Owing to the particularity of a polyester fiber material,the polyester mooring undergoes large axial tensile deformation over long-term use.Large axial tensile deformation significantly impacts the dynamic response of...Owing to the particularity of a polyester fiber material,the polyester mooring undergoes large axial tensile deformation over long-term use.Large axial tensile deformation significantly impacts the dynamic response of the mooring system.In addition,the degrees of large axial tension caused by different elastic moduli are also different,and the force on the mooring line is also different.Therefore,it is of great significance to study the influence of elastic modulus on the dynamic results of the mooring systems under large axial tension.Conventional numerical software fails to consider the axial tension deformation of the mooring.Based on the theory of slender rods,this paper derives the formula for large axial tension using the method of overall coordinates and overall slope coordinates and provides the calculation programs.Considering a polyester mooring system as an example,the calculation program and numerical software are used to calculate and compare the static and dynamic analyses to verify the reliability of the calculation program.To make the force change of the mooring obvious,the elastic moduli of three different orders of magnitude are compared and analyzed,and the dynamic response results after large axial tension are compared.This study concludes that the change in the elastic modulus of the polyester mooring changes the result of the vertex tension by generating an axial tension.The smaller the elastic modulus,the larger the forced oscillation motion amplitude of the top point of the mooring line,the more obvious the axial tension phenomenon,and the smaller the force on the top of the polyester mooring.展开更多
In this study,an image binarization optimization algorithm,based on local threshold algorithms,is proposed because global and traditional local threshold segmentation algorithms cannot effectively address the problems...In this study,an image binarization optimization algorithm,based on local threshold algorithms,is proposed because global and traditional local threshold segmentation algorithms cannot effectively address the problems of nonuniform backgrounds of wood defect images.The proposed algorithm calculates the threshold by the mean,standard deviation and the extreme value of the window.The results indicate that this modified algorithm enhances the image segmentation for wood defect images on a complex background,which is much superior to the global threshold algorithm and the Bernsen algorithm,and slightly better than the Niblack algorithm and Sauvola algorithm.Compared with similar models,the algorithm proposed in this paper has higher segmentation accuracy,as high as 92.6%for wood defect images with a complex background.展开更多
Experimental studies are carried out with slender bodies vertically exiting out of the water using a high-speed camera. The mechanisms for the formation, development, and collapse of the cavity around the slender body...Experimental studies are carried out with slender bodies vertically exiting out of the water using a high-speed camera. The mechanisms for the formation, development, and collapse of the cavity around the slender body are explored. The dynamic characteristics of the shoulder cavity and the trail cavity during the water-exit of low-speed bodies are analyzed for various water depths and initial velocities. The results show that the initial velocity has a great influence on the formation, development, and collapse of the cavity. The length and the thickness of the shoulder cavity vary non-linearly with the depth.展开更多
Objective: The aim of this study was to investigate the value of the combined expression of the gastric mucosal differentiation protein pepsinogen C(PGC) and gastric cancer(GC)-associated antigen MG7 for the diagnosis...Objective: The aim of this study was to investigate the value of the combined expression of the gastric mucosal differentiation protein pepsinogen C(PGC) and gastric cancer(GC)-associated antigen MG7 for the diagnosis of GC and prediction of the development from precancerous conditions to GC.Methods: The gastric mucosal biopsies of 285 subjects enrolled from a region with a high incidence of GC were obtained and histopathologically examined. Subjects testing negative for GC(n=208) were followed up from 1998 to 2015. The levels of PGC and MG7 in the biopsies were determined by immunohistochemistry.Results: PGC was positive in 91.4% of the non-atrophic gastritis, 26.5% of the atrophic gastritis, and 0% of the GC. MG7 was positive in 15.0% of the non-atrophic gastritis, 82.4% of the atrophic gastritis, and 94.8% of the GC. The non-atrophic gastritis group was predominantly "PGC+MG7-". The atrophic gastritis and GC groups were predominantly "PGC-MG7+". The rate of GC in subjects with "PGC-MG7+" staining was 113.4-fold higher [95% confidence interval(95% CI): 15.3-869.4, P<0.001] than that in subjects with other staining patterns.The sensitivity and specificity of the "PGC-MG7+" pattern were 92.2% and 78.8% for the detection of GC and77.2% and 97.9% for GC and precancerous disease, respectively. In the follow-up cohort of non-GC subjects, the risk of developing GC was higher in those with the "PGC-MG7+" staining pattern.Conclusions: Our data suggest that the "PGC-MG7+" pattern can be employed as a useful follow-up panel for detecting individuals with a high risk of GC, and the dynamic assessment of the follow-up panel needs multi-centre large-scale validation in the future.展开更多
