Effects of Chinese chestnut powder on starch digestion,texture properties,and staling characteristics of bread

Chestnut is a high nutritional value food that has been widely used as a tonic in traditional Chinese medicine.As an emerging functional food ingredient,Chinese chestnuts are rich in a range of bioactive nutrients such as starch,dietary fiber,fat,protein,trace metal element and vitamins A,B,C,D and other nutrients.In our study,Chinese chestnut powder(CCP)were added into bread formulation at 2%-6%levels(based on flour weight)to produce fresh bread with enhanced anti-staling characteristics and starch digestion inhibitory ability.The texture properties,retrogradation enthalpy,water distribution,and estimated glycemic index(eGI)of wheat bread containing CCP as a functional additive were also investigated.The results showed that incorporation of CCP apparently affected bread texture,resulting in increased hardness,as well as decreased the specific volume of wheat bread.These influences were generally proportional to the amount of CCP used.It was found that adding too much CCP resulted in a dark red color,showing increased significantly higher total color difference(ΔE)and L values.Conversely,addition of CCP significantly reduced starch digestion rate and digestion extent in bread,and the reduction degree was positively related to the amount of CCP applied.The greatest reduction in eGI value from 79.40(control)to 75.02(6%CPP bread)was observed.Meanwhile,the content of resistant starch of 6%CPP bread was about 1.36 times higher than that of control bread.CCP also reduced crumb water loss and drove the water shift from the bound to the mobile state after stored for 7 days.The retrogradation enthalpy analyses further confirmed that CCP inhibited starch retrogradation and recrystallization.These results suggested that Chinese chestnut powder could be incorporated into fresh bread to provide health functions,such as lowering potential glycaemic response and improving anti-staling characteristics of bread.

血清microRNA-21、microRNA-193a-3p表达与结直肠癌患者手术预后的关系

目的探究血清microRNA-21(miR-21)、microRNA-193a-3p(miR-193a-3p)水平与结直肠癌患者手术预后的关系。方法回顾性分析2020年1月—2022年1月苏州大学附属第一医院收治112例结直肠癌患者的病历资料。患者均接受结直肠癌根治术,术后随访16个月,记录患者的预后生存结局,多因素逐步Logistic回归分析结直肠癌患者手术预后的影响因素,评估血清miR-21、miR-193a-3p对结直肠癌患者预后的预测效能。结果112例结直肠癌患者死亡22例,病死率为19.64%;生存90例,生存率为80.36%。死亡组术前血清miR-21 mRNA相对表达量、临床分期Ⅲ期占比、淋巴结转移率均高于生存组(P<0.05),血清miR-193a-3p m RNA相对表达量低于生存组(P<0.05)。多因素逐步Logistic回归分析结果显示,临床分期Ⅲ期[OR=3.777(95%CI:1.399,10.194)]、淋巴结转移[OR=5.099(95%CI:1.715,15.156)]、miR-21表达升高[OR=4.889(95%CI:1.645,14.533)]、miR-193a-3p表达降低[OR=4.402(95%CI:1.481,13.084)]均是直肠癌患者预后的影响因素(P<0.05)。受试者工作特性曲线分析结果显示,血清miR-21、miR-193a-3p单一及联合预测结直肠癌预后的敏感性分别为69.04%(95%CI:0.487,0.813)、72.73%(95%CI:0.495,0.884)、86.36%(95%CI:0.640,0.964),特异性分别为62.22%(95%CI:0.513,0.720)、68.89%(95%CI:0.581,0.780)、90.00%(95%CI:0.814,0.950),曲线下面积分别为0.782、0.731和0.901。结论结直肠癌患者术前miR-21、miR-193a-3p表达与术后预后密切相关,且在结直肠癌患者的预后结局中表现出良好的预测效能。

政策协调、不确定性与大型技术系统创新——中国核电技术赶超的案例研究

后发国家技术赶超需要实现“市场规模”和“技术自主”的双重目标,但现实中这一进程普遍面临技术依赖的“追赶者陷阱”的问题。论文采用个案内过程追踪的研究方法和“政策子系统”的分析视角,基于中国核电50年的技术赶超历程,解释了后发国家如何通过政策协调实现大型技术系统的技术赶超。研究发现,大型技术系统的创新绩效与其所在政策子系统的特性密切相关,核电政策子系统具有碎片化的结构和行为目标,需要同步进行政府部门间协调和政府对市场协调,协调机制主要包括国家意志、行政指令、共识信号和市场竞争等。政策协调通过降低大型技术系统中产业主体面临的供需不确定性,解决产业主体专用化投资不足的激励困境。跳出“追赶者陷阱”的关键在于建立国产化率目标硬约束与多种协调机制。研究进一步深化了对技术赶超中政府角色的认识,弥补了已有文献对于大型技术系统产业管理体制研究不足的理论缺口,对新型举国体制下提高系统创新能力有一定的启示。

