Unmanned Aerial Vehicles(UAVs)are gaining increasing attention in many fields,such as military,logistics,and hazardous site mapping.Utilizing UAVs to assist communications is one of the promising applications and rese...Unmanned Aerial Vehicles(UAVs)are gaining increasing attention in many fields,such as military,logistics,and hazardous site mapping.Utilizing UAVs to assist communications is one of the promising applications and research directions.The future Industrial Internet places higher demands on communication quality.The easy deployment,dynamic mobility,and low cost of UAVs make them a viable tool for wireless communication in the Industrial Internet.Therefore,UAVs are considered as an integral part of Industry 4.0.In this article,three typical use cases of UAVs-assisted communications in Industrial Internet are first summarized.Then,the state-of-the-art technologies for drone-assisted communication in support of the Industrial Internet are presented.According to the current research,it can be assumed that UAV-assisted communication can support the future Industrial Internet to a certain extent.Finally,the potential research directions and open challenges in UAV-assisted communications in the upcoming future Industrial Internet are discussed.展开更多
Anaerobic bacteria infections remain a major threat to humans.Oxidative stress mediated by photodynamic therapy(PDT)has shown great potential in antimicrobial applications,attributing to its controllability and non-re...Anaerobic bacteria infections remain a major threat to humans.Oxidative stress mediated by photodynamic therapy(PDT)has shown great potential in antimicrobial applications,attributing to its controllability and non-resistance.However,the hypoxic infection microenvironment severely compromises the therapeutic outcomes.Here,we designed a nanoplatform comprising the initiator of alkyl radicals(R-),2,2’-azobis[2-(2-imidazolin-2-yl)propane]dihydrochloride(AIPH)-loaded oxidized mesoporous carbon nanoparticles(OMCN)and then coated with a phase change material(PCM)nanoparticle for oxygen-independent PDT to combat anaerobic infections.Upon near-infrared(NIR)light irradiation,OMCN mediates the generation of heat to melt PCM,which could trigger the liberation and decomposition of AIPH to produce R.and further induce the oxidative damage to bacteria,and cooperate with optothermal effects to eradicate anaerobic bacteria.As results,the nanoplatform displays strong synergistic antibacterial behavior,effectively eliminating anaerobic Propionibacterium acnes(P.acnes)in vitro under hypoxic conditions,and successfully treating P.acnes-infected cutaneous abscess in mice models.Moreover,no distinct toxicity appears through the entire course of treatment.Collectively,this light-activated oxygen-independent PDT offers a novel approach to combat anaerobic bacteria infections.展开更多
基金supported in part by National Key Research&Devel-opment Program of China(2021YFB2900801)in part by Guangdong Basic and Applied Basic Research Foundation(2022A1515110335)in party by Fundamental Research Funds for the Central Universities(FRF-TP-22-094A1).
文摘Unmanned Aerial Vehicles(UAVs)are gaining increasing attention in many fields,such as military,logistics,and hazardous site mapping.Utilizing UAVs to assist communications is one of the promising applications and research directions.The future Industrial Internet places higher demands on communication quality.The easy deployment,dynamic mobility,and low cost of UAVs make them a viable tool for wireless communication in the Industrial Internet.Therefore,UAVs are considered as an integral part of Industry 4.0.In this article,three typical use cases of UAVs-assisted communications in Industrial Internet are first summarized.Then,the state-of-the-art technologies for drone-assisted communication in support of the Industrial Internet are presented.According to the current research,it can be assumed that UAV-assisted communication can support the future Industrial Internet to a certain extent.Finally,the potential research directions and open challenges in UAV-assisted communications in the upcoming future Industrial Internet are discussed.
基金financially supported by the Key Technologies R&D Program of Henan(212102310231)the Open Project Program of Key Laboratory for Analytical Science of Food Safety and Biology,Ministry of Education(FS2204)
文摘Anaerobic bacteria infections remain a major threat to humans.Oxidative stress mediated by photodynamic therapy(PDT)has shown great potential in antimicrobial applications,attributing to its controllability and non-resistance.However,the hypoxic infection microenvironment severely compromises the therapeutic outcomes.Here,we designed a nanoplatform comprising the initiator of alkyl radicals(R-),2,2’-azobis[2-(2-imidazolin-2-yl)propane]dihydrochloride(AIPH)-loaded oxidized mesoporous carbon nanoparticles(OMCN)and then coated with a phase change material(PCM)nanoparticle for oxygen-independent PDT to combat anaerobic infections.Upon near-infrared(NIR)light irradiation,OMCN mediates the generation of heat to melt PCM,which could trigger the liberation and decomposition of AIPH to produce R.and further induce the oxidative damage to bacteria,and cooperate with optothermal effects to eradicate anaerobic bacteria.As results,the nanoplatform displays strong synergistic antibacterial behavior,effectively eliminating anaerobic Propionibacterium acnes(P.acnes)in vitro under hypoxic conditions,and successfully treating P.acnes-infected cutaneous abscess in mice models.Moreover,no distinct toxicity appears through the entire course of treatment.Collectively,this light-activated oxygen-independent PDT offers a novel approach to combat anaerobic bacteria infections.
