Intelligent electronic devices(IEDs)are interconnected via communication networks and play pivotal roles in transmitting grid-related operational data and executing control instructions.In the context of the heightene...Intelligent electronic devices(IEDs)are interconnected via communication networks and play pivotal roles in transmitting grid-related operational data and executing control instructions.In the context of the heightened security challenges within smart grids,IEDs pose significant risks due to inherent hardware and software vulner-abilities,as well as the openness and vulnerability of communication protocols.Smart grid security,distinct from traditional internet security,mainly relies on monitoring network security events at the platform layer,lacking an effective assessment mechanism for IEDs.Hence,we incorporate considerations for both cyber-attacks and physical faults,presenting security assessment indicators and methods specifically tailored for IEDs.Initially,we outline the security monitoring technology for IEDs,considering the necessary data sources for their security assessment.Subsequently,we classify IEDs and establish a comprehensive security monitoring index system,incorporating factors such as running states,network traffic,and abnormal behaviors.This index system contains 18 indicators in 3 categories.Additionally,we elucidate quantitative methods for various indicators and propose a hybrid security assessment method known as GRCW-hybrid,combining grey relational analysis(GRA),analytic hierarchy process(AHP),and entropy weight method(EWM).According to the proposed assessment method,the security risk level of IEDs can be graded into 6 levels,namely 0,1,2,3,4,and 5.The higher the level,the greater the security risk.Finally,we assess and simulate 15 scenarios in 3 categories,which are based on monitoring indicators and real-world situations encountered by IEDs.The results show that calculated security risk level based on the proposed assessment method are consistent with actual simulation.Thus,the reasonableness and effectiveness of the proposed index system and assessment method are validated.展开更多
Global warming threatens freshwater ecosystems and compromises fish survival.To elucidate the role of miRNAs in the livers of heat stressed largemouth bass,juvenile fish was subject to heat stress under 37°C.Both...Global warming threatens freshwater ecosystems and compromises fish survival.To elucidate the role of miRNAs in the livers of heat stressed largemouth bass,juvenile fish was subject to heat stress under 37°C.Both mRNA-seq and miRNA-seq were conducted on the liver tissues under control and heat stress conditions.Differential gene expression analysis and enrichment analysis were performed on mRNA and miRNA expression profiles.A total of 406 differentially expressed genes(DEGs)were discovered,of which 212 were up-regulated and 194 were down-regulated.Most of the DEGs were significantly implicated in the regulation of“protein processing in endoplasmic reticulum”,“proteasome”,“steroid biosynthesis”,and“ornithine decarboxylase inhibitor activity”pathways.In addition,47 differentially expressed miRNAs(DEMs)were identified in largemouth bass livers under heat stress,including 21 up-regulated and 25 down-regulated miRNAs.A negatively regulated miRNA-mRNA network including 12 miRNAs and 19 mRNAs was constructed with DEMs involved in“protein degradation”,“calcium ion regulation”,“cell apoptosis”,and“lipid metabolism”.Moreover,this study indicated novel-miR-144 activated the IRE1 signaling pathway by targeting txndc5 to induce liver apoptosis in largemouth bass under heat stress.This study revealed the involvement of miRNA regulation in largemouth bass in response to heat stress.展开更多
Teaching and research activities are of great significance to the professional development of teachers.The basic psychological needs of teachers include autonomy,competence,and attribution.The engagement of teachers i...Teaching and research activities are of great significance to the professional development of teachers.The basic psychological needs of teachers include autonomy,competence,and attribution.The engagement of teachers in teaching and research activities can be analyzed from these three perspectives.Under the management system of teaching and research,teachers generally lack autonomy in the organization of teaching and research activities;they are also lack scientific research knowledge and ability;in addition,under the influence of harmonious interpersonal relationships and the culture of individualism,there is a dearth in real communication among teachers.In light of this,we propose targeted countermeasures to promote the vitality of teaching and research activities.展开更多