建立我国自主知识产权的致癌性小鼠模型

致癌性试验是药物非临床安全性评价的重要内容之一。当前国内外普遍采用并认可基于ICH S1B指南建立的药物非临床致癌性试验替代方案。遗传修饰致癌性小鼠模型是替代方案中“卡脖子”的关键技术问题。从1997年ICH S1B指南发布至今,我国制药行业主要依赖进口获得小鼠模型,其价格高昂、进口周期长、条件严苛,且由于模型资源唯一,制药行业承受着成本高昂和供应链不稳的双重压力。本文概述了国内外致癌性试验相关指导原则,介绍了国内外主要的致癌性小鼠模型,包括Tg.rasH2、KI.C57-ras、p53^(+/-)小鼠等的构建、验证与应用历程,并展望了建立我国自主知识产权的致癌性小鼠模型以及标准化生产供应的途径。

基于可解释机器学习的重症监护室脓毒症患者死亡风险预测

为了有效预测重症监护室脓毒症患者的死亡风险并分析影响结局的因素,建立了脓毒症患者死亡风险预测模型,为脓毒症患者的早期预防和死亡风险控制提供科学的参考依据。本研究以重症监护医学信息市场数据库作为数据来源,从中挑选符合要求的病患,使用贝叶斯网络模型训练相关特征预测脓毒症患者的死亡风险。纳入2 352例脓毒症患者,以患者是否死亡作为最终结局建立模型,模型的风险预测准确率为78.7%,优于逻辑回归模型(72.3%)和决策树模型(71.0%)。贝叶斯网络模型相较于其他模型具有更高的信服力,能够准确预测脓毒症患者的死亡风险,模型的可解释性能够辅助医护人员进行临床决策,同时能够更加合理、科学地分配医疗资源。

氧化苦参碱水凝胶通过激活角化细胞Nrf2/HO-1通路促进创面愈合

背景:慢性创面炎症和氧化应激阻碍了角化细胞的再生,氧化苦参碱具有抗氧化、抗炎等多种生物活性,可能具有促进创面愈合的潜在效应。目的:探讨氧化苦参碱对创面愈合的作用,以及对H_(2)O_(2)诱导人角质形成细胞系HaCaT细胞氧化应激损伤的保护作用。方法:①体内实验:分别制备含0,0.05,0.1,0.2 g/L氧化苦参碱的甲基丙烯酰化透明质酸(HAMA)水凝胶。在75只糖尿病小鼠背中部制作直径12 mm的全层皮肤缺损模型,随机分5组干预,每组15只:模型组创面包扎固定,单纯水凝胶组以HAMA水凝胶覆盖创面,低、中、高剂量氧化苦参碱组分别以含0.05,0.1,0.2 g/L氧化苦参碱的HAMA水凝胶覆盖创面,光固化后包扎固定,14 d内进行相关指标的检测。②体外实验:将人角质形成细胞系HaCaT分5组培养,正常组常规培养,H_(2)O_(2)组及低、中、高浓度氧化苦参碱组均加入H_(2)O_(2)干预4 h,然后分别更换为含0,0.05,0.1,0.2 g/L氧化苦参碱的培养基,培养24 h后进行相关指标的检测。结果与结论:①体内实验:与模型组比较,单纯水凝胶组小鼠创面愈合率无明显变化,低、中、高剂量氧化苦参碱组治疗后7,14 d的创面愈合率升高(P<0.05)。治疗后14 d的创面样本切片病理观察显示,与模型组相比,中、高剂量氧化苦参碱组再生表皮层厚度、显微血管数量与胶原沉积均增加(P<0.05)。术后7 d的创面样本Western blotting检测显示,与模型组相比,中、高剂量氧化苦参碱组肿瘤坏死因子α与白细胞介素6的蛋白表达降低(P<0.05)。②体外实验:CCK-8检测、EdU及Ki67染色显示,与H_(2)O_(2)组相比,中、高浓度氧化苦参碱组细胞增殖能力明显升高(P<0.05)。与H_(2)O_(2)组相比,中、高浓度氧化苦参碱组线粒体膜电位升高(P<0.05)、活性氧含量降低(P<0.05)。Western blotting检测显示,与H_(2)O_(2)组相比,高浓度氧化苦参碱组Nrf2核蛋白、Nrf2总蛋白、HO-1蛋白及超氧化物歧化酶1蛋白的表达增加(P<0.05)。③结果表明:氧化苦参碱能够通过上调Nrf2、HO-1蛋白减轻HaCat细胞的氧化应激损伤,加速创面愈合。

