Backround N-terminal pro-brain natriuretic peptide （NT-proBNP） is a reliable predictor in acute coronary artery disease （CAD）. Little is known about patients with stable CAD, especially Chinese patients with CAD. ...Backround N-terminal pro-brain natriuretic peptide （NT-proBNP） is a reliable predictor in acute coronary artery disease （CAD）. Little is known about patients with stable CAD, especially Chinese patients with CAD. The aim of the present study was to investigate the association of NT-proBNP levels with the severity of CAD in patients with normal left ventricular ejection fraction. Methods A total of 658 consecutive patients were divided into two groups based on angiograms： CAD group （n=484） and angiographic normal control group （n=174）. The severity of CAD was evaluated by modified Gensini score, and its relationship with NT-proBNP was analyzed. Results The prevalence of risk factors such as age, male gender, diabetes mellitus （DM）, dyslipidemia, smoking, and family history of CAD in the CAD group were higher than that in the control group. In multivariate regression model analysis, age, gender, and DM were determinants of the presence of CAD. NT-pro BNP was found to be an independent predictor for CAD （OR：1.66 （95% CI： 1.06-2.61）, P 〈0.05）. In a receiver operating characteristic （ROC）curve analysis, an NT-proBNP value of 641.15 pmol/L was identified as a cut-off value in the diagnosis or exclusion of CAD （area under curve （AUC）=0.56, 95% CI： 0.51-0.61）. Furthermore, NT-proBNP was positively correlated with Gensini score （r=0.14, P 〈0.001） in patients with CAD. Conclusion NT-proBNP was an independent predictor for Chinese patients with CAD, suggesting that the NT-proBNP level might be associated with the presence and the severity of CAD.展开更多
基于机器学习(Machine Learning,ML)的天气预报模型近些年取得了显著进展,展示了优越的预报性能.与欧洲中期天气预报中心(European Centre for Medium-Range Weather Forecasts,ECMWF)的高分辨率预报(High-Resolution Forecasts,HRES)相...基于机器学习(Machine Learning,ML)的天气预报模型近些年取得了显著进展,展示了优越的预报性能.与欧洲中期天气预报中心(European Centre for Medium-Range Weather Forecasts,ECMWF)的高分辨率预报(High-Resolution Forecasts,HRES)相比,FuXi等先进的基于ML的天气预报模型,在统计预报指标上表现出色.然而,这些模型存在着共同的局限性,即随着预报时间步长的增加,预报结果趋于平滑,导致极端天气事件强度的低估.为了解决这一问题,本文研发了FuXi-Extreme模型.该模型采用去噪扩散概率模型(Denoising Diffusion Probabilistic Model,DDPM),增强了FuXi模型在5天预报中的地表预报数据细节.对极端总降水量(Total Precipitation,TP)、10m风速(10-meter Wind Speed,WS10)和2m温度(2-meter Temperature,T2M)的评估表明,FuXi-Extreme在性能上优于FuXi和HRES.此外,基于国际热带气旋最佳路径资料集(International Best Track Archive for Climate Stewardship,IBTrACS)的评估显示,与HRES相比,FuXi和FuXi-Extreme在热带气旋(Tropical Cyclone,TC)路径预报方面表现优异,但在TC强度预报方面仍有不足.展开更多
文章报道了发现于西藏东南部芒康盆地上始新统的鼠李科植物叶化石标本.化石叶缘全缘或微波状,二级脉间距规则,弧曲向上并与其上的二级脉在叶缘处结合并与叶缘融合,形成真曲脉序;二级脉在中上部较为密集,三级脉密集相互平行,横贯二级脉之...文章报道了发现于西藏东南部芒康盆地上始新统的鼠李科植物叶化石标本.化石叶缘全缘或微波状,二级脉间距规则,弧曲向上并与其上的二级脉在叶缘处结合并与叶缘融合,形成真曲脉序;二级脉在中上部较为密集,三级脉密集相互平行,横贯二级脉之间,这些叶脉特征与美洲分布的灭绝类群——似勾儿茶叶属(Berhamniphyllum Jones and Dilcher)非常相似.百分之四十的二级脉集中于叶的上半部是当前化石的一个典型特征,未见于该属的其他类群,于是将当前化石定为君容似勾儿茶叶新种(Berhamniphyllum junrongiae Z. K. Zhou, T. X. Wang et J.Huang sp. nov.).进一步研究发现,仅凭叶脉特征不能将勾儿茶属(Berchemia)和Rhamnidium、Karwinskia等三个属区分开来,似勾儿茶叶属(Berhamniphyllum)代表了这几个属的一个灭绝的共同祖先,本文对产于云南和山东等地三种勾儿茶属化石进行了归并,并将其归并入似勾儿茶叶属中.根据形态学、分子系统证据和化石记录,将勾儿茶属、Rhamnidium、Karwinskia和似勾儿茶叶属定义为勾儿茶复合群(Berchemia complex).本文还讨论了勾儿茶复合群地理分布格局的演变历史,认为勾儿茶复合群于晚白垩世晚期起源于南美哥伦比亚,在始新世经中美洲扩散到北美,后又从北美经过北大西洋陆桥扩散至欧洲并从欧洲扩散至非洲.东亚的勾儿茶复合群是经白令陆桥扩散而来,时间不晚于始新世,这一类群在东亚最早出现于西藏芒康,其后再扩散至亚洲其他地区.展开更多
基金Wu Naqiong and Ma Fenglian contributed equally to this study. This work is partly supported by grants from National Natural Scientific Foundation of China （No. 81070171 and No. 81241121）, Specialized Research Fund for the Doctoral Program of Higher Education of China （No. 20111106110013）, Capital Special Foundation of Clinical Application Research （No. Z121107001012015）, Capital Health Development Fund （No. 2011400302）, and Beijing Natural Science Foundation （No. 7131014） No conflict of interest needs to be declared.
