Exercise-with-melatonin therapy improves sleep disorder and motor dysfunction in a rat model of ischemic stroke

Exercise-with-melatonin therapy has complementary and synergistic effects on spinal cord injury and Alzheimer's disease,but its effect on stroke is still poorly understood.In this study,we established a rat model of ischemic stroke by occluding the middle cerebral artery for 60 minutes.We treated the rats with exercise and melatonin therapy for 7 consecutive days.Results showed that exercise-with-melatonin therapy significantly prolonged sleep duration in the model rats,increased delta power values,and regularized delta power rhythm.Additionally,exercise-with-melatonin therapy improved coordination,endurance,and grip strength,as well as learning and memory abilities.At the same time,it led to higher hippocampal CA1 neuron activity and postsynaptic density thickness and lower expression of glutamate receptor 2 than did exercise or melatonin therapy alone.These findings suggest that exercise-withmelatonin therapy can alleviate sleep disorder and motor dysfunction by increasing glutamate receptor 2 protein expression and regulating hippocampal CA1 synaptic plasticity.

基于学科知识图谱的信息技术在线课程设计研究

针对目前基础教育领域在线教学评价方式单一、学生学习反馈不及时等显著问题,结合知识图谱的特点以及学习元平台的优势,构建一门高中信息技术在线课程。该门课程充分发挥学科知识图谱的特色功能,突破传统网络课程的限制,为教师开展多元化教学评价、实现因材施教提供有力支持。从学科知识图谱的构建、课程的前期设计、课程的实施过程和课程的后期引导四个方面对在线课程的设计进行详细阐述,以期为基础教育领域在线课程的教学评价与管理提供启示。在研究中构建一门基于学科知识图谱的“信息技术基础”在线课程,并利用学习元平台进行学科知识图谱与在线课程资源的整合,通过呈现实时动态可视化的学生课程学习成绩、学习认知地图以及学习参与水平,实现在线教学评价的实时反馈和个性化指导,在一定程度上回应当前基础教育阶段在线教学评价存在的反馈不及时、学生诊断不精准的问题。