城市老年人抑郁与认知功能的相关性及性别差异研究

背景我国人口老龄化问题日趋严重,抑郁是老年人群中较为常见的精神疾病之一,可导致显著的残疾和死亡风险增加。研究发现抑郁与认知障碍之间关联密切,并且这种关系可能受到性别的影响。在老年人群中,抑郁与认知功能及不同认知领域之间相关性的性别差异尚不明确。目的对城市老年人抑郁和认知功能状况进行调查,并分析抑郁与认知功能的相关性及性别差异。方法2022年9—10月采用分层抽样方法,选取安徽省合肥市某社区的65岁及以上老年居民作为调查对象。收集其一般资料,采用老年抑郁量表(GDS)、痴呆简易筛查量表(BSSD)分别对抑郁和认知功能状况进行评估,探讨老年人抑郁的相关因素,并分析抑郁、性别因素及二者的交互作用对认知功能的影响。结果共纳入328名老年人,抑郁的总体检出率为14.9%。回归分析结果显示,饮酒(OR=0.362,95%CI=0.155~0.847)、与子女居住(OR=2.445,95%CI=1.021~5.853)是抑郁的独立相关因素(P<0.05)。析因设计的方差分析显示,抑郁老年人的BSSD总分及语言(命令)理解、计算/注意、地点定向、时间定向和即刻记忆因子分均低于非抑郁老年人(P<0.05)。女性BSSD总分及常识/图片理解和地点定向因子分均低于男性,而语言(命令)理解得分高于男性(P<0.05)。抑郁与性别在常识/图片理解、语言(命令)理解和地点定向上的交互作用显著(P<0.05)。结论城市老年人抑郁风险较高,合并抑郁的老年人可能存在一定的认知功能减退,并伴有性别差异。应加强关注老年人抑郁和痴呆等精神问题,尤其是针对女性老年群体,有必要制定个体化的综合干预措施,提高老年人心理健康水平和生活质量。

Evaluation of the efficacy and safety of endoscopic band ligation in the treatment of bleeding from mild to moderate gastric varices type 1

BACKGROUND According to practice guidelines,endoscopic band ligation(EBL)and endoscopic tissue adhesive injection(TAI)are recommended for treating bleeding from esophagogastric varices.However,EBL and TAI are known to cause serious complications,such as hemorrhage from dislodged ligature rings caused by EBL and hemorrhage from operation-related ulcers resulting from TAI.However,the optimal therapy for mild to moderate type 1 gastric variceal hemorrhage(GOV1)has not been determined.Therefore,the aim of this study was to discover an individualized treatment for mild to moderate GOV1.AIM To compare the efficacy,safety and costs of EBL and TAI for the treatment of mild and moderate GOV1.METHODS A clinical analysis of the data retrieved from patients with mild or moderate GOV1 gastric varices who were treated under endoscopy was also conducted.Patients were allocated to an EBL group or an endoscopic TAI group.The differences in the incidence of varicose relief,operative time,operation success rate,mortality rate within 6 wk,rebleeding rate,6-wk operation-related ulcer healing rate,complication rate and average operation cost were compared between the two groups of patients.RESULTS The total effective rate of the two treatments was similar,but the efficacy of EBL(66.7%)was markedly better than that of TAI(39.2%)(P<0.05).The operation success rate in both groups was 100%,and the 6-wk mortality rate in both groups was 0%.The average operative time(26 min)in the EBL group was significantly shorter than that in the TAI group(46 min)(P<0.01).The rate of delayed postoperative rebleeding in the EBL group was significantly lower than that in the TAI group(11.8%vs 45.1%)(P<0.01).At 6 wk after the operation,the healing rate of operation-related ulcers in the EBL group was 80.4%,which was significantly greater than that in the TAI group(35.3%)(P<0.01).The incidence of postoperative complications in the two groups was similar.The average cost and other related economic factors were greater for the EBL than for the TAI(P<0.01).CONCLUSION For mild to moderate GOV1,patients with EBL had a greater one-time varix eradication rate,a greater 6-wk operation-related ulcer healing rate,a lower delayed rebleeding rate and a lower cost than patients with TAI.