文摘Backround N-terminal pro-brain natriuretic peptide （NT-proBNP） is a reliable predictor in acute coronary artery disease （CAD）. Little is known about patients with stable CAD, especially Chinese patients with CAD. The aim of the present study was to investigate the association of NT-proBNP levels with the severity of CAD in patients with normal left ventricular ejection fraction. Methods A total of 658 consecutive patients were divided into two groups based on angiograms： CAD group （n=484） and angiographic normal control group （n=174）. The severity of CAD was evaluated by modified Gensini score, and its relationship with NT-proBNP was analyzed. Results The prevalence of risk factors such as age, male gender, diabetes mellitus （DM）, dyslipidemia, smoking, and family history of CAD in the CAD group were higher than that in the control group. In multivariate regression model analysis, age, gender, and DM were determinants of the presence of CAD. NT-pro BNP was found to be an independent predictor for CAD （OR：1.66 （95% CI： 1.06-2.61）, P 〈0.05）. In a receiver operating characteristic （ROC）curve analysis, an NT-proBNP value of 641.15 pmol/L was identified as a cut-off value in the diagnosis or exclusion of CAD （area under curve （AUC）=0.56, 95% CI： 0.51-0.61）. Furthermore, NT-proBNP was positively correlated with Gensini score （r=0.14, P 〈0.001） in patients with CAD. Conclusion NT-proBNP was an independent predictor for Chinese patients with CAD, suggesting that the NT-proBNP level might be associated with the presence and the severity of CAD.
文摘文章报道了发现于西藏东南部芒康盆地上始新统的鼠李科植物叶化石标本.化石叶缘全缘或微波状,二级脉间距规则,弧曲向上并与其上的二级脉在叶缘处结合并与叶缘融合,形成真曲脉序;二级脉在中上部较为密集,三级脉密集相互平行,横贯二级脉之间,这些叶脉特征与美洲分布的灭绝类群——似勾儿茶叶属(Berhamniphyllum Jones and Dilcher)非常相似.百分之四十的二级脉集中于叶的上半部是当前化石的一个典型特征,未见于该属的其他类群,于是将当前化石定为君容似勾儿茶叶新种(Berhamniphyllum junrongiae Z. K. Zhou, T. X. Wang et J.Huang sp. nov.).进一步研究发现,仅凭叶脉特征不能将勾儿茶属(Berchemia)和Rhamnidium、Karwinskia等三个属区分开来,似勾儿茶叶属(Berhamniphyllum)代表了这几个属的一个灭绝的共同祖先,本文对产于云南和山东等地三种勾儿茶属化石进行了归并,并将其归并入似勾儿茶叶属中.根据形态学、分子系统证据和化石记录,将勾儿茶属、Rhamnidium、Karwinskia和似勾儿茶叶属定义为勾儿茶复合群(Berchemia complex).本文还讨论了勾儿茶复合群地理分布格局的演变历史,认为勾儿茶复合群于晚白垩世晚期起源于南美哥伦比亚,在始新世经中美洲扩散到北美,后又从北美经过北大西洋陆桥扩散至欧洲并从欧洲扩散至非洲.东亚的勾儿茶复合群是经白令陆桥扩散而来,时间不晚于始新世,这一类群在东亚最早出现于西藏芒康,其后再扩散至亚洲其他地区.