The complex and volatile international landscape has significantly impacted global grain supply security. This study uses a complex network analysis model to examine the evolution and trends of the global major grain ...The complex and volatile international landscape has significantly impacted global grain supply security. This study uses a complex network analysis model to examine the evolution and trends of the global major grain trade from 1990 to 2020, focusing on network topology, centrality ranking, and community structure. There are three major findings. First, the global major grain trade network has expanded in scale, with a growing emphasis on diversification and balance. During the study period, the United States, Canada, China, and Brazil were the core nodes of the network. Grain-exporting countries were mainly situated in Asia, the Americas, and Europe, and importing countries in Asia, Africa, and Europe. Second, a significant increase in the number of high centrality countries with high export capacity occurred, benefiting from natural advantages such as fertile land and favorable climates. Third, the main global grain trade network is divided into four communities, with the Americas-Europe community being the largest and most widespread. The formation of the community pattern was influenced by geographic proximity, driven by the core exporting countries. Therefore, the world needs to enhance the existing trade model, promote the multi-polarization of the grain trade network, and establish a global vision for the future community. Countries and regions should participate actively in global grain trade security governance and institutional reform, expand trade links with other countries, and optimize import and export policies to reduce trade risks.展开更多
Objective:To evaluate the effectiveness and safety of modified Xiaoyao powder for postpartum depression(PPD)by conducting a systematic review of randomized controlled trials(RCTs).Methods:The Chinese National Knowledg...Objective:To evaluate the effectiveness and safety of modified Xiaoyao powder for postpartum depression(PPD)by conducting a systematic review of randomized controlled trials(RCTs).Methods:The Chinese National Knowledge Infrastructure Databases(CNKI),the Chinese Scientific Journals Database(VIP),Wanfang,Google Scholar,the SinoMed,Embase,Cochrane Library,and PubMed databases were searched from their inception to April 25,2023.The Cochrane Risk of Bias tool was used to assess the quality of the trials.We applied the risk ratio to present dichotomous data and the mean difference to present continuous data.Data with similar characteristics were pooled for meta-analysis and heterogeneity was assessed using I2.Results:This review included 35 trials involving 2848 participants.The quality of the included studies was low(unclear randomization processes and insufficient reporting of blinding).Participants treated with modified Xiaoyao powder plus Western medicine showed lower Hamilton Depression Scale(HAMD)depression score than those who used Western medicine alone(mean difference=-2.15;95%confidence interval:-2.52 to 1.78;P<.00001),and higher effective rate(relative risk=1.19;95%confidence interval:1.15 to 1.24;P<.00001),When comparing modified Xiaoyao alone with Western medicine,the HAMD depression score remained low,however,the efficacy rate was higher in the modified Xiaoyao group.Regarding adverse events,the modified Xiaoyao group reported weight gain,nausea,and diarrhea,but no severe adverse events were reported.Conclusion:Modified Xiaoyao may help relieve depression in PPD when used alone or in combination with Western medicine,with minor side effects.Therefore,future high-quality,large-sample size RCTs are warranted.展开更多
Polishing plays an indispensable role in optical processing,especially for large-aperture optical reflective mirrors with freeform surfaces.Robotic polishing requires effective control of the contact force between the...Polishing plays an indispensable role in optical processing,especially for large-aperture optical reflective mirrors with freeform surfaces.Robotic polishing requires effective control of the contact force between the robot and the mirror during processing.In order to maintain a constant contact force during polishing,traditional polishing robots rely on closed-loop control of air cylinders,whose performances heavily rely on high-fidelity force sensing and real-time control.This paper proposes to employ a compliant constant-force mechanism in the end-effector of a polishing robot to passively maintain a constant force between the robot and the mirror,thus eliminating the requirement for force sensing and closed-loop control.The compliant constant force mechanism utilizing the second bending mode of fixed-guided compliant beams is adopted and elaborated for the passive end-effector.An end-effector providing a constant contact force of 40 N is designed and prototyped.The polishing experiment shows that the passive constant-force end-effector provides stable contact force between the robot and the mirror with fluctuation within 3.43 N,and achieves RMS(Root Mean Square)lower thanλ/10(λ=632.8 nm)of the polished surface of the largeaperture optical reflective mirror.It is concluded that the constant-force compliant mechanism provides a low-cost and reliable solution for force control in robotic polishing.展开更多