Research on thermal insulation materials properties under HTHP conditions for deep oil and gas reservoir rock ITP-Coring

Deep oil and gas reservoirs are under high-temperature conditions,but traditional coring methods do not consider temperature-preserved measures and ignore the influence of temperature on rock porosity and permeability,resulting in distorted resource assessments.The development of in situ temperaturepreserved coring(ITP-Coring)technology for deep reservoir rock is urgent,and thermal insulation materials are key.Therefore,hollow glass microsphere/epoxy resin thermal insulation materials(HGM/EP materials)were proposed as thermal insulation materials.The materials properties under coupled hightemperature and high-pressure(HTHP)conditions were tested.The results indicated that high pressures led to HGM destruction and that the materials water absorption significantly increased;additionally,increasing temperature accelerated the process.High temperatures directly caused the thermal conductivity of the materials to increase;additionally,the thermal conduction and convection of water caused by high pressures led to an exponential increase in the thermal conductivity.High temperatures weakened the matrix,and high pressures destroyed the HGM,which resulted in a decrease in the tensile mechanical properties of the materials.The materials entered the high elastic state at 150℃,and the mechanical properties were weakened more obviously,while the pressure led to a significant effect when the water absorption was above 10%.Meanwhile,the tensile strength/strain were 13.62 MPa/1.3%and 6.09 MPa/0.86%at 100℃ and 100 MPa,respectively,which meet the application requirements of the self-designed coring device.Finally,K46-f40 and K46-f50 HGM/EP materials were proven to be suitable for ITP-Coring under coupled conditions below 100℃ and 100 MPa.To further improve the materials properties,the interface layer and EP matrix should be optimized.The results can provide references for the optimization and engineering application of materials and thus technical support for deep oil and gas resource development.

不同氮磷营养条件对中肋骨条藻和球等鞭金藻生长及元素组成的影响

为了探究氮磷比(N/P)失衡和不同藻种对海洋微藻的生长和元素组成及营养利用的影响,本研究分别在正常条件(f/2培养基)、低N/P条件(氮限制)和高N/P条件(磷限制)下,连续培养了中肋骨条藻(Skeletonema costatum)和球等鞭金藻(Isochrysis galbana)两种微藻各15 d,培养过程中测定了两种微藻的细胞密度、叶绿素a浓度、藻细胞的元素含量(C、N、P)和化学计量比,以及培养液中无机盐的含量。结果表明:氮限制条件促进两种微藻的增殖,而磷限制条件抑制了两种微藻增殖;营养失衡不利于藻细胞叶绿素a的积累;在不同N/P条件下两种藻的C含量变化较小,而随着时间推移,两种藻细胞的N和P元素含量均有所降低,且在两种藻细胞的高N/P组中N含量均达到最高,不同N/P条件对细胞N元素含量有极显著影响;两种藻细胞在低N/P组和高N/P组中的P含量均同对照组无显著性差异;不同藻种对细胞C元素和P元素的含量有显著性影响;中肋骨条藻在高N/P组和低N/P组的C/N值、在低N/P组的C/P值以及在高N/P组的N/P值均同对照组存在显著性差异;球等鞭金藻在三种条件下的各元素比值均与对照组无明显差异;不同N/P条件只对细胞N/P值有极显著影响;氮限制增加了NO_(3)^(-)-N的利用率,磷限制降低了NO_(3)^(-)-N的利用率,而这两种营养失衡均对藻细胞利用PO _(4)^(3-)-P的影响很小。

基于医疗临床数据的两阶段专业级大语言模型微调

通用大语言模型(large language model,LLM)缺乏对专业领域知识理解的深度和广度,对专业领域问题回答的准确度不够,常常产生幻觉,阻碍了大语言模型的商业应用落地。因此,基于专业领域特有数据提高大型语言模型的专业性成为当前大语言模型应用落地的关键挑战。针对通用大语言模型在特定领域知识理解与生成内容专业性不够的问题进行了研究。基于P-Tuning v2与Freeze两种参数高效微调方法,提出了一种专业级大语言模型的两阶段微调框架。依赖该框架与肝胆科临床数据对ChatGLM-6B进行微调,得到一个针对肝胆专科的专业级大语言模型,命名为MedGLM.H。根据实验显示,微调后的大语言模型对于肝胆专科问题的准确率从31%提升到了62%;得分率从57%提升到了73%。在进行两阶段微调后,模型在肝胆专科的问答中表现出更高的准确性与专业性,根据三名临床医生进行的对话实验,证明了微调后的模型在更专业的医疗场景中具备应用潜力。

