Effects of massage on newborn infants with jaundice: A meta-analysis

Objective:This meta-analysis aims to systematically evaluate the effects of massage on infants with jaundice.Methods:Multiple electronic databases,including Cochrane Library,PubMed,EMBASE,Web of Science,China Biology Medicine (CBM),Wan Fang Data,VIP Database for Chinese Technical Periodicals and China National Knowledge Infrastructure (CNKI),were used to search for studies on the effects of massage on infants with jaundice.Data were analysed by Rev Man 5.3.Results:A total of 14 randomised controlled trials with 1889 patients were included.Statistically significant difference in percutaneous bilirubin [MD =-1.21,95% CI (-1.90,-0.52),P< 0.05;MD =-2.00,95% CI (-2.68,-1.32),P<0.05;MD=-2.00,95% CI (2.56,-1.44),P<0.05;MD=-1.93,95% CI (-2.44,-1.43),P< 0.05] was found between two groups at 48,72,96 and 168 h.Studies on the serum total bilirubin level were divided into two subgroups according to sample size,and the results of subgroup analysis showed that the serum total bilirubin level in the intervention group was significantly lower than that in the control group [MD =-52.06,95% CI (-57.76,-46.36),P< 0.05 and MD =-10.65,95% CI (-14.66,-6.63),P < 0.05].Statistically significant difference in defecation frequency was observed between the two groups at 48 h after birth[SMD =0.44,95%CI (0.02,0.87),P< 0.05].Conclusion:Massage can decrease serum total bilirubin and percutaneous bilirubin levels and increasing defecation frequency.However,due to heterogeneity among studies,numerous multi-centre,largesample and high-quality randomised controlled trials are needed to verify the effects of massage.

The effect of Tai Chi exercise on motor function and sleep quality in patients with stroke:A meta-analysis

Objective:The meta-analysis is to objectively evaluate the efficacy of Tai Chi exercise for motor function and sleep quality in patients with stroke.Methods:Randomized controlled trials(RCTs)about the effects of Tai Chi versus a non-exercise or conventional rehabilitation exercise control group on motor function and sleep quality in patients with stroke were searched from multiple electronic databases(PubMed,Web of Science,the Cochrane Library,EMBASE,AMED,CBM,CNKI,Wanfang and VIP)until August 2016.Two investigators independently screened eligible studies,extracted data,and assessed the methodological quality by using the quality evaluation criteria for RCTs recommended by Cochrane Handbook.Then meta-analysis was performed by RevMan5.3 software.Results:A total of 17 RCTs with 1209 participants were included.The meta-analysis indicated that there was a significant difference on improving the balance function(P<0.001)and ability of daily activity(P=0.0003)of patients with stroke between Tai Chi group and control group.However,no significant effect was found on Tai Chi for walking function and sleep quality(P>0.05).Conclusion:Tai Chi exercise can significantly improve the balance function and ability of daily activities of patients with stroke,and there are no significant differences in walking function and sleep quality.Therefore,lots of multicenter,large-sample,higher quality randomized controlled trials are needed to verify the effects of Tai Chi exercise in improving walking function and sleep quality for patients with stroke.

Improved perovskite solar cell efficiency by tuning the colloidal size and free ion concentration in precursor solution using formic acid additive

Improving the quality of the perovskite active layer is crucial to obtaining high performance perovskite solar cells(PSCs). In this work, by introducing formic acid into the formamidinium lead iodide(FAPbI3)precursor solution, we managed to achieve reduced colloidal size in the solution, leading to more uniform deposition of FAPbI3 film with lower trap state density and higher carrier mobility. The solar cells based on the FAPbI3 absorber layer modified with formic acid show significantly better photovoltaic performance than that on the reference FAPbI3 film without formic acid. The device performance shows a close correlation with the colloidal size. Within the range studied from 6.7 to 1.0 nm, the smaller the colloidal size is, the higher the solar cell efficiency. More specifically, the cell efficiency is improved from17.82% for the control cell without formic acid to 19.81% when 0.764 M formic acid was used. Formic acid has also been added into a CH3NH3PbI3(MAPbI3) precursor solution, which exhibits a similar effect on the resulting MAPb I3 films and solar cells, with efficiency improved from 16.07% to 17.00%.

Research progress of physical activity among patients with coronary heart disease： a literature review

As early as 2000 years ago, Huangdineijing, a classic Traditional Chinese Medicine book, has recorded that the heart plays a leading role in the operation of all organs, and if the function of the heart is unnormal, then the organs of the subordinates cannot perform their duties, thus affecting the normal physiological function activities. It also pointed out that temperate physical activity could make the body＇s airflow smooth, qi and blood balanced, and visceral function active, which was conducive to the physical and mental health of the human body. In modern medicine, coronary heart disease is also one of the most common coronary disease which affects people＇s health. And physical activity is proved to be closely related to rehabilitation and prognosis of patients with coronary heart disease. Since physical activity is good for coronary heart disease, so what is the current level of physical activity in patients with coronary heart disease？ And what is the causes of different levels of it？ Here, we reviewed the measurement and influencing factors of physical activity for coronary heart disease patients. This literature provided a basis for medical personnels to develop personalized exercise program.