In order to control the working wavelength range of the fiber surface plasmon resonance(SPR)temperature sensor and realize the wavelength division multiplexing type multi-channel fiber SPR temperature sensor,by compre...In order to control the working wavelength range of the fiber surface plasmon resonance(SPR)temperature sensor and realize the wavelength division multiplexing type multi-channel fiber SPR temperature sensor,by comprehensively investigating the influence of liquids with different thermal-optical coefficients and solid packaging materials on the performance of fiber SPR temperature sensor,a dual-channel fiber SPR temperature sensor based on liquid-solid cascade encapsulation was designed and fabricated.The liquid temperature sensing stage encapsulated in capillary worked in 616.03 nm-639.05 nm band,the solid sensing stage coated with pouring sealant worked in 719.37 nm-825.27 nm band,and the two stages were cascaded to form a fiber dual-channel temperature sensor.The testing results indicated that when the temperature range was 35℃-95℃,the sensitivity of two-stage temperature detection was−0.384 nm/℃and−1.765 nm/℃respectively.The proposed fiber sensor has simple fabrication and excellent performance which can be widely used in various fields of dual-channel temperature measurement and temperature compensation.展开更多
Objective: To investigate the bioactive components of Sangqi Qingxuan formula(SQQX), predict the pharmacological targets, and explore the mechanism of hypertensive vascular remodeling(HVR).Methods: Network pharmacolog...Objective: To investigate the bioactive components of Sangqi Qingxuan formula(SQQX), predict the pharmacological targets, and explore the mechanism of hypertensive vascular remodeling(HVR).Methods: Network pharmacology was adopted to predict how SQQX acts in HVR. The effectiveness was assessed by blood pressure measurements and pathological morphology observation based on a spontaneously hypertensive rat model, while the mechanism of SQQX on HVR was validated by immunohistochemistry(IHC) and western blot(WB) according to the results of network pharmacology.Results: There were 130 bioactive components of SQQX and 231 drug targets predicted by the Traditional Chinese Medicine Systems Pharmacology Database. Subsequently, 181 common targets were identified for SQQX against HVR, with TP53, MAPK1, and AKT1 as the core targets. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses was employed to identify the top 20 enriched functions and the top 20 pathways(P <.01). Finally, the key role of the ERK/MAPK signaling pathway in HVR was determined. The in vivo results suggested that SQQX reduced systolic blood pressure and increased the ratio of thoracic aortic wall thickness to lumen diameter. Additionally, compared with the model group, SQQX increased the expression of smooth muscle 22 alpha(IHC: P <.001;WB:P <.05) and decreased the expression of osteopontin(IHC: P <.001;WB: P <.05), ERK1/2(IHC: P <.001;WB: ERK1 & ERK2, all P <.05), p-ERK1/2(IHC: P <.001;WB: ERK1 & ERK2, all P <.05), and the ratio of pERK1/2 to ERK1/2 protein(IHC: P <.001).Conclusions: SQQX, which has multiple bioactive ingredients and potential targets, is an effective treatment for HVR. The mechanism of antihypertensive and vascular protection may be related to the inhibition of phenotypic transformation of vascular smooth muscle cells and the ERK/MAPK signaling pathway.展开更多
Based on the study of parse wood materials,the fitting empirical equation of tree growth was obtained,a function with tree growth as a variable and time as an independent variable.Through mathematical operations such ...Based on the study of parse wood materials,the fitting empirical equation of tree growth was obtained,a function with tree growth as a variable and time as an independent variable.Through mathematical operations such as function derivation,the mature age of tree growth was obtained,and the obtained expected mature age of Saliz matsudana was 21a.And the application,research directions and precautions of the mature ages were proposed.展开更多
Fiber cladding surface plasmon resonance(SPR)sensors have few structures,and a clad SPR sensor based on S-type fiber is proposed in this paper.This new type of fiber cladding SPR sensor was formed by electrofusing an ...Fiber cladding surface plasmon resonance(SPR)sensors have few structures,and a clad SPR sensor based on S-type fiber is proposed in this paper.This new type of fiber cladding SPR sensor was formed by electrofusing an S-shaped structure on the fiber to couple the light in the fiber core to the cladding.In this paper,the effects of fiber parameters on the performance of the sensor were studied by simulation and experiment.Based on the conclusion that the smaller the core diameter is,the closer the working band of the SPR resonance is to long wavelengths,and that the geometric characteristics mean that a multimode fiber can receive the fiber cladding light from a small core diameter few-mode fiber,a dual channel SPR sensor with a double S-type fiber cascade was proposed.In the refractive index detection range of 1.333–1.385refractive index units(RIU),the resonant working band of channel I is 627.66 nm–759.78 nm,with an average sensitivity of 2540.77 nm/RIU,and the resonant working band of channel II is 518.24 nm–658.2 nm,with an average sensitivity of2691.54 nm/RIU.The processing method for the S-type fiber cladding SPR sensor is simple,effectively solving the problem of this type of SPR sensor structure and the difficult realization of a dual channel.The sensor is expected to be used in the fields of medical treatment and biological analysis.展开更多
