Moisture-enabled electricity(ME)is a method of converting the potential energy of water in the external environment into electrical energy through the interaction of functional materials with water molecules and can b...Moisture-enabled electricity(ME)is a method of converting the potential energy of water in the external environment into electrical energy through the interaction of functional materials with water molecules and can be directly applied to energy harvesting and signal expression.However,ME can be unreliable in numerous applications due to its sluggish response to moisture,thus sacrificing the value of fast energy harvesting and highly accurate information representation.Here,by constructing a moisture-electric-moisture-sensitive(ME-MS)heterostructure,we develop an efficient ME generator with ultra-fast electric response to moisture achieved by triggering Grotthuss protons hopping in the sensitized ZnO,which modulates the heterostructure built-in interfacial potential,enables quick response(0.435 s),an unprecedented ultra-fast response rate of 972.4 mV s^(−1),and a durable electrical signal output for 8 h without any attenuation.Our research provides an efficient way to generate electricity and important insight for a deeper understanding of the mechanisms of moisture-generated carrier migration in ME generator,which has a more comprehensive working scene and can serve as a typical model for human health monitoring and smart medical electronics design.展开更多
Based on an analysis of the limitations of conventional production component methods for natural gas development planning,this study proposes a new one that uses life cycle models for the trend fitting and prediction ...Based on an analysis of the limitations of conventional production component methods for natural gas development planning,this study proposes a new one that uses life cycle models for the trend fitting and prediction of production.In this new method,the annual production of old and new wells is predicted by year first and then is summed up to yield the production for the planning period.It shows that the changes in the production of old wells in old blocks can be fitted and predicted using the vapor pressure model(VPM),with precision of 80%e95%,which is 6.6%e13.2%higher than that of other life cycle models.Furthermore,a new production prediction process and method for new wells have been established based on this life cycle model to predict the production of medium-to-shallow gas reservoirs in western Sichuan Basin,with predication error of production rate in 2021 and 2022 being 6%and 3%respectively.The new method can be used to guide the medium-and long-term planning or annual scheme preparation for gas development.It is also applicable to planning for large single gas blocks that require continuous infill drilling and adjustment to improve gas recovery.展开更多
Hydrocarbon production in oil and gas fields generally progresses through stages of production ramp-up,plateau(peak),and decline during field development,with the whole process primarily modeled and forecasted using l...Hydrocarbon production in oil and gas fields generally progresses through stages of production ramp-up,plateau(peak),and decline during field development,with the whole process primarily modeled and forecasted using lifecycle models.SINOPEC's conventional gas reservoirs are dominated by carbonates,low-permeability tight sandstone,condensate,volcanic rocks,and medium-to-high-permeability sandstone.This study identifies the optimal production forecasting models by comparing the fitting coefficients of different models and calculating the relative errors in technically recoverable reserves.To improve forecast precision,it suggests substituting exponential smoothing method-derived predictions for anomalous data caused by subjective influences like market dynamics and maintenance activities.The preferred models for carbonate gas reservoir production forecasts are the generalized Weng's,Beta,Class-I generalized mathematical,and Hu-Chen models.The Vapor pressure and Beta models are optimal for forecasting the annual productivity of wells(APW)from gas-bearing low-permeability tight sandstone reservoirs.The Wang-Li,Beta,and Yu QT tb models are apt for moderate-to-small-reserves,single low-permeability tight sandstone gas reservoirs.The Rayleigh,Hu-Chen,and generalized Weng's models are suitable for condensate gas reservoirs.For medium-to-high-permeability sandstone gas reservoirs,the lognormal,generalized gamma,and Beta models are recommended.展开更多