The taut mooring system using synthetic fiber ropes has overcome the shortcomings such as the large self-weight of the mooring lines and provides better mooring performance for the floating structures.The polyester ro...The taut mooring system using synthetic fiber ropes has overcome the shortcomings such as the large self-weight of the mooring lines and provides better mooring performance for the floating structures.The polyester rope has attracted much attention among numerous synthetic fiber rope materials due to its lightweight,low price,corrosion resistance,and high strength.Thus,the mooring characteristics of it are worth studying.Polyester mooring lines are flexible in deep water,when a marine structure is moored by them,the geometric nonlinearity such as large displacement,large stretch,and large bending deformation,and the material nonlinearity like viscoelastic of the polyester ropes become complex integrated problems to be studied.Considering the nonlinear phenomenon,the simulation and calculation of a polyester line were carried out by the absolute nodal coordinate formulation(ANCF)in this paper since the ANCF method has advantages in dealing with the significant deformation problems of the flexible structures.In addition,a chain mooring line was also simulated for comparison,and the results show that the polyester ropes reduce the self-weight of the mooring lines and provide sufficient mooring strength at the same time,and the nonlinear phenomenon of the polyester ropes is different from that of the chain mooring lines.展开更多
Pine wilt disease caused by the pinewood nematode Bursaphelenchus xylophilus has led to the death of a large number of pine trees in China.This destructive disease has the characteristics of bring wide-spread,fast ons...Pine wilt disease caused by the pinewood nematode Bursaphelenchus xylophilus has led to the death of a large number of pine trees in China.This destructive disease has the characteristics of bring wide-spread,fast onset,and long incubation time.Most importantly,in China,the fatality rate in pines is as high as 100%.The key to reducing this mortality is how to quickly find the infected trees.We proposed a method of automatically identifying infected trees by a convolution neural network and bounding box tool.This method rapidly locates the infected area by classifying and recognizing remote sensing images obtained by high resolution earth observation Satellite.The recognition accuracy of the test data set was 99.4%,and the remote sensing image combined with convolution neural network algorithm can identify and determine the distribution of the infected trees.It can provide strong technical support for the prevention and control of pine wilt disease.展开更多
Traditional fire smoke detection methods mostly rely on manual algorithm extraction and sensor detection;however,these methods are slow and expensive to achieve discrimination.We proposed an improved convolutional neu...Traditional fire smoke detection methods mostly rely on manual algorithm extraction and sensor detection;however,these methods are slow and expensive to achieve discrimination.We proposed an improved convolutional neural network(CNN)to achieve fast analysis.The improved CNN can be used to liberate manpower.The network does not require complicated manual feature extraction to identify forest fire smoke.First,to alleviate the computational pressure and speed up the discrimination efficiency,kernel principal component analysis was performed on the experimental data set.To improve the robustness of the CNN and to avoid overfitting,optimization strategies were applied in multi-convolution kernels and batch normalization to improve loss functions.The experimental analysis shows that the CNN proposed in this study can learn the feature information automatically for smoke images in the early stages of fire automatically with a high recognition rate.As a result,the improved CNN enriches the theory of smoke discrimination in the early stages of a forest fire.展开更多
Risk analysis of key systems have become a growing topic late of because of the development of offshore structures. Equipment failures of offioading system and fire accidents were analyzed based on the floating produc...Risk analysis of key systems have become a growing topic late of because of the development of offshore structures. Equipment failures of offioading system and fire accidents were analyzed based on the floating production, storage and offioading (FPSO) features. Fault tree analysis (FTA), and failure modes and effects analysis (FMEA) methods were examined based on information already researched on modules of relex reliability studio (RRS). Equipment failures were also analyzed qualitatively by establishing a fault tree and Boolean structure function based on the shortage of failure cases, statistical data, and risk control measures examined. Failure modes of fire accident were classified according to the different areas of fire occurrences during the FMEA process, using risk priority number (RPN) methods to evaluate their severity rank. The qualitative analysis of FTA gave the basic insight of forming the failure modes of FPSO offioading, and the fire FMEA gave the priorities and suggested processes. The research has practical importance for the security analysis problems of FPSO.展开更多
Electrical pollution is a worldwide concern,because it is potentially harmful to human health.Trees not only play a significant role in moderating the climate,but also can be used as shields against electrical polluti...Electrical pollution is a worldwide concern,because it is potentially harmful to human health.Trees not only play a significant role in moderating the climate,but also can be used as shields against electrical pollution.Shielding effects on the electric field strength under transmission lines by two tree species,Populus alba and Larix gmelinii,were examined in this study.The electrical resistivity at different heights of trees was measured using a PiCUS sonic tomograph,which can image the electrical impedance for trees.The electric field strength around the trees was measured with an elf field strength measurement system,HI-3604,and combined with tree resistivity to develop a model for calculating the electric field intensity around trees using the finite element method.In addition,the feasibility of the finite element method was confirmed by comparing the calculated results and experimental data.The results showed that the trees did reduce the electric field strength.The electric field intensity was reduced by 95.6%,and P.alba was better than L.gmelinii at shielding.展开更多