The cement mixing (CM) pile is a common method of improving soft offshore ground. The strength growth of CM piles under complex conditions is affected by many factors, especially the cement and moisture contents, and ...The cement mixing (CM) pile is a common method of improving soft offshore ground. The strength growth of CM piles under complex conditions is affected by many factors, especially the cement and moisture contents, and shows significant uncertainty. To investigate the stochasticity of the early strength of CM piles and its impact on the displacement and stability of a seawall, a series of laboratory tests and numerical analyses were carried out in this study. Vane shear tests were conducted on the cement-solidified soil to determine the relationships between the undrained shear strength s_(u) of the cement soil curing in the seawater and the cement content a_(c), as well as the in situ soil moisture content w. It can be inferred that the 24 h undrained shear strength follows a normal distribution. A numerical model considering the random CM pile strength was established to investigate the deformation of the seawall. Due to the uncertainty of CM pile strength, the displacement of the seawall demonstrates a certain discreteness. The decrease of the mean undrained shear strength of CM piles causes a corresponding increase in the average displacement of the seawall. When the mean strength of CM piles is lower than a certain threshold, there is a risk of instability. Furthermore, the heterogeneity of the strength within an individual CM pile also has an impact on seawall displacement. Attention should be paid to the uncertainty of CM pile strength to control displacement and stability.展开更多
基金The financial support from the Program for Science and Technology of Henan Province of China(Grant No.242102210148)Henan Center for Outstanding Overseas Scientists(Grant No.GZS2022011)Songshan Laboratory Pre-Research Project(Grant No.YYJC032022022).
文摘Intelligent electronic devices(IEDs)are interconnected via communication networks and play pivotal roles in transmitting grid-related operational data and executing control instructions.In the context of the heightened security challenges within smart grids,IEDs pose significant risks due to inherent hardware and software vulner-abilities,as well as the openness and vulnerability of communication protocols.Smart grid security,distinct from traditional internet security,mainly relies on monitoring network security events at the platform layer,lacking an effective assessment mechanism for IEDs.Hence,we incorporate considerations for both cyber-attacks and physical faults,presenting security assessment indicators and methods specifically tailored for IEDs.Initially,we outline the security monitoring technology for IEDs,considering the necessary data sources for their security assessment.Subsequently,we classify IEDs and establish a comprehensive security monitoring index system,incorporating factors such as running states,network traffic,and abnormal behaviors.This index system contains 18 indicators in 3 categories.Additionally,we elucidate quantitative methods for various indicators and propose a hybrid security assessment method known as GRCW-hybrid,combining grey relational analysis(GRA),analytic hierarchy process(AHP),and entropy weight method(EWM).According to the proposed assessment method,the security risk level of IEDs can be graded into 6 levels,namely 0,1,2,3,4,and 5.The higher the level,the greater the security risk.Finally,we assess and simulate 15 scenarios in 3 categories,which are based on monitoring indicators and real-world situations encountered by IEDs.The results show that calculated security risk level based on the proposed assessment method are consistent with actual simulation.Thus,the reasonableness and effectiveness of the proposed index system and assessment method are validated.
基金Supported by the Scientific Fund of Jiangsu Province (No.BY2015039-10)the Aquatic Three Project of Jiangsu Province (No.Y2017-37)+2 种基金the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)the Top-notch Academic Programs Project of Jiangsu Higher Education Institutions (TAPP)the Jiangsu Funding Program for Excellent Postdoctoral Talent
文摘Global warming threatens freshwater ecosystems and compromises fish survival.To elucidate the role of miRNAs in the livers of heat stressed largemouth bass,juvenile fish was subject to heat stress under 37°C.Both mRNA-seq and miRNA-seq were conducted on the liver tissues under control and heat stress conditions.Differential gene expression analysis and enrichment analysis were performed on mRNA and miRNA expression profiles.A total of 406 differentially expressed genes(DEGs)were discovered,of which 212 were up-regulated and 194 were down-regulated.Most of the DEGs were significantly implicated in the regulation of“protein processing in endoplasmic reticulum”,“proteasome”,“steroid biosynthesis”,and“ornithine decarboxylase inhibitor activity”pathways.In addition,47 differentially expressed miRNAs(DEMs)were identified in largemouth bass livers under heat stress,including 21 up-regulated and 25 down-regulated miRNAs.A negatively regulated miRNA-mRNA network including 12 miRNAs and 19 mRNAs was constructed with DEMs involved in“protein degradation”,“calcium ion regulation”,“cell apoptosis”,and“lipid metabolism”.Moreover,this study indicated novel-miR-144 activated the IRE1 signaling pathway by targeting txndc5 to induce liver apoptosis in largemouth bass under heat stress.This study revealed the involvement of miRNA regulation in largemouth bass in response to heat stress.