Objective:Acute myeloid leukemia(AML)is primarily a malignant disorder affecting the elderly.We aimed to compare the outcomes of different treatment patterns in elderly AML patients and to propose a prognostic scoring...Objective:Acute myeloid leukemia(AML)is primarily a malignant disorder affecting the elderly.We aimed to compare the outcomes of different treatment patterns in elderly AML patients and to propose a prognostic scoring system that could predict survival and aid therapeutic decisions.Methods:Patients aged≥60 years who had been diagnosed with AML at 7 hospitals in China were enrolled(n=228).Treatment patterns included standard chemotherapy,low intensity therapy,and best supportive care(BSC).Results:The early mortality rates were 31%,6.8%,and 6.3%for the BSC,low intensity therapy,and standard chemotherapy groups,respectively.The complete remission rate of the standard chemotherapy group was higher than that of the low intensity therapy group.The median overall survival(OS)was 561 days and 222 days for the standard chemotherapy and low intensity therapy groups,respectively,and were both longer than that of the BSC group(86 days).Based on multivariate analyses,we defined a prognostic scoring system that enabled classification of patients into 3 risk groups,in an attempt to predict the OS of patients receiving chemotherapies and low intensity therapies.Low and intermediate risk patients benefited more from standard chemotherapies than from low intensity therapies.However,the median OS was comparable between standard chemotherapies and low intensity therapies in high risk patients.Conclusions:Our prognostic scoring system could predict survival and help select appropriate therapies for elderly AML patients.Standard chemotherapy is important for elderly AML patients,particularly for those categorized into low and intermediate risk groups.展开更多
Optimal plant height is crucial in modern agriculture, influencing lodging resistance and facilitating mechanized crop production. Upland cotton (Gossypium hirsutum) is the most important fiber crop globally;however, ...Optimal plant height is crucial in modern agriculture, influencing lodging resistance and facilitating mechanized crop production. Upland cotton (Gossypium hirsutum) is the most important fiber crop globally;however, the genetic basis underlying plant height remains largely unexplored. In this study, we conducted a genome-wide association study to identify a major locus controlling plant height (PH1) in upland cotton. This locus encodes gibberellin 2-oxidase 1A (GhPH1) and features a 1133-bp structural variation (PAVPH1) located approximately 16 kb upstream. The presence or absence of PAVPH1 influences the expression of GhPH1, thereby affecting plant height. Further analysis revealed that a gibberellin-regulating transcription factor (GhGARF) recognizes and binds to a specific CATTTG motif in both the GhPH1 promoter and PAVPH1. This interaction downregulates GhPH1, indicating that PAVPH1 functions as a distant upstream silencer. Intriguingly, we found that DWARF53 (D53), a key repressor of the strigolactone (SL) signaling pathway, directly interacts with GhGARF to inhibit its binding to targets. Moreover, we identified a previously unrecognized gibberellin-SL crosstalk mechanism mediated by the GhD53-GhGARF-GhPH1/PAVPH1 module, which is crucial for regulating plant height in upland cotton. These findings shed light on the genetic basis and gene interaction network underlying plant height, providing valuable insights for the development of semi-dwarf cotton varieties through precise modulation of GhPH1 expression.展开更多
Aqueous rechargeable batteries with high safety have been considered as the main energy source to power portable and wearable electronics.Herein,we report the first construction of quasi-solid-state aqueous tin-iodine...Aqueous rechargeable batteries with high safety have been considered as the main energy source to power portable and wearable electronics.Herein,we report the first construction of quasi-solid-state aqueous tin-iodine batteries by exploiting Sn foil as anode,carbon cloth as cathode,and gel electrolytes.The anode reversibly converts from K_(2)Sn(OH)_(6) to metal Sn,thus eliminating the formation of metal dendrites.Meanwhile,gel electrolytes alleviate anode corrosion and enhance the utilization of the anode.Therefore,the asfabricated quasi-solid-state batteries manifest an areal capacity of 700μAh cm^(-2)(211 mAh g^(-1) equal to theoretical capacity)and excellent cycling stability without obvious capacity degradation after 120 cycles at 1mA cm^(-2).Remarkably,the designed batteries sealed by different package materials including plastic,glass,wood,and cardboard operated steadily,thereby enlarging the application scenario for these batteries.This work enriches the family of aqueous rechargeable batteries and sheds light on the construction of high-performance quasi-solid-state aqueous batteries.展开更多
基金the Natural Science Foundation of Beijing Municipality(2222075)National Natural Science Foundation of China(22279010,21671020,51673026)Analysis&Testing Center,Beijing Institute of Technology.