A series of tests of a full-scale river icebreaker was conducted to investigate the characteristics of ice-induced hull vibration.The test was conducted when the river icebreaker was operating in an ice-covered river ...A series of tests of a full-scale river icebreaker was conducted to investigate the characteristics of ice-induced hull vibration.The test was conducted when the river icebreaker was operating in an ice-covered river at temperatures of-4 to 0°C with ice thicknesses of 300 to 400 mm.In the tests,the ice condition and icebreaker speed were chosen as the main influence factors.By analyzing the measured test data,we identified some important points regarding ice-induced hull vibration.When the river icebreaker navigates in an area with complete ice coverage,the peak value of the acceleration amplitude spectrum is highest.Also,the vibration response excited by the icebreaking load in an area with complete ice coverage exhibits more frequencies.With an increase in icebreaker speed,the vibration acceleration response gradually increases.However,habitability of the bow region on the main and driving decks is maintained due to the harmless vibration levels.In addition,the icebreaking operation of the river icebreaker causes violent local vibration of the grillage on the main deck.展开更多
Background: Fluorouracil-based preoperative chemoradiotherapy has become the standard treatment for stage Ⅱ/Ⅲ rectal cancer. In order to improve the overall survival (OS) and disease-flee survival (DFS), we add...Background: Fluorouracil-based preoperative chemoradiotherapy has become the standard treatment for stage Ⅱ/Ⅲ rectal cancer. In order to improve the overall survival (OS) and disease-flee survival (DFS), we added oxaliplatin to the standard treatment, and compared the effectiveness of these two treatment patterns. Methods: A total of 206 patients enrolled in the prospective study had histologically confirmed rectal cancer of clinical stage Ⅱ/Ⅲ during July 2007 to July 2010. They were randomized into the experimental group received oxaliplatin and capecitabine in combination with radiotherapy, and the control group received capecitabine in combination with radiotherapy. All patients received surgery in 6-10 weeks after chemoradiotherapy and adjuvant chemotherapy with mFOLFOX6. The primary endpoints were DFS and OS, and the secondary endpoints included toxicity, compliance, and histopathological response. Results: The 3-year OS in the experimental group and the control group was 90.29% vs. 86.41% (P〉0.05), and the 3-year DFS was 80.58% vs. 69.90% (P〉0.05). The pathological complete remission (pCR) rates were 23.30% and 19.42%, respectively (P=0.497). The 3-year local recurrence rates were 4.85% vs. 5.83% (P=0.694), and the 3-year distant metastasis rates were 16.50% and 28.16%, respectively (P=0.045). There were no significant differences in most grade 3-4 toxicities between two groups, however, grade 3-4 diarrhea occurred in 16.50% (17/103) of the experimental group, compared with 6.80% (7/103) of the control group (P=0.030). Also, the total grade 3-4 acute toxicity showed a significant difference (10.68% vs. 21.36%, P=0.037). Conclusions: The experimental treatment did not lead significantly improved OS and DFS, and thus longer follow-up is warranted for our patient cohort. Adding oxaliplatin to capecitabine-based preoperative chemoradiotherapy can significantly reduce metastasis, but has only minimal impact on local recurrence. Although grade 3-4 toxicity rate increased (primarily gastrointestinal toxicity), patients can stand to be followed up with allopathic treatment.展开更多
Gearbox in offshore wind turbines is a component with the highest failure rates during operation. Analysis of gearbox repair policy that includes economic considerations is important for the effective operation of off...Gearbox in offshore wind turbines is a component with the highest failure rates during operation. Analysis of gearbox repair policy that includes economic considerations is important for the effective operation of offshore wind farms. From their initial perfect working states, gearboxes degrade with time, which leads to decreased working efficiency. Thus, offshore wind turbine gearboxes can be considered to be multi-state systems with the various levels of productivity for different working states. To efficiently compute the time-dependent distribution of this multi-state system and analyze its reliability, application of the nonhomogeneous continuous-time Markov process(NHCTMP) is appropriate for this type of object. To determine the relationship between operation time and maintenance cost, many factors must be taken into account, including maintenance processes and vessel requirements. Finally, an optimal repair policy can be formulated based on this relationship.展开更多
The stiffened cylindrical shell is commonly used for the pressure hull of submersibles and the legs of offshore platforms. There are various failure modes because of uncertainty with the structural size and material p...The stiffened cylindrical shell is commonly used for the pressure hull of submersibles and the legs of offshore platforms. There are various failure modes because of uncertainty with the structural size and material properties, uncertainty of the calculation model and machining errors. Correlations among failure modes must be considered with the structural reliability of stiffened cylindrical shells. However, the traditional method cannot consider the correlations effectively. The aim of this study is to present a method of reliability analysis for stiffened cylindrical shells which considers the correlations among failure modes. Firstly, the joint failure probability calculation formula of two related failure modes is derived through use of the 2D joint probability density function. Secondly, the full probability formula of the tandem structural system is given with consideration to the correlations among failure modes. At last, the accuracy of the system reliability calculation is verified through use of the Monte Carlo simulation. Result of the analysis shows the failure probability of stiffened cylindrical shells can be gained through adding the failure probability of each mode.展开更多