文摘Teaching and research activities are of great significance to the professional development of teachers.The basic psychological needs of teachers include autonomy,competence,and attribution.The engagement of teachers in teaching and research activities can be analyzed from these three perspectives.Under the management system of teaching and research,teachers generally lack autonomy in the organization of teaching and research activities;they are also lack scientific research knowledge and ability;in addition,under the influence of harmonious interpersonal relationships and the culture of individualism,there is a dearth in real communication among teachers.In light of this,we propose targeted countermeasures to promote the vitality of teaching and research activities.
基金funded by the National Natural Science Foundation of China(42271313)the Chinese Academy of Agricultural Sciences Innovation Project(CAAS-ASTIP2021-AII)the Central Public-interest Scientific Institution Basal Research Fund,China(JBYW-AII-2022-06,JBYWAII-2022-40)。
文摘The complex and volatile international landscape has significantly impacted global grain supply security. This study uses a complex network analysis model to examine the evolution and trends of the global major grain trade from 1990 to 2020, focusing on network topology, centrality ranking, and community structure. There are three major findings. First, the global major grain trade network has expanded in scale, with a growing emphasis on diversification and balance. During the study period, the United States, Canada, China, and Brazil were the core nodes of the network. Grain-exporting countries were mainly situated in Asia, the Americas, and Europe, and importing countries in Asia, Africa, and Europe. Second, a significant increase in the number of high centrality countries with high export capacity occurred, benefiting from natural advantages such as fertile land and favorable climates. Third, the main global grain trade network is divided into four communities, with the Americas-Europe community being the largest and most widespread. The formation of the community pattern was influenced by geographic proximity, driven by the core exporting countries. Therefore, the world needs to enhance the existing trade model, promote the multi-polarization of the grain trade network, and establish a global vision for the future community. Countries and regions should participate actively in global grain trade security governance and institutional reform, expand trade links with other countries, and optimize import and export policies to reduce trade risks.
基金supported by the State Administration of Traditional Chinese Medicine High-level Key Discipline Construction Project of Traditional Chinese Medicine-Beijing University of Traditional Chinese Medicine Combined Fundamentals of Chinese and Western Medicine(Pharmacology Discipline,Project No.zyyzdxk-2023256).
文摘Objective:To evaluate the effectiveness and safety of modified Xiaoyao powder for postpartum depression(PPD)by conducting a systematic review of randomized controlled trials(RCTs).Methods:The Chinese National Knowledge Infrastructure Databases(CNKI),the Chinese Scientific Journals Database(VIP),Wanfang,Google Scholar,the SinoMed,Embase,Cochrane Library,and PubMed databases were searched from their inception to April 25,2023.The Cochrane Risk of Bias tool was used to assess the quality of the trials.We applied the risk ratio to present dichotomous data and the mean difference to present continuous data.Data with similar characteristics were pooled for meta-analysis and heterogeneity was assessed using I2.Results:This review included 35 trials involving 2848 participants.The quality of the included studies was low(unclear randomization processes and insufficient reporting of blinding).Participants treated with modified Xiaoyao powder plus Western medicine showed lower Hamilton Depression Scale(HAMD)depression score than those who used Western medicine alone(mean difference=-2.15;95%confidence interval:-2.52 to 1.78;P<.00001),and higher effective rate(relative risk=1.19;95%confidence interval:1.15 to 1.24;P<.00001),When comparing modified Xiaoyao alone with Western medicine,the HAMD depression score remained low,however,the efficacy rate was higher in the modified Xiaoyao group.Regarding adverse events,the modified Xiaoyao group reported weight gain,nausea,and diarrhea,but no severe adverse events were reported.Conclusion:Modified Xiaoyao may help relieve depression in PPD when used alone or in combination with Western medicine,with minor side effects.Therefore,future high-quality,large-sample size RCTs are warranted.