文摘Moisture-enabled electricity(ME)is a method of converting the potential energy of water in the external environment into electrical energy through the interaction of functional materials with water molecules and can be directly applied to energy harvesting and signal expression.However,ME can be unreliable in numerous applications due to its sluggish response to moisture,thus sacrificing the value of fast energy harvesting and highly accurate information representation.Here,by constructing a moisture-electric-moisture-sensitive(ME-MS)heterostructure,we develop an efficient ME generator with ultra-fast electric response to moisture achieved by triggering Grotthuss protons hopping in the sensitized ZnO,which modulates the heterostructure built-in interfacial potential,enables quick response(0.435 s),an unprecedented ultra-fast response rate of 972.4 mV s^(−1),and a durable electrical signal output for 8 h without any attenuation.Our research provides an efficient way to generate electricity and important insight for a deeper understanding of the mechanisms of moisture-generated carrier migration in ME generator,which has a more comprehensive working scene and can serve as a typical model for human health monitoring and smart medical electronics design.
基金funded by the project entitled Technical Countermeasures for the Quantitative Characterization and Adjustment of Residual Gas in Tight Sandstone Gas Reservoirs of the Daniudi Gas Field(P20065-1)organized by the Science&Technology R&D Department of Sinopec.
文摘Based on an analysis of the limitations of conventional production component methods for natural gas development planning,this study proposes a new one that uses life cycle models for the trend fitting and prediction of production.In this new method,the annual production of old and new wells is predicted by year first and then is summed up to yield the production for the planning period.It shows that the changes in the production of old wells in old blocks can be fitted and predicted using the vapor pressure model(VPM),with precision of 80%e95%,which is 6.6%e13.2%higher than that of other life cycle models.Furthermore,a new production prediction process and method for new wells have been established based on this life cycle model to predict the production of medium-to-shallow gas reservoirs in western Sichuan Basin,with predication error of production rate in 2021 and 2022 being 6%and 3%respectively.The new method can be used to guide the medium-and long-term planning or annual scheme preparation for gas development.It is also applicable to planning for large single gas blocks that require continuous infill drilling and adjustment to improve gas recovery.
基金funded by the project entitled Technical Countermeasures for the Quantitative Characterization and Adjustment of Residual Gas in Tight Sandstone Gas Reservoirs of the Daniudi Gas Field(P20065-1)organized by the Science&Technology R&D Department of SINOPEC.
文摘Hydrocarbon production in oil and gas fields generally progresses through stages of production ramp-up,plateau(peak),and decline during field development,with the whole process primarily modeled and forecasted using lifecycle models.SINOPEC's conventional gas reservoirs are dominated by carbonates,low-permeability tight sandstone,condensate,volcanic rocks,and medium-to-high-permeability sandstone.This study identifies the optimal production forecasting models by comparing the fitting coefficients of different models and calculating the relative errors in technically recoverable reserves.To improve forecast precision,it suggests substituting exponential smoothing method-derived predictions for anomalous data caused by subjective influences like market dynamics and maintenance activities.The preferred models for carbonate gas reservoir production forecasts are the generalized Weng's,Beta,Class-I generalized mathematical,and Hu-Chen models.The Vapor pressure and Beta models are optimal for forecasting the annual productivity of wells(APW)from gas-bearing low-permeability tight sandstone reservoirs.The Wang-Li,Beta,and Yu QT tb models are apt for moderate-to-small-reserves,single low-permeability tight sandstone gas reservoirs.The Rayleigh,Hu-Chen,and generalized Weng's models are suitable for condensate gas reservoirs.For medium-to-high-permeability sandstone gas reservoirs,the lognormal,generalized gamma,and Beta models are recommended.
基金This work was supported by grants from the Beijing Committee of Science and Technology(Grant No.Z181100001718162)the Fundamental Research Funds for the Central Universities(Grant No.3332020071)+2 种基金the CAMS Innovation Fund for Medical Sciences(Grant No.2018-I2M-1-002)the Capital’s Funds for Health Improvement and Research(Grant No.2018-4-4089)the Beijing Municipal Natural Science Foundation(Grant No.7182178).