Objective:The aim of this study was to validate the accuracy of a new automatic method for scar segmentation and compare its performance with that of two other frequently used segmentation algorithms.Methods:Twenty-si...Objective:The aim of this study was to validate the accuracy of a new automatic method for scar segmentation and compare its performance with that of two other frequently used segmentation algorithms.Methods:Twenty-six late gadolinium enhancement cardiovascular magnetic resonance images of diseased hearts were segmented by the full width at half maximum(FWHM)method,the n standard deviations(n SD)method,and our new automatic method.The results of the three methods were compared with the consensus ground truth obtained by manual segmentation of the ventricular boundaries.Results:Our automatic method yielded the highest Dice score and the lowest volume difference compared with the consensus ground truth segmentation.The n SD method produced large variations in the Dice score and the volume difference.The FWHM method yielded the lowest Dice score and the greatest volume difference compared with the automatic,6SD,and 8SD methods,but resulted in less variation when different observers segmented the images.Conclusion:The automatic method introduced in this study is highly reproducible and objective.Because it requires no manual intervention,it may be useful for processing large datasets produced in clinical applications.展开更多
Tilapia skin gelatin hydrolysates(TSGH)were obtained by complex protease hydrolysis.The amino acid sequences of 50 peptides in TSGH were identified,and most of these peptides were found to contain the-Gly-Pro-sequence...Tilapia skin gelatin hydrolysates(TSGH)were obtained by complex protease hydrolysis.The amino acid sequences of 50 peptides in TSGH were identified,and most of these peptides were found to contain the-Gly-Pro-sequence.The osteoporosis(OP)rat model induced by retinoic acid was prepared,and the effects of different doses of TSGH on OP in vivo were evaluated.Serum calcium(Ca)and phosphate(P),alkaline phosphatase activity,and osteocalcin levels in OP rats were regulated by TSGH.The bone length,dry weight index,maximum load,and Ca content of OP rats significantly increased by treatment TSGH in a dosedependent manner.Micro-CT images of the femurs and tibias of the rats indicated that the bone mineral density,cortical bone thickness,and cortical/trabecular bone area ratios were recovered and that OP symptoms were improved.Tartrate-resistant acid phosphate and hematoxylin-eosin staining showed that osteoclast numbers and histomorphological changes in the femurs in OP rats could be recovered by TSGH.展开更多
The distant hybridization was used in lodging-resistance breeding of Platycodon grandiflorus. The parents were Platycodon grandiflorus (♀) and Campanula medium (♂). 187 seeds of F1 were harvested by using the inter-...The distant hybridization was used in lodging-resistance breeding of Platycodon grandiflorus. The parents were Platycodon grandiflorus (♀) and Campanula medium (♂). 187 seeds of F1 were harvested by using the inter-generic hybridization in 2009 and 2010, 2 repeat, and 88 normal plants were obtained. The characteristics of leaves, stems and branches were the same as female for F1 generation, F2 generation, backcross generation and S1 generation, and there were some different characteristics with female which were flower colors, branching habit and plant height. A lodging-resistance plant was selected in F1, which was about 75 cm high, deep pink flower color and developed lateral branches. The DNA groups of each generation were separated by 1% agarose gel electrophoresis and there were not significant differences. Among the each generation many flower colors and forms were obtained.展开更多
Oenothera speciosa, belonging to thermophilous plant, cannot overwinter in Beijing. To enhance the overwintering rate of Oenothera speciosa, the seeds were treated through silico ion implantation (SII), with five vari...Oenothera speciosa, belonging to thermophilous plant, cannot overwinter in Beijing. To enhance the overwintering rate of Oenothera speciosa, the seeds were treated through silico ion implantation (SII), with five various fluence ranges (1 × 109 - 1 × 1011 ions/cm2) of 40 MeV and four various fluence ranges (1 × 1010 - 5 × 1011 ions/cm2) of 35 MeV, respectively. M1 generations of various SII-treated Oenothera speciosa lines can overwinter, and the highest overwinter rate (41.3%) was observed in Oenothera speciosa lines treated with 35 MeV and fluence 5 × 1010 ions/cm2. M2 and M3 generations of all treated lines were able to overwinter smoothly. The results indicated that SII treatment can enhance the cold-resistance of Oenothera speciosa heritably. Furthermore, physiological indexes including relative electrical conductivity, MDA contents and proline contents of SII-treated Oenothera speciosa pot seedlings were detected after low temperature stress. The results revealed that relative electrical conductivities and MDA contents of M1, M2 and M3 generations of SII-treated Oenothera speciosa plants were lower than that of control, whereas the proline contents were higher than control in the LJ°C cold stress. Taken together, the cold resistance of SII-treated Oenothera speciosa plants was improved, which made it possible to be used as a perennial flower in landscaping in Beijing.展开更多
To the Editor:Abdominal aortic aneurysm(AAA)is a life-threatening vascular disease.Surgical intervention is typically recommended when the maximum AAA diameter reaches a threshold of 5.5cm for men and 5.0cm for women,...To the Editor:Abdominal aortic aneurysm(AAA)is a life-threatening vascular disease.Surgical intervention is typically recommended when the maximum AAA diameter reaches a threshold of 5.5cm for men and 5.0cm for women,or when an AAA experiences a rapid expansion of greater than 1.0cm/year.[1]Survival after AAA repair is inuenced by various factors,and the identication of independent prognostic factors and the development of accurate prediction models are crucial for optimal treatment planning,counseling,and postoperative follow-up.Although several scoring systems with varying degrees of accuracy have been developed to predict the risk of mortality after intervention for patients with ruptured AAA.展开更多