基金National Natural Science Foundation of China(Grant No.U1913213)West Light Foundation of the Chinese Academy of Sciences(Grant No.XAB2016A10)Shanxi Provincial Key Research and Development Projects of China(Grant No.2018ZDXM-GY-105).
文摘Polishing plays an indispensable role in optical processing,especially for large-aperture optical reflective mirrors with freeform surfaces.Robotic polishing requires effective control of the contact force between the robot and the mirror during processing.In order to maintain a constant contact force during polishing,traditional polishing robots rely on closed-loop control of air cylinders,whose performances heavily rely on high-fidelity force sensing and real-time control.This paper proposes to employ a compliant constant-force mechanism in the end-effector of a polishing robot to passively maintain a constant force between the robot and the mirror,thus eliminating the requirement for force sensing and closed-loop control.The compliant constant force mechanism utilizing the second bending mode of fixed-guided compliant beams is adopted and elaborated for the passive end-effector.An end-effector providing a constant contact force of 40 N is designed and prototyped.The polishing experiment shows that the passive constant-force end-effector provides stable contact force between the robot and the mirror with fluctuation within 3.43 N,and achieves RMS(Root Mean Square)lower thanλ/10(λ=632.8 nm)of the polished surface of the largeaperture optical reflective mirror.It is concluded that the constant-force compliant mechanism provides a low-cost and reliable solution for force control in robotic polishing.
基金supported by the National Natural Science Foundation of China(Grant No.61705025)the Natural Science Foundation of Heilongjiang Province,China(Grant No.F2018027)+3 种基金partially supported by Chongqing Natural Science Foundation(Grant Nos.cstc2019jcyj-msxmX0431 and cstc2018jcyjAX0817)the Science and Technology Project Affiliated to the Education Department of Chongqing Municipality(Grant Nos.KJQN201801217,KJQN201901226,and KJ1710247)Chongqing Key Laboratory of Geological Environment Monitoring and Disaster Early-Warning in Three Gorges Reservoir Area(Grant Nos.ZD2020A0103 and ZD2020A0102)the Fundamental Research Funds for Chongqing Three Gorges University of China(Grant No.19ZDPY08).
文摘In order to control the working wavelength range of the fiber surface plasmon resonance(SPR)temperature sensor and realize the wavelength division multiplexing type multi-channel fiber SPR temperature sensor,by comprehensively investigating the influence of liquids with different thermal-optical coefficients and solid packaging materials on the performance of fiber SPR temperature sensor,a dual-channel fiber SPR temperature sensor based on liquid-solid cascade encapsulation was designed and fabricated.The liquid temperature sensing stage encapsulated in capillary worked in 616.03 nm-639.05 nm band,the solid sensing stage coated with pouring sealant worked in 719.37 nm-825.27 nm band,and the two stages were cascaded to form a fiber dual-channel temperature sensor.The testing results indicated that when the temperature range was 35℃-95℃,the sensitivity of two-stage temperature detection was−0.384 nm/℃and−1.765 nm/℃respectively.The proposed fiber sensor has simple fabrication and excellent performance which can be widely used in various fields of dual-channel temperature measurement and temperature compensation.
基金supported by the National Natural Science Foundation of China (81774105)。
文摘Objective: To investigate the bioactive components of Sangqi Qingxuan formula(SQQX), predict the pharmacological targets, and explore the mechanism of hypertensive vascular remodeling(HVR).Methods: Network pharmacology was adopted to predict how SQQX acts in HVR. The effectiveness was assessed by blood pressure measurements and pathological morphology observation based on a spontaneously hypertensive rat model, while the mechanism of SQQX on HVR was validated by immunohistochemistry(IHC) and western blot(WB) according to the results of network pharmacology.Results: There were 130 bioactive components of SQQX and 231 drug targets predicted by the Traditional Chinese Medicine Systems Pharmacology Database. Subsequently, 181 common targets were identified for SQQX against HVR, with TP53, MAPK1, and AKT1 as the core targets. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses was employed to identify the top 20 enriched functions and the top 20 pathways(P <.01). Finally, the key role of the ERK/MAPK signaling pathway in HVR was determined. The in vivo results suggested that SQQX reduced systolic blood pressure and increased the ratio of thoracic aortic wall thickness to lumen diameter. Additionally, compared with the model group, SQQX increased the expression of smooth muscle 22 alpha(IHC: P <.001;WB:P <.05) and decreased the expression of osteopontin(IHC: P <.001;WB: P <.05), ERK1/2(IHC: P <.001;WB: ERK1 & ERK2, all P <.05), p-ERK1/2(IHC: P <.001;WB: ERK1 & ERK2, all P <.05), and the ratio of pERK1/2 to ERK1/2 protein(IHC: P <.001).Conclusions: SQQX, which has multiple bioactive ingredients and potential targets, is an effective treatment for HVR. The mechanism of antihypertensive and vascular protection may be related to the inhibition of phenotypic transformation of vascular smooth muscle cells and the ERK/MAPK signaling pathway.