文摘Objective:Acute myeloid leukemia(AML)is primarily a malignant disorder affecting the elderly.We aimed to compare the outcomes of different treatment patterns in elderly AML patients and to propose a prognostic scoring system that could predict survival and aid therapeutic decisions.Methods:Patients aged≥60 years who had been diagnosed with AML at 7 hospitals in China were enrolled(n=228).Treatment patterns included standard chemotherapy,low intensity therapy,and best supportive care(BSC).Results:The early mortality rates were 31%,6.8%,and 6.3%for the BSC,low intensity therapy,and standard chemotherapy groups,respectively.The complete remission rate of the standard chemotherapy group was higher than that of the low intensity therapy group.The median overall survival(OS)was 561 days and 222 days for the standard chemotherapy and low intensity therapy groups,respectively,and were both longer than that of the BSC group(86 days).Based on multivariate analyses,we defined a prognostic scoring system that enabled classification of patients into 3 risk groups,in an attempt to predict the OS of patients receiving chemotherapies and low intensity therapies.Low and intermediate risk patients benefited more from standard chemotherapies than from low intensity therapies.However,the median OS was comparable between standard chemotherapies and low intensity therapies in high risk patients.Conclusions:Our prognostic scoring system could predict survival and help select appropriate therapies for elderly AML patients.Standard chemotherapy is important for elderly AML patients,particularly for those categorized into low and intermediate risk groups.
基金funded by The National Key Research and Development Program of China(grant nos.2021YFF1000101 to S.H.and 2022YFD1200300 to X.D.)the National Natural Science Foundation of China(grant no.32122062 to S.H.)the Agricultural Science,Technology Innovation Program of the Chinese Academy of Agricultural Sciences and Henan Provincial Department of Science and Technology research project(grant no.232102111076).
文摘Optimal plant height is crucial in modern agriculture, influencing lodging resistance and facilitating mechanized crop production. Upland cotton (Gossypium hirsutum) is the most important fiber crop globally;however, the genetic basis underlying plant height remains largely unexplored. In this study, we conducted a genome-wide association study to identify a major locus controlling plant height (PH1) in upland cotton. This locus encodes gibberellin 2-oxidase 1A (GhPH1) and features a 1133-bp structural variation (PAVPH1) located approximately 16 kb upstream. The presence or absence of PAVPH1 influences the expression of GhPH1, thereby affecting plant height. Further analysis revealed that a gibberellin-regulating transcription factor (GhGARF) recognizes and binds to a specific CATTTG motif in both the GhPH1 promoter and PAVPH1. This interaction downregulates GhPH1, indicating that PAVPH1 functions as a distant upstream silencer. Intriguingly, we found that DWARF53 (D53), a key repressor of the strigolactone (SL) signaling pathway, directly interacts with GhGARF to inhibit its binding to targets. Moreover, we identified a previously unrecognized gibberellin-SL crosstalk mechanism mediated by the GhD53-GhGARF-GhPH1/PAVPH1 module, which is crucial for regulating plant height in upland cotton. These findings shed light on the genetic basis and gene interaction network underlying plant height, providing valuable insights for the development of semi-dwarf cotton varieties through precise modulation of GhPH1 expression.
基金sponsored by the NSFC(grant nos.21671020,51673026,22035005,and 52073159)the Natural Science Foundation of Beijing Municipality(grant no.2222075)+1 种基金the National Key R&D Program of China(grant no.2017YFB1104300)the Analysis&Testing Center,Beijing Institute of Technology.
文摘Aqueous rechargeable batteries with high safety have been considered as the main energy source to power portable and wearable electronics.Herein,we report the first construction of quasi-solid-state aqueous tin-iodine batteries by exploiting Sn foil as anode,carbon cloth as cathode,and gel electrolytes.The anode reversibly converts from K_(2)Sn(OH)_(6) to metal Sn,thus eliminating the formation of metal dendrites.Meanwhile,gel electrolytes alleviate anode corrosion and enhance the utilization of the anode.Therefore,the asfabricated quasi-solid-state batteries manifest an areal capacity of 700μAh cm^(-2)(211 mAh g^(-1) equal to theoretical capacity)and excellent cycling stability without obvious capacity degradation after 120 cycles at 1mA cm^(-2).Remarkably,the designed batteries sealed by different package materials including plastic,glass,wood,and cardboard operated steadily,thereby enlarging the application scenario for these batteries.This work enriches the family of aqueous rechargeable batteries and sheds light on the construction of high-performance quasi-solid-state aqueous batteries.