The toxic effects of 1-methyl-3-octylimidazolium bromide ([C8mim]Br) on wheat seedlings were evaluated. Wheat seedlings were cultivated in aqueous solution with [C8mim]Br at different concentrations (0, 1, 2, 4, 6,...The toxic effects of 1-methyl-3-octylimidazolium bromide ([C8mim]Br) on wheat seedlings were evaluated. Wheat seedlings were cultivated in aqueous solution with [C8mim]Br at different concentrations (0, 1, 2, 4, 6, 8 mg/L). The contents of photosynthetic pigment and proline, peroxidation of membrane lipid, and activities of antioxidation enzymes (superoxide dismutase, catalase, peroxidase and ascorbate peroxidase) in leaves were measured on day 7 after treatment with [C8mim]Br. The results showed that [C8mim]Br significantly decreased the contents of photosynthetic pigments, activities of antioxidant enzymes in the wheat leaves and in dry weight of seedlings, while increased the proline content and membrane lipid peroxidation. The results suggested that [C8mim]Br can inhibit photosynthesis and lead to oxidative stress to wheat seedlings.展开更多
基金Supported by the Specialized Research Project for LS17-2 Semi-submersible Production Platform(LSZX-2020-HN-05-0405)the Engineering Development Program of Deepwater Semisubmersible Production Storage and Unloading Platform of China(SSBQ-2020-HN-02-04)。
文摘Owing to the particularity of a polyester fiber material,the polyester mooring undergoes large axial tensile deformation over long-term use.Large axial tensile deformation significantly impacts the dynamic response of the mooring system.In addition,the degrees of large axial tension caused by different elastic moduli are also different,and the force on the mooring line is also different.Therefore,it is of great significance to study the influence of elastic modulus on the dynamic results of the mooring systems under large axial tension.Conventional numerical software fails to consider the axial tension deformation of the mooring.Based on the theory of slender rods,this paper derives the formula for large axial tension using the method of overall coordinates and overall slope coordinates and provides the calculation programs.Considering a polyester mooring system as an example,the calculation program and numerical software are used to calculate and compare the static and dynamic analyses to verify the reliability of the calculation program.To make the force change of the mooring obvious,the elastic moduli of three different orders of magnitude are compared and analyzed,and the dynamic response results after large axial tension are compared.This study concludes that the change in the elastic modulus of the polyester mooring changes the result of the vertex tension by generating an axial tension.The smaller the elastic modulus,the larger the forced oscillation motion amplitude of the top point of the mooring line,the more obvious the axial tension phenomenon,and the smaller the force on the top of the polyester mooring.
基金supported by National Forestry Public Welfare Industry Scientific Research Special Subsidy Project(201304502)
文摘In this study,an image binarization optimization algorithm,based on local threshold algorithms,is proposed because global and traditional local threshold segmentation algorithms cannot effectively address the problems of nonuniform backgrounds of wood defect images.The proposed algorithm calculates the threshold by the mean,standard deviation and the extreme value of the window.The results indicate that this modified algorithm enhances the image segmentation for wood defect images on a complex background,which is much superior to the global threshold algorithm and the Bernsen algorithm,and slightly better than the Niblack algorithm and Sauvola algorithm.Compared with similar models,the algorithm proposed in this paper has higher segmentation accuracy,as high as 92.6%for wood defect images with a complex background.
文摘Experimental studies are carried out with slender bodies vertically exiting out of the water using a high-speed camera. The mechanisms for the formation, development, and collapse of the cavity around the slender body are explored. The dynamic characteristics of the shoulder cavity and the trail cavity during the water-exit of low-speed bodies are analyzed for various water depths and initial velocities. The results show that the initial velocity has a great influence on the formation, development, and collapse of the cavity. The length and the thickness of the shoulder cavity vary non-linearly with the depth.
基金supported by grants from the National Science and Technology Support Program (No. 2015BAI13B07)the Science Technology Project in Liaoning Province (No. 2012225016).
文摘Objective: The aim of this study was to investigate the value of the combined expression of the gastric mucosal differentiation protein pepsinogen C(PGC) and gastric cancer(GC)-associated antigen MG7 for the diagnosis of GC and prediction of the development from precancerous conditions to GC.Methods: The gastric mucosal biopsies of 285 subjects enrolled from a region with a high incidence of GC were obtained and histopathologically examined. Subjects testing negative for GC(n=208) were followed up from 1998 to 2015. The levels of PGC and MG7 in the biopsies were determined by immunohistochemistry.Results: PGC was positive in 91.4% of the non-atrophic gastritis, 26.5% of the atrophic gastritis, and 0% of the GC. MG7 was positive in 15.0% of the non-atrophic gastritis, 82.4% of the atrophic gastritis, and 94.8% of the GC. The non-atrophic gastritis group was predominantly "PGC+MG7-". The atrophic gastritis and GC groups were predominantly "PGC-MG7+". The rate of GC in subjects with "PGC-MG7+" staining was 113.4-fold higher [95% confidence interval(95% CI): 15.3-869.4, P<0.001] than that in subjects with other staining patterns.The sensitivity and specificity of the "PGC-MG7+" pattern were 92.2% and 78.8% for the detection of GC and77.2% and 97.9% for GC and precancerous disease, respectively. In the follow-up cohort of non-GC subjects, the risk of developing GC was higher in those with the "PGC-MG7+" staining pattern.Conclusions: Our data suggest that the "PGC-MG7+" pattern can be employed as a useful follow-up panel for detecting individuals with a high risk of GC, and the dynamic assessment of the follow-up panel needs multi-centre large-scale validation in the future.
基金Supported by the Specialized Research Project for LS17-2 Semi-submersible Production Platform(LSZX-2020-HN-05-0405).