Automated detection of myopic maculopathy from color fundus photographs using deep convolutional neural networks

Background:Myopic maculopathy(MM)has become a major cause of visual impairment and blindness worldwide,especially in East Asian countries.Deep learning approaches such as deep convolutional neural networks(DCNN)have been successfully applied to identify some common retinal diseases and show great potential for the intelligent analysis of MM.This study aimed to build a reliable approach for automated detection of MM from retinal fundus images using DCNN models.Methods:A dual-stream DCNN(DCNN-DS)model that perceives features from both original images and corresponding processed images by color histogram distribution optimization method was designed for classification of no MM,tessellated fundus(TF),and pathologic myopia(PM).A total of 36,515 gradable images from four hospitals were used for DCNN model development,and 14,986 gradable images from the other two hospitals for external testing.We also compared the performance of the DCNN-DS model and four ophthalmologists on 3000 randomly sampledfundus images.Results:The DCNN-DS model achieved sensitivities of 93.3%and 91.0%,specificities of 99.6%and 98.7%,areas under the receiver operating characteristic curves(AUCs)of 0.998 and 0.994 for detecting PM,whereas sensitivities of 98.8%and 92.8%,specificities of 95.6%and 94.1%,AUCs of 0.986 and 0.970 for detecting TF in two external testing datasets.In the sampled testing dataset,the sensitivities of four ophthalmologists ranged from 88.3%to 95.8%and 81.1%to 89.1%,and the specificities ranged from 95.9%to 99.2%and 77.8%to 97.3%for detecting PM and TF,respectively.Meanwhile,the DCNN-DS model achieved sensitivities of 90.8%and 97.9%and specificities of 99.1%and 94.0%for detecting PMand T,respectively.Conclusions:The proposed DCNN-DS approach demonstrated reliable performance with high sensitivity,specificity,and AUC to classify different MM levels on fundus photographs sourced from clinics.It can help identify MM automatically among the large myopic groups and show great potential for real-life applications.

Role of Intracellular Distribution of Feline and Bovine SAMHD1 Proteins in Lentiviral Restriction

Human SAMHD1(h SAM)restricts lentiviruses at the reverse transcription step through its d NTP triphosphohydrolase(d NTPase)activity.Besides humans,several mammalian species such as cats and cows that carry their own lentiviruses also express SAMHD1.However,the intracellular distribution of feline and bovine SAMHD1(f SAM and b SAM)and its significance in their lentiviral restriction function is not known.Here,we demonstrated that f SAM and b SAM were both predominantly localized to the nucleus and nuclear localization signal(11KRPR14)-deleted f SAM and b SAM relocalized to the cytoplasm.Both cytoplasmic f SAM and b SAM retained the antiviral function against different lentiviruses and cytoplasmic f SAM could restrict Vpx-encoding SIV and HIV-2 more efficiently than its wild-type(WT)protein as cytoplasmic h SAM.Further investigation revealed that cytoplasmic f SAM was resistant to Vpx-induced degradation like cytoplasmic h SAM,while cytoplasmic b SAM was not,but they all demonstrated the same in vitro d NTPase activity and all could interact with Vpx as their WT proteins,indicating that cytoplasmic h SAM and f SAM can suppress more SIV and HIV-2 by being less sensitive to Vpx-mediated degradation.Our results suggested that f SAM-and b SAM-mediated lentiviral restriction does not require their nuclear localization and that f SAM shares more common features with h SAM.These findings may provide insights for the establishment of alternative animal models to study SAMHD1 in vivo.

Encapsulation of polyethylene glycol in cellulose-based porous capsules for latent heat storage and light-to-thermal conversion

Phase change materials are potential candidates for the application of latent heat storage.Herein,we fabricated porous capsules as shape-stable materials from cellulose-based polyelectrolyte complex,which were first prepared using cellulose 6-(N-pyridinium)hexanoyl ester as the cationic polyelectrolyte and carboxymethyl cellulose as the anionic polyelectrolyte to encapsulate polyethylene glycol by the vacuum impregnation method.Furthermore,the multi-walled carbon nanotube or graphene oxide,which were separately composited into the polyelectrolytes complex capsules to enhance thermal conductivity and light-to-thermal conversion efficiency.These capsules owned a typical core–shell structure,with an extremely high polyethylene glycol loading up to 34.33 g∙g^(‒1).After loading of polyethylene glycol,the resulted cellulose-based composite phase change materials exhibited high thermal energy storage ability with the latent heat up to 142.2 J∙g^(‒1),which was 98.5%of pure polyethylene glycol.Further results showed that the composite phase change materials demonstrated good form-stable property and thermal stability.Moreover,studies involving light-to-thermal conversion determined that composite phase change materials exhibited outstanding light-to-thermal conversion performance.Considering their exceptional comprehensive features,innovative composite phase change materials generated from cellulose presented a highly interesting choice for thermal management and renewable thermal energy storage.

Urban Inclusiveness and Entrepreneurship:Evidence from Microdata on Migrants

With the progressive reforms of China’s household registration system,China has unleashed its demographic dividends over the time and promoted the economic growth.Guided by the new vision of development,urban inclusiveness,especially the urban inclusiveness to the migrant population,will become a force for driving economic growth.Using the 2016 China Migrants Dynamic Survey(CMDS)dataset,we measure urban inclusiveness with the level of migrants’access to same public services and social security as local residents and explore the effects of urban inclusiveness on migrants’entrepreneurship.The results show that urban inclusiveness encourages migrants to start businesses and has a positive effect on the level of entrepreneurship.The urban environmental conditions and heterogeneity of individual laborers have different regulating effects on the influence of urban inclusiveness on individual entrepreneurial choice.The findings offer important inspirations for policy making in reforming the Chinese urban systems and promoting migrants’entrepreneurship.