文摘Based on the study of parse wood materials,the fitting empirical equation of tree growth was obtained,a function with tree growth as a variable and time as an independent variable.Through mathematical operations such as function derivation,the mature age of tree growth was obtained,and the obtained expected mature age of Saliz matsudana was 21a.And the application,research directions and precautions of the mature ages were proposed.
基金the National Natural Science Foundation of China(Grant No.61705025)Chongqing Natural Science Foundation(Grant Nos.cstc2019jcyjmsxmX0431 and cstc2018jcyjAX0817)+2 种基金the Science and Technology Project Affiliated to the Education Department of Chongqing Municipality(Grant Nos.KJQN201801217,KJQN201901226,KJQN202001214,and KJ1710247)Chongqing Key Laboratory of Geological Environment Monitoring and Disaster Early-Warning in Three Gorges Reservoir Area(Grant Nos.ZD2020A0103 and ZD2020A0102)Fundamental Research Funds for Chongqing Three Gorges University of China(Grant No.19ZDPY08).
文摘Fiber cladding surface plasmon resonance(SPR)sensors have few structures,and a clad SPR sensor based on S-type fiber is proposed in this paper.This new type of fiber cladding SPR sensor was formed by electrofusing an S-shaped structure on the fiber to couple the light in the fiber core to the cladding.In this paper,the effects of fiber parameters on the performance of the sensor were studied by simulation and experiment.Based on the conclusion that the smaller the core diameter is,the closer the working band of the SPR resonance is to long wavelengths,and that the geometric characteristics mean that a multimode fiber can receive the fiber cladding light from a small core diameter few-mode fiber,a dual channel SPR sensor with a double S-type fiber cascade was proposed.In the refractive index detection range of 1.333–1.385refractive index units(RIU),the resonant working band of channel I is 627.66 nm–759.78 nm,with an average sensitivity of 2540.77 nm/RIU,and the resonant working band of channel II is 518.24 nm–658.2 nm,with an average sensitivity of2691.54 nm/RIU.The processing method for the S-type fiber cladding SPR sensor is simple,effectively solving the problem of this type of SPR sensor structure and the difficult realization of a dual channel.The sensor is expected to be used in the fields of medical treatment and biological analysis.
基金supported by the Finance Science and Technology Project of Hainan Province(No.ZDKJ202019)the Key Research and Development Program of Zhejiang Province(No.2021C03014)the Natural Science Foundation of Zhejiang Province(No.LR22E080005),China.
文摘The cement mixing (CM) pile is a common method of improving soft offshore ground. The strength growth of CM piles under complex conditions is affected by many factors, especially the cement and moisture contents, and shows significant uncertainty. To investigate the stochasticity of the early strength of CM piles and its impact on the displacement and stability of a seawall, a series of laboratory tests and numerical analyses were carried out in this study. Vane shear tests were conducted on the cement-solidified soil to determine the relationships between the undrained shear strength s_(u) of the cement soil curing in the seawater and the cement content a_(c), as well as the in situ soil moisture content w. It can be inferred that the 24 h undrained shear strength follows a normal distribution. A numerical model considering the random CM pile strength was established to investigate the deformation of the seawall. Due to the uncertainty of CM pile strength, the displacement of the seawall demonstrates a certain discreteness. The decrease of the mean undrained shear strength of CM piles causes a corresponding increase in the average displacement of the seawall. When the mean strength of CM piles is lower than a certain threshold, there is a risk of instability. Furthermore, the heterogeneity of the strength within an individual CM pile also has an impact on seawall displacement. Attention should be paid to the uncertainty of CM pile strength to control displacement and stability.