文摘The taut mooring system using synthetic fiber ropes has overcome the shortcomings such as the large self-weight of the mooring lines and provides better mooring performance for the floating structures.The polyester rope has attracted much attention among numerous synthetic fiber rope materials due to its lightweight,low price,corrosion resistance,and high strength.Thus,the mooring characteristics of it are worth studying.Polyester mooring lines are flexible in deep water,when a marine structure is moored by them,the geometric nonlinearity such as large displacement,large stretch,and large bending deformation,and the material nonlinearity like viscoelastic of the polyester ropes become complex integrated problems to be studied.Considering the nonlinear phenomenon,the simulation and calculation of a polyester line were carried out by the absolute nodal coordinate formulation(ANCF)in this paper since the ANCF method has advantages in dealing with the significant deformation problems of the flexible structures.In addition,a chain mooring line was also simulated for comparison,and the results show that the polyester ropes reduce the self-weight of the mooring lines and provide sufficient mooring strength at the same time,and the nonlinear phenomenon of the polyester ropes is different from that of the chain mooring lines.
基金supported by the National Science and Technology Major Project of China’s High Resolution Earth Observation System(21-Y30B02-9001-19/22)the Heilongjiang Provincial Natural Science Foundation of China(YQ2020C018)。
文摘Pine wilt disease caused by the pinewood nematode Bursaphelenchus xylophilus has led to the death of a large number of pine trees in China.This destructive disease has the characteristics of bring wide-spread,fast onset,and long incubation time.Most importantly,in China,the fatality rate in pines is as high as 100%.The key to reducing this mortality is how to quickly find the infected trees.We proposed a method of automatically identifying infected trees by a convolution neural network and bounding box tool.This method rapidly locates the infected area by classifying and recognizing remote sensing images obtained by high resolution earth observation Satellite.The recognition accuracy of the test data set was 99.4%,and the remote sensing image combined with convolution neural network algorithm can identify and determine the distribution of the infected trees.It can provide strong technical support for the prevention and control of pine wilt disease.
基金National Natural Science Foundation of China(31670717)Natural Science Foundation of Heilongjiang Province(LH2020C051)。
文摘Traditional fire smoke detection methods mostly rely on manual algorithm extraction and sensor detection;however,these methods are slow and expensive to achieve discrimination.We proposed an improved convolutional neural network(CNN)to achieve fast analysis.The improved CNN can be used to liberate manpower.The network does not require complicated manual feature extraction to identify forest fire smoke.First,to alleviate the computational pressure and speed up the discrimination efficiency,kernel principal component analysis was performed on the experimental data set.To improve the robustness of the CNN and to avoid overfitting,optimization strategies were applied in multi-convolution kernels and batch normalization to improve loss functions.The experimental analysis shows that the CNN proposed in this study can learn the feature information automatically for smoke images in the early stages of fire automatically with a high recognition rate.As a result,the improved CNN enriches the theory of smoke discrimination in the early stages of a forest fire.
基金Supported by the Fundamental Research Funds for the Central Universities (HEUCFR1109)"111" projects foundation (Grant No.B07019) from State Administration of Foreign Experts Affairs of China and Ministry of Education of China
文摘Risk analysis of key systems have become a growing topic late of because of the development of offshore structures. Equipment failures of offioading system and fire accidents were analyzed based on the floating production, storage and offioading (FPSO) features. Fault tree analysis (FTA), and failure modes and effects analysis (FMEA) methods were examined based on information already researched on modules of relex reliability studio (RRS). Equipment failures were also analyzed qualitatively by establishing a fault tree and Boolean structure function based on the shortage of failure cases, statistical data, and risk control measures examined. Failure modes of fire accident were classified according to the different areas of fire occurrences during the FMEA process, using risk priority number (RPN) methods to evaluate their severity rank. The qualitative analysis of FTA gave the basic insight of forming the failure modes of FPSO offioading, and the fire FMEA gave the priorities and suggested processes. The research has practical importance for the security analysis problems of FPSO.
基金financially supported by the National Key Research and Development Program(2017YFD0600101)the Central University Basic Research and Operating Expenses of Special Funding(2572016CB04)the Harbin Application Technology Research and Development Projects(2016RQQXJ134)
文摘Electrical pollution is a worldwide concern,because it is potentially harmful to human health.Trees not only play a significant role in moderating the climate,but also can be used as shields against electrical pollution.Shielding effects on the electric field strength under transmission lines by two tree species,Populus alba and Larix gmelinii,were examined in this study.The electrical resistivity at different heights of trees was measured using a PiCUS sonic tomograph,which can image the electrical impedance for trees.The electric field strength around the trees was measured with an elf field strength measurement system,HI-3604,and combined with tree resistivity to develop a model for calculating the electric field intensity around trees using the finite element method.In addition,the feasibility of the finite element method was confirmed by comparing the calculated results and experimental data.The results showed that the trees did reduce the electric field strength.The electric field intensity was reduced by 95.6%,and P.alba was better than L.gmelinii at shielding.
基金This study was funded by the National keyResearch and Development program (2016YFC0303406)FundamentalResearch Funds for the Central University (HEUCFD1515,HEUCFM170113)+2 种基金High Technology Ship Funds of Ministry ofIndustry and Information of China, Assembly Advanced Research Fundof China (No. 6140210020105)China Postdoctoral Science Foundation(No. 2014M552661)Major innovation projects of High TechnologyShip Funds of Ministry of Industry and Information of China, Navalpre-research project, National Natural Science Foundation of China(Nos. 51209052 and 51 709 063).
文摘A series of tests of a full-scale river icebreaker was conducted to investigate the characteristics of ice-induced hull vibration.The test was conducted when the river icebreaker was operating in an ice-covered river at temperatures of-4 to 0°C with ice thicknesses of 300 to 400 mm.In the tests,the ice condition and icebreaker speed were chosen as the main influence factors.By analyzing the measured test data,we identified some important points regarding ice-induced hull vibration.When the river icebreaker navigates in an area with complete ice coverage,the peak value of the acceleration amplitude spectrum is highest.Also,the vibration response excited by the icebreaking load in an area with complete ice coverage exhibits more frequencies.With an increase in icebreaker speed,the vibration acceleration response gradually increases.However,habitability of the bow region on the main and driving decks is maintained due to the harmless vibration levels.In addition,the icebreaking operation of the river icebreaker causes violent local vibration of the grillage on the main deck.
文摘Background: Fluorouracil-based preoperative chemoradiotherapy has become the standard treatment for stage Ⅱ/Ⅲ rectal cancer. In order to improve the overall survival (OS) and disease-flee survival (DFS), we added oxaliplatin to the standard treatment, and compared the effectiveness of these two treatment patterns. Methods: A total of 206 patients enrolled in the prospective study had histologically confirmed rectal cancer of clinical stage Ⅱ/Ⅲ during July 2007 to July 2010. They were randomized into the experimental group received oxaliplatin and capecitabine in combination with radiotherapy, and the control group received capecitabine in combination with radiotherapy. All patients received surgery in 6-10 weeks after chemoradiotherapy and adjuvant chemotherapy with mFOLFOX6. The primary endpoints were DFS and OS, and the secondary endpoints included toxicity, compliance, and histopathological response. Results: The 3-year OS in the experimental group and the control group was 90.29% vs. 86.41% (P〉0.05), and the 3-year DFS was 80.58% vs. 69.90% (P〉0.05). The pathological complete remission (pCR) rates were 23.30% and 19.42%, respectively (P=0.497). The 3-year local recurrence rates were 4.85% vs. 5.83% (P=0.694), and the 3-year distant metastasis rates were 16.50% and 28.16%, respectively (P=0.045). There were no significant differences in most grade 3-4 toxicities between two groups, however, grade 3-4 diarrhea occurred in 16.50% (17/103) of the experimental group, compared with 6.80% (7/103) of the control group (P=0.030). Also, the total grade 3-4 acute toxicity showed a significant difference (10.68% vs. 21.36%, P=0.037). Conclusions: The experimental treatment did not lead significantly improved OS and DFS, and thus longer follow-up is warranted for our patient cohort. Adding oxaliplatin to capecitabine-based preoperative chemoradiotherapy can significantly reduce metastasis, but has only minimal impact on local recurrence. Although grade 3-4 toxicity rate increased (primarily gastrointestinal toxicity), patients can stand to be followed up with allopathic treatment.
文摘Gearbox in offshore wind turbines is a component with the highest failure rates during operation. Analysis of gearbox repair policy that includes economic considerations is important for the effective operation of offshore wind farms. From their initial perfect working states, gearboxes degrade with time, which leads to decreased working efficiency. Thus, offshore wind turbine gearboxes can be considered to be multi-state systems with the various levels of productivity for different working states. To efficiently compute the time-dependent distribution of this multi-state system and analyze its reliability, application of the nonhomogeneous continuous-time Markov process(NHCTMP) is appropriate for this type of object. To determine the relationship between operation time and maintenance cost, many factors must be taken into account, including maintenance processes and vessel requirements. Finally, an optimal repair policy can be formulated based on this relationship.
基金The Defence Advance Research Program of Science and Technology of Ship Industry(Grant No.11J1.3.1)
文摘The stiffened cylindrical shell is commonly used for the pressure hull of submersibles and the legs of offshore platforms. There are various failure modes because of uncertainty with the structural size and material properties, uncertainty of the calculation model and machining errors. Correlations among failure modes must be considered with the structural reliability of stiffened cylindrical shells. However, the traditional method cannot consider the correlations effectively. The aim of this study is to present a method of reliability analysis for stiffened cylindrical shells which considers the correlations among failure modes. Firstly, the joint failure probability calculation formula of two related failure modes is derived through use of the 2D joint probability density function. Secondly, the full probability formula of the tandem structural system is given with consideration to the correlations among failure modes. At last, the accuracy of the system reliability calculation is verified through use of the Monte Carlo simulation. Result of the analysis shows the failure probability of stiffened cylindrical shells can be gained through adding the failure probability of each mode.
基金This work was supported by grants from the National Key Research and Development Program of China(2016YFC1301002 to Jianzeng Dong)the National Natural Science Foundation of China(81901841 to Dongdong Deng,81671650 and 81971569 to Yi He)Dongdong Deng also acknowledges support from Dalian University of Technology(DUT18RC(3)068).
文摘Objective:The aim of this study was to validate the accuracy of a new automatic method for scar segmentation and compare its performance with that of two other frequently used segmentation algorithms.Methods:Twenty-six late gadolinium enhancement cardiovascular magnetic resonance images of diseased hearts were segmented by the full width at half maximum(FWHM)method,the n standard deviations(n SD)method,and our new automatic method.The results of the three methods were compared with the consensus ground truth obtained by manual segmentation of the ventricular boundaries.Results:Our automatic method yielded the highest Dice score and the lowest volume difference compared with the consensus ground truth segmentation.The n SD method produced large variations in the Dice score and the volume difference.The FWHM method yielded the lowest Dice score and the greatest volume difference compared with the automatic,6SD,and 8SD methods,but resulted in less variation when different observers segmented the images.Conclusion:The automatic method introduced in this study is highly reproducible and objective.Because it requires no manual intervention,it may be useful for processing large datasets produced in clinical applications.