数字化转型、全球价值链嵌入与制造业企业TFP

本文认为,依托数字化转型,价值链分工地位能够得以改善,从而可能改变以往“低端嵌入”对制造业全要素生产率(TFP)造成的不利影响,而且,随着参与全球价值链程度的深化,其对制造业全要素生产率的提升也具有积极作用。进一步利用WIOD数据库、中国工业企业数据库以及中国海关数据库的匹配数据,基于企业层面的实证研究发现,数字化转型对制造业企业TFP影响的现实效应证实了前述理论判断,即数字化转型通过改善全球价值链分工地位以及提升全球价值链参与度对制造业企业TFP提高产生积极影响。因此,制造业企业要抓住数字技术带来的战略机遇,通过大力推进数字化转型,改善全球价值链分工地位和强化扎根全球价值链能力,充分发挥融入全球价值链对提升TFP的积极作用。

双边价值链关联:中国FDI和OFDI的作用差异分析

长期以来,“引进来”是中国参与全球价值链的重要方式,而目前中国开放发展已从以往“引进来”为主转向“引进来”和“走出去”并重的新阶段。那么,从参与全球价值链角度看,二者作用究竟有何不同是理论研究中需要阐明的重要问题。在理论分析基础上,测算1995—2018年中国与63个伙伴国之间的双边价值链关联程度指数,并采用双向固定效应模型进行实证分析。结果表明:(1)“引进来”和“走出去”均有助于提高价值链总体关联程度;(2)从关联方式看,“引进来”的价值链后向关联效应更加明显,“走出去”则价值链前向关联效应更明显;(3)机制分析发现,中间品贸易对形成双边价值链关联效应起到重要作用。因此,“引进来”和“走出去”并重有助于探寻形成更高水平开放新格局,更好地实现中国产业链供应链的“固链”和“强链”。

基于可解释贝叶斯加权模型的ICU急性肾损伤患者死亡风险预测

基于贝叶斯网络构建贝叶斯加权模型,进行重症监护病房(Intensive Care Unit,ICU)急性肾损伤患者死亡风险预测。以MIMIC-Ⅲ(Medical Information Mark for Intensive CareⅢ)数据库中急性肾损伤患者为研究对象,建立基础贝叶斯分类器,采用AUC(Area Under Curve)和Accuracy进行混合加权计算的集成策略构建贝叶斯加权模型。实验结果表明,贝叶斯加权模型的AUC值为80.8%、Accuracy值为73.2%、F1-score值为72.4%,预测效果优于单独的贝叶斯网络模型、逻辑回归、支持向量机和随机森林。贝叶斯加权模型具有可解释的概率推理流程,对ICU急性肾损伤患者的死亡风险预测有一定的参考价值。

基于RFID技术的装备维修物资管理系统设计

为提升装备维修过程中的物资管理效率,设计了一种基于RFID技术的装备维修物资管理系统。根据装备管理对象特点明确管理业务需求,设计了系统的软、硬件组成与工作流程,建立了数据库对象逻辑关系,开发了管理系统程序,通过物资出入库、设备清点业务验证了系统功能。

基于能量函数塑形的直流微电网多电力弹簧电压平稳控制方法

直流微电网低惯性响应特性常导致系统存在不确定性扰动时母线电压波动越限。针对这一问题,文中以直流电力弹簧(DCES)为核心构建智能负载,解析直流电机动能与智能负载惯量能量间的映射关系,实现需求侧等效虚拟惯量注入,快速补偿不确定性扰动造成的DCES输出电压偏差;针对多DCES协同控制,设计动态事件触发机制,以最小通信需求求解全局一致性误差,实现各DCES输出电压期望轨迹实时在线更新;提出了具有最小相位特性的反馈线性化控制器,将传统电压-电流双环控制转化为能量单环控制,构建DCES能量函数,重塑状态变量空间为Grassmann流形,实现系统完全解耦和精确线性化转换,准确跟踪各DCES输出电压期望轨迹,同时确保全局渐近稳定。基于dSPACE的实验结果表明:系统存在外部不确定扰动和内部参数摄动情形下,所提方法可实现直流微电网母线电压的平稳控制,具有动态响应快、稳定性好、鲁棒性强、抗扰性优的特点。

