分和前列腺特异性抗原(prostate specific antigen,PSA)的变化,回顾性分析阿帕替尼靶向治疗4个疗程(平均约112 d)后患者的近期疗效,并对靶向治疗后出现的不良反应进行初步分析。结果:25例患者平均发病年龄72(53~81)岁,病理类型均为腺癌,除3例失访,无完全缓解(complete response,CR),部分缓解(povtial response,PR)11例(44%),疾病稳定(stable disease,SD)8例(32%),疾病进展(progresive disease,PD)3例(12%)。客观缓解率(objective remission rate,ORR)为44%,疾病控制率(disease control rate,DCR)为76%。25例患者治疗中出现一系列不良反应,其中乏力22例(88%)、胃肠道反应15例(60%),血压升高7例(28%),手足综合征6例(24%),头晕不适、蛋白尿等其他不良反应,经对症处理后好转。结论:甲磺酸阿帕替尼治疗常规治疗失败的mCRPC近期疗效满意,治疗过程中不良反应的发生率较高,但多为轻中度反应,需要积极对症处理。今后仍需进一步探索该药治疗mCRPC的机制,为更多患者寻求更为有效的治疗策略。

A Win-Win Undergraduate Graduation Design Model for Students, Teachers, and Training Platforms

Undergraduate graduation design is an important link in the process of undergraduate training,and university platforms have invested a lot of manpower and material resources for this purpose.However,while carrying out student training,it has gradually become the consensus of most university platforms to achieve a win-win situation for teachers and training platforms in order to achieve optimization of resource allocation and motivation of student training.After discussion and practice,this paper proposes a set of undergraduate graduation design training concepts and training modes with a win-win situation for students,teachers,and training platforms.

Biomass carbon materials for high-performance secondary battery electrodes:A review

Recently,the challenges pertaining to the recycling of metal-based electrode materials and the resulting environmental pollution have impeded the advancement of battery technology.Consequently,biomass-derived carbon materials,distinguished by their eco-friendliness and consistent performance,stand as a pivotal solution to this predicament.Researchers have made significant strides in the integration of porous carbon materials derived from biomass into battery systems.Nevertheless,these materials face issues such as limited efficiency,modest yields,and a complex fabrication process.This paper endeavors to summarize the recent advancements in the utilization of biomass-derived carbon materials within the realm of batteries,offering a comprehensive examination of their battery performance from three distinct perspectives:synthesis,structure,and application.We posit that composite materials composed of biomass-derived carbon align with the trajectory of future development and present extensive potential for application.Ultimately,we will expound upon our profound outlook regarding the furtherance of biomass-derived carbon materials.

Study on the Effect of Self-Help Mindfulness Therapy on Rumination in Patients with Depression

Objective:To evaluate the nursing effect of self-help mindfulness therapy for patients with depression.Methods:120 cases of depression patients admitted to the Department of Psychosomatic Disorders of our hospital between January 2020 and January 2023 were selected.After being grouped by the random draw method,60 cases in the observation group adopted self-help mindfulness therapy and 60 cases in the control group adopted conventional nursing care,the nursing effects were subsequently compared.Results:Before nursing,there was no difference in the comparison of clinical symptom scores,rumination scores,positive psychological scores,and self-esteem scores between the two groups(P>0.05).After nursing,the clinical symptom scores of the observation group were lower than those of the control group;the rumination scores were lower than those of the control group;the positive psychological scores were higher than those of the control group;and the self-esteem scores were higher than those of the control group,and all of them were statistically significant(P<0.05).Conclusion:Self-help mindfulness therapy can improve the clinical symptoms of patients with depression and their rumination,and enhance their positive psychological state and self-esteem level,which has high nursing advantages.