基金National Natural Science Foundation of China(Grant No.31360381)for the financial support on this research。
文摘Tilapia skin gelatin hydrolysates(TSGH)were obtained by complex protease hydrolysis.The amino acid sequences of 50 peptides in TSGH were identified,and most of these peptides were found to contain the-Gly-Pro-sequence.The osteoporosis(OP)rat model induced by retinoic acid was prepared,and the effects of different doses of TSGH on OP in vivo were evaluated.Serum calcium(Ca)and phosphate(P),alkaline phosphatase activity,and osteocalcin levels in OP rats were regulated by TSGH.The bone length,dry weight index,maximum load,and Ca content of OP rats significantly increased by treatment TSGH in a dosedependent manner.Micro-CT images of the femurs and tibias of the rats indicated that the bone mineral density,cortical bone thickness,and cortical/trabecular bone area ratios were recovered and that OP symptoms were improved.Tartrate-resistant acid phosphate and hematoxylin-eosin staining showed that osteoclast numbers and histomorphological changes in the femurs in OP rats could be recovered by TSGH.
文摘The distant hybridization was used in lodging-resistance breeding of Platycodon grandiflorus. The parents were Platycodon grandiflorus (♀) and Campanula medium (♂). 187 seeds of F1 were harvested by using the inter-generic hybridization in 2009 and 2010, 2 repeat, and 88 normal plants were obtained. The characteristics of leaves, stems and branches were the same as female for F1 generation, F2 generation, backcross generation and S1 generation, and there were some different characteristics with female which were flower colors, branching habit and plant height. A lodging-resistance plant was selected in F1, which was about 75 cm high, deep pink flower color and developed lateral branches. The DNA groups of each generation were separated by 1% agarose gel electrophoresis and there were not significant differences. Among the each generation many flower colors and forms were obtained.
文摘Oenothera speciosa, belonging to thermophilous plant, cannot overwinter in Beijing. To enhance the overwintering rate of Oenothera speciosa, the seeds were treated through silico ion implantation (SII), with five various fluence ranges (1 × 109 - 1 × 1011 ions/cm2) of 40 MeV and four various fluence ranges (1 × 1010 - 5 × 1011 ions/cm2) of 35 MeV, respectively. M1 generations of various SII-treated Oenothera speciosa lines can overwinter, and the highest overwinter rate (41.3%) was observed in Oenothera speciosa lines treated with 35 MeV and fluence 5 × 1010 ions/cm2. M2 and M3 generations of all treated lines were able to overwinter smoothly. The results indicated that SII treatment can enhance the cold-resistance of Oenothera speciosa heritably. Furthermore, physiological indexes including relative electrical conductivity, MDA contents and proline contents of SII-treated Oenothera speciosa pot seedlings were detected after low temperature stress. The results revealed that relative electrical conductivities and MDA contents of M1, M2 and M3 generations of SII-treated Oenothera speciosa plants were lower than that of control, whereas the proline contents were higher than control in the LJ°C cold stress. Taken together, the cold resistance of SII-treated Oenothera speciosa plants was improved, which made it possible to be used as a perennial flower in landscaping in Beijing.
基金Basic Scientific Research Project of the Educational Department of Liaoning Province(No.JYTMS20230083)National Natural Science Foundation of China(No.82001828)National Natural Science Foundation of China(No.U21A20387)
文摘To the Editor:Abdominal aortic aneurysm(AAA)is a life-threatening vascular disease.Surgical intervention is typically recommended when the maximum AAA diameter reaches a threshold of 5.5cm for men and 5.0cm for women,or when an AAA experiences a rapid expansion of greater than 1.0cm/year.[1]Survival after AAA repair is inuenced by various factors,and the identication of independent prognostic factors and the development of accurate prediction models are crucial for optimal treatment planning,counseling,and postoperative follow-up.Although several scoring systems with varying degrees of accuracy have been developed to predict the risk of mortality after intervention for patients with ruptured AAA.
基金supported by the National Natural Science Foundation of China(No. 20273019,20573034)the Innovation Project for University Prominent Research Talents of Henan,China(No. 2006KYCX021)the Project-sponsored by SRF for ROCS,SEM(No. [2006]331)
文摘The toxic effects of 1-methyl-3-octylimidazolium bromide ([C8mim]Br) on wheat seedlings were evaluated. Wheat seedlings were cultivated in aqueous solution with [C8mim]Br at different concentrations (0, 1, 2, 4, 6, 8 mg/L). The contents of photosynthetic pigment and proline, peroxidation of membrane lipid, and activities of antioxidation enzymes (superoxide dismutase, catalase, peroxidase and ascorbate peroxidase) in leaves were measured on day 7 after treatment with [C8mim]Br. The results showed that [C8mim]Br significantly decreased the contents of photosynthetic pigments, activities of antioxidant enzymes in the wheat leaves and in dry weight of seedlings, while increased the proline content and membrane lipid peroxidation. The results suggested that [C8mim]Br can inhibit photosynthesis and lead to oxidative stress to wheat seedlings.