Quantifying peripapillary vessel density and retinal nerve fibre layer in type 1 diabetic children without clinically detectable retinopathy using OCTA

AIM:To quantify changes in radial peripapillary capillary vessel density(ppVD)and the peripapillary retinal nerve fiber layer(pRNFL)in children with type 1 diabetes without clinical diabetic retinopathy by optical coherence tomography angiography(OCTA),providing a basis for early retinopathy in children with type 1 diabetes.METHODS:This was a retrospective study.A total of 30 patients(3–14y)with type 1 diabetes without clinical diabetic retinopathy(NDR group)were included.A total of 30 age-matched healthy subjects were included as the normal control group(CON group).The HbA1c level in the last 3mo was measured once in the NDR group.The pRNFL thickness and ppVD were automatically measured,and the mean pRNFL and ppVD were calculated in the nasal,inferior,temporal,and superior quadrants.The changes in ppVD and pRNFL in the two groups were analyzed.RESULTS:Compared with CON group,the nasal and superior ppVDs decreased in the NDR group(all P<0.01).The thickness of the nasal pRNFL decreased significantly(P<0.01),while the inferior,temporal and superior pRNFLs slightly decreased but not significant in the NDR group(all P>0.05).Person and Spearman correlation analysis of ppVD and pRNFL thickness in each quadrant of the NDR group showed a positive correlation between nasal and superior(all P<0.01),while inferior and temporal had no significant correlation(all P>0.05).There was no significant correlation between the HbA1c level and ppVD and pRNFL in any quadrant(all P>0.05).There was no significant correlation between the course of diabetes mellitus and ppVD and pRNFL in any quadrant(all P>0.05).CONCLUSION:ppVD and pRNFL decrease in eyes of children with type 1 diabetes before clinically detectable retinopathy and OCTA is helpful for early monitoring.

区域国别音乐研究的理论方法与书写转化——基于越南岱族、侬族音乐的田野考察

区域国别音乐研究关注海外他者的音乐表演行为,深入描写与系统阐释其文化认知观念,通过运用多重语言能力,结合海外音乐民族志的田野实践与书写转化,对海外的某个特定区域或国家的音乐文化进行跨学科研究,以揭示海外他者音乐社会生活中的地方性知识。区域国别音乐研究通过对他国音乐文化进行扎实深入的田野工作和海外实践,运用民族音乐学双重视角互视与多点音乐民族志方法,以及历史民族音乐学逆推顺述与多重互证,结合后殖民理论的离散音乐与文化认同,书写具有反本质主义立场的海外音乐民族志文本,以获得中国立场和全球视野下对世界知识体系真正深入的研究与理解。

Bibliometric analysis of research in epilepsy and comorbid depression from 2014 to 2023

BACKGROUND Epilepsy and depression have complicated bidirectional relationships.Our study aimed to explore the field of epilepsy comorbid with depression in a bibliometric perspective from 2014-2023.AIM To improve our understanding of epilepsy and depression by evaluating the relationship between epilepsy and depression,bibliometric analyses were performed.METHODS Epilepsy and depression-related publications from the last decade were retrieved from the Web of Science Core Collection.We conducted bibliometric and visual analysis using VOSviewer and CiteSpace,examining authorships,countries,institutions,journals of publication,co-citations of references,connections between keywords,clusters of keywords,and keywords with citation bursts.RESULTS Over the past ten years,we collected 1045 research papers focusing on the field of epilepsy and comorbid depression.Publications on epilepsy and depression have shown a general upward trend over time,though with some fluctuations.The United States,with 287 articles,and the University of Melbourne,contributing 34 articles,were the top countries and institutions,respectively.In addition,in the field of epilepsy and depression,Professor Lee,who has published 30 articles,was the most contributing author.The hot topics pay attention to the quality of life in patients with epilepsy and depression.CONCLUSION We reported that quality of life and stigma in patients with epilepsy comorbid with depression are possible future hot topics and directions in the field of epilepsy and depression research.

350MW级压缩空气储能系统配气方式优化研究

建立了350MW级先进压缩空气储能系统膨胀侧核心设备的数学模型,基于EBSILON热力学仿真软件仿真计算了不同膨胀机配气方式对压缩空气储能系统热力性能的影响趋势。计算结果表明:采用“节流+补气”配气方式时,压缩空气储能系统整体运行经济性更高,且储气库压力波动范围越大,经济性优势越明显,应对电网调峰调频指令的负荷响应能力更好。