An Integrated Model of Smart Home Applications User Experience Based on Cognitive Dissonance

This study constructs an integrated model of user experience in smart home applications(apps)to deeply explore the impact of cognitive dissonance on users’emotional responses,subsequent behaviors,and experiential outcomes.The research emphasizes the importance of addressing emotional management in the design and development of smart home apps.The findings indicate that emotional response plays a critical mediating role in the user experience of these apps,offering new insights for further optimization.By understanding users’emotional reactions and behavioral patterns under cognitive dissonance,developers can more effectively improve interface design and enhance the overall user experience.

改性钴镁铝类水滑石对乙烯-醋酸乙烯共聚物阻燃和力学性能的影响

采用共沉淀微波晶化法合成了不同量硬脂酸钠表面改性的钴镁铝类水滑石。X射线衍射测试指出合成的所有类水滑石晶体均有高的结晶度,d_(003)值证实了硬脂酸根和硝酸根离子没有插入到类水滑石的层间。红外光谱、扫描电镜和接触角测试均证实了随着改性剂用量的逐渐增加,类水滑石表面硬脂酸钠的负载量也逐渐增加。热分析表明改性剂的负载量对类水滑石的热降解温度有较大的影响。当类水滑石以总质量的20%的比例添加到乙烯-醋酸乙烯共聚物(EVA)中制成复合材料时,氧指数和力学测试指出钴离子的加入,使得钴镁铝类水滑石比镁铝类水滑石对复合材料氧指数和断裂伸长率均有明显的提高。硬脂酸钠以前驱体质量的2%进行改性的钴镁铝类水滑石/EVA复合材料的强度、韧性和阻燃性能表现最好。

Study on the Effect of Shuanghuanglian Powder Needle Combined with Cefoperazone and Sulbactam Sodium on Pseudomonas aeruginosa in Vitro

Objective: To explore the antibacterial activity of combined use of Shuanghuanglian and cefoperazone sulbactam sodium on resistant strains of Pseudomonas aeruginosa. Methods: The Pseudomonas aeruginosa strains which were sensitive and resistant to cefoperazone sulbactam sodium were selected to prepare different test bacterial solutions respectively;The experimental liquid of Shuanghuanglian and Cefoperazone Sulbactam Sodium were prepared separately and set as different test groups and control groups;The Drug Sensitivity Tests of Shuanghuanglian and cefoperazone sulbactam sodium at different concentration gradients which were used alone or used in combination were carried out for different strains with sensitivity and resistance, And use standard entry as a reference control. Result: The results of drug sensitivity test of Shuanghuanglian combined with Cefoperazone-Sulbactam sodium against the resistant strains of Pseudomonas aeruginosa were compared with the results of drug sensitivity test of the two separately used, and the difference was statistically significant (P 〈 0.05) [The drug sensitivity test results of Shuanghuanglian and cefoperazone sulbactam sodium to Pseudomonas aeruginosa resistant strains were statistically significant compared with the drug sensitivity test results of Shuanghuanglian and Cefoperazone Sulbactam Sodium used separately (P 〈 0.05)];There was a dependence between strains and concentration in the effect of the combination of the two drugs. Conclusion: The combination of Shuanghuanglian and cefoperazone sulbactam sodium has synergistic antibacterial or bactericidal effect on Pseudomonas aeruginosa resistant strains. .

奏响中国音乐华章——“首届中国钢琴音乐周”纪实与思考

2019年立夏时节,"首届中国钢琴音乐周"(以下简称"音乐周")在星海音乐学院拉开帷幕,为期四天的音乐周活动中,中国钢琴界的学者、演奏家、作曲家、钢琴教育者和学习者、爱好者齐聚一堂,共享中国钢琴音乐的美好,共同展望和规划中国钢琴音乐发展的未来。

“新农科”背景下农林高校化学类专业“九抓”课程建设

为培养具有国际竞争力的人才,“新农科”建设是我国振兴高等农林教育的重要举措。以东北林业大学化学类专业的课程建设为例,从课程内容选择和优化、教学设计、课程思政与示范引领、编著教材、教学评价、第二课堂、实验与实践、产教融合和国际化联合办学等九个方面的改革和收获进行探讨,为本科农林院校一流专业的课程建设